Gene Human Homo sapiens

PPIE

peptidylprolyl isomerase E

gene with protein product

Human PPIEMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 1p34.2NCBI: 1:39,738,882-39,763,914 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000001.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 1:39,692,182-39,766,108 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: CyP-33, MGC3736, MGC111222, CypE

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:9258

Silence this gene

The order page opens with PPIE and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for PPIE

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What PPIE does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From PPIE to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

PPIE

Reading the record for PPIE from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for PPIE opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What PPIE does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where PPIE is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein PPIE encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with PPIE

Waiting for the record before reading STRING.

06 Pathways

Where PPIE acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to PPIE

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of PPIE

Waiting for the record before reading ClinVar.

09 Constraint

How much variation PPIE tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within PPIE

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the PPIE locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention PPIE

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_006112.4matches ENST00000324379.10	transcript variant 1	protein coding	MANE Select	10	4,339 nt	301 aaNP_006103.1	Ready in a moment
XM_006710290.5matches ENST00000871304.2	transcript variant X4	protein coding model	none	10	4,300 nt	288 aaXP_006710353.1	Ready in a moment
XM_047430138.1matches ENST00000497370.5	transcript variant X5	protein coding model	none	11	1,583 nt	248 aaXP_047286094.1	Ready in a moment
XM_047430061.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_006112.4matches ENST00000324379.10	transcript variant 1	protein coding	MANE Select	10	4,339 nt	301 aaNP_006103.1	Ready in a moment
XM_006710290.5matches ENST00000871304.2	transcript variant X4	protein coding model	none	10	4,300 nt	288 aaXP_006710353.1	Ready in a moment
XM_047430138.1matches ENST00000497370.5	transcript variant X5	protein coding model	none	11	1,583 nt	248 aaXP_047286094.1	Ready in a moment
XM_047430061.1	Ready in a moment

PPIE

What PPIE does

The RNA a design targets

From PPIE to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

PPIE

What PPIE does

The RNA a design targets

Where PPIE is expressed

The protein PPIE encodes

Proteins STRING associates with PPIE

Where PPIE acts, as Reactome curates it

Diseases linked to PPIE

Classified variants of PPIE

How much variation PPIE tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within PPIE

Long non-coding RNAs at the PPIE locus

Papers that mention PPIE

PPIE

What PPIE does

Gene summary

Protein function

The RNA a design targets

RefSeq 13 transcripts

A window on one transcript

Ensembl 80 transcripts

A window on one transcript

From PPIE to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where PPIE is expressed

The protein PPIE encodes

Proteins STRING associates with PPIE

Where PPIE acts, as Reactome curates it

Diseases linked to PPIE

Classified variants of PPIE

How much variation PPIE tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within PPIE

Long non-coding RNAs at the PPIE locus

Papers that mention PPIE

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 13 transcripts

A window on one transcript

Ensembl 80 transcripts

A window on one transcript