Gene Human Homo sapiens

SYCP1

synaptonemal complex protein 1

gene with protein product

Human SYCP1MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 1p13.2NCBI: 1:114,854,088-114,995,370 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000001.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 1:114,854,836-114,995,370 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: HOM-TES-14, SCP1, CT8

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-03 ET · HGNC:11487

Silence this gene

The order page opens with SYCP1 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for SYCP1

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What SYCP1 does

Enables double-stranded DNA binding activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where SYCP1 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein SYCP1 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with SYCP1

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where SYCP1 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to SYCP1

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of SYCP1

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation SYCP1 tolerates

pLI 0.05790 and LOEUF 0.515 in gnomAD v4 (GRCh38), on ENST00000369522.8.

gnomAD

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within SYCP1

No annotated microRNA lies within SYCP1 in Ensembl release 116, on GRCh38.p14.

Ensembl · miRBase

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12 Long non-coding RNAs

Long non-coding RNAs at the SYCP1 locus

1 long non-coding RNA gene overlaps SYCP1 in Ensembl release 116, antisense, without a symbol.

Ensembl

Order against a long non-coding RNA

Ready in a moment

13 Literature

Papers that mention SYCP1

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From SYCP1 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for SYCP1 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

SYCP1

Reading the record for SYCP1 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for SYCP1 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What SYCP1 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where SYCP1 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein SYCP1 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with SYCP1

Waiting for the record before reading STRING.

06 Pathways

Where SYCP1 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to SYCP1

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of SYCP1

Waiting for the record before reading ClinVar.

09 Constraint

How much variation SYCP1 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within SYCP1

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the SYCP1 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention SYCP1

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_003176.4matches ENST00000369522.8	transcript variant 1	protein coding	MANE Select	32	3,462 nt	976 aaNP_003167.2	Ready in a moment
XM_017002184.2	transcript variant X2	protein coding model	none	32	3,505 nt	976 aaXP_016857673.1	Ready in a moment
XM_006710859.2matches ENST00000369518.2	transcript variant X1	protein coding model	none	32	3,499 nt	976 aaXP_006710922.1	Ready in a moment
NM_001282541.2matches ENST00000618516.4	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_003176.4matches ENST00000369522.8	transcript variant 1	protein coding	MANE Select	32	3,462 nt	976 aaNP_003167.2	Ready in a moment
XM_017002184.2	transcript variant X2	protein coding model	none	32	3,505 nt	976 aaXP_016857673.1	Ready in a moment
XM_006710859.2matches ENST00000369518.2	transcript variant X1	protein coding model	none	32	3,499 nt	976 aaXP_006710922.1	Ready in a moment
NM_001282541.2matches ENST00000618516.4	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000369522.8matches NM_003176.4	SYCP1-202	protein coding	MANE SelectEnsembl canonical	32	3,462 nt	976 aaENSP00000358535.3	Ready in a moment
ENST00001145255.1	SYCP1-216	protein coding	none	32	3,489 nt	976 aaENSP00000809567.1	Ready in a moment
ENST00000369518.2	SYCP1-201	protein coding	none	32	3,455 nt	976 aaENSP00000358531.1	Ready in a moment
ENST00000618516.4	SYCP1-210	protein coding	none	32	3,109 nt	976 aaENSP00000480997.1	Ready in a moment
ENST00000613524.4	SYCP1-209	protein coding	none	31	3,034 nt	951 aaENSP00000482532.1	Ready in a moment
ENST00000455987.5	SYCP1-203	protein coding	none	28	2,554 nt	792 aaENSP00000410011.1	Ready in a moment
ENST00001128635.1	SYCP1-215	protein coding	none	7	1,242 nt	152 aaENSP00000798440.1	Ready in a moment
ENST00001098243.1	SYCP1-211	protein coding	none	9	1,017 nt	204 aaENSP00000768049.1	Ready in a moment
ENST00001098246.1	SYCP1-214	protein coding	none	8	1,014 nt	204 aaENSP00000768052.1	Ready in a moment
ENST00001098245.1	SYCP1-213	protein coding	none	9	1,006 nt	204 aaENSP00000768051.1	Ready in a moment
ENST00001098244.1	SYCP1-212	protein coding	none	9	913 nt	172 aaENSP00000768050.1	Ready in a moment
ENST00000477590.1	SYCP1-206	protein coding cds not defined	none	4	800 nt	none	Ready in a moment
ENST00000493377.1	SYCP1-208	protein coding cds not defined	none	5	783 nt	none	Ready in a moment
ENST00000482717.5	SYCP1-207	protein coding cds not defined	none	9	763 nt	none	Ready in a moment
ENST00000477215.5	SYCP1-205	protein coding cds not defined	none	6	579 nt	none	Ready in a moment
ENST00000468191.1	SYCP1-204	protein coding cds not defined	none	3	396 nt	none	Ready in a moment

SYCP1

What SYCP1 does

The RNA a design targets

Where SYCP1 is expressed

The protein SYCP1 encodes

Proteins STRING associates with SYCP1

Where SYCP1 acts, as Reactome curates it

Diseases linked to SYCP1

Classified variants of SYCP1

How much variation SYCP1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within SYCP1

Long non-coding RNAs at the SYCP1 locus

Papers that mention SYCP1

From SYCP1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

SYCP1

What SYCP1 does

The RNA a design targets

Where SYCP1 is expressed

The protein SYCP1 encodes

Proteins STRING associates with SYCP1

Where SYCP1 acts, as Reactome curates it

Diseases linked to SYCP1

Classified variants of SYCP1

How much variation SYCP1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within SYCP1

Long non-coding RNAs at the SYCP1 locus

Papers that mention SYCP1

SYCP1

What SYCP1 does

Gene summary

Protein function

The RNA a design targets

RefSeq 12 transcripts

A window on one transcript

Ensembl 16 transcripts

A window on one transcript

Where SYCP1 is expressed

The protein SYCP1 encodes

Proteins STRING associates with SYCP1

Where SYCP1 acts, as Reactome curates it

Diseases linked to SYCP1

Classified variants of SYCP1

How much variation SYCP1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within SYCP1

Long non-coding RNAs at the SYCP1 locus

Papers that mention SYCP1

From SYCP1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 12 transcripts

A window on one transcript

Ensembl 16 transcripts

A window on one transcript