Gene Human Homo sapiens

TBL1Y

transducin beta like 1 Y-linked

gene with protein product

Human TBL1YMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band Yp11.2NCBI: Y:6,910,697-7,091,683 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000024.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: Y:6,910,562-7,101,970 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: TBL1

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:18502

Silence this gene

The order page opens with TBL1Y and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for TBL1Y

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What TBL1Y does

The protein encoded by this gene has sequence similarity with members of the…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where TBL1Y is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

04 Protein

The protein TBL1Y encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with TBL1Y

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where TBL1Y acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to TBL1Y

39 Open Targets disease associations; nonsyndromic deafness first, at 0.24.

Open Targets

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08 Variants

Classified variants of TBL1Y

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation TBL1Y tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within TBL1Y

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the TBL1Y locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention TBL1Y

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From TBL1Y to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for TBL1Y Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

TBL1Y

Reading the record for TBL1Y from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for TBL1Y opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What TBL1Y does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where TBL1Y is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein TBL1Y encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with TBL1Y

Waiting for the record before reading STRING.

06 Pathways

Where TBL1Y acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to TBL1Y

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of TBL1Y

Waiting for the record before reading ClinVar.

09 Constraint

How much variation TBL1Y tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within TBL1Y

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the TBL1Y locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention TBL1Y

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_033284.2matches ENST00000383032.6	transcript variant 1	protein coding	MANE Select	19	2,396 nt	522 aaNP_150600.1	Ready in a moment
NM_134258.2matches ENST00000355162.7	transcript variant 2	protein coding	none	18	2,365 nt	522 aaNP_599020.1	Ready in a moment
NM_134259.2matches ENST00000346432.4	transcript variant 3	protein coding	none	18	2,301 nt	522 aaNP_599021.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_033284.2matches ENST00000383032.6	transcript variant 1	protein coding	MANE Select	19	2,396 nt	522 aaNP_150600.1	Ready in a moment
NM_134258.2matches ENST00000355162.7	transcript variant 2	protein coding	none	18	2,365 nt	522 aaNP_599020.1	Ready in a moment
NM_134259.2matches ENST00000346432.4	transcript variant 3	protein coding	none	18	2,301 nt	522 aaNP_599021.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000383032.6matches NM_033284.2	TBL1Y-203	protein coding	MANE SelectEnsembl canonical	19	2,396 nt	522 aaENSP00000372499.1	Ready in a moment
ENST00001131397.1	TBL1Y-206	protein coding	none	19	6,023 nt	522 aaENSP00000811350.1	Ready in a moment
ENST00000355162.7	TBL1Y-202	protein coding	none	18	5,992 nt	522 aaENSP00000347289.2	Ready in a moment
ENST00000346432.4	TBL1Y-201	protein coding	none	18	5,928 nt	522 aaENSP00000328879.4	Ready in a moment
ENST00000973318.1	TBL1Y-205	nonsense mediated decay	none	18	2,121 nt	163 aaENSP00000643135.1	Ready in a moment
ENST00000651523.1	TBL1Y-204	protein coding	none	5	523 nt	139 aaENSP00000498861.1	Ready in a moment

TBL1Y

What TBL1Y does

The RNA a design targets

Where TBL1Y is expressed

The protein TBL1Y encodes

Proteins STRING associates with TBL1Y

Where TBL1Y acts, as Reactome curates it

Diseases linked to TBL1Y

Classified variants of TBL1Y

How much variation TBL1Y tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TBL1Y

Long non-coding RNAs at the TBL1Y locus

Papers that mention TBL1Y

From TBL1Y to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

TBL1Y

What TBL1Y does

The RNA a design targets

Where TBL1Y is expressed

The protein TBL1Y encodes

Proteins STRING associates with TBL1Y

Where TBL1Y acts, as Reactome curates it

Diseases linked to TBL1Y

Classified variants of TBL1Y

How much variation TBL1Y tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TBL1Y

Long non-coding RNAs at the TBL1Y locus

Papers that mention TBL1Y

TBL1Y

What TBL1Y does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

A window on one transcript

Ensembl 6 transcripts

A window on one transcript

Where TBL1Y is expressed

The protein TBL1Y encodes

Proteins STRING associates with TBL1Y

Where TBL1Y acts, as Reactome curates it

Diseases linked to TBL1Y

Classified variants of TBL1Y

How much variation TBL1Y tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TBL1Y

Long non-coding RNAs at the TBL1Y locus

Papers that mention TBL1Y

From TBL1Y to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

A window on one transcript

Ensembl 6 transcripts

A window on one transcript