Gene Human Homo sapiens

TH

tyrosine hydroxylase

gene with protein product

Human THMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 11p15.5NCBI: 11:2,163,929-2,171,815 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000011.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 11:2,163,929-2,171,968 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: DYT5b

Gene identity, from HGNC · HGNC 2026-09-25 · read 2026-09-26 ET · HGNC:11782

Silence this gene

The order page opens with TH and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for TH

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

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Ready in a moment

01 Summary and function

What TH does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From TH to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

TH

Reading the record for TH from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for TH opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What TH does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where TH is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein TH encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with TH

Waiting for the record before reading STRING.

06 Pathways

Where TH acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to TH

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of TH

Waiting for the record before reading ClinVar.

09 Constraint

How much variation TH tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within TH

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the TH locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention TH

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_000360.4matches ENST00000352909.8	transcript variant 2	protein coding	MANE Select	13	1,827 nt	497 aaNP_000351.2	Ready in a moment
NM_199292.3matches ENST00000381178.6	transcript variant 1	protein coding	none	14	1,920 nt	528 aaNP_954986.2	Ready in a moment
NM_199293.3matches ENST00000381175.6	transcript variant 3	protein coding	none	14	1,908 nt	524 aaNP_954987.2	Ready in a moment
NM_001440535.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_000360.4matches ENST00000352909.8	transcript variant 2	protein coding	MANE Select	13	1,827 nt	497 aaNP_000351.2	Ready in a moment
NM_199292.3matches ENST00000381178.6	transcript variant 1	protein coding	none	14	1,920 nt	528 aaNP_954986.2	Ready in a moment
NM_199293.3matches ENST00000381175.6	transcript variant 3	protein coding	none	14	1,908 nt	524 aaNP_954987.2	Ready in a moment
NM_001440535.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000352909.8matches NM_000360.4	TH-203	protein coding	MANE SelectEnsembl canonical	13	1,827 nt	497 aaENSP00000325951.4	Ready in a moment
ENST00001123688.1	TH-217	nonsense mediated decay	none	12	2,194 nt	69 aaENSP00000793493.1	Ready in a moment
ENST00000941211.2	TH-213	protein coding	none	13	2,156 nt	556 aaENSP00000611270.1	Ready in a moment
ENST00000381178.6	TH-206	protein coding	none	14	2,073 nt	528 aaENSP00000370571.1	Ready in a moment
ENST00000853117.2	TH-212	protein coding	none	13	1,992 nt	501 aaENSP00000523176.1	Ready in a moment
ENST00000941212.2	TH-214	protein coding	none	13	1,991 nt	552 aaENSP00000611271.1	Ready in a moment
ENST00000381175.6	TH-205	protein coding	none	14	1,908 nt	524 aaENSP00000370567.1	Ready in a moment
ENST00001123687.1	TH-216	nonsense mediated decay	none	13	1,814 nt	69 aaENSP00000793492.1	Ready in a moment
ENST00001014565.1	TH-215	nonsense mediated decay	none	13	1,662 nt	48 aaENSP00000684382.1	Ready in a moment
ENST00000333684.10	TH-202	protein coding	none	11	1,545 nt	403 aaENSP00000328814.6	Ready in a moment
ENST00000324155.8	TH-201	nonsense mediated decay	none	12	1,115 nt	44 aaENSP00000325831.3	Ready in a moment
ENST00000381168.7	TH-204	nonsense mediated decay	none	10	985 nt	48 aaENSP00000370560.3	Ready in a moment
ENST00000416223.5	TH-208	nonsense mediated decay	none	7	483 nt	45 aaENSP00000403440.1	Ready in a moment
ENST00000412076.1	TH-207	protein coding	none	6	347 nt	116 aaENSP00000403546.1	Ready in a moment
ENST00000469226.1	TH-210	retained intron	none	4	963 nt	none	Ready in a moment
ENST00000461172.1	TH-209	retained intron	none	2	839 nt	none	Ready in a moment
ENST00000479437.5	TH-211	retained intron	none	5	745 nt	none	Ready in a moment

TH

What TH does

The RNA a design targets

From TH to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

TH

What TH does

The RNA a design targets

Where TH is expressed

The protein TH encodes

Proteins STRING associates with TH

Where TH acts, as Reactome curates it

Diseases linked to TH

Classified variants of TH

How much variation TH tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TH

Long non-coding RNAs at the TH locus

Papers that mention TH

TH

What TH does

Gene summary

Protein function

The RNA a design targets

RefSeq 6 transcripts

A window on one transcript

Ensembl 17 transcripts

A window on one transcript

From TH to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where TH is expressed

The protein TH encodes

Proteins STRING associates with TH

Where TH acts, as Reactome curates it

Diseases linked to TH

Classified variants of TH

How much variation TH tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TH

Long non-coding RNAs at the TH locus

Papers that mention TH

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 6 transcripts

A window on one transcript

Ensembl 17 transcripts

A window on one transcript