Gene Human Homo sapiens

TRAV8-6

T cell receptor alpha variable 8-6

T cell receptor gene

Mouse: no ortholog is named for this gene: the Alliance, NCBI and Ensembl Compara answered and named none.
Rat: no ortholog is named for this gene: the Alliance, NCBI and Ensembl Compara answered and named none.

HGNC lists no MANE Select pair for this gene.

Location: Cytogenetic band 14q11.2NCBI: 14:21,978,679-21,979,120 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000014.9, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 14:21,978,459-21,979,120 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-03 ET · HGNC:12151

Silence this gene

The order page opens with TRAV8-6 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for TRAV8-6

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What TRAV8-6 does

NCBI Gene answered in a shape this page does not read, so nothing is shown for the gene summary. Reference 668a4f0a-3c3.

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

0 RefSeq and 1 Ensembl transcript on GRCh38.p14; Ensembl canonical ENST00000390443.3.

NCBI Datasets · Ensembl

Ready in a moment

03 Expression by tissue

Where TRAV8-6 is expressed

54 GTEx tissues; the highest median in Whole Blood, 2.28 TPM.

GTEx

Ready in a moment

04 Protein

The protein TRAV8-6 encodes

113 residues, reviewed A0A0B4J262; 9 entries from the member databases this page shows along the chain; mean pLDDT 90.38; no experimental structure at PDBe.

UniProt · InterPro · AlphaFold DB · PDBe

Ready in a moment

05 Interactions

Proteins STRING associates with TRAV8-6

STRING v12.0 has no protein named TRAV8-6 in human.

STRING

Ready in a moment

06 Pathways

Where TRAV8-6 acts, as Reactome curates it

Reactome v97 maps no pathway to A0A0B4J262 in human.

Reactome

Ready in a moment

07 Disease associations

Diseases linked to TRAV8-6

6 Open Targets disease associations; bacterial infectious disease with sepsis first, at 0.01.

Open Targets

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08 Variants

Classified variants of TRAV8-6

ClinVar: 20 records for TRAV8-6, 9 pathogenic or likely pathogenic.

ClinVar

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09 Constraint

How much variation TRAV8-6 tolerates

pLI none and LOEUF none in gnomAD v4 (GRCh38).

gnomAD

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10 Orthologs

The same gene in mouse, rat and human

Mouse: no ortholog named by the 3 votes that answered; rat: no ortholog named by the 3 votes that answered. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 658d7460-b29.

Alliance · NCBI · Ensembl Compara

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within TRAV8-6

No annotated microRNA lies within TRAV8-6 in Ensembl release 116, on GRCh38.p14.

Ensembl · miRBase

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the TRAV8-6 locus

No annotated long non-coding RNA overlaps TRAV8-6 in Ensembl release 116, on GRCh38.p14.

Ensembl

Ready in a moment

13 Literature

Papers that mention TRAV8-6

284 PubMed-indexed papers mention TRAV8-6 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.

Europe PMC

Ready in a moment

14 Silencing this gene

From TRAV8-6 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for TRAV8-6 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

TRAV8-6

Reading the record for TRAV8-6 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for TRAV8-6 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What TRAV8-6 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where TRAV8-6 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein TRAV8-6 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with TRAV8-6

Waiting for the record before reading STRING.

06 Pathways

Where TRAV8-6 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to TRAV8-6

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of TRAV8-6

Waiting for the record before reading ClinVar.

09 Constraint

How much variation TRAV8-6 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within TRAV8-6

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the TRAV8-6 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention TRAV8-6

Waiting for the record before reading Europe PMC.

TRAV8-6

T cell receptor alpha variable 8-6

T cell receptor gene

Mouse: no ortholog is named for this gene: the Alliance, NCBI and Ensembl Compara answered and named none.
Rat: no ortholog is named for this gene: the Alliance, NCBI and Ensembl Compara answered and named none.

HGNC lists no MANE Select pair for this gene.

Location

Cytogenetic band 14q11.2NCBI: 14:21,978,679-21,979,120 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000014.9, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 14:21,978,459-21,979,120 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-03 ET · HGNC:12151

Ensembl transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000390443.3	TRAV8-6-201	tr v gene	Ensembl canonical	2	561 nt	113 aaENSP00000450505.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

ENST00000390443.3

TRAV8-6-201

tr v gene

Ensembl canonical

561 nt

113 aaENSP00000450505.1

Ready in a moment

From TRAV8-6 to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Run the controls

A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.

Pick the product

AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

For research use only. Not for use in diagnostic or therapeutic procedures.

Ensembl transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000390443.3	TRAV8-6-201	tr v gene	Ensembl canonical	2	561 nt	113 aaENSP00000450505.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

ENST00000390443.3

TRAV8-6-201

tr v gene

Ensembl canonical

561 nt

113 aaENSP00000450505.1

Ready in a moment

TRAV8-6

What TRAV8-6 does

The RNA a design targets

Where TRAV8-6 is expressed

The protein TRAV8-6 encodes

Proteins STRING associates with TRAV8-6

Where TRAV8-6 acts, as Reactome curates it

Diseases linked to TRAV8-6

Classified variants of TRAV8-6

How much variation TRAV8-6 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TRAV8-6

Long non-coding RNAs at the TRAV8-6 locus

Papers that mention TRAV8-6

From TRAV8-6 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

TRAV8-6

What TRAV8-6 does

The RNA a design targets

Where TRAV8-6 is expressed

The protein TRAV8-6 encodes

Proteins STRING associates with TRAV8-6

Where TRAV8-6 acts, as Reactome curates it

Diseases linked to TRAV8-6

Classified variants of TRAV8-6

How much variation TRAV8-6 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TRAV8-6

Long non-coding RNAs at the TRAV8-6 locus

Papers that mention TRAV8-6

TRAV8-6

What TRAV8-6 does

Gene summary

Protein function

The RNA a design targets

RefSeq 0 transcripts

Ensembl 1 transcript

A window on one transcript

Where TRAV8-6 is expressed

The protein TRAV8-6 encodes

Proteins STRING associates with TRAV8-6

Where TRAV8-6 acts, as Reactome curates it

Diseases linked to TRAV8-6

Classified variants of TRAV8-6

How much variation TRAV8-6 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TRAV8-6

Long non-coding RNAs at the TRAV8-6 locus

Papers that mention TRAV8-6

From TRAV8-6 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 0 transcripts

Ensembl 1 transcript

A window on one transcript