Reading the record for TRDMT1 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for TRDMT1 opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 10p13NCBI: 10:17,137,336-17,201,672 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000010.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 10:17,137,336-17,202,054 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
This gene encodes a protein responsible for the methylation of aspartic acid…
NCBI Gene summary
Ready in a moment
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
17 RefSeq and 41 Ensembl transcripts on GRCh38.p14; MANE Select NM_004412.7.
NCBI Datasets · Ensembl
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Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where TRDMT1 is expressed
54 GTEx tissues; the highest median in Brain - Cerebellum, 4.65 TPM.
GTEx
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04 / Protein
The protein TRDMT1 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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05 / Interactions
Proteins STRING associates with TRDMT1
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; DNMT3B, DNMT3A, DNMT3L lead.
STRING v12.0
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06 / Pathways
Where TRDMT1 acts, as Reactome curates it
Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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07 / Disease associations
Diseases linked to TRDMT1
208 Open Targets disease associations; neurodegenerative disease first, at 0.37.
Open Targets
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08 / Variants
Classified variants of TRDMT1
ClinVar: 102 records for TRDMT1, 14 pathogenic or likely pathogenic.
ClinVar
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09 / Constraint
How much variation TRDMT1 tolerates
pLI below 0.0001 and LOEUF 1.21 in gnomAD v4 (GRCh38), on ENST00000377799.8.
gnomAD
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10 / Orthologs
The same gene in mouse, rat and human
Mouse Trdmt1 by 3 of 3 votes; rat Trdmt1 by 3 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference fbbacf90-451.
Alliance · NCBI · Ensembl Compara
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11 /MicroRNAs
MicroRNAs hosted within TRDMT1
No annotated microRNA lies within TRDMT1 in Ensembl release 116, on GRCh38.p14.
Ensembl · miRBase
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12 / Long non-coding RNAs
Long non-coding RNAs at the TRDMT1 locus
1 long non-coding RNA gene overlaps TRDMT1 in Ensembl release 116, without a symbol.
Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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14 / Silencing this gene
From TRDMT1 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa.
Provided by RefSeq, Jun 2010, through NCBI Gene. NCBI disclaimer
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495)
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 1787Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
UniProtKB function · 2026_03 · read · UniProt O14717UniProt data are available under the Creative Commons Attribution 4.0 licence.
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 17 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
NM_004412.7NM_004412.7MANE Select
NM_001321007.2NM_001321007.2
NM_001351219.2NM_001351219.2
NM_001321006.2NM_001321006.2
NM_001351221.2NM_001351221.2
XM_005252374.5XM_005252374.5
XM_047424695.1XM_047424695.1
XM_047424697.1XM_047424697.1
NM_001351222.2NM_001351222.2
NM_001351223.2NM_001351223.2
NM_001351220.2NM_001351220.2
XM_024447855.2XM_024447855.2
XM_047424693.1XM_047424693.1
XM_047424694.1XM_047424694.1
XM_017015801.2XM_017015801.2
XM_047424696.1XM_047424696.1
XM_047424698.1XM_047424698.1
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 5 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Not listed, because the source places them on another assembly only: XM_054364947.1 (not placed on GRCh38.p14); XM_054364948.1 (not placed on GRCh38.p14); XM_054364949.1 (not placed on GRCh38.p14); XM_054364950.1 (not placed on GRCh38.p14); XM_054364951.1 (not placed on GRCh38.p14); XM_054364952.1 (not placed on GRCh38.p14); XM_054364953.1 (not placed on GRCh38.p14); XM_054364954.1 (not placed on GRCh38.p14); XM_054364955.1 (not placed on GRCh38.p14).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.38.0; GCF_000001405.40-RS_2025_08 · read · NCBI Gene 1787Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 41 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 7 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
391 residues, reviewed O14717; 11 entries from the member databases this page shows along the chain; mean pLDDT 87.06; 2 PDB entries.
UniProt · InterPro · AlphaFold DB · PDBe
1 curated, 0 inferred Reactome pathways for O14717 in human, v97.
Reactome
744 PubMed-indexed papers mention TRDMT1 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
