Gene Human Homo sapiens

TVP23C

trans-golgi network vesicle protein 23 homolog C

gene with protein product

Human TVP23CMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 17p12NCBI: 17:15,502,264-15,563,483 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000017.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 17:15,502,264-15,563,595 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: MGC8763
Previous symbols: FAM18B2

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-03 ET · HGNC:30453

Silence this gene

The order page opens with TVP23C and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for TVP23C

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What TVP23C does

Predicted to be involved in protein secretion and vesicle-mediated transport.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where TVP23C is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

04 Protein

The protein TVP23C encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with TVP23C

The 11 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; CDRT4, CDRT15, CCDC182 lead.

STRING v12.0

Ready in a moment

06 Pathways

Where TVP23C acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to TVP23C

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

08 Variants

Classified variants of TVP23C

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

09 Constraint

How much variation TVP23C tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within TVP23C

No annotated microRNA lies within TVP23C in Ensembl release 116, on GRCh38.p14.

Ensembl · miRBase

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the TVP23C locus

1 long non-coding RNA gene overlaps TVP23C in Ensembl release 116, without a symbol.

Ensembl

Order against a long non-coding RNA

Ready in a moment

13 Literature

Papers that mention TVP23C

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From TVP23C to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for TVP23C Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

TVP23C

Reading the record for TVP23C from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for TVP23C opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What TVP23C does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where TVP23C is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein TVP23C encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with TVP23C

Waiting for the record before reading STRING.

06 Pathways

Where TVP23C acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to TVP23C

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of TVP23C

Waiting for the record before reading ClinVar.

09 Constraint

How much variation TVP23C tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within TVP23C

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the TVP23C locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention TVP23C

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001135036.2matches ENST00000518321.6	transcript variant 2	protein coding	MANE Select	6	4,079 nt	203 aaNP_001128508.1	Ready in a moment
NM_145301.3matches ENST00000225576.7	transcript variant 1	protein coding	none	6	1,466 nt	276 aaNP_660344.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001135036.2matches ENST00000518321.6	transcript variant 2	protein coding	MANE Select	6	4,079 nt	203 aaNP_001128508.1	Ready in a moment
NM_145301.3matches ENST00000225576.7	transcript variant 1	protein coding	none	6	1,466 nt	276 aaNP_660344.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000518321.6matches NM_001135036.2	TVP23C-205	protein coding	MANE SelectEnsembl canonical	6	4,079 nt	203 aaENSP00000464052.1	Ready in a moment
ENST00000584811.5	TVP23C-210	protein coding	none	7	2,989 nt	141 aaENSP00000463371.1	Ready in a moment
ENST00000428082.6	TVP23C-203	protein coding	none	7	1,911 nt	205 aaENSP00000406387.2	Ready in a moment
ENST00000438826.7	TVP23C-204	protein coding	none	7	1,852 nt	205 aaENSP00000413355.3	Ready in a moment
ENST00000225576.7	TVP23C-201	protein coding	none	6	1,527 nt	276 aaENSP00000225576.3	Ready in a moment
ENST00000523573.5	TVP23C-207	nonsense mediated decay	none	7	764 nt	53 aaENSP00000428748.1	Ready in a moment
ENST00000521179.5	TVP23C-206	nonsense mediated decay	none	6	591 nt	37 aaENSP00000428373.1	Ready in a moment
ENST00000419890.3	TVP23C-202	protein coding	none	6	537 nt	110 aaENSP00000409988.2	Ready in a moment
ENST00000581273.5	TVP23C-208	nonsense mediated decay	none	3	488 nt	60 aaENSP00000465522.1	Ready in a moment
ENST00000583206.1	TVP23C-209	protein coding cds not defined	none	2	701 nt	none	Ready in a moment

TVP23C

What TVP23C does

The RNA a design targets

Where TVP23C is expressed

The protein TVP23C encodes

Proteins STRING associates with TVP23C

Where TVP23C acts, as Reactome curates it

Diseases linked to TVP23C

Classified variants of TVP23C

How much variation TVP23C tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TVP23C

Long non-coding RNAs at the TVP23C locus

Papers that mention TVP23C

From TVP23C to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

TVP23C

What TVP23C does

The RNA a design targets

Where TVP23C is expressed

The protein TVP23C encodes

Proteins STRING associates with TVP23C

Where TVP23C acts, as Reactome curates it

Diseases linked to TVP23C

Classified variants of TVP23C

How much variation TVP23C tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TVP23C

Long non-coding RNAs at the TVP23C locus

Papers that mention TVP23C

TVP23C

What TVP23C does

Gene summary

Protein function

The RNA a design targets

RefSeq 2 transcripts

A window on one transcript

Ensembl 10 transcripts

A window on one transcript

Where TVP23C is expressed

The protein TVP23C encodes

Proteins STRING associates with TVP23C

Where TVP23C acts, as Reactome curates it

Diseases linked to TVP23C

Classified variants of TVP23C

How much variation TVP23C tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within TVP23C

Long non-coding RNAs at the TVP23C locus

Papers that mention TVP23C

From TVP23C to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 2 transcripts

A window on one transcript

Ensembl 10 transcripts

A window on one transcript