Gene Human Homo sapiens

USP41P

ubiquitin specific peptidase 41, pseudogene

pseudogene

Human USP41PMouseRat

Reading the ortholog votes for mouse and rat.

HGNC lists no MANE Select pair for this gene.

Location: Cytogenetic band 22q11.21NCBI: 22:20,363,616-20,377,260 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000022.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 22:20,363,621-20,377,251 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: USP18B
Previous symbols: USP41

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-05 ET · HGNC:20070

Silence this gene

The order page opens with USP41P and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for USP41P

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What USP41P does

NCBI Gene answered in a shape this page does not read, so nothing is shown for the summary. Reference 0947c0e3-e10.

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where USP41P is expressed

54 GTEx tissues; the highest median in Testis, 0.414 TPM.

GTEx

Ready in a moment

04 Protein

The protein USP41P encodes

UniProt did not give one reviewed entry for USP41P in human, so InterPro, AlphaFold DB and PDBe were not asked and no protein entry is shown.

UniProt

Ready in a moment

05 Interactions

Proteins STRING associates with USP41P

STRING v12.0 has no protein named USP41P in human.

STRING

Ready in a moment

06 Pathways

Where USP41P acts, as Reactome curates it

UniProt did not give one reviewed entry for USP41P in human, so Reactome was not asked and no pathway list is shown.

UniProt

Ready in a moment

07 Disease associations

Diseases linked to USP41P

1,316 Open Targets disease associations; breast cancer first, at 0.10.

Open Targets

Ready in a moment

08 Variants

Classified variants of USP41P

ClinVar holds no record for USP41P.

ClinVar

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09 Constraint

How much variation USP41P tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within USP41P

No annotated microRNA lies within USP41P in Ensembl release 116, on GRCh38.p14.

Ensembl · miRBase

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the USP41P locus

1 long non-coding RNA gene overlaps USP41P in Ensembl release 116, without a symbol.

Ensembl

Order against a long non-coding RNA

Ready in a moment

13 Literature

Papers that mention USP41P

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From USP41P to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for USP41P Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

USP41P

Reading the record for USP41P from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for USP41P opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What USP41P does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where USP41P is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein USP41P encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with USP41P

Waiting for the record before reading STRING.

06 Pathways

Where USP41P acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to USP41P

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of USP41P

Waiting for the record before reading ClinVar.

09 Constraint

How much variation USP41P tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within USP41P

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the USP41P locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention USP41P

Waiting for the record before reading Europe PMC.

USP41P

ubiquitin specific peptidase 41, pseudogene

pseudogene

Human USP41PMouseRat

Reading the ortholog votes for mouse and rat.

HGNC lists no MANE Select pair for this gene.

Location

Cytogenetic band 22q11.21NCBI: 22:20,363,616-20,377,260 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000022.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 22:20,363,621-20,377,251 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Also known as

USP18B

Previous symbols

USP41

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-05 ET · HGNC:20070

Ensembl transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000292729.12	USP41P-201	transcribed unprocessed pseudogene	Ensembl canonical	8	920 nt	none	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

ENST00000292729.12

USP41P-201

transcribed unprocessed pseudogene

Ensembl canonical

920 nt

none

Ready in a moment

From USP41P to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Run the controls

A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.

Pick the product

AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

For research use only. Not for use in diagnostic or therapeutic procedures.

Ensembl transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000292729.12	USP41P-201	transcribed unprocessed pseudogene	Ensembl canonical	8	920 nt	none	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

ENST00000292729.12

USP41P-201

transcribed unprocessed pseudogene

Ensembl canonical

920 nt

none

Ready in a moment

USP41P

What USP41P does

The RNA a design targets

Where USP41P is expressed

The protein USP41P encodes

Proteins STRING associates with USP41P

Where USP41P acts, as Reactome curates it

Diseases linked to USP41P

Classified variants of USP41P

How much variation USP41P tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within USP41P

Long non-coding RNAs at the USP41P locus

Papers that mention USP41P

From USP41P to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

USP41P

What USP41P does

The RNA a design targets

Where USP41P is expressed

The protein USP41P encodes

Proteins STRING associates with USP41P

Where USP41P acts, as Reactome curates it

Diseases linked to USP41P

Classified variants of USP41P

How much variation USP41P tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within USP41P

Long non-coding RNAs at the USP41P locus

Papers that mention USP41P

USP41P

What USP41P does

The RNA a design targets

RefSeq 0 transcripts

Ensembl 1 transcript

A window on one transcript

Where USP41P is expressed

The protein USP41P encodes

Proteins STRING associates with USP41P

Where USP41P acts, as Reactome curates it

Diseases linked to USP41P

Classified variants of USP41P

How much variation USP41P tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within USP41P

Long non-coding RNAs at the USP41P locus

Papers that mention USP41P

From USP41P to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

RefSeq 0 transcripts

Ensembl 1 transcript

A window on one transcript