Gene Human Homo sapiens

UTS2B

urotensin 2B

gene with protein product

Human UTS2BMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 3q28NCBI: 3:191,267,168-191,346,182 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000003.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 3:191,267,168-191,330,572 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: URP, U2B
Previous symbols: UTS2D

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-03 ET · HGNC:30894

Silence this gene

The order page opens with UTS2B and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for UTS2B

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What UTS2B does

Predicted to enable G protein-coupled receptor binding activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where UTS2B is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

04 Protein

The protein UTS2B encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with UTS2B

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where UTS2B acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to UTS2B

59 Open Targets disease associations; hypothyroidism first, at 0.42.

Open Targets

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08 Variants

Classified variants of UTS2B

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation UTS2B tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within UTS2B

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the UTS2B locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention UTS2B

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From UTS2B to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for UTS2B Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

UTS2B

Reading the record for UTS2B from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for UTS2B opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What UTS2B does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where UTS2B is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein UTS2B encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with UTS2B

Waiting for the record before reading STRING.

06 Pathways

Where UTS2B acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to UTS2B

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of UTS2B

Waiting for the record before reading ClinVar.

09 Constraint

How much variation UTS2B tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within UTS2B

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the UTS2B locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention UTS2B

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_198152.5matches ENST00000340524.10	none given	protein coding	MANE Select	9	2,385 nt	119 aaNP_937795.2	Ready in a moment
XM_047447899.1matches ENST00000899455.2	transcript variant X3	protein coding model	none	8	17,637 nt	119 aaXP_047303855.1	Ready in a moment
XM_011512631.3matches ENST00000427544.7	transcript variant X2	protein coding model	none	8	2,224 nt	119 aaXP_011510933.1	Ready in a moment
XM_017006091.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_198152.5matches ENST00000340524.10	none given	protein coding	MANE Select	9	2,385 nt	119 aaNP_937795.2	Ready in a moment
XM_047447899.1matches ENST00000899455.2	transcript variant X3	protein coding model	none	8	17,637 nt	119 aaXP_047303855.1	Ready in a moment
XM_011512631.3matches ENST00000427544.7	transcript variant X2	protein coding model	none	8	2,224 nt	119 aaXP_011510933.1	Ready in a moment
XM_017006091.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000340524.10matches NM_198152.5	UTS2B-201	protein coding	MANE SelectEnsembl canonical	9	2,385 nt	119 aaENSP00000340526.5	Ready in a moment
ENST00001144493.1	UTS2B-212	protein coding	none	9	2,431 nt	119 aaENSP00000807869.1	Ready in a moment
ENST00000915518.2	UTS2B-211	protein coding	none	7	2,248 nt	119 aaENSP00000585581.1	Ready in a moment
ENST00000899455.2	UTS2B-210	protein coding	none	8	2,027 nt	119 aaENSP00000569514.1	Ready in a moment
ENST00000427544.7	UTS2B-203	protein coding	none	5	1,822 nt	119 aaENSP00000398761.2	Ready in a moment
ENST00000432514.5	UTS2B-204	protein coding	none	7	1,005 nt	38 aaENSP00000401028.1	Ready in a moment
ENST00000440476.5	UTS2B-205	nonsense mediated decay	none	4	839 nt	81 aaENSP00000398540.1	Ready in a moment
ENST00000446788.5	UTS2B-206	nonsense mediated decay	none	6	836 nt	132 aaENSP00000415628.1	Ready in a moment
ENST00000425357.1	UTS2B-202	nonsense mediated decay	none	5	701 nt	81 aaENSP00000404406.1	Ready in a moment
ENST00000490825.1	UTS2B-209	protein coding cds not defined	none	4	712 nt	none	Ready in a moment
ENST00000464814.1	UTS2B-208	retained intron	none	2	561 nt	none	Ready in a moment
ENST00000463450.1	UTS2B-207	protein coding cds not defined	none	4	555 nt	none	Ready in a moment

UTS2B

What UTS2B does

The RNA a design targets

Where UTS2B is expressed

The protein UTS2B encodes

Proteins STRING associates with UTS2B

Where UTS2B acts, as Reactome curates it

Diseases linked to UTS2B

Classified variants of UTS2B

How much variation UTS2B tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within UTS2B

Long non-coding RNAs at the UTS2B locus

Papers that mention UTS2B

From UTS2B to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

UTS2B

What UTS2B does

The RNA a design targets

Where UTS2B is expressed

The protein UTS2B encodes

Proteins STRING associates with UTS2B

Where UTS2B acts, as Reactome curates it

Diseases linked to UTS2B

Classified variants of UTS2B

How much variation UTS2B tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within UTS2B

Long non-coding RNAs at the UTS2B locus

Papers that mention UTS2B

UTS2B

What UTS2B does

Gene summary

Protein function

The RNA a design targets

RefSeq 4 transcripts

A window on one transcript

Ensembl 12 transcripts

A window on one transcript

Where UTS2B is expressed

The protein UTS2B encodes

Proteins STRING associates with UTS2B

Where UTS2B acts, as Reactome curates it

Diseases linked to UTS2B

Classified variants of UTS2B

How much variation UTS2B tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within UTS2B

Long non-coding RNAs at the UTS2B locus

Papers that mention UTS2B

From UTS2B to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 4 transcripts

A window on one transcript

Ensembl 12 transcripts

A window on one transcript