Gene Human Homo sapiens

WDR64

WD repeat domain 64

gene with protein product

Human WDR64MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 1q43NCBI: 1:241,652,281-241,802,777 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000001.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 1:241,652,278-241,802,777 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: FLJ32978

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-03 ET · HGNC:26570

Silence this gene

The order page opens with WDR64 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for WDR64

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What WDR64 does

NCBI Gene carries no curated summary for this gene.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where WDR64 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein WDR64 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with WDR64

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where WDR64 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to WDR64

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of WDR64

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation WDR64 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within WDR64

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the WDR64 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention WDR64

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From WDR64 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for WDR64 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

WDR64

Reading the record for WDR64 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for WDR64 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What WDR64 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where WDR64 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein WDR64 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with WDR64

Waiting for the record before reading STRING.

06 Pathways

Where WDR64 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to WDR64

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of WDR64

Waiting for the record before reading ClinVar.

09 Constraint

How much variation WDR64 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within WDR64

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the WDR64 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention WDR64

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001367482.1matches ENST00000437684.7	none given	protein coding	MANE Select	28	5,042 nt	1,091 aaNP_001354411.1	Ready in a moment
XM_017000315.2	transcript variant X1	protein coding model	none	28	4,780 nt	1,007 aaXP_016855804.1	Ready in a moment
XM_047445900.1	transcript variant X2	protein coding model	none	25	4,563 nt	930 aaXP_047301856.1	Ready in a moment
XM_011544086.4	transcript variant X3	protein coding model	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001367482.1matches ENST00000437684.7	none given	protein coding	MANE Select	28	5,042 nt	1,091 aaNP_001354411.1	Ready in a moment
XM_017000315.2	transcript variant X1	protein coding model	none	28	4,780 nt	1,007 aaXP_016855804.1	Ready in a moment
XM_047445900.1	transcript variant X2	protein coding model	none	25	4,563 nt	930 aaXP_047301856.1	Ready in a moment
XM_011544086.4	transcript variant X3	protein coding model	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000437684.7matches NM_001367482.1	WDR64-204	protein coding	MANE SelectEnsembl canonical	28	5,042 nt	1,091 aaENSP00000402446.4	Ready in a moment
ENST00001144738.1	WDR64-211	protein coding	none	28	5,045 nt	1,091 aaENSP00000812884.1	Ready in a moment
ENST00000366552.7	WDR64-201	protein coding	none	27	5,015 nt	1,081 aaENSP00000355510.2	Ready in a moment
ENST00000425826.3	WDR64-203	nonsense mediated decay	none	29	3,964 nt	603 aaENSP00000406342.3	Ready in a moment
ENST00000414635.5	WDR64-202	protein coding	none	17	2,306 nt	685 aaENSP00000406656.1	Ready in a moment
ENST00000472717.6	WDR64-206	nonsense mediated decay	none	15	1,661 nt	522 aaENSP00000431729.2	Ready in a moment
ENST00001103131.1	WDR64-209	nonsense mediated decay	none	4	913 nt	98 aaENSP00000772935.1	Ready in a moment
ENST00001127787.1	WDR64-210	protein coding	none	3	583 nt	110 aaENSP00000797592.1	Ready in a moment
ENST00000461971.5	WDR64-205	protein coding cds not defined	none	6	656 nt	none	Ready in a moment
ENST00000478331.1	WDR64-207	retained intron	none	6	624 nt	none	Ready in a moment
ENST00000496914.1	WDR64-208	protein coding cds not defined	none	4	597 nt	none	Ready in a moment

WDR64

What WDR64 does

The RNA a design targets

Where WDR64 is expressed

The protein WDR64 encodes

Proteins STRING associates with WDR64

Where WDR64 acts, as Reactome curates it

Diseases linked to WDR64

Classified variants of WDR64

How much variation WDR64 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within WDR64

Long non-coding RNAs at the WDR64 locus

Papers that mention WDR64

From WDR64 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

WDR64

What WDR64 does

The RNA a design targets

Where WDR64 is expressed

The protein WDR64 encodes

Proteins STRING associates with WDR64

Where WDR64 acts, as Reactome curates it

Diseases linked to WDR64

Classified variants of WDR64

How much variation WDR64 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within WDR64

Long non-coding RNAs at the WDR64 locus

Papers that mention WDR64

WDR64

What WDR64 does

Gene summary

Protein function

The RNA a design targets

RefSeq 7 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript

Where WDR64 is expressed

The protein WDR64 encodes

Proteins STRING associates with WDR64

Where WDR64 acts, as Reactome curates it

Diseases linked to WDR64

Classified variants of WDR64

How much variation WDR64 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within WDR64

Long non-coding RNAs at the WDR64 locus

Papers that mention WDR64

From WDR64 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 7 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript