Gene Mouse Mus musculus

Cox8c

cytochrome c oxidase subunit 8C

protein coding

HumanMouse Cox8cRat

Reading the ortholog votes for human and rat.

HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 12 ENCBI: 12:102,865,565-102,866,793 on the plus strand, GRCm39 (GCF_000001635.27), sequence NC_000078.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: 12:102,865,530-102,866,797 on the plus strand, GRCm39 (GCA_000001635.9), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: COX8-3, COXVIII-3, 1700007F21Rik

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-02 ET · MGI:1922733Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Cox8c and mouse filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Cox8c

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What Cox8c does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From Cox8c to a sequence that silences it

The AUMsilence platform designs the sequences against the mouse transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Mouse Mus musculus

Cox8c

Reading the record for Cox8c from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Cox8c opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Cox8c does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Cox8c is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Cox8c encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Cox8c

Waiting for the record before reading STRING.

06 Pathways

Where Cox8c acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Cox8c

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Cox8c

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Cox8c tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Cox8c

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Cox8c locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Cox8c

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSMUST00000053611.6	Cox8c-201	protein coding	Ensembl canonical	2	503 nt	72 aaENSMUSP00000056155.4	Ready in a moment
ENSMUST00000549979.1	Cox8c-202	protein coding	none	2	513 nt	64 aaENSMUSP00000328342.1	Ready in a moment
ENSMUST00000585166.1	Cox8c-204	protein coding	none	2	509 nt	92 aaENSMUSP00000363531.1	Ready in a moment
ENSMUST00000585165.1	Cox8c-203	protein coding	none	2	508 nt	60 aaENSMUSP00000363530.1	Ready in a moment

Cox8c

What Cox8c does

The RNA a design targets

From Cox8c to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Cox8c

What Cox8c does

The RNA a design targets

Where Cox8c is expressed

The protein Cox8c encodes

Proteins STRING associates with Cox8c

Where Cox8c acts, as Reactome curates it

Diseases linked to Cox8c

Classified variants of Cox8c

How much variation Cox8c tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Cox8c

Long non-coding RNAs at the Cox8c locus

Papers that mention Cox8c

Cox8c

What Cox8c does

Gene summary

Protein function

The RNA a design targets

RefSeq 1 transcript

A window on one transcript

Ensembl 4 transcripts

A window on one transcript

From Cox8c to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where Cox8c is expressed

The protein Cox8c encodes

Proteins STRING associates with Cox8c

Where Cox8c acts, as Reactome curates it

Diseases linked to Cox8c

Classified variants of Cox8c

How much variation Cox8c tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Cox8c

Long non-coding RNAs at the Cox8c locus

Papers that mention Cox8c

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 1 transcript

A window on one transcript

Ensembl 4 transcripts

A window on one transcript