Gene Mouse Mus musculus

Dsc2

desmocollin 2

protein coding

HumanMouse Dsc2Rat

Reading the ortholog votes for human and rat.

HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 18 A2NCBI: 18:20,163,690-20,192,611 on the minus strand, GRCm39 (GCF_000001635.27), sequence NC_000084.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: 18:20,163,675-20,192,717 on the minus strand, GRCm39 (GCA_000001635.9), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-02 ET · MGI:103221Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Dsc2 and mouse filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Dsc2

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What Dsc2 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From Dsc2 to a sequence that silences it

The AUMsilence platform designs the sequences against the mouse transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Mouse Mus musculus

Dsc2

Reading the record for Dsc2 from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Dsc2 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Dsc2 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Dsc2 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Dsc2 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Dsc2

Waiting for the record before reading STRING.

06 Pathways

Where Dsc2 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Dsc2

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Dsc2

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Dsc2 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Dsc2

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Dsc2 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Dsc2

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001317365.1matches ENSMUST00000075214.10	transcript variant Dsc2a	protein coding	RefSeq Select	16	4,594 ntexons sum to 4,584 nt; the record carries 10 nt beyond them	902 aaNP_001304294.1	Ready in a moment
NM_001317363.1	transcript variant 3	protein coding	none	18	4,675 ntexons sum to 4,665 nt; the record carries 10 nt beyond them	705 aaNP_001304292.1	Ready in a moment
NM_013505.4matches ENSMUST00000039247.12	transcript variant Dsc2b	protein coding	none	17	4,640 ntexons sum to 4,630 nt; the record carries 10 nt beyond them	848 aaNP_038533.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001317365.1matches ENSMUST00000075214.10	transcript variant Dsc2a	protein coding	RefSeq Select	16	4,594 ntexons sum to 4,584 nt; the record carries 10 nt beyond them	902 aaNP_001304294.1	Ready in a moment
NM_001317363.1	transcript variant 3	protein coding	none	18	4,675 ntexons sum to 4,665 nt; the record carries 10 nt beyond them	705 aaNP_001304292.1	Ready in a moment
NM_013505.4matches ENSMUST00000039247.12	transcript variant Dsc2b	protein coding	none	17	4,640 ntexons sum to 4,630 nt; the record carries 10 nt beyond them	848 aaNP_038533.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSMUST00000075214.10	Dsc2-202	protein coding	Ensembl canonical	16	4,705 nt	902 aaENSMUSP00000074702.3	Ready in a moment
ENSMUST00000430975.1	Dsc2-207	protein coding	none	16	4,813 nt	848 aaENSMUSP00000209338.1	Ready in a moment
ENSMUST00000039247.12	Dsc2-201	protein coding	none	17	4,736 nt	848 aaENSMUSP00000042905.5	Ready in a moment
ENSMUST00000430973.1	Dsc2-205	protein coding	none	17	4,732 nt	848 aaENSMUSP00000209336.1	Ready in a moment
ENSMUST00000430974.1	Dsc2-206	nonsense mediated decay	none	16	4,404 nt	64 aaENSMUSP00000209337.1	Ready in a moment
ENSMUST00000128464.2	Dsc2-203	nonsense mediated decay	none	18	3,774 nt	131 aaENSMUSP00000123010.2	Ready in a moment
ENSMUST00000155407.2	Dsc2-204	protein coding	none	4	2,429 nt	240 aaENSMUSP00000116063.2	Ready in a moment

Dsc2

What Dsc2 does

The RNA a design targets

From Dsc2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Dsc2

What Dsc2 does

The RNA a design targets

Where Dsc2 is expressed

The protein Dsc2 encodes

Proteins STRING associates with Dsc2

Where Dsc2 acts, as Reactome curates it

Diseases linked to Dsc2

Classified variants of Dsc2

How much variation Dsc2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Dsc2

Long non-coding RNAs at the Dsc2 locus

Papers that mention Dsc2

Dsc2

What Dsc2 does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

A window on one transcript

Ensembl 7 transcripts

A window on one transcript

From Dsc2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where Dsc2 is expressed

The protein Dsc2 encodes

Proteins STRING associates with Dsc2

Where Dsc2 acts, as Reactome curates it

Diseases linked to Dsc2

Classified variants of Dsc2

How much variation Dsc2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Dsc2

Long non-coding RNAs at the Dsc2 locus

Papers that mention Dsc2

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

A window on one transcript

Ensembl 7 transcripts

A window on one transcript