Reading the record for Fbxo44 from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for Fbxo44 opens with the record, which decides which product it carries. The order page itself is open now.
HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.
Location
Cytogenetic band 4 E2NCBI: 4:148,237,256-148,244,663 on the minus strand, GRCm39 (GCF_000001635.27), sequence NC_000070.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: no location was read.Coordinates are one-based with both ends included, as each source reports them.
Also known as
FBG3, FBX30, Fbx6a, Fbxo6a, 5730411K09
Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read · MGI:1354744Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Notes from the sources
Ensembl did not answer (upstream error).
Ensembl did not answer (upstream error); the Ensembl location and release are missing
Silence this gene
The order page opens with Fbxo44 and mouse filled in. The sequences are designed against the transcripts below; the price is on that page.
Predicted to enable ubiquitin-like ligase-substrate adaptor activity.
NCBI Gene summary
Ready in a moment
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
30 RefSeq transcripts on GRCm39; RefSeq Select NM_173401.5. Ensembl is not answering, so the Ensembl transcripts could not be shown. Try again later. Reference 6f6e9755-7b7.
NCBI Datasets
Ready in a moment
Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where Fbxo44 is expressed
Expression by tissue: not available for mouse. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.
Ready in a moment
Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
04 / Protein
The protein Fbxo44 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
05 / Interactions
Proteins STRING associates with Fbxo44
Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
06 / Pathways
Where Fbxo44 acts, as Reactome curates it
Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
07 / Disease associations
Diseases linked to Fbxo44
Disease associations: not available for mouse. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.
Ready in a moment
Not available
Disease associations: not available for mouse. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.
08 / Variants
Classified variants of Fbxo44
Clinical variants: not available for mouse. ClinVar holds human variants only.
Ready in a moment
Not available
Clinical variants: not available for mouse. ClinVar holds human variants only.
09 / Constraint
How much variation Fbxo44 tolerates
Constraint: not available for mouse. gnomAD and Open Targets carry constraint for human genes only.
Ready in a moment
Not available
Constraint: not available for mouse. gnomAD and Open Targets carry constraint for human genes only.
10 / Orthologs
The same gene in mouse, rat and human
Human FBXO44 by 2 of 2 votes; rat Fbxo44 by 2 of 2 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 374212b5-642.
Alliance · NCBI
Ready in a moment
11 /MicroRNAs
MicroRNAs hosted within Fbxo44
Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference 867d99e4-8e2.
Ready in a moment
12 / Long non-coding RNAs
Long non-coding RNAs at the Fbxo44 locus
Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference 867d99e4-8e2.
Ready in a moment
13 / Literature
Papers that mention Fbxo44
213 PubMed-indexed papers mention Fbxo44 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers the human symbol where it differs from this one only in case.
Europe PMC
Ready in a moment
14 / Silencing this gene
From Fbxo44 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the mouse transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; gut; and male reproductive gland or organ. Orthologous to human FBXO44 (F-box protein 44).
Provided by Alliance of Genome Resources, Jun 2026, through NCBI Gene. NCBI disclaimer
Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex. The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation. In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation. Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation
NCBI Gene summary · NCBI Gene annotation RS_2024_02 · read · NCBI Gene 230903Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
UniProtKB function · 2026_03 · read · UniProt Q8BK26UniProt data are available under the Creative Commons Attribution 4.0 licence.
Placed on GRCm39 (GCF_000001635.27). MANE Select: not available for mouse. The reference here is the RefSeq Select transcript and the Ensembl canonical transcript, which need not be the same model.
RefSeq 30 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
NM_173401.5NM_173401.5RefSeq Select
XM_030253505.2XM_030253505.2
XM_030253504.2XM_030253504.2
XM_030253506.2XM_030253506.2
XM_030253507.2XM_030253507.2
XM_017320180.3XM_017320180.3
XM_030253508.1XM_030253508.1
XM_030253502.2XM_030253502.2
NM_001161852.2NM_001161852.2
XM_017320177.2XM_017320177.2
XM_017320178.3XM_017320178.3
XM_017320176.2XM_017320176.2
NM_001161851.2NM_001161851.2
XM_030253503.2XM_030253503.2
XM_030253501.2XM_030253501.2
XM_030253500.2XM_030253500.2
NM_001355702.1NM_001355702.1
NM_001355701.1NM_001355701.1
XR_004941880.1XR_004941880.1
XR_004941883.1XR_004941883.1
XR_003954934.2XR_003954934.2
XR_004941881.1XR_004941881.1
XR_881428.4XR_881428.4
XR_004941882.1XR_004941882.1
XR_003954936.2XR_003954936.2
XR_003954935.2XR_003954935.2
XR_003954933.2XR_003954933.2
NR_104375.1NR_104375.1
NR_104374.1NR_104374.1
XR_003954937.2XR_003954937.2
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.38.0; GCF_000001635.27-RS_2024_02 · read · NCBI Gene 230903Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 0 transcripts
Ensembl is not answering, so the Ensembl transcripts could not be shown. Try again later.
Reference 6f6e9755-7b7
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for mouse: GRCm39.
Expression by tissue: not available for mouse. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.
Mouse tissue expression, from Bgee and Expression Atlas, joins this page in a later phase. Nothing from the human ortholog is shown in its place; its own page is a step away through the species switch above.
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; Skp1a, Cul4b, Cul1 lead.
STRING v12.0
0 curated, 2 inferred Reactome pathways for Q8BK26 in mouse, v97.
Reactome
255 residues, reviewed Q8BK26; 13 entries from the member databases this page shows along the chain; mean pLDDT 93; no experimental structure at PDBe.
