Gene Mouse Mus musculus

Flnb

filamin, beta

protein coding

HumanMouse FlnbRat

Reading the ortholog votes for human and rat.

HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 14 A1NCBI: 14:14,518,185-14,651,852 on the minus strand, GRCm39 (GCF_000001635.27), sequence NC_000080.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: no location was read.Coordinates are one-based with both ends included, as each source reports them.
Also known as: Fln-b

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-01 ET · MGI:2446089Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Notes from the sources

Ensembl did not answer (upstream error).
Ensembl did not answer (upstream error); the Ensembl location and release are missing

Silence this gene

The order page opens with Flnb and mouse filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Flnb

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What Flnb does

Predicted to enable identical protein binding activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

3 RefSeq transcripts on GRCm39; RefSeq Select NM_134080.1. Ensembl is not answering, so the Ensembl transcripts could not be shown. Try again later. Reference 80466231-01a.

NCBI Datasets

Ready in a moment

03 Expression by tissue

Where Flnb is expressed

Expression by tissue: not available for mouse. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.

Ready in a moment

04 Protein

The protein Flnb encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with Flnb

The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; Tln2, Tln1, Fblim1 lead.

STRING v12.0

Ready in a moment

06 Pathways

Where Flnb acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to Flnb

Disease associations: not available for mouse. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.

Ready in a moment

08 Variants

Classified variants of Flnb

Clinical variants: not available for mouse. ClinVar holds human variants only.

Ready in a moment

09 Constraint

How much variation Flnb tolerates

Constraint: not available for mouse. gnomAD and Open Targets carry constraint for human genes only.

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Human FLNB by 3 of 3 votes; rat Flnb by 2 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference ab1d744b-9bd.

Alliance · NCBI · Ensembl Compara

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within Flnb

Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference b3e9f639-b3d.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the Flnb locus

Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference b3e9f639-b3d.

Ready in a moment

13 Literature

Papers that mention Flnb

2,322 PubMed-indexed papers mention Flnb at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers the human symbol where it differs from this one only in case.

Europe PMC

Ready in a moment

14 Silencing this gene

From Flnb to a sequence that silences it

The AUMsilence platform designs the sequences against the mouse transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for Flnb Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Mouse Mus musculus

Flnb

Reading the record for Flnb from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Flnb opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Flnb does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Flnb is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Flnb encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Flnb

Waiting for the record before reading STRING.

06 Pathways

Where Flnb acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Flnb

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Flnb

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Flnb tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Flnb

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Flnb locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Flnb

Waiting for the record before reading Europe PMC.

Flnb

filamin, beta

protein coding

HumanMouse FlnbRat

Reading the ortholog votes for human and rat.

HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.

Location

Cytogenetic band 14 A1NCBI: 14:14,518,185-14,651,852 on the minus strand, GRCm39 (GCF_000001635.27), sequence NC_000080.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: no location was read.Coordinates are one-based with both ends included, as each source reports them.

Also known as

Fln-b

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-01 ET · MGI:2446089Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Notes from the sources

Ensembl did not answer (upstream error).
Ensembl did not answer (upstream error); the Ensembl location and release are missing

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_134080.1matches ENSMUST00000544071.1	transcript variant 2	protein coding	RefSeq Select	46	9,083 ntexons sum to 9,067 nt; the record carries 16 nt beyond them	2,591 aaNP_598841.1	Ready in a moment
NM_001081427.1matches ENSMUST00000052678.10	transcript variant 1	protein coding	none	46	9,118 ntexons sum to 9,100 nt; the record carries 18 nt beyond them	2,602 aaNP_001074896.1	Ready in a moment
XM_006518050.2matches ENSMUST00000544070.1	transcript variant X1	protein coding model	none	45	9,064 nt	2,578 aaXP_006518113.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_134080.1matches ENSMUST00000544071.1

transcript variant 2

protein coding

RefSeq Select

9,083 ntexons sum to 9,067 nt; the record carries 16 nt beyond them

2,591 aaNP_598841.1

Ready in a moment

NM_001081427.1matches ENSMUST00000052678.10

transcript variant 1

protein coding

none

9,118 ntexons sum to 9,100 nt; the record carries 18 nt beyond them

2,602 aaNP_001074896.1

Ready in a moment

XM_006518050.2matches ENSMUST00000544070.1

transcript variant X1

protein coding model

none

9,064 nt

2,578 aaXP_006518113.1

Ready in a moment

From Flnb to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Run the controls

A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.

Pick the product

AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

For research use only. Not for use in diagnostic or therapeutic procedures.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_134080.1matches ENSMUST00000544071.1	transcript variant 2	protein coding	RefSeq Select	46	9,083 ntexons sum to 9,067 nt; the record carries 16 nt beyond them	2,591 aaNP_598841.1	Ready in a moment
NM_001081427.1matches ENSMUST00000052678.10	transcript variant 1	protein coding	none	46	9,118 ntexons sum to 9,100 nt; the record carries 18 nt beyond them	2,602 aaNP_001074896.1	Ready in a moment
XM_006518050.2matches ENSMUST00000544070.1	transcript variant X1	protein coding model	none	45	9,064 nt	2,578 aaXP_006518113.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_134080.1matches ENSMUST00000544071.1

transcript variant 2

protein coding

RefSeq Select

9,083 ntexons sum to 9,067 nt; the record carries 16 nt beyond them

2,591 aaNP_598841.1

Ready in a moment

NM_001081427.1matches ENSMUST00000052678.10

transcript variant 1

protein coding

none

9,118 ntexons sum to 9,100 nt; the record carries 18 nt beyond them

2,602 aaNP_001074896.1

Ready in a moment

XM_006518050.2matches ENSMUST00000544070.1

transcript variant X1

protein coding model

none

9,064 nt

2,578 aaXP_006518113.1

Ready in a moment

Flnb

What Flnb does

The RNA a design targets

Where Flnb is expressed

The protein Flnb encodes

Proteins STRING associates with Flnb

Where Flnb acts, as Reactome curates it

Diseases linked to Flnb

Classified variants of Flnb

How much variation Flnb tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Flnb

Long non-coding RNAs at the Flnb locus

Papers that mention Flnb

From Flnb to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Flnb

What Flnb does

The RNA a design targets

Where Flnb is expressed

The protein Flnb encodes

Proteins STRING associates with Flnb

Where Flnb acts, as Reactome curates it

Diseases linked to Flnb

Classified variants of Flnb

How much variation Flnb tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Flnb

Long non-coding RNAs at the Flnb locus

Papers that mention Flnb

Flnb

What Flnb does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

A window on one transcript

Ensembl 0 transcripts

Where Flnb is expressed

The protein Flnb encodes

Proteins STRING associates with Flnb

Where Flnb acts, as Reactome curates it

Diseases linked to Flnb

Classified variants of Flnb

How much variation Flnb tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Flnb

Long non-coding RNAs at the Flnb locus

Papers that mention Flnb

From Flnb to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

A window on one transcript

Ensembl 0 transcripts