Gene Mouse Mus musculus

Fry

FRY microtubule binding protein

protein coding

HumanMouse FryRat

Reading the ortholog votes for human and rat.

HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 5 G3NCBI: 5:150,042,083-150,421,218 on the plus strand, GRCm39 (GCF_000001635.27), sequence NC_000071.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: 5:150,042,110-150,421,411 on the plus strand, GRCm39 (GCA_000001635.9), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: cg003, 13CDNA73, mKIAA4143, D930046M03, 9330186A19Rik

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-03 ET · MGI:2443895Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Fry and mouse filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Fry

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What Fry does

Enables enzyme inhibitor activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where Fry is expressed

Expression by tissue: not available for mouse. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.

Ready in a moment

04 Protein

The protein Fry encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with Fry

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where Fry acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to Fry

Disease associations: not available for mouse. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.

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08 Variants

Classified variants of Fry

Clinical variants: not available for mouse. ClinVar holds human variants only.

Ready in a moment

09 Constraint

How much variation Fry tolerates

Constraint: not available for mouse. gnomAD and Open Targets carry constraint for human genes only.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within Fry

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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12 Long non-coding RNAs

Long non-coding RNAs at the Fry locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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13 Literature

Papers that mention Fry

Europe PMC is not answering, so the literature search could not be shown. Try again later. Reference cd1c7f6e-7a4.

Ready in a moment

14 Silencing this gene

From Fry to a sequence that silences it

The AUMsilence platform designs the sequences against the mouse transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for Fry Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Mouse Mus musculus

Fry

Reading the record for Fry from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Fry opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Fry does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Fry is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Fry encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Fry

Waiting for the record before reading STRING.

06 Pathways

Where Fry acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Fry

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Fry

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Fry tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Fry

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Fry locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Fry

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_172887.2matches ENSMUST00000087204.10	none given	protein coding	RefSeq Select	61	10,753 ntexons sum to 10,730 nt; the record carries 23 nt beyond them	3,020 aaNP_766475.2	Ready in a moment
XM_030254574.2	transcript variant X9	protein coding model	none	65	11,175 nt	2,979 aaXP_030110434.1	Ready in a moment
XM_006504930.5	transcript variant X6	protein coding model	none	63	11,093 nt	3,029 aaXP_006504993.1	Ready in a moment
XM_006504932.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_172887.2matches ENSMUST00000087204.10	none given	protein coding	RefSeq Select	61	10,753 ntexons sum to 10,730 nt; the record carries 23 nt beyond them	3,020 aaNP_766475.2	Ready in a moment
XM_030254574.2	transcript variant X9	protein coding model	none	65	11,175 nt	2,979 aaXP_030110434.1	Ready in a moment
XM_006504930.5	transcript variant X6	protein coding model	none	63	11,093 nt	3,029 aaXP_006504993.1	Ready in a moment
XM_006504932.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSMUST00000087204.10	Fry-201	protein coding	Ensembl canonical	61	11,086 nt	3,020 aaENSMUSP00000084454.6	Ready in a moment
ENSMUST00000239118.3	Fry-218	protein coding	none	61	10,811 nt	3,017 aaENSMUSP00000158877.2	Ready in a moment
ENSMUST00000202566.4	Fry-212	protein coding	none	20	4,379 nt	1,016 aaENSMUSP00000144657.2	Ready in a moment
ENSMUST00000200863.2	Fry-203	protein coding	none	13	3,288 nt	653 aaENSMUSP00000143845.2	Ready in a moment
ENSMUST00000202530.4	Fry-211	protein coding	none	6	704 nt	159 aaENSMUSP00000144277.2	Ready in a moment
ENSMUST00000200960.4	Fry-204	protein coding	none	5	687 nt	89 aaENSMUSP00000144674.2	Ready in a moment
ENSMUST00000202600.4	Fry-214	protein coding	none	4	592 nt	175 aaENSMUSP00000144317.2	Ready in a moment
ENSMUST00000202630.3	Fry-215	retained intron	none	1	3,980 nt	none	Ready in a moment
ENSMUST00000202070.2	Fry-210	retained intron	none	1	3,684 nt	none	Ready in a moment
ENSMUST00000203000.4	Fry-217	retained intron	none	7	3,670 nt	none	Ready in a moment
ENSMUST00000202841.2	Fry-216	retained intron	none	20	2,784 nt	none	Ready in a moment
ENSMUST00000200750.2	Fry-202	retained intron	none	1	2,618 nt	none	Ready in a moment
ENSMUST00000201854.2	Fry-209	retained intron	none	1	2,364 nt	none	Ready in a moment
ENSMUST00000201196.2	Fry-206	retained intron	none	11	2,204 nt	none	Ready in a moment
ENSMUST00000202571.2	Fry-213	retained intron	none	1	1,878 nt	none	Ready in a moment
ENSMUST00000201628.2	Fry-207	retained intron	none	1	1,761 nt	none	Ready in a moment
ENSMUST00000200964.2	Fry-205	retained intron	none	3	937 nt	none	Ready in a moment
ENSMUST00000201634.2	Fry-208	retained intron	none	2	398 nt	none	Ready in a moment

Fry

What Fry does

The RNA a design targets

Where Fry is expressed

The protein Fry encodes

Proteins STRING associates with Fry

Where Fry acts, as Reactome curates it

Diseases linked to Fry

Classified variants of Fry

How much variation Fry tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Fry

Long non-coding RNAs at the Fry locus

Papers that mention Fry

From Fry to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Fry

What Fry does

The RNA a design targets

Where Fry is expressed

The protein Fry encodes

Proteins STRING associates with Fry

Where Fry acts, as Reactome curates it

Diseases linked to Fry

Classified variants of Fry

How much variation Fry tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Fry

Long non-coding RNAs at the Fry locus

Papers that mention Fry

Fry

What Fry does

Gene summary

Protein function

The RNA a design targets

RefSeq 11 transcripts

A window on one transcript

Ensembl 18 transcripts

A window on one transcript

Where Fry is expressed

The protein Fry encodes

Proteins STRING associates with Fry

Where Fry acts, as Reactome curates it

Diseases linked to Fry

Classified variants of Fry

How much variation Fry tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Fry

Long non-coding RNAs at the Fry locus

Papers that mention Fry

From Fry to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 11 transcripts

A window on one transcript

Ensembl 18 transcripts

A window on one transcript