Gene Mouse Mus musculus

Poln

DNA polymerase N

protein coding

HumanMouse PolnRat

Reading the ortholog votes for human and rat.

HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 5 B2NCBI: 5:34,164,523-34,326,870 on the minus strand, GRCm39 (GCF_000001635.27), sequence NC_000071.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: 5:34,164,523-34,326,929 on the minus strand, GRCm39 (GCA_000001635.9), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: POL4P

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-06 ET · MGI:2675617Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Poln and mouse filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Poln

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What Poln does

Predicted to enable DNA-directed DNA polymerase activity and cyclin binding…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where Poln is expressed

Expression by tissue: not available for mouse. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.

Ready in a moment

04 Protein

The protein Poln encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with Poln

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where Poln acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to Poln

Disease associations: not available for mouse. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.

Ready in a moment

08 Variants

Classified variants of Poln

Clinical variants: not available for mouse. ClinVar holds human variants only.

Ready in a moment

09 Constraint

How much variation Poln tolerates

Constraint: not available for mouse. gnomAD and Open Targets carry constraint for human genes only.

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within Poln

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the Poln locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention Poln

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From Poln to a sequence that silences it

The AUMsilence platform designs the sequences against the mouse transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for Poln Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Mouse Mus musculus

Poln

Reading the record for Poln from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Poln opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Poln does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Poln is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Poln encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Poln

Waiting for the record before reading STRING.

06 Pathways

Where Poln acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Poln

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Poln

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Poln tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Poln

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Poln locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Poln

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_181857.5matches ENSMUST00000042954.12 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	none given	protein coding	RefSeq Select	not placed	2,919 nt	864 aaNP_862905.2	Ready in a moment
NM_001289803.2matches ENSMUST00000202409.3 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	none given	protein coding	none	not placed	2,865 nt	846 aaNP_001276732.2	Ready in a moment
NM_001289804.2matches ENSMUST00000202638.5 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	none given	protein coding	none	not placed	2,836 nt	820 aaNP_001276733.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_181857.5matches ENSMUST00000042954.12 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	none given	protein coding	RefSeq Select	not placed	2,919 nt	864 aaNP_862905.2	Ready in a moment
NM_001289803.2matches ENSMUST00000202409.3 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	none given	protein coding	none	not placed	2,865 nt	846 aaNP_001276732.2	Ready in a moment
NM_001289804.2matches ENSMUST00000202638.5 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	none given	protein coding	none	not placed	2,836 nt	820 aaNP_001276733.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSMUST00000042954.12	Poln-201	protein coding	Ensembl canonical	25	3,034 nt	866 aaENSMUSP00000036110.8	Ready in a moment
ENSMUST00000202409.3	Poln-205	protein coding	none	24	2,980 nt	848 aaENSMUSP00000144578.2	Ready in a moment
ENSMUST00000202638.5	Poln-206	protein coding	none	25	2,951 nt	822 aaENSMUSP00000143793.2	Ready in a moment
ENSMUST00000578650.1	Poln-209	protein coding	none	3	510 nt	50 aaENSMUSP00000357013.1	Ready in a moment
ENSMUST00000583017.1	Poln-210	protein coding	none	3	446 nt	50 aaENSMUSP00000361382.1	Ready in a moment
ENSMUST00000202076.2	Poln-204	retained intron	none	2	2,399 nt	none	Ready in a moment
ENSMUST00000201251.4	Poln-202	protein coding cds not defined	none	3	529 nt	none	Ready in a moment
ENSMUST00000202027.2	Poln-203	protein coding cds not defined	none	6	458 nt	none	Ready in a moment
ENSMUST00000202741.5	Poln-207	protein coding cds not defined	none	5	407 nt	none	Ready in a moment
ENSMUST00000202825.2	Poln-208	protein coding cds not defined	none	2	392 nt	none	Ready in a moment

Poln

What Poln does

The RNA a design targets

Where Poln is expressed

The protein Poln encodes

Proteins STRING associates with Poln

Where Poln acts, as Reactome curates it

Diseases linked to Poln

Classified variants of Poln

How much variation Poln tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Poln

Long non-coding RNAs at the Poln locus

Papers that mention Poln

From Poln to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Poln

What Poln does

The RNA a design targets

Where Poln is expressed

The protein Poln encodes

Proteins STRING associates with Poln

Where Poln acts, as Reactome curates it

Diseases linked to Poln

Classified variants of Poln

How much variation Poln tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Poln

Long non-coding RNAs at the Poln locus

Papers that mention Poln

Poln

What Poln does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

Ensembl 10 transcripts

A window on one transcript

Where Poln is expressed

The protein Poln encodes

Proteins STRING associates with Poln

Where Poln acts, as Reactome curates it

Diseases linked to Poln

Classified variants of Poln

How much variation Poln tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Poln

Long non-coding RNAs at the Poln locus

Papers that mention Poln

From Poln to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

Ensembl 10 transcripts

A window on one transcript