Gene Mouse Mus musculus

Sptbn4

spectrin beta, non-erythrocytic 4

protein coding

HumanMouse Sptbn4Rat

Reading the ortholog votes for human and rat.

HGNC and MANE Select: not available for mouse. HGNC names human genes; MGI is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 7 A3NCBI: 7:27,055,808-27,147,128 on the minus strand, GRCm39 (GCF_000001635.27), sequence NC_000073.7, annotation GCF_000001635.27-RS_2024_02 of 2024-02-01Ensembl: 7:27,055,808-27,147,111 on the minus strand, GRCm39 (GCA_000001635.9), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: qv, dyn, lnd, SpbIV, Spnb4, ROSA62, nmf261, nmf379, 1700022P15Rik, 5830426A08Rik

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-02 ET · MGI:1890574Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Sptbn4 and mouse filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Sptbn4

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

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Ready in a moment

01 Summary and function

What Sptbn4 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From Sptbn4 to a sequence that silences it

The AUMsilence platform designs the sequences against the mouse transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Mouse Mus musculus

Sptbn4

Reading the record for Sptbn4 from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Sptbn4 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Sptbn4 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Sptbn4 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Sptbn4 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Sptbn4

Waiting for the record before reading STRING.

06 Pathways

Where Sptbn4 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Sptbn4

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Sptbn4

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Sptbn4 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Sptbn4

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Sptbn4 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Sptbn4

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_032610.2matches ENSMUST00000011895.14	transcript variant sigma1	protein coding	RefSeq Select	36	8,737 nt	2,561 aaNP_115999.2	Ready in a moment
XM_006540437.3	transcript variant X1	protein coding model	none	36	8,776 nt	2,580 aaXP_006540500.1	Ready in a moment
NM_001199235.1matches ENSMUST00000108362.8	transcript variant sigma6b	protein coding	none	18	4,861 nt	1,241 aaNP_001186164.1	Ready in a moment
NM_001199234.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_032610.2matches ENSMUST00000011895.14	transcript variant sigma1	protein coding	RefSeq Select	36	8,737 nt	2,561 aaNP_115999.2	Ready in a moment
XM_006540437.3	transcript variant X1	protein coding model	none	36	8,776 nt	2,580 aaXP_006540500.1	Ready in a moment
NM_001199235.1matches ENSMUST00000108362.8	transcript variant sigma6b	protein coding	none	18	4,861 nt	1,241 aaNP_001186164.1	Ready in a moment
NM_001199234.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSMUST00000011895.14	Sptbn4-201	protein coding	Ensembl canonical	36	8,747 nt	2,561 aaENSMUSP00000011895.8	Ready in a moment
ENSMUST00000108362.8	Sptbn4-202	protein coding	none	18	4,861 nt	1,241 aaENSMUSP00000103999.2	Ready in a moment
ENSMUST00000108364.8	Sptbn4-204	protein coding	none	19	4,740 nt	1,241 aaENSMUSP00000104001.2	Ready in a moment
ENSMUST00000108363.8	Sptbn4-203	protein coding	none	19	4,724 nt	1,241 aaENSMUSP00000104000.2	Ready in a moment
ENSMUST00000152572.2	Sptbn4-206	protein coding	none	3	493 nt	128 aaENSMUSP00000120738.2	Ready in a moment
ENSMUST00000137414.2	Sptbn4-205	protein coding cds not defined	none	2	369 nt	none	Ready in a moment

Sptbn4

What Sptbn4 does

The RNA a design targets

From Sptbn4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Sptbn4

What Sptbn4 does

The RNA a design targets

Where Sptbn4 is expressed

The protein Sptbn4 encodes

Proteins STRING associates with Sptbn4

Where Sptbn4 acts, as Reactome curates it

Diseases linked to Sptbn4

Classified variants of Sptbn4

How much variation Sptbn4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Sptbn4

Long non-coding RNAs at the Sptbn4 locus

Papers that mention Sptbn4

Sptbn4

What Sptbn4 does

Gene summary

Protein function

The RNA a design targets

RefSeq 5 transcripts

A window on one transcript

Ensembl 6 transcripts

A window on one transcript

From Sptbn4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where Sptbn4 is expressed

The protein Sptbn4 encodes

Proteins STRING associates with Sptbn4

Where Sptbn4 acts, as Reactome curates it

Diseases linked to Sptbn4

Classified variants of Sptbn4

How much variation Sptbn4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Sptbn4

Long non-coding RNAs at the Sptbn4 locus

Papers that mention Sptbn4

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 5 transcripts

A window on one transcript

Ensembl 6 transcripts

A window on one transcript