Gene Rat Rattus norvegicus

App

amyloid beta precursor protein

protein coding

HumanMouseRat App

Reading the ortholog votes for human and mouse.

HGNC and MANE Select: not available for rat. HGNC names human genes; RGD is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 11q11NCBI: 11:37,506,207-37,722,970 on the minus strand, GRCr8 (GCF_036323735.1), sequence NC_086029.1, annotation GCF_036323735.1-RS_2026_08 of 2026-08-17Ensembl: 11:37,506,408-37,722,971 on the minus strand, GRCr8 (GCA_036323735.1), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: Abeta

Gene identity, from NCBI Datasets · NCBI Datasets 18.37.0 · read 2026-09-23 ET · RGD:2139Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with App and rat filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for App

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What App does

Enables growth factor receptor binding activity; peptidase activator…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where App is expressed

Expression by tissue: not available for rat. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.

Ready in a moment

04 Protein

The protein App encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with App

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where App acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to App

Disease associations: not available for rat. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.

Ready in a moment

08 Variants

Classified variants of App

Clinical variants: not available for rat. ClinVar holds human variants only.

Ready in a moment

09 Constraint

How much variation App tolerates

Constraint: not available for rat. gnomAD and Open Targets carry constraint for human genes only.

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within App

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the App locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention App

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From App to a sequence that silences it

The AUMsilence platform designs the sequences against the rat transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for App Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Rat Rattus norvegicus

App

Reading the record for App from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for App opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What App does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where App is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein App encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with App

Waiting for the record before reading STRING.

06 Pathways

Where App acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to App

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of App

Waiting for the record before reading ClinVar.

09 Constraint

How much variation App tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within App

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the App locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention App

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_019288.2matches ENSRNOT00000164631.1	none given	protein coding	RefSeq Select	18	2,340 nt	770 aaNP_062161.1	Ready in a moment
XM_006248008.6	transcript variant X1	protein coding model	none	17	3,307 nt	752 aaXP_006248070.1	Ready in a moment
XM_006248009.6matches ENSRNOT00000044081.7	transcript variant X2	protein coding model	none	17	3,304 nt	751 aaXP_006248071.1	Ready in a moment
XM_006248010.6	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_019288.2matches ENSRNOT00000164631.1	none given	protein coding	RefSeq Select	18	2,340 nt	770 aaNP_062161.1	Ready in a moment
XM_006248008.6	transcript variant X1	protein coding model	none	17	3,307 nt	752 aaXP_006248070.1	Ready in a moment
XM_006248009.6matches ENSRNOT00000044081.7	transcript variant X2	protein coding model	none	17	3,304 nt	751 aaXP_006248071.1	Ready in a moment
XM_006248010.6	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSRNOT00000164631.1	App-204	protein coding	Ensembl canonical	18	2,340 nt	770 aaENSRNOP00000111736.1	Ready in a moment
ENSRNOT00000044081.7	App-201	protein coding	none	17	3,104 nt	751 aaENSRNOP00000040243.5	Ready in a moment
ENSRNOT00000048854.8	App-202	protein coding	none	16	2,936 nt	695 aaENSRNOP00000041613.5	Ready in a moment
ENSRNOT00000104573.2	App-203	protein coding	none	16	2,431 nt	733 aaENSRNOP00000078198.2	Ready in a moment

App

What App does

The RNA a design targets

Where App is expressed

The protein App encodes

Proteins STRING associates with App

Where App acts, as Reactome curates it

Diseases linked to App

Classified variants of App

How much variation App tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within App

Long non-coding RNAs at the App locus

Papers that mention App

From App to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

App

What App does

The RNA a design targets

Where App is expressed

The protein App encodes

Proteins STRING associates with App

Where App acts, as Reactome curates it

Diseases linked to App

Classified variants of App

How much variation App tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within App

Long non-coding RNAs at the App locus

Papers that mention App

App

What App does

Gene summary

Protein function

The RNA a design targets

RefSeq 7 transcripts

A window on one transcript

Ensembl 4 transcripts

A window on one transcript

Where App is expressed

The protein App encodes

Proteins STRING associates with App

Where App acts, as Reactome curates it

Diseases linked to App

Classified variants of App

How much variation App tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within App

Long non-coding RNAs at the App locus

Papers that mention App

From App to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 7 transcripts

A window on one transcript

Ensembl 4 transcripts

A window on one transcript