HGNC and MANE Select: not available for rat. HGNC names human genes; RGD is the authority here, and MANE Select is defined for human transcripts only.
Location
Cytogenetic band 7q21NCBI: 7:37,196,783-37,285,955 on the plus strand, GRCr8 (GCF_036323735.1), sequence NC_086025.1, annotation GCF_036323735.1-RS_2026_08 of 2026-08-17Ensembl: reading the location.Coordinates are one-based with both ends included, as each source reports them.
Also known as
RGD1311640
Gene identity, from NCBI Datasets · NCBI Datasets 18.41.0 · read · RGD:1311640Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Silence this gene
Sequences are designed using the AUMsilence™ platform against the Cep290 transcripts. Prices are on the order page.
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
Reading NCBI Datasets and Ensembl.
Ready in a moment
Reading NCBI Datasets and Ensembl.
03 / Expression by tissue
Where Cep290 is expressed
Ready in a moment
14 / Silencing this gene
From Cep290 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the rat Cep290 transcripts.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
The median is the middle sample of a tissue, so a gene expressed in a few cells of a mixed tissue reads low here and may still be the one your cell type needs. Nothing on this panel is adjusted or averaged across tissues; each figure is the source's own, and a tissue GTEx did not sample is absent from the chart.
Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
04 / Protein
The protein Cep290 encodes
Ready in a moment
05 / Interactions
Proteins STRING associates with Cep290
Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
06 / Pathways
Where Cep290 acts, as Reactome curates it
Ready in a moment
07 / Disease associations
Diseases linked to Cep290
Ready in a moment
Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
08 / Variants
Classified variants of Cep290
Ready in a moment
Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
09 / Constraint
How much variation Cep290 tolerates
Ready in a moment
Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
10 / Orthologs
The same gene in mouse, rat and human
Reading the Alliance, NCBI, Ensembl Compara and RGD.
Ready in a moment
11 /MicroRNAs
MicroRNAs hosted within Cep290
Reading Ensembl and miRBase.
Ready in a moment
12 / Long non-coding RNAs
Long non-coding RNAs at the Cep290 locus
Reading Ensembl.
Ready in a moment
13 / Literature
Papers that mention Cep290
Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
Predicted to enable identical protein binding activity. UniProt has 0 reviewed entries named Cep290 in rat.
NCBI Gene summary
Expression by tissue: not available for rat. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.
UniProt did not give one reviewed entry for Cep290 in rat, so InterPro, AlphaFold DB and PDBe were not asked and no protein entry is shown.
UniProt
UniProt did not give one reviewed entry for Cep290 in rat, so Reactome was not asked and no pathway list is shown.
UniProt
Disease associations: not available for rat. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.
Clinical variants: not available for rat. ClinVar holds human variants only.
Constraint: not available for rat. gnomAD and Open Targets carry constraint for human genes only.
Gene summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; positive regulation of DNA-templated transcription; and positive regulation of intracellular protein transport. Predicted to act upstream of or within several processes, including determination of left/right symmetry; photoreceptor cell maintenance; and retina development in camera-type eye. Located in ciliary basal body. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome 14; Joubert syndrome 5; Leber congenital amaurosis 10; Meckel syndrome 4; and Senior-Loken syndrome. Orthologous to human CEP290 (centrosomal protein 290).
Provided by Alliance of Genome Resources, Jul 2025, through NCBI Gene. NCBI disclaimer
Protein function
Not available
UniProt has 0 reviewed entries named Cep290 in rat.
NCBI Gene summary · NCBI Gene annotation RS_2026_08 · read · NCBI Gene 314787Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Expression by tissue: not available for rat. GTEx holds human tissues only, and the Human Protein Atlas is keyed on human genes.
Rat tissue expression, from Bgee and Expression Atlas, joins this page in a later phase. Nothing from the human ortholog is shown in its place; its own page is a step away through the species switch above.
Not available
Disease associations: not available for rat. Open Targets and ClinGen curate human genes only. The human ortholog's page carries the associations.
Not available
Clinical variants: not available for rat. ClinVar holds human variants only.
Not available
Constraint: not available for rat. gnomAD and Open Targets carry constraint for human genes only.
3,172 PubMed-indexed papers mention Cep290 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers the human symbol where it differs from this one only in case.
Ensembl: 7:37,196,783-37,285,955 on the plus strand, GRCr8 (GCA_036323735.1), release 116
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; Iqcb1, Ccp110, Cc2d2a lead.
STRING v12.0
12 RefSeq transcripts on GRCr8; RefSeq Select NM_001135755.2. Ensembl transcripts: Ensembl did not answer in time. Reference 9396547c-974.
NCBI Datasets
Human CEP290 by 2 of 2 votes; mouse Cep290 by 2 of 2 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 7e4498ed-f91.
Alliance · NCBI
No annotated microRNA lies within Cep290 in Ensembl release 116, on GRCr8.
Ensembl
Overlapping long non-coding RNAs: Ensembl did not answer in time. Reference 4540e71a-dfd.
Placed on GRCr8 (GCF_036323735.1). MANE Select: not available for rat. The reference here is the RefSeq Select transcript and the Ensembl canonical transcript, which need not be the same model.
RefSeq 12 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
NM_001135755.2NM_001135755.2RefSeq Select
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Not listed, because the source places them on another assembly only: XM_087557211.1 (not placed on GRCr8); XM_087557212.1 (not placed on GRCr8); XM_087557213.1 (not placed on GRCr8); XM_087557214.1 (not placed on GRCr8); XM_087557215.1 (not placed on GRCr8); XM_087557216.1 (not placed on GRCr8); XM_087557217.1 (not placed on GRCr8); XR_015624044.1 (not placed on GRCr8); XR_015624045.1 (not placed on GRCr8); XR_015624046.1 (not placed on GRCr8).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.41.0; GCF_036323735.1-RS_2026_08 · read · NCBI Gene 314787Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl
Ensembl transcripts: Ensembl did not answer in time.
Reference 9396547c-974
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for rat: GRCr8.
NM_001401003.1NM_001401003.1
XM_087623223.1XM_087623223.1
XM_017594843.3XM_017594843.3
XM_087623224.1XM_087623224.1
XM_087623222.1XM_087623222.1
XM_087623225.1XM_087623225.1
XM_039079092.2XM_039079092.2
XM_087623226.1XM_087623226.1
XR_005486624.3XR_005486624.3
XR_015663251.1XR_015663251.1
XR_015663250.1XR_015663250.1
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 58 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
