Gene Rat Rattus norvegicus

Ell3

elongation factor for RNA polymerase II 3

protein coding

HumanMouseRat Ell3

Reading the ortholog votes for human and mouse.

HGNC and MANE Select: not available for rat. HGNC names human genes; RGD is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 3q35NCBI: 3:128,866,755-128,870,892 on the minus strand, GRCr8 (GCF_036323735.1), sequence NC_086021.1, annotation GCF_036323735.1-RS_2026_08 of 2026-08-17Ensembl: 3:128,864,777-128,870,852 on the minus strand, GRCr8 (GCA_036323735.1), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-09-30 ET · RGD:1309917Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Ell3 and rat filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Ell3

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

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Ready in a moment

01 Summary and function

What Ell3 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From Ell3 to a sequence that silences it

The AUMsilence platform designs the sequences against the rat transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Rat Rattus norvegicus

Ell3

Reading the record for Ell3 from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Ell3 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Ell3 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Ell3 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Ell3 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Ell3

Waiting for the record before reading STRING.

06 Pathways

Where Ell3 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Ell3

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Ell3

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Ell3 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Ell3

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Ell3 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Ell3

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001430077.1matches ENSRNOT00000140394.1	transcript variant 2	protein coding	RefSeq Select	11	1,646 nt	393 aaNP_001417006.1	Ready in a moment
XM_006234832.6	transcript variant X1	protein coding model	none	11	1,775 nt	357 aaXP_006234894.1	Ready in a moment
XM_087610804.1	transcript variant X2	protein coding model	none	11	1,757 nt	351 aaXP_087466930.1	Ready in a moment
NM_001011957.1matches ENSRNOT00000133076.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001430077.1matches ENSRNOT00000140394.1	transcript variant 2	protein coding	RefSeq Select	11	1,646 nt	393 aaNP_001417006.1	Ready in a moment
XM_006234832.6	transcript variant X1	protein coding model	none	11	1,775 nt	357 aaXP_006234894.1	Ready in a moment
XM_087610804.1	transcript variant X2	protein coding model	none	11	1,757 nt	351 aaXP_087466930.1	Ready in a moment
NM_001011957.1matches ENSRNOT00000133076.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSRNOT00000140394.1	Ell3-203	protein coding	Ensembl canonical	11	1,629 nt	393 aaENSRNOP00000101184.1	Ready in a moment
ENSRNOT00000133076.1	Ell3-202	protein coding	none	10	1,786 nt	361 aaENSRNOP00000102332.1	Ready in a moment
ENSRNOT00000036823.4	Ell3-201	protein coding	none	11	1,147 nt	358 aaENSRNOP00000031619.3	Ready in a moment

Ell3

What Ell3 does

The RNA a design targets

From Ell3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Ell3

What Ell3 does

The RNA a design targets

Where Ell3 is expressed

The protein Ell3 encodes

Proteins STRING associates with Ell3

Where Ell3 acts, as Reactome curates it

Diseases linked to Ell3

Classified variants of Ell3

How much variation Ell3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Ell3

Long non-coding RNAs at the Ell3 locus

Papers that mention Ell3

Ell3

What Ell3 does

Gene summary

Protein function

The RNA a design targets

RefSeq 4 transcripts

A window on one transcript

Ensembl 3 transcripts

A window on one transcript

From Ell3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where Ell3 is expressed

The protein Ell3 encodes

Proteins STRING associates with Ell3

Where Ell3 acts, as Reactome curates it

Diseases linked to Ell3

Classified variants of Ell3

How much variation Ell3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Ell3

Long non-coding RNAs at the Ell3 locus

Papers that mention Ell3

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 4 transcripts

A window on one transcript

Ensembl 3 transcripts

A window on one transcript