Gene Rat Rattus norvegicus

Mrps18c

mitochondrial ribosomal protein S18C

protein coding

HGNC and MANE Select: not available for rat. HGNC names human genes; RGD is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 14p22NCBI: 14:9,116,688-9,123,100 on the minus strand, GRCr8 (GCF_036323735.1), sequence NC_086032.1, annotation GCF_036323735.1-RS_2026_08 of 2026-08-17Ensembl: 14:9,019,769-9,122,906 on the minus strand, GRCr8 (GCA_036323735.1), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-09-30 ET · RGD:1307997Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Mrps18c and rat filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Mrps18c

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

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Ready in a moment

01 Summary and function

What Mrps18c does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Ready in a moment

03 Expression by tissue

Where Mrps18c is expressed

Ready in a moment

14 Silencing this gene

From Mrps18c to a sequence that silences it

The AUMsilence platform designs the sequences against the rat transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Rat Rattus norvegicus

Mrps18c

Reading the record for Mrps18c from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Mrps18c opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Mrps18c does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Mrps18c is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Mrps18c encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Mrps18c

Waiting for the record before reading STRING.

06 Pathways

Where Mrps18c acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Mrps18c

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Mrps18c

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Mrps18c tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Mrps18c

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Mrps18c locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Mrps18c

Waiting for the record before reading Europe PMC.

Mrps18c

mitochondrial ribosomal protein S18C

protein coding

HGNC and MANE Select: not available for rat. HGNC names human genes; RGD is the authority here, and MANE Select is defined for human transcripts only.

Location

Cytogenetic band 14p22NCBI: 14:9,116,688-9,123,100 on the minus strand, GRCr8 (GCF_036323735.1), sequence NC_086032.1, annotation GCF_036323735.1-RS_2026_08 of 2026-08-17Ensembl: 14:9,019,769-9,122,906 on the minus strand, GRCr8 (GCA_036323735.1), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-09-30 ET · RGD:1307997Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001105996.1matches ENSRNOT00000002962.7	none given	protein coding	RefSeq Select	6	809 nt	143 aaNP_001099466.1	Ready in a moment
XM_087639209.1	transcript variant X1	protein coding model	none	6	451 nt	89 aaXP_087495335.1	Ready in a moment
XM_087639210.1matches ENSRNOT00000110810.2	transcript variant X2	protein coding model	none	5	406 nt	88 aaXP_087495336.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_001105996.1matches ENSRNOT00000002962.7

none given

protein coding

RefSeq Select

809 nt

143 aaNP_001099466.1

Ready in a moment

XM_087639209.1

transcript variant X1

protein coding model

none

451 nt

89 aaXP_087495335.1

Ready in a moment

XM_087639210.1matches ENSRNOT00000110810.2

transcript variant X2

protein coding model

none

406 nt

88 aaXP_087495336.1

Ready in a moment

From Mrps18c to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001105996.1matches ENSRNOT00000002962.7	none given	protein coding	RefSeq Select	6	809 nt	143 aaNP_001099466.1	Ready in a moment
XM_087639209.1	transcript variant X1	protein coding model	none	6	451 nt	89 aaXP_087495335.1	Ready in a moment
XM_087639210.1matches ENSRNOT00000110810.2	transcript variant X2	protein coding model	none	5	406 nt	88 aaXP_087495336.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_001105996.1matches ENSRNOT00000002962.7

none given

protein coding

RefSeq Select

809 nt

143 aaNP_001099466.1

Ready in a moment

XM_087639209.1

transcript variant X1

protein coding model

none

451 nt

89 aaXP_087495335.1

Ready in a moment

XM_087639210.1matches ENSRNOT00000110810.2

transcript variant X2

protein coding model

none

406 nt

88 aaXP_087495336.1

Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENSRNOT00000002936.8	Mrps18c-201	protein coding	Ensembl canonical	13	2,234 nt	574 aaENSRNOP00000002936.6	Ready in a moment
ENSRNOT00000172121.1	Mrps18c-205	protein coding	none	13	1,726 nt	461 aaENSRNOP00000101145.1	Ready in a moment
ENSRNOT00000002962.7	Mrps18c-202	protein coding	none	6	809 nt	143 aaENSRNOP00000002962.6	Ready in a moment
ENSRNOT00000113506.2	Mrps18c-204	protein coding	none	6	713 nt	197 aaENSRNOP00000081962.2	Ready in a moment
ENSRNOT00000110810.2	Mrps18c-203	protein coding	none	4	327 nt	88 aaENSRNOP00000087564.2	Ready in a moment

Mrps18c

What Mrps18c does

The RNA a design targets

Where Mrps18c is expressed

From Mrps18c to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Mrps18c

What Mrps18c does

The RNA a design targets

Where Mrps18c is expressed

The protein Mrps18c encodes

Proteins STRING associates with Mrps18c

Where Mrps18c acts, as Reactome curates it

Diseases linked to Mrps18c

Classified variants of Mrps18c

How much variation Mrps18c tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Mrps18c

Long non-coding RNAs at the Mrps18c locus

Papers that mention Mrps18c

Mrps18c

What Mrps18c does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

A window on one transcript

Ensembl 5 transcripts

A window on one transcript

Where Mrps18c is expressed

From Mrps18c to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

The protein Mrps18c encodes

Proteins STRING associates with Mrps18c

Where Mrps18c acts, as Reactome curates it

Diseases linked to Mrps18c

Classified variants of Mrps18c

How much variation Mrps18c tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Mrps18c

Long non-coding RNAs at the Mrps18c locus

Papers that mention Mrps18c

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

A window on one transcript

Ensembl 5 transcripts

A window on one transcript