Gene Rat Rattus norvegicus

Sesn3

sestrin 3

protein coding

HumanMouseRat Sesn3

Reading the ortholog votes for human and mouse.

HGNC and MANE Select: not available for rat. HGNC names human genes; RGD is the authority here, and MANE Select is defined for human transcripts only.

Location: Cytogenetic band 8q12NCBI: 8:19,415,353-19,470,943 on the plus strand, GRCr8 (GCF_036323735.1), sequence NC_086026.1, annotation GCF_036323735.1-RS_2026_08 of 2026-08-17Ensembl: 8:19,415,347-19,466,904 on the plus strand, GRCr8 (GCA_036323735.1), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from NCBI Datasets · NCBI Datasets 18.38.0 · read 2026-10-01 ET · RGD:1309470Data from NCBI, provided as is; NCBI's policies and disclaimers apply.

Silence this gene

The order page opens with Sesn3 and rat filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for Sesn3

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

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Ready in a moment

01 Summary and function

What Sesn3 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From Sesn3 to a sequence that silences it

The AUMsilence platform designs the sequences against the rat transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Rat Rattus norvegicus

Sesn3

Reading the record for Sesn3 from NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for Sesn3 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What Sesn3 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where Sesn3 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein Sesn3 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with Sesn3

Waiting for the record before reading STRING.

06 Pathways

Where Sesn3 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to Sesn3

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of Sesn3

Waiting for the record before reading ClinVar.

09 Constraint

How much variation Sesn3 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within Sesn3

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the Sesn3 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention Sesn3

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001108125.1matches ENSRNOT00000124821.1	none given	protein coding	RefSeq Select	10	2,921 nt	492 aaNP_001101595.1	Ready in a moment
XM_087626136.1	transcript variant X11	protein coding model	none	10	9,835 nt	476 aaXP_087482262.1	Ready in a moment
XR_015665240.1	transcript variant X2	non coding model	none	11	8,334 nt	none	Ready in a moment
XR_015665243.1	transcript variant X5	non coding model	none	12	7,792 nt	none	Ready in a moment
Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001108125.1matches ENSRNOT00000124821.1	none given	protein coding	RefSeq Select	10	2,921 nt	492 aaNP_001101595.1	Ready in a moment
XM_087626136.1	transcript variant X11	protein coding model	none	10	9,835 nt	476 aaXP_087482262.1	Ready in a moment
XR_015665240.1	transcript variant X2	non coding model	none	11	8,334 nt	none	Ready in a moment
XR_015665243.1	transcript variant X5	non coding model	none	12	7,792 nt	none	Ready in a moment
Ready in a moment

Sesn3

What Sesn3 does

The RNA a design targets

From Sesn3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Sesn3

What Sesn3 does

The RNA a design targets

Where Sesn3 is expressed

The protein Sesn3 encodes

Proteins STRING associates with Sesn3

Where Sesn3 acts, as Reactome curates it

Diseases linked to Sesn3

Classified variants of Sesn3

How much variation Sesn3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Sesn3

Long non-coding RNAs at the Sesn3 locus

Papers that mention Sesn3

Sesn3

What Sesn3 does

Gene summary

Protein function

The RNA a design targets

RefSeq 12 transcripts

A window on one transcript

Ensembl 0 transcripts

From Sesn3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where Sesn3 is expressed

The protein Sesn3 encodes

Proteins STRING associates with Sesn3

Where Sesn3 acts, as Reactome curates it

Diseases linked to Sesn3

Classified variants of Sesn3

How much variation Sesn3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within Sesn3

Long non-coding RNAs at the Sesn3 locus

Papers that mention Sesn3

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 12 transcripts

A window on one transcript

Ensembl 0 transcripts