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Pathway Human Homo sapiens

Voltage gated Potassium channels

R-HSA-1296072 in Reactome release 97: under Potassium Channels, with 43 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-1296072 (mouse), R-RNO-1296072 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 43 genes in this human pathway; showing 1 to 43, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
GeneKCNA1AuthorityHGNC:6218Mapping file id3736 NCBI fileEvidenceTAS
GeneKCNA10AuthorityHGNC:6219Mapping file id3744 NCBI fileEvidenceTAS
GeneKCNA2AuthorityHGNC:6220Mapping file id3737 NCBI fileEvidenceTAS
GeneKCNA3AuthorityHGNC:6221Mapping file id3738 NCBI fileEvidenceTAS
GeneKCNA4AuthorityHGNC:6222Mapping file id3739 NCBI fileEvidenceTAS
GeneKCNA5AuthorityHGNC:6224Mapping file id3741 NCBI fileEvidenceTAS
GeneKCNA6AuthorityHGNC:6225Mapping file id3742 NCBI fileEvidenceTAS
GeneKCNA7AuthorityHGNC:6226Mapping file id3743 NCBI fileEvidenceTAS
GeneKCNAB1AuthorityHGNC:6228Mapping file id7881 NCBI fileEvidenceTAS
GeneKCNAB2AuthorityHGNC:6229Mapping file id8514 NCBI fileEvidenceTAS
GeneKCNAB3AuthorityHGNC:6230Mapping file id9196 NCBI fileEvidenceTAS
GeneKCNB1AuthorityHGNC:6231Mapping file id3745 NCBI fileEvidenceTAS
GeneKCNB2AuthorityHGNC:6232Mapping file id9312 NCBI fileEvidenceTAS
GeneKCNC1AuthorityHGNC:6233Mapping file id3746 NCBI fileEvidenceTAS
GeneKCNC2AuthorityHGNC:6234Mapping file id3747 NCBI fileEvidenceTAS
GeneKCNC3AuthorityHGNC:6235Mapping file id3748 NCBI fileEvidenceTAS
GeneKCNC4AuthorityHGNC:6236Mapping file id3749 NCBI fileEvidenceTAS
GeneKCND1AuthorityHGNC:6237Mapping file id3750 NCBI fileEvidenceTAS
GeneKCND2AuthorityHGNC:6238Mapping file id3751 NCBI fileEvidenceTAS
GeneKCND3AuthorityHGNC:6239Mapping file id3752 NCBI fileEvidenceTAS
GeneKCNF1AuthorityHGNC:6246Mapping file id3754 NCBI fileEvidenceTAS
GeneKCNG1AuthorityHGNC:6248Mapping file id3755 NCBI fileEvidenceTAS
GeneKCNG2AuthorityHGNC:6249Mapping file id26251 NCBI fileEvidenceTAS
GeneKCNG3AuthorityHGNC:18306Mapping file id170850 NCBI fileEvidenceTAS
GeneKCNG4AuthorityHGNC:19697Mapping file id93107 NCBI fileEvidenceTAS
GeneKCNH1AuthorityHGNC:6250Mapping file id3756 NCBI fileEvidenceTAS
GeneKCNH2AuthorityHGNC:6251Mapping file id3757 NCBI fileEvidenceTAS
GeneKCNH3AuthorityHGNC:6252Mapping file id23416 NCBI fileEvidenceTAS
GeneKCNH4AuthorityHGNC:6253Mapping file id23415 NCBI fileEvidenceTAS
GeneKCNH5AuthorityHGNC:6254Mapping file id27133 NCBI fileEvidenceTAS
GeneKCNH6AuthorityHGNC:18862Mapping file id81033 NCBI fileEvidenceTAS
GeneKCNH7AuthorityHGNC:18863Mapping file id90134 NCBI fileEvidenceTAS
GeneKCNH8AuthorityHGNC:18864Mapping file id131096 NCBI fileEvidenceTAS
GeneKCNQ1AuthorityHGNC:6294Mapping file id3784 NCBI fileEvidenceTAS
GeneKCNQ2AuthorityHGNC:6296Mapping file id3785 NCBI fileEvidenceTAS
GeneKCNQ3AuthorityHGNC:6297Mapping file id3786 NCBI fileEvidenceTAS
GeneKCNQ4AuthorityHGNC:6298Mapping file id9132 NCBI fileEvidenceTAS
GeneKCNQ5AuthorityHGNC:6299Mapping file id56479 NCBI fileEvidenceTAS
GeneKCNS1AuthorityHGNC:6300Mapping file id3787 NCBI fileEvidenceTAS
GeneKCNS2AuthorityHGNC:6301Mapping file id3788 NCBI fileEvidenceTAS
GeneKCNS3AuthorityHGNC:6302Mapping file id3790 NCBI fileEvidenceTAS
GeneKCNV1AuthorityHGNC:18861Mapping file id27012 NCBI fileEvidenceTAS
GeneKCNV2AuthorityHGNC:19698Mapping file id169522 NCBI fileEvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.