Pathway Human Homo sapiens

Acyl chain remodelling of PS

R-HSA-1482801 in Reactome release 97: under Glycerophospholipid biosynthesis, with 22 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-1482801 (mouse), R-RNO-1482801 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-1482801.5
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2012-06-12
Last updated: 2018-03-26
Events inside: 8, counted from the record

In the acyl chain remodelling pathway (Lands cycle), phosphatidylserine (PS) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008; Hishikawa et al. 2008).

Literature Reactome attaches

Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoformsJ Biol Chem, 2010, vol. 285, p. 36100-11PubMed 20705608
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2J Biol Chem, 2002, vol. 277, p. 48535-49PubMed 12359733
Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2J Biol Chem, 2008, vol. 283, p. 19049-57PubMed 18458083
Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversityProc Natl Acad Sci U S A, 2008, vol. 105, p. 2830-5PubMed 18287005

Reactome's record lists 14 orthologous events, R-RNO-1482801 (Rattus norvegicus), R-MMU-1482801 (Mus musculus) among the species this site serves, and 12 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-09-30 ET · Reactome pathway browser"Acyl chain remodelling of PS". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-1482801 with StableID: R-HSA-1482801.5 (accessed 2026-09-30 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 22 genes in this human pathway; showing 1 to 22, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneLPCAT3	AuthorityHGNC:30244	Mapping file id10162 NCBI file	EvidenceTAS
GeneLPCAT4	AuthorityHGNC:30059	Mapping file id254531 NCBI file	EvidenceTAS
GeneMBOAT1	AuthorityHGNC:21579	Mapping file id154141 NCBI file	EvidenceTAS
GeneOSBPL10	AuthorityHGNC:16395	Mapping file id114884 NCBI file	EvidenceTAS
GeneOSBPL5	AuthorityHGNC:16392	Mapping file id114879 NCBI file	EvidenceTAS
GeneOSBPL8	AuthorityHGNC:16396	Mapping file id114882 NCBI file	EvidenceTAS
GenePLA1A	AuthorityHGNC:17661	Mapping file id51365 NCBI file	EvidenceTAS
GenePLA2G10	AuthorityHGNC:9029	Mapping file id8399 NCBI file	EvidenceTAS
GenePLA2G12A	AuthorityHGNC:18554	Mapping file id81579 NCBI file	EvidenceTAS
GenePLA2G1B	AuthorityHGNC:9030	Mapping file id5319 NCBI file	EvidenceTAS
GenePLA2G2A	AuthorityHGNC:9031	Mapping file id5320 NCBI file	EvidenceTAS
GenePLA2G2D	AuthorityHGNC:9033	Mapping file id26279 NCBI file	EvidenceTAS
GenePLA2G2E	AuthorityHGNC:13414	Mapping file id30814 NCBI file	EvidenceTAS
GenePLA2G2F	AuthorityHGNC:30040	Mapping file id64600 NCBI file	EvidenceTAS
GenePLA2G4A	AuthorityHGNC:9035	Mapping file id5321 NCBI file	EvidenceTAS
GenePLA2G4B	AuthorityHGNC:9036	Mapping file id100137049 NCBI file	EvidenceTAS
GenePLA2G4D	AuthorityHGNC:30038	Mapping file id283748 NCBI file	EvidenceTAS
GenePLA2G4E	AuthorityHGNC:24791	Mapping file id123745 NCBI file	EvidenceTAS
GenePLA2G4F	AuthorityHGNC:27396	Mapping file id255189 NCBI file	EvidenceTAS
GenePLA2G5	AuthorityHGNC:9038	Mapping file id5322 NCBI file	EvidenceTAS
GenePLA2R1	AuthorityHGNC:9042	Mapping file id22925 NCBI file	EvidenceTAS
GenePLAAT3	AuthorityHGNC:17825	Mapping file id11145 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Glycerophospholipid biosynthesisR-HSA-1483206129 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.