Pathway Human Homo sapiens

Initiation of Nuclear Envelope (NE) Reformation

R-HSA-2995383 in Reactome release 97: under Nuclear Envelope (NE) Reassembly, with 19 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-2995383 (mouse), R-RNO-2995383 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-2995383.7
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2013-03-12
Last updated: 2020-03-16
Events inside: 7, counted from the record

Reassembly of the nuclear envelope (NE) is initiated at late anaphase/early telophase when BANF1 (BAF), which is dispersed throughout the cytoplasm during metaphase, accumulates on the surfaces of coalesced chromosomes. This is coordinated with the chromatin association of membranes and inner nuclear membrane proteins that include EMD (emerin), TMPO (LAP2beta), LEMD3 (MAN1) and LEMD2 (LEM2), and lamins (Haraguchi et al. 2008, reviewed by Wandke and Kutay 2013). The DNA-cross-bridging activity of BANF1 is required for individual chromosomes to properly coalesce for enclosure in a single nucleus (Samwer et al. 2017).

Literature Reactome attaches

Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assemblyJ. Cell. Sci., 2008, vol. 121, p. 2540-54PubMed 18628300
Enclosing chromatin: reassembly of the nucleus after open mitosisCell, 2013, vol. 152, p. 1222-5PubMed 23498932
DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic ChromosomesCell, 2017, vol. 170, p. 956-972.e23PubMed 28841419

Reactome's record lists 12 orthologous events, R-RNO-2995383 (Rattus norvegicus), R-MMU-2995383 (Mus musculus) among the species this site serves, and 10 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-10-01 ET · Reactome pathway browser"Initiation of Nuclear Envelope (NE) Reformation". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-2995383 with StableID: R-HSA-2995383.7 (accessed 2026-10-01 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 19 genes in this human pathway; showing 1 to 19, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneANKLE2	AuthorityHGNC:29101	Mapping file id23141 NCBI file	EvidenceTAS
GeneBANF1	AuthorityHGNC:17397	Mapping file id8815 NCBI file	EvidenceTAS
GeneCCNB1	AuthorityHGNC:1579	Mapping file id891 NCBI file	EvidenceTAS
GeneCCNB2	AuthorityHGNC:1580	Mapping file id9133 NCBI file	EvidenceTAS
GeneCDK1	AuthorityHGNC:1722	Mapping file id983 NCBI file	EvidenceTAS
GeneEMD	AuthorityHGNC:3331	Mapping file id2010 NCBI file	EvidenceTAS
GeneKPNB1	AuthorityHGNC:6400	Mapping file id3837 NCBI file	EvidenceTAS
GeneLBR	AuthorityHGNC:6518	Mapping file id3930 NCBI file	EvidenceTAS
GeneLEMD2	AuthorityHGNC:21244	Mapping file id221496 NCBI file	EvidenceTAS
GeneLEMD3	AuthorityHGNC:28887	Mapping file id23592 NCBI file	EvidenceTAS
GeneLMNA	AuthorityHGNC:6636	Mapping file id4000 NCBI file	EvidenceTAS
GeneLMNB1	AuthorityHGNC:6637	Mapping file id4001 NCBI file	EvidenceTAS
GenePPP2CA	AuthorityHGNC:9299	Mapping file id5515 NCBI file	EvidenceTAS
GenePPP2R1A	AuthorityHGNC:9302	Mapping file id5518 NCBI file	EvidenceTAS
GenePPP2R2A	AuthorityHGNC:9304	Mapping file id5520 NCBI file	EvidenceTAS
GeneSIRT2	AuthorityHGNC:10886	Mapping file id22933 NCBI file	EvidenceTAS
GeneTMPO	AuthorityHGNC:11875	Mapping file id7112 NCBI file	EvidenceTAS
GeneVRK1	AuthorityHGNC:12718	Mapping file id7443 NCBI file	EvidenceTAS
GeneVRK2	AuthorityHGNC:12719	Mapping file id7444 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Nuclear Envelope (NE) ReassemblyR-HSA-299541077 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.