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Pathway Human Homo sapiens

Olfactory Signaling Pathway

R-HSA-381753 in Reactome release 97: under Sensory Perception, with 418 genes placed in it by the mapping files and 1 child pathway in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-381753 (mouse). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 418 genes in this human pathway; showing 101 to 200, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 5
GeneOR1M1AuthorityHGNC:8220Mapping file id125963 NCBI fileEvidenceIEA
GeneOR1N1AuthorityHGNC:8221Mapping file id138883 NCBI fileEvidenceIEA
GeneOR1N2AuthorityHGNC:15111Mapping file id138882 NCBI fileEvidenceIEA, TAS
GeneOR1P1AuthorityHGNC:8222Mapping file idENSG00000262085 Ensembl fileEvidenceIEA
GeneOR1Q1AuthorityHGNC:8223Mapping file id158131 NCBI fileEvidenceIEA
GeneOR1S1AuthorityHGNC:8227Mapping file id219959 NCBI fileEvidenceIEA
GeneOR1S2AuthorityHGNC:15141Mapping file id219958 NCBI fileEvidenceIEA
GeneOR2A1AuthorityHGNC:8229Mapping file id346528 NCBI fileEvidenceIEA, TAS
GeneOR2A12AuthorityHGNC:15082Mapping file id346525 NCBI fileEvidenceIEA
GeneOR2A14AuthorityHGNC:15084Mapping file id135941 NCBI fileEvidenceIEA
GeneOR2A2AuthorityHGNC:8230Mapping file id442361 NCBI fileEvidenceIEA
GeneOR2A25AuthorityHGNC:19562Mapping file id392138 NCBI fileEvidenceIEA, TAS
GeneOR2A4AuthorityHGNC:14729Mapping file id79541 NCBI fileEvidenceIEA
GeneOR2A42AuthorityHGNC:31230Mapping file id402317 NCBI fileEvidenceIEA, TAS
GeneOR2A5AuthorityHGNC:8232Mapping file id393046 NCBI fileEvidenceIEA
GeneOR2A7AuthorityHGNC:8234Mapping file id401427 NCBI fileEvidenceIEA, TAS
GeneOR2AE1AuthorityHGNC:15087Mapping file id81392 NCBI fileEvidenceIEA
GeneOR2AG1AuthorityHGNC:15142Mapping file id144125 NCBI fileEvidenceIEA
GeneOR2AG2AuthorityHGNC:15143Mapping file id338755 NCBI fileEvidenceIEA
GeneOR2AJ1AuthorityHGNC:15001Mapping file id127608 NCBI fileEvidenceIEA
GeneOR2AK2AuthorityHGNC:19569Mapping file id391191 NCBI fileEvidenceIEA
GeneOR2AP1AuthorityHGNC:15335Mapping file id121129 NCBI fileEvidenceIEA
GeneOR2AT4AuthorityHGNC:19620Mapping file id341152 NCBI fileEvidenceIEA, TAS
GeneOR2B11AuthorityHGNC:31249Mapping file id127623 NCBI fileEvidenceIEA, TAS
GeneOR2B2AuthorityHGNC:13966Mapping file id81697 NCBI fileEvidenceIEA
GeneOR2B3AuthorityHGNC:8238Mapping file id442184 NCBI fileEvidenceIEA
GeneOR2B6AuthorityHGNC:8241Mapping file id26212 NCBI fileEvidenceIEA
GeneOR2C1AuthorityHGNC:8242Mapping file id4993 NCBI fileEvidenceIEA, TAS
GeneOR2C3AuthorityHGNC:15005Mapping file id81472 NCBI fileEvidenceIEA
GeneOR2D2AuthorityHGNC:8244Mapping file id120776 NCBI fileEvidenceIEA
GeneOR2D3AuthorityHGNC:15146Mapping file id120775 NCBI fileEvidenceIEA
GeneOR2F1AuthorityHGNC:8246Mapping file id26211 NCBI fileEvidenceIEA, TAS
GeneOR2F2AuthorityHGNC:8247Mapping file id135948 NCBI fileEvidenceIEA
GeneOR2G2AuthorityHGNC:15007Mapping file id81470 NCBI fileEvidenceIEA
GeneOR2G3AuthorityHGNC:15008Mapping file id81469 NCBI fileEvidenceIEA
GeneOR2G6AuthorityHGNC:27019Mapping file id391211 NCBI fileEvidenceIEA
GeneOR2H1AuthorityHGNC:8252Mapping file id26716 NCBI fileEvidenceIEA
GeneOR2H2AuthorityHGNC:8253Mapping file id7932 NCBI fileEvidenceIEA
GeneOR2I1AuthorityHGNC:8258Mapping file id442197 NCBI fileEvidenceIEA
GeneOR2J1AuthorityHGNC:8259Mapping file id442185 NCBI fileEvidenceIEA, TAS
GeneOR2J2AuthorityHGNC:8260Mapping file id26707 NCBI fileEvidenceIEA, TAS
GeneOR2J3AuthorityHGNC:8261Mapping file id442186 NCBI fileEvidenceIEA, TAS
GeneOR2K2AuthorityHGNC:8264Mapping file id26248 NCBI fileEvidenceIEA
GeneOR2L13AuthorityHGNC:19578Mapping file id284521 NCBI fileEvidenceIEA, TAS
GeneOR2L2AuthorityHGNC:8266Mapping file id26246 NCBI fileEvidenceIEA
GeneOR2L3AuthorityHGNC:15009Mapping file id391192 NCBI fileEvidenceIEA
GeneOR2L5AuthorityHGNC:15011Mapping file id81466 NCBI fileEvidenceIEA
GeneOR2L8AuthorityHGNC:15014Mapping file id391190 NCBI fileEvidenceIEA
GeneOR2M2AuthorityHGNC:8268Mapping file id391194 NCBI fileEvidenceIEA, TAS
GeneOR2M3AuthorityHGNC:8269Mapping file id127062 NCBI fileEvidenceIEA
GeneOR2M4AuthorityHGNC:8270Mapping file id26245 NCBI fileEvidenceIEA
GeneOR2M5AuthorityHGNC:19576Mapping file id127059 NCBI fileEvidenceIEA
GeneOR2M7AuthorityHGNC:19594Mapping file id391196 NCBI fileEvidenceIEA, TAS
GeneOR2S2AuthorityHGNC:8276Mapping file id56656 NCBI fileEvidenceIEA, TAS
GeneOR2T1AuthorityHGNC:8277Mapping file id26696 NCBI fileEvidenceIEA, TAS
GeneOR2T10AuthorityHGNC:19573Mapping file id127069 NCBI fileEvidenceIEA
GeneOR2T11AuthorityHGNC:19574Mapping file id127077 NCBI fileEvidenceIEA
GeneOR2T12AuthorityHGNC:19592Mapping file id127064 NCBI fileEvidenceIEA
GeneOR2T2AuthorityHGNC:14725Mapping file id401992 NCBI fileEvidenceIEA
GeneOR2T27AuthorityHGNC:31252Mapping file id403239 NCBI fileEvidenceIEA
GeneOR2T29AuthorityHGNC:31253Mapping file id343563 NCBI fileEvidenceIEA
GeneOR2T3AuthorityHGNC:14727Mapping file id343173 NCBI fileEvidenceIEA
GeneOR2T33AuthorityHGNC:31255Mapping file id391195 NCBI fileEvidenceIEA
GeneOR2T34AuthorityHGNC:31256Mapping file id127068 NCBI fileEvidenceIEA
GeneOR2T35AuthorityHGNC:31257Mapping file id403244 NCBI fileEvidenceIEA
GeneOR2T4AuthorityHGNC:15016Mapping file id127074 NCBI fileEvidenceIEA, TAS
GeneOR2T5AuthorityHGNC:15017Mapping file id401993 NCBI fileEvidenceIEA
GeneOR2T6AuthorityHGNC:15018Mapping file id254879 NCBI fileEvidenceIEA
GeneOR2T7AuthorityHGNC:15019Mapping file idENSG00000227152 Ensembl fileEvidenceIEA
GeneOR2T8AuthorityHGNC:15020Mapping file id343172 NCBI fileEvidenceIEA
GeneOR2V1AuthorityHGNC:8280Mapping file id26693 NCBI fileEvidenceIEA
GeneOR2V2AuthorityHGNC:15341Mapping file id285659 NCBI fileEvidenceIEA
GeneOR2W1AuthorityHGNC:8281Mapping file id26692 NCBI fileEvidenceIEA, TAS
GeneOR2W3AuthorityHGNC:15021Mapping file id343171 NCBI fileEvidenceIEA, TAS
GeneOR2Y1AuthorityHGNC:14837Mapping file id134083 NCBI fileEvidenceIEA
GeneOR2Z1AuthorityHGNC:15391Mapping file id284383 NCBI fileEvidenceIEA
GeneOR3A1AuthorityHGNC:8282Mapping file id4994 NCBI fileEvidenceIEA, TAS
GeneOR3A2AuthorityHGNC:8283Mapping file id4995 NCBI fileEvidenceIEA
GeneOR3A3AuthorityHGNC:8284Mapping file id8392 NCBI fileEvidenceIEA
GeneOR4A15AuthorityHGNC:15152Mapping file id81328 NCBI fileEvidenceIEA
GeneOR4A16AuthorityHGNC:15153Mapping file id81327 NCBI fileEvidenceIEA
GeneOR4A47AuthorityHGNC:31266Mapping file id403253 NCBI fileEvidenceIEA
GeneOR4A5AuthorityHGNC:15162Mapping file id81318 NCBI fileEvidenceIEA
GeneOR4A8AuthorityHGNC:15165Mapping file idENSG00000225997 Ensembl fileEvidenceIEA
GeneOR4B1AuthorityHGNC:8290Mapping file id119765 NCBI fileEvidenceIEA
GeneOR4C11AuthorityHGNC:15167Mapping file id219429 NCBI fileEvidenceIEA
GeneOR4C12AuthorityHGNC:15168Mapping file id283093 NCBI fileEvidenceIEA, TAS
GeneOR4C13AuthorityHGNC:15169Mapping file id283092 NCBI fileEvidenceIEA
GeneOR4C15AuthorityHGNC:15171Mapping file id81309 NCBI fileEvidenceIEA
GeneOR4C16AuthorityHGNC:15172Mapping file id219428 NCBI fileEvidenceIEA
GeneOR4C3AuthorityHGNC:14697Mapping file id256144 NCBI fileEvidenceIEA
GeneOR4C45AuthorityHGNC:31270Mapping file id403257 NCBI fileEvidenceIEA
GeneOR4C46AuthorityHGNC:31271Mapping file id119749 NCBI fileEvidenceIEA
GeneOR4C5AuthorityHGNC:14702Mapping file id79346 NCBI fileEvidenceIEA
GeneOR4C6AuthorityHGNC:14743Mapping file id219432 NCBI fileEvidenceIEA
GeneOR4D1AuthorityHGNC:8293Mapping file id26689 NCBI fileEvidenceIEA
GeneOR4D10AuthorityHGNC:15173Mapping file id390197 NCBI fileEvidenceIEA
GeneOR4D11AuthorityHGNC:15174Mapping file id219986 NCBI fileEvidenceIEA
GeneOR4D2AuthorityHGNC:8294Mapping file id124538 NCBI fileEvidenceIEA, TAS
GeneOR4D5AuthorityHGNC:14852Mapping file id219875 NCBI fileEvidenceIEA

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.