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Pathway Human Homo sapiens

ABC-family protein mediated transport

R-HSA-382556 in Reactome release 97: under Transport of small molecules, with 90 genes placed in it by the mapping files and 2 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-382556 (mouse), R-RNO-382556 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 90 genes in this human pathway; showing 1 to 90, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
GeneABCA10AuthorityHGNC:30Mapping file id10349 NCBI fileEvidenceTAS
GeneABCA12AuthorityHGNC:14637Mapping file id26154 NCBI fileEvidenceTAS
GeneABCA2AuthorityHGNC:32Mapping file id20 NCBI fileEvidenceTAS
GeneABCA3AuthorityHGNC:33Mapping file id21 NCBI fileEvidenceTAS
GeneABCA4AuthorityHGNC:34Mapping file id24 NCBI fileEvidenceTAS
GeneABCA5AuthorityHGNC:35Mapping file id23461 NCBI fileEvidenceTAS
GeneABCA6AuthorityHGNC:36Mapping file id23460 NCBI fileEvidenceTAS
GeneABCA7AuthorityHGNC:37Mapping file id10347 NCBI fileEvidenceTAS
GeneABCA8AuthorityHGNC:38Mapping file id10351 NCBI fileEvidenceTAS
GeneABCA9AuthorityHGNC:39Mapping file id10350 NCBI fileEvidenceTAS
GeneABCB1AuthorityHGNC:40Mapping file id5243 NCBI fileEvidenceTAS
GeneABCB10AuthorityHGNC:41Mapping file id23456 NCBI fileEvidenceTAS
GeneABCB4AuthorityHGNC:45Mapping file id5244 NCBI fileEvidenceTAS
GeneABCB5AuthorityHGNC:46Mapping file id340273 NCBI fileEvidenceTAS
GeneABCB6AuthorityHGNC:47Mapping file id10058 NCBI fileEvidenceTAS
GeneABCB7AuthorityHGNC:48Mapping file id22 NCBI fileEvidenceTAS
GeneABCB8AuthorityHGNC:49Mapping file id11194 NCBI fileEvidenceTAS
GeneABCB9AuthorityHGNC:50Mapping file id23457 NCBI fileEvidenceTAS
GeneABCC1AuthorityHGNC:51Mapping file id4363 NCBI fileEvidenceTAS
GeneABCC10AuthorityHGNC:52Mapping file id89845 NCBI fileEvidenceTAS
GeneABCC11AuthorityHGNC:14639Mapping file id85320 NCBI fileEvidenceTAS
GeneABCC2AuthorityHGNC:53Mapping file id1244 NCBI fileEvidenceTAS
GeneABCC3AuthorityHGNC:54Mapping file id8714 NCBI fileEvidenceTAS
GeneABCC4AuthorityHGNC:55Mapping file id10257 NCBI fileEvidenceTAS
GeneABCC5AuthorityHGNC:56Mapping file id10057 NCBI fileEvidenceTAS
GeneABCC6AuthorityHGNC:57Mapping file id368 NCBI fileEvidenceTAS
GeneABCC9AuthorityHGNC:60Mapping file id10060 NCBI fileEvidenceTAS
GeneABCD1AuthorityHGNC:61Mapping file id215 NCBI fileEvidenceTAS
GeneABCD2AuthorityHGNC:66Mapping file id225 NCBI fileEvidenceTAS
GeneABCD3AuthorityHGNC:67Mapping file id5825 NCBI fileEvidenceTAS
GeneABCF1AuthorityHGNC:70Mapping file id23 NCBI fileEvidenceTAS
GeneABCG1AuthorityHGNC:73Mapping file id9619 NCBI fileEvidenceTAS
GeneABCG4AuthorityHGNC:13884Mapping file id64137 NCBI fileEvidenceTAS
GeneABCG5AuthorityHGNC:13886Mapping file id64240 NCBI fileEvidenceTAS
GeneABCG8AuthorityHGNC:13887Mapping file id64241 NCBI fileEvidenceTAS
GeneADRM1AuthorityHGNC:15759Mapping file id11047 NCBI fileEvidenceTAS
GeneAPOA1AuthorityHGNC:600Mapping file id335 NCBI fileEvidenceTAS
GeneCFTRAuthorityHGNC:1884Mapping file id1080 NCBI fileEvidenceTAS
GeneDERL1AuthorityHGNC:28454Mapping file id79139 NCBI fileEvidenceTAS
GeneDERL2AuthorityHGNC:17943Mapping file id51009 NCBI fileEvidenceTAS
GeneDERL3AuthorityHGNC:14236Mapping file id91319 NCBI fileEvidenceTAS
GeneEIF2S1AuthorityHGNC:3265Mapping file id1965 NCBI fileEvidenceTAS
GeneEIF2S2AuthorityHGNC:3266Mapping file id8894 NCBI fileEvidenceTAS
GeneEIF2S3AuthorityHGNC:3267Mapping file id1968 NCBI fileEvidenceTAS
GeneERLEC1AuthorityHGNC:25222Mapping file id27248 NCBI fileEvidenceTAS
GeneERLIN1AuthorityHGNC:16947Mapping file id10613 NCBI fileEvidenceTAS
GeneERLIN2AuthorityHGNC:1356Mapping file id11160 NCBI fileEvidenceTAS
GeneKCNJ11AuthorityHGNC:6257Mapping file id3767 NCBI fileEvidenceTAS
GeneOS9AuthorityHGNC:16994Mapping file id10956 NCBI fileEvidenceTAS
GenePEX19AuthorityHGNC:9713Mapping file id5824 NCBI fileEvidenceTAS
GenePEX3AuthorityHGNC:8858Mapping file id8504 NCBI fileEvidenceTAS
GenePSMA1AuthorityHGNC:9530Mapping file id5682 NCBI fileEvidenceTAS
GenePSMA2AuthorityHGNC:9531Mapping file id5683 NCBI fileEvidenceTAS
GenePSMA3AuthorityHGNC:9532Mapping file id5684 NCBI fileEvidenceTAS
GenePSMA4AuthorityHGNC:9533Mapping file id5685 NCBI fileEvidenceTAS
GenePSMA5AuthorityHGNC:9534Mapping file id5686 NCBI fileEvidenceTAS
GenePSMA6AuthorityHGNC:9535Mapping file id5687 NCBI fileEvidenceTAS
GenePSMA7AuthorityHGNC:9536Mapping file id5688 NCBI fileEvidenceTAS
GenePSMB1AuthorityHGNC:9537Mapping file id5689 NCBI fileEvidenceTAS
GenePSMB2AuthorityHGNC:9539Mapping file id5690 NCBI fileEvidenceTAS
GenePSMB3AuthorityHGNC:9540Mapping file id5691 NCBI fileEvidenceTAS
GenePSMB4AuthorityHGNC:9541Mapping file id5692 NCBI fileEvidenceTAS
GenePSMB5AuthorityHGNC:9542Mapping file id5693 NCBI fileEvidenceTAS
GenePSMB6AuthorityHGNC:9543Mapping file id5694 NCBI fileEvidenceTAS
GenePSMB7AuthorityHGNC:9544Mapping file id5695 NCBI fileEvidenceTAS
GenePSMC1AuthorityHGNC:9547Mapping file id5700 NCBI fileEvidenceTAS
GenePSMC2AuthorityHGNC:9548Mapping file id5701 NCBI fileEvidenceTAS
GenePSMC3AuthorityHGNC:9549Mapping file id5702 NCBI fileEvidenceTAS
GenePSMC4AuthorityHGNC:9551Mapping file id5704 NCBI fileEvidenceTAS
GenePSMC5AuthorityHGNC:9552Mapping file id5705 NCBI fileEvidenceTAS
GenePSMC6AuthorityHGNC:9553Mapping file id5706 NCBI fileEvidenceTAS
GenePSMD1AuthorityHGNC:9554Mapping file id5707 NCBI fileEvidenceTAS
GenePSMD11AuthorityHGNC:9556Mapping file id5717 NCBI fileEvidenceTAS
GenePSMD12AuthorityHGNC:9557Mapping file id5718 NCBI fileEvidenceTAS
GenePSMD13AuthorityHGNC:9558Mapping file id5719 NCBI fileEvidenceTAS
GenePSMD14AuthorityHGNC:16889Mapping file id10213 NCBI fileEvidenceTAS
GenePSMD2AuthorityHGNC:9559Mapping file id5708 NCBI fileEvidenceTAS
GenePSMD3AuthorityHGNC:9560Mapping file id5709 NCBI fileEvidenceTAS
GenePSMD6AuthorityHGNC:9564Mapping file id9861 NCBI fileEvidenceTAS
GenePSMD7AuthorityHGNC:9565Mapping file id5713 NCBI fileEvidenceTAS
GenePSMD8AuthorityHGNC:9566Mapping file id5714 NCBI fileEvidenceTAS
GeneRNF185AuthorityHGNC:26783Mapping file id91445 NCBI fileEvidenceTAS
GeneRNF5AuthorityHGNC:10068Mapping file id6048 NCBI fileEvidenceTAS
GeneRPS27AAuthorityHGNC:10417Mapping file id6233 NCBI fileEvidenceTAS
GeneSEL1LAuthorityHGNC:10717Mapping file id6400 NCBI fileEvidenceTAS
GeneSEM1AuthorityHGNC:10845Mapping file id7979 NCBI fileEvidenceTAS
GeneUBA52AuthorityHGNC:12458Mapping file id7311 NCBI fileEvidenceTAS
GeneUBBAuthorityHGNC:12463Mapping file id7314 NCBI fileEvidenceTAS
GeneUBCAuthorityHGNC:12468Mapping file id7316 NCBI fileEvidenceTAS
GeneVCPAuthorityHGNC:12666Mapping file id7415 NCBI fileEvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.