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Pathway Human Homo sapiens

Transport of small molecules

R-HSA-382551 in Reactome release 97: a top-level pathway, with 722 genes placed in it by the mapping files and 11 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-382551 (mouse), R-RNO-382551 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 722 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 8
GeneA2MAuthorityHGNC:7Mapping file id2 NCBI fileEvidenceTAS
GeneABCA1AuthorityHGNC:29Mapping file id19 NCBI fileEvidenceTAS
GeneABCA10AuthorityHGNC:30Mapping file id10349 NCBI fileEvidenceTAS
GeneABCA12AuthorityHGNC:14637Mapping file id26154 NCBI fileEvidenceTAS
GeneABCA2AuthorityHGNC:32Mapping file id20 NCBI fileEvidenceTAS
GeneABCA3AuthorityHGNC:33Mapping file id21 NCBI fileEvidenceTAS
GeneABCA4AuthorityHGNC:34Mapping file id24 NCBI fileEvidenceTAS
GeneABCA5AuthorityHGNC:35Mapping file id23461 NCBI fileEvidenceTAS
GeneABCA6AuthorityHGNC:36Mapping file id23460 NCBI fileEvidenceTAS
GeneABCA7AuthorityHGNC:37Mapping file id10347 NCBI fileEvidenceTAS
GeneABCA8AuthorityHGNC:38Mapping file id10351 NCBI fileEvidenceTAS
GeneABCA9AuthorityHGNC:39Mapping file id10350 NCBI fileEvidenceTAS
GeneABCB1AuthorityHGNC:40Mapping file id5243 NCBI fileEvidenceTAS
GeneABCB10AuthorityHGNC:41Mapping file id23456 NCBI fileEvidenceTAS
GeneABCB4AuthorityHGNC:45Mapping file id5244 NCBI fileEvidenceTAS
GeneABCB5AuthorityHGNC:46Mapping file id340273 NCBI fileEvidenceTAS
GeneABCB6AuthorityHGNC:47Mapping file id10058 NCBI fileEvidenceTAS
GeneABCB7AuthorityHGNC:48Mapping file id22 NCBI fileEvidenceTAS
GeneABCB8AuthorityHGNC:49Mapping file id11194 NCBI fileEvidenceTAS
GeneABCB9AuthorityHGNC:50Mapping file id23457 NCBI fileEvidenceTAS
GeneABCC1AuthorityHGNC:51Mapping file id4363 NCBI fileEvidenceTAS
GeneABCC10AuthorityHGNC:52Mapping file id89845 NCBI fileEvidenceTAS
GeneABCC11AuthorityHGNC:14639Mapping file id85320 NCBI fileEvidenceTAS
GeneABCC2AuthorityHGNC:53Mapping file id1244 NCBI fileEvidenceTAS
GeneABCC3AuthorityHGNC:54Mapping file id8714 NCBI fileEvidenceTAS
GeneABCC4AuthorityHGNC:55Mapping file id10257 NCBI fileEvidenceTAS
GeneABCC5AuthorityHGNC:56Mapping file id10057 NCBI fileEvidenceTAS
GeneABCC6AuthorityHGNC:57Mapping file id368 NCBI fileEvidenceTAS
GeneABCC9AuthorityHGNC:60Mapping file id10060 NCBI fileEvidenceTAS
GeneABCD1AuthorityHGNC:61Mapping file id215 NCBI fileEvidenceTAS
GeneABCD2AuthorityHGNC:66Mapping file id225 NCBI fileEvidenceTAS
GeneABCD3AuthorityHGNC:67Mapping file id5825 NCBI fileEvidenceTAS
GeneABCF1AuthorityHGNC:70Mapping file id23 NCBI fileEvidenceTAS
GeneABCG1AuthorityHGNC:73Mapping file id9619 NCBI fileEvidenceTAS
GeneABCG2AuthorityHGNC:74Mapping file id9429 NCBI fileEvidenceTAS
GeneABCG4AuthorityHGNC:13884Mapping file id64137 NCBI fileEvidenceTAS
GeneABCG5AuthorityHGNC:13886Mapping file id64240 NCBI fileEvidenceTAS
GeneABCG8AuthorityHGNC:13887Mapping file id64241 NCBI fileEvidenceTAS
GeneACO1AuthorityHGNC:117Mapping file id48 NCBI fileEvidenceTAS
GeneADCY1AuthorityHGNC:232Mapping file id107 NCBI fileEvidenceTAS
GeneADCY2AuthorityHGNC:233Mapping file id108 NCBI fileEvidenceTAS
GeneADCY3AuthorityHGNC:234Mapping file id109 NCBI fileEvidenceTAS
GeneADCY4AuthorityHGNC:235Mapping file id196883 NCBI fileEvidenceTAS
GeneADCY5AuthorityHGNC:236Mapping file id111 NCBI fileEvidenceTAS
GeneADCY6AuthorityHGNC:237Mapping file id112 NCBI fileEvidenceTAS
GeneADCY7AuthorityHGNC:238Mapping file id113 NCBI fileEvidenceTAS
GeneADCY8AuthorityHGNC:239Mapping file id114 NCBI fileEvidenceTAS
GeneADCY9AuthorityHGNC:240Mapping file id115 NCBI fileEvidenceTAS
GeneADD1AuthorityHGNC:243Mapping file id118 NCBI fileEvidenceTAS
GeneADD2AuthorityHGNC:244Mapping file id119 NCBI fileEvidenceTAS
GeneADD3AuthorityHGNC:245Mapping file id120 NCBI fileEvidenceTAS
GeneADRM1AuthorityHGNC:15759Mapping file id11047 NCBI fileEvidenceTAS
GeneAFG3L2AuthorityHGNC:315Mapping file id10939 NCBI fileEvidenceTAS
GeneAHCYL2AuthorityHGNC:22204Mapping file id23382 NCBI fileEvidenceTAS
GeneAKAP1AuthorityHGNC:367Mapping file id8165 NCBI fileEvidenceIEA
GeneALBAuthorityHGNC:399Mapping file id213 NCBI fileEvidenceTAS
GeneAMNAuthorityHGNC:14604Mapping file id81693 NCBI fileEvidenceTAS
GeneANGPTL3AuthorityHGNC:491Mapping file id27329 NCBI fileEvidenceTAS
GeneANGPTL4AuthorityHGNC:16039Mapping file id51129 NCBI fileEvidenceTAS
GeneANGPTL8AuthorityHGNC:24933Mapping file id55908 NCBI fileEvidenceTAS
GeneANKHAuthorityHGNC:15492Mapping file id56172 NCBI fileEvidenceTAS
GeneANO1AuthorityHGNC:21625Mapping file id55107 NCBI fileEvidenceTAS
GeneANO10AuthorityHGNC:25519Mapping file id55129 NCBI fileEvidenceTAS
GeneANO2AuthorityHGNC:1183Mapping file id57101 NCBI fileEvidenceTAS
GeneANO3AuthorityHGNC:14004Mapping file id63982 NCBI fileEvidenceTAS
GeneANO4AuthorityHGNC:23837Mapping file id121601 NCBI fileEvidenceTAS
GeneANO5AuthorityHGNC:27337Mapping file id203859 NCBI fileEvidenceTAS
GeneANO6AuthorityHGNC:25240Mapping file id196527 NCBI fileEvidenceTAS
GeneANO7AuthorityHGNC:31677Mapping file id50636 NCBI fileEvidenceTAS
GeneANO8AuthorityHGNC:29329Mapping file id57719 NCBI fileEvidenceTAS
GeneANO9AuthorityHGNC:20679Mapping file id338440 NCBI fileEvidenceTAS
GeneAP2A1AuthorityHGNC:561Mapping file id160 NCBI fileEvidenceTAS
GeneAP2A2AuthorityHGNC:562Mapping file id161 NCBI fileEvidenceTAS
GeneAP2B1AuthorityHGNC:563Mapping file id163 NCBI fileEvidenceTAS
GeneAP2M1AuthorityHGNC:564Mapping file id1173 NCBI fileEvidenceTAS
GeneAP2S1AuthorityHGNC:565Mapping file id1175 NCBI fileEvidenceTAS
GeneAPOA1AuthorityHGNC:600Mapping file id335 NCBI fileEvidenceTAS
GeneAPOA2AuthorityHGNC:601Mapping file id336 NCBI fileEvidenceTAS
GeneAPOA4AuthorityHGNC:602Mapping file id337 NCBI fileEvidenceIEA, TAS
GeneAPOA5AuthorityHGNC:17288Mapping file id116519 NCBI fileEvidenceIEA, TAS
GeneAPOBAuthorityHGNC:603Mapping file id338 NCBI fileEvidenceIEA, TAS
GeneAPOBRAuthorityHGNC:24087Mapping file id55911 NCBI fileEvidenceTAS
GeneAPOC1AuthorityHGNC:607Mapping file id341 NCBI fileEvidenceIEA, TAS
GeneAPOC2AuthorityHGNC:609Mapping file id344 NCBI fileEvidenceIEA, TAS
GeneAPOC3AuthorityHGNC:610Mapping file id345 NCBI fileEvidenceTAS
GeneAPOC4AuthorityHGNC:611Mapping file id346 NCBI fileEvidenceIEA, TAS
GeneAPODAuthorityHGNC:612Mapping file id347 NCBI fileEvidenceTAS
GeneAPOEAuthorityHGNC:613Mapping file id348 NCBI fileEvidenceIEA, TAS
GeneAPOFAuthorityHGNC:615Mapping file id319 NCBI fileEvidenceTAS
GeneAQP1AuthorityHGNC:633Mapping file id358 NCBI fileEvidenceTAS
GeneAQP10AuthorityHGNC:16029Mapping file id89872 NCBI fileEvidenceTAS
GeneAQP11AuthorityHGNC:19940Mapping file id282679 NCBI fileEvidenceTAS
GeneAQP12AAuthorityHGNC:19941Mapping file id375318 NCBI fileEvidenceTAS
GeneAQP2AuthorityHGNC:634Mapping file id359 NCBI fileEvidenceTAS
GeneAQP3AuthorityHGNC:636Mapping file id360 NCBI fileEvidenceTAS
GeneAQP4AuthorityHGNC:637Mapping file id361 NCBI fileEvidenceTAS
GeneAQP5AuthorityHGNC:638Mapping file id362 NCBI fileEvidenceTAS
GeneAQP6AuthorityHGNC:639Mapping file id363 NCBI fileEvidenceIEA
GeneAQP7AuthorityHGNC:640Mapping file id364 NCBI fileEvidenceTAS
GeneAQP8AuthorityHGNC:642Mapping file id343 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.