Pathway Human Homo sapiens
Transport of small molecules
R-HSA-382551 in Reactome release 97: a top-level pathway, with 722 genes placed in it by the mapping files and 11 child pathways in the hierarchy.
The same number in the other species
Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-382551 (mouse), R-RNO-382551 (rat). Whether the event was inferred from this one is what the record says.
01The record
Reactome's own record of this pathway
What this tells you
The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.
Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions.
[R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.
On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available.
[R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required.
[R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.
A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].
- [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
- [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
- [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
- [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
- [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
02The genes
Genes Reactome places in this human pathway
The mapping files place 722 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.
| Gene | Authority id | Mapping file id | Evidence codes |
|---|---|---|---|
| GeneA2M | AuthorityHGNC:7 | Mapping file id2 NCBI file | EvidenceTAS |
| GeneABCA1 | AuthorityHGNC:29 | Mapping file id19 NCBI file | EvidenceTAS |
| GeneABCA10 | AuthorityHGNC:30 | Mapping file id10349 NCBI file | EvidenceTAS |
| GeneABCA12 | AuthorityHGNC:14637 | Mapping file id26154 NCBI file | EvidenceTAS |
| GeneABCA2 | AuthorityHGNC:32 | Mapping file id20 NCBI file | EvidenceTAS |
| GeneABCA3 | AuthorityHGNC:33 | Mapping file id21 NCBI file | EvidenceTAS |
| GeneABCA4 | AuthorityHGNC:34 | Mapping file id24 NCBI file | EvidenceTAS |
| GeneABCA5 | AuthorityHGNC:35 | Mapping file id23461 NCBI file | EvidenceTAS |
| GeneABCA6 | AuthorityHGNC:36 | Mapping file id23460 NCBI file | EvidenceTAS |
| GeneABCA7 | AuthorityHGNC:37 | Mapping file id10347 NCBI file | EvidenceTAS |
| GeneABCA8 | AuthorityHGNC:38 | Mapping file id10351 NCBI file | EvidenceTAS |
| GeneABCA9 | AuthorityHGNC:39 | Mapping file id10350 NCBI file | EvidenceTAS |
| GeneABCB1 | AuthorityHGNC:40 | Mapping file id5243 NCBI file | EvidenceTAS |
| GeneABCB10 | AuthorityHGNC:41 | Mapping file id23456 NCBI file | EvidenceTAS |
| GeneABCB4 | AuthorityHGNC:45 | Mapping file id5244 NCBI file | EvidenceTAS |
| GeneABCB5 | AuthorityHGNC:46 | Mapping file id340273 NCBI file | EvidenceTAS |
| GeneABCB6 | AuthorityHGNC:47 | Mapping file id10058 NCBI file | EvidenceTAS |
| GeneABCB7 | AuthorityHGNC:48 | Mapping file id22 NCBI file | EvidenceTAS |
| GeneABCB8 | AuthorityHGNC:49 | Mapping file id11194 NCBI file | EvidenceTAS |
| GeneABCB9 | AuthorityHGNC:50 | Mapping file id23457 NCBI file | EvidenceTAS |
| GeneABCC1 | AuthorityHGNC:51 | Mapping file id4363 NCBI file | EvidenceTAS |
| GeneABCC10 | AuthorityHGNC:52 | Mapping file id89845 NCBI file | EvidenceTAS |
| GeneABCC11 | AuthorityHGNC:14639 | Mapping file id85320 NCBI file | EvidenceTAS |
| GeneABCC2 | AuthorityHGNC:53 | Mapping file id1244 NCBI file | EvidenceTAS |
| GeneABCC3 | AuthorityHGNC:54 | Mapping file id8714 NCBI file | EvidenceTAS |
| GeneABCC4 | AuthorityHGNC:55 | Mapping file id10257 NCBI file | EvidenceTAS |
| GeneABCC5 | AuthorityHGNC:56 | Mapping file id10057 NCBI file | EvidenceTAS |
| GeneABCC6 | AuthorityHGNC:57 | Mapping file id368 NCBI file | EvidenceTAS |
| GeneABCC9 | AuthorityHGNC:60 | Mapping file id10060 NCBI file | EvidenceTAS |
| GeneABCD1 | AuthorityHGNC:61 | Mapping file id215 NCBI file | EvidenceTAS |
| GeneABCD2 | AuthorityHGNC:66 | Mapping file id225 NCBI file | EvidenceTAS |
| GeneABCD3 | AuthorityHGNC:67 | Mapping file id5825 NCBI file | EvidenceTAS |
| GeneABCF1 | AuthorityHGNC:70 | Mapping file id23 NCBI file | EvidenceTAS |
| GeneABCG1 | AuthorityHGNC:73 | Mapping file id9619 NCBI file | EvidenceTAS |
| GeneABCG2 | AuthorityHGNC:74 | Mapping file id9429 NCBI file | EvidenceTAS |
| GeneABCG4 | AuthorityHGNC:13884 | Mapping file id64137 NCBI file | EvidenceTAS |
| GeneABCG5 | AuthorityHGNC:13886 | Mapping file id64240 NCBI file | EvidenceTAS |
| GeneABCG8 | AuthorityHGNC:13887 | Mapping file id64241 NCBI file | EvidenceTAS |
| GeneACO1 | AuthorityHGNC:117 | Mapping file id48 NCBI file | EvidenceTAS |
| GeneADCY1 | AuthorityHGNC:232 | Mapping file id107 NCBI file | EvidenceTAS |
| GeneADCY2 | AuthorityHGNC:233 | Mapping file id108 NCBI file | EvidenceTAS |
| GeneADCY3 | AuthorityHGNC:234 | Mapping file id109 NCBI file | EvidenceTAS |
| GeneADCY4 | AuthorityHGNC:235 | Mapping file id196883 NCBI file | EvidenceTAS |
| GeneADCY5 | AuthorityHGNC:236 | Mapping file id111 NCBI file | EvidenceTAS |
| GeneADCY6 | AuthorityHGNC:237 | Mapping file id112 NCBI file | EvidenceTAS |
| GeneADCY7 | AuthorityHGNC:238 | Mapping file id113 NCBI file | EvidenceTAS |
| GeneADCY8 | AuthorityHGNC:239 | Mapping file id114 NCBI file | EvidenceTAS |
| GeneADCY9 | AuthorityHGNC:240 | Mapping file id115 NCBI file | EvidenceTAS |
| GeneADD1 | AuthorityHGNC:243 | Mapping file id118 NCBI file | EvidenceTAS |
| GeneADD2 | AuthorityHGNC:244 | Mapping file id119 NCBI file | EvidenceTAS |
| GeneADD3 | AuthorityHGNC:245 | Mapping file id120 NCBI file | EvidenceTAS |
| GeneADRM1 | AuthorityHGNC:15759 | Mapping file id11047 NCBI file | EvidenceTAS |
| GeneAFG3L2 | AuthorityHGNC:315 | Mapping file id10939 NCBI file | EvidenceTAS |
| GeneAHCYL2 | AuthorityHGNC:22204 | Mapping file id23382 NCBI file | EvidenceTAS |
| GeneAKAP1 | AuthorityHGNC:367 | Mapping file id8165 NCBI file | EvidenceIEA |
| GeneALB | AuthorityHGNC:399 | Mapping file id213 NCBI file | EvidenceTAS |
| GeneAMN | AuthorityHGNC:14604 | Mapping file id81693 NCBI file | EvidenceTAS |
| GeneANGPTL3 | AuthorityHGNC:491 | Mapping file id27329 NCBI file | EvidenceTAS |
| GeneANGPTL4 | AuthorityHGNC:16039 | Mapping file id51129 NCBI file | EvidenceTAS |
| GeneANGPTL8 | AuthorityHGNC:24933 | Mapping file id55908 NCBI file | EvidenceTAS |
| GeneANKH | AuthorityHGNC:15492 | Mapping file id56172 NCBI file | EvidenceTAS |
| GeneANO1 | AuthorityHGNC:21625 | Mapping file id55107 NCBI file | EvidenceTAS |
| GeneANO10 | AuthorityHGNC:25519 | Mapping file id55129 NCBI file | EvidenceTAS |
| GeneANO2 | AuthorityHGNC:1183 | Mapping file id57101 NCBI file | EvidenceTAS |
| GeneANO3 | AuthorityHGNC:14004 | Mapping file id63982 NCBI file | EvidenceTAS |
| GeneANO4 | AuthorityHGNC:23837 | Mapping file id121601 NCBI file | EvidenceTAS |
| GeneANO5 | AuthorityHGNC:27337 | Mapping file id203859 NCBI file | EvidenceTAS |
| GeneANO6 | AuthorityHGNC:25240 | Mapping file id196527 NCBI file | EvidenceTAS |
| GeneANO7 | AuthorityHGNC:31677 | Mapping file id50636 NCBI file | EvidenceTAS |
| GeneANO8 | AuthorityHGNC:29329 | Mapping file id57719 NCBI file | EvidenceTAS |
| GeneANO9 | AuthorityHGNC:20679 | Mapping file id338440 NCBI file | EvidenceTAS |
| GeneAP2A1 | AuthorityHGNC:561 | Mapping file id160 NCBI file | EvidenceTAS |
| GeneAP2A2 | AuthorityHGNC:562 | Mapping file id161 NCBI file | EvidenceTAS |
| GeneAP2B1 | AuthorityHGNC:563 | Mapping file id163 NCBI file | EvidenceTAS |
| GeneAP2M1 | AuthorityHGNC:564 | Mapping file id1173 NCBI file | EvidenceTAS |
| GeneAP2S1 | AuthorityHGNC:565 | Mapping file id1175 NCBI file | EvidenceTAS |
| GeneAPOA1 | AuthorityHGNC:600 | Mapping file id335 NCBI file | EvidenceTAS |
| GeneAPOA2 | AuthorityHGNC:601 | Mapping file id336 NCBI file | EvidenceTAS |
| GeneAPOA4 | AuthorityHGNC:602 | Mapping file id337 NCBI file | EvidenceIEA, TAS |
| GeneAPOA5 | AuthorityHGNC:17288 | Mapping file id116519 NCBI file | EvidenceIEA, TAS |
| GeneAPOB | AuthorityHGNC:603 | Mapping file id338 NCBI file | EvidenceIEA, TAS |
| GeneAPOBR | AuthorityHGNC:24087 | Mapping file id55911 NCBI file | EvidenceTAS |
| GeneAPOC1 | AuthorityHGNC:607 | Mapping file id341 NCBI file | EvidenceIEA, TAS |
| GeneAPOC2 | AuthorityHGNC:609 | Mapping file id344 NCBI file | EvidenceIEA, TAS |
| GeneAPOC3 | AuthorityHGNC:610 | Mapping file id345 NCBI file | EvidenceTAS |
| GeneAPOC4 | AuthorityHGNC:611 | Mapping file id346 NCBI file | EvidenceIEA, TAS |
| GeneAPOD | AuthorityHGNC:612 | Mapping file id347 NCBI file | EvidenceTAS |
| GeneAPOE | AuthorityHGNC:613 | Mapping file id348 NCBI file | EvidenceIEA, TAS |
| GeneAPOF | AuthorityHGNC:615 | Mapping file id319 NCBI file | EvidenceTAS |
| GeneAQP1 | AuthorityHGNC:633 | Mapping file id358 NCBI file | EvidenceTAS |
| GeneAQP10 | AuthorityHGNC:16029 | Mapping file id89872 NCBI file | EvidenceTAS |
| GeneAQP11 | AuthorityHGNC:19940 | Mapping file id282679 NCBI file | EvidenceTAS |
| GeneAQP12A | AuthorityHGNC:19941 | Mapping file id375318 NCBI file | EvidenceTAS |
| GeneAQP2 | AuthorityHGNC:634 | Mapping file id359 NCBI file | EvidenceTAS |
| GeneAQP3 | AuthorityHGNC:636 | Mapping file id360 NCBI file | EvidenceTAS |
| GeneAQP4 | AuthorityHGNC:637 | Mapping file id361 NCBI file | EvidenceTAS |
| GeneAQP5 | AuthorityHGNC:638 | Mapping file id362 NCBI file | EvidenceTAS |
| GeneAQP6 | AuthorityHGNC:639 | Mapping file id363 NCBI file | EvidenceIEA |
| GeneAQP7 | AuthorityHGNC:640 | Mapping file id364 NCBI file | EvidenceTAS |
| GeneAQP8 | AuthorityHGNC:642 | Mapping file id343 NCBI file | EvidenceTAS |
Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.
- Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.
03The hierarchy
Parents and children in this release's hierarchy
Parents
None: this is a top-level pathway of the release.
Children
- ABC-family protein mediated transportR-HSA-38255690 genes
- Aquaporin-mediated transportR-HSA-44571752 genes
- Glycosphingolipid transportR-HSA-98455768 genes
- Intracellular oxygen transportR-HSA-89816073 genes
- Ion channel transportR-HSA-983712185 genes
- Iron uptake and transportR-HSA-91793758 genes
- Miscellaneous transport and binding eventsR-HSA-522334529 genes
- Mitochondrial calcium ion transportR-HSA-894921523 genes
- O2/CO2 exchange in erythrocytesR-HSA-148092613 genes
- Plasma lipoprotein assembly, remodeling, and clearanceR-HSA-17482475 genes
- SLC-mediated transmembrane transportR-HSA-425407245 genes
Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.
- Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.