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Pathway Human Homo sapiens

Mitotic G2-G2/M phases

R-HSA-453274 in Reactome release 97: under Cell Cycle, Mitotic, with 193 genes placed in it by the mapping files and 2 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-453274 (mouse), R-RNO-453274 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 193 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 2
GeneACTR1AAuthorityHGNC:167Mapping file id10121 NCBI fileEvidenceTAS
GeneADRM1AuthorityHGNC:15759Mapping file id11047 NCBI fileEvidenceTAS
GeneAJUBAAuthorityHGNC:20250Mapping file id84962 NCBI fileEvidenceTAS
GeneAKAP9AuthorityHGNC:379Mapping file id10142 NCBI fileEvidenceTAS
GeneALMS1AuthorityHGNC:428Mapping file id7840 NCBI fileEvidenceTAS
GeneAURKAAuthorityHGNC:11393Mapping file id6790 NCBI fileEvidenceTAS
GeneBORAAuthorityHGNC:24724Mapping file id79866 NCBI fileEvidenceTAS
GeneBTRCAuthorityHGNC:1144Mapping file id8945 NCBI fileEvidenceTAS
GeneCCNA1AuthorityHGNC:1577Mapping file id8900 NCBI fileEvidenceTAS
GeneCCNA2AuthorityHGNC:1578Mapping file id890 NCBI fileEvidenceTAS
GeneCCNB1AuthorityHGNC:1579Mapping file id891 NCBI fileEvidenceTAS
GeneCCNB2AuthorityHGNC:1580Mapping file id9133 NCBI fileEvidenceTAS
GeneCCNHAuthorityHGNC:1594Mapping file id902 NCBI fileEvidenceTAS
GeneCCP110AuthorityHGNC:24342Mapping file id9738 NCBI fileEvidenceTAS
GeneCDC25AAuthorityHGNC:1725Mapping file id993 NCBI fileEvidenceTAS
GeneCDC25BAuthorityHGNC:1726Mapping file id994 NCBI fileEvidenceTAS
GeneCDC25CAuthorityHGNC:1727Mapping file id995 NCBI fileEvidenceTAS
GeneCDK1AuthorityHGNC:1722Mapping file id983 NCBI fileEvidenceTAS
GeneCDK11AAuthorityHGNC:1730Mapping file id728642 NCBI fileEvidenceTAS
GeneCDK11BAuthorityHGNC:1729Mapping file id984 NCBI fileEvidenceTAS
GeneCDK2AuthorityHGNC:1771Mapping file id1017 NCBI fileEvidenceTAS
GeneCDK5RAP2AuthorityHGNC:18672Mapping file id55755 NCBI fileEvidenceTAS
GeneCDK7AuthorityHGNC:1778Mapping file id1022 NCBI fileEvidenceTAS
GeneCDKN1AAuthorityHGNC:1784Mapping file id1026 NCBI fileEvidenceTAS
GeneCENPFAuthorityHGNC:1857Mapping file id1063 NCBI fileEvidenceTAS
GeneCEP131AuthorityHGNC:29511Mapping file id22994 NCBI fileEvidenceTAS
GeneCEP135AuthorityHGNC:29086Mapping file id9662 NCBI fileEvidenceTAS
GeneCEP152AuthorityHGNC:29298Mapping file id22995 NCBI fileEvidenceTAS
GeneCEP164AuthorityHGNC:29182Mapping file id22897 NCBI fileEvidenceTAS
GeneCEP192AuthorityHGNC:25515Mapping file id55125 NCBI fileEvidenceTAS
GeneCEP250AuthorityHGNC:1859Mapping file id11190 NCBI fileEvidenceTAS
GeneCEP290AuthorityHGNC:29021Mapping file id80184 NCBI fileEvidenceTAS
GeneCEP41AuthorityHGNC:12370Mapping file id95681 NCBI fileEvidenceTAS
GeneCEP43AuthorityHGNC:17012Mapping file id11116 NCBI fileEvidenceTAS
GeneCEP57AuthorityHGNC:30794Mapping file id9702 NCBI fileEvidenceTAS
GeneCEP63AuthorityHGNC:25815Mapping file id80254 NCBI fileEvidenceTAS
GeneCEP70AuthorityHGNC:29972Mapping file id80321 NCBI fileEvidenceTAS
GeneCEP72AuthorityHGNC:25547Mapping file id55722 NCBI fileEvidenceTAS
GeneCEP76AuthorityHGNC:25727Mapping file id79959 NCBI fileEvidenceTAS
GeneCEP78AuthorityHGNC:25740Mapping file id84131 NCBI fileEvidenceTAS
GeneCETN2AuthorityHGNC:1867Mapping file id1069 NCBI fileEvidenceTAS
GeneCKAP5AuthorityHGNC:28959Mapping file id9793 NCBI fileEvidenceTAS
GeneCLASP1AuthorityHGNC:17088Mapping file id23332 NCBI fileEvidenceTAS
GeneCNTRLAuthorityHGNC:1858Mapping file id11064 NCBI fileEvidenceTAS
GeneCPAPAuthorityHGNC:17272Mapping file id55835 NCBI fileEvidenceTAS
GeneCSNK1DAuthorityHGNC:2452Mapping file id1453 NCBI fileEvidenceTAS
GeneCSNK1EAuthorityHGNC:2453Mapping file id1454 NCBI fileEvidenceTAS
GeneCUL1AuthorityHGNC:2551Mapping file id8454 NCBI fileEvidenceTAS
GeneDCTN1AuthorityHGNC:2711Mapping file id1639 NCBI fileEvidenceTAS
GeneDCTN2AuthorityHGNC:2712Mapping file id10540 NCBI fileEvidenceTAS
GeneDCTN3AuthorityHGNC:2713Mapping file id11258 NCBI fileEvidenceTAS
GeneDYNC1H1AuthorityHGNC:2961Mapping file id1778 NCBI fileEvidenceTAS
GeneDYNC1I2AuthorityHGNC:2964Mapping file id1781 NCBI fileEvidenceTAS
GeneDYNLL1AuthorityHGNC:15476Mapping file id8655 NCBI fileEvidenceTAS
GeneE2F1AuthorityHGNC:3113Mapping file id1869 NCBI fileEvidenceTAS
GeneE2F3AuthorityHGNC:3115Mapping file id1871 NCBI fileEvidenceTAS
GeneEP300AuthorityHGNC:3373Mapping file id2033 NCBI fileEvidenceTAS
GeneFBXL18AuthorityHGNC:21874Mapping file id80028 NCBI fileEvidenceTAS
GeneFBXL7AuthorityHGNC:13604Mapping file id23194 NCBI fileEvidenceTAS
GeneFBXW11AuthorityHGNC:13607Mapping file id23291 NCBI fileEvidenceTAS
GeneFKBPLAuthorityHGNC:13949Mapping file id63943 NCBI fileEvidenceTAS
GeneFOXM1AuthorityHGNC:3818Mapping file id2305 NCBI fileEvidenceTAS
GeneFZR1AuthorityHGNC:24824Mapping file id51343 NCBI fileEvidenceTAS
GeneGTSE1AuthorityHGNC:13698Mapping file id51512 NCBI fileEvidenceTAS
GeneHAUS1AuthorityHGNC:25174Mapping file id115106 NCBI fileEvidenceTAS
GeneHAUS2AuthorityHGNC:25530Mapping file id55142 NCBI fileEvidenceTAS
GeneHAUS3AuthorityHGNC:28719Mapping file id79441 NCBI fileEvidenceTAS
GeneHAUS4AuthorityHGNC:20163Mapping file id54930 NCBI fileEvidenceTAS
GeneHAUS5AuthorityHGNC:29130Mapping file id23354 NCBI fileEvidenceTAS
GeneHAUS6AuthorityHGNC:25948Mapping file id54801 NCBI fileEvidenceTAS
GeneHAUS7AuthorityHGNC:32979Mapping file id55559 NCBI fileEvidenceTAS
GeneHAUS8AuthorityHGNC:30532Mapping file id93323 NCBI fileEvidenceTAS
GeneHJURPAuthorityHGNC:25444Mapping file id55355 NCBI fileEvidenceTAS
GeneHMMRAuthorityHGNC:5012Mapping file id3161 NCBI fileEvidenceTAS
GeneHSP90AA1AuthorityHGNC:5253Mapping file id3320 NCBI fileEvidenceTAS
GeneHSP90AB1AuthorityHGNC:5258Mapping file id3326 NCBI fileEvidenceTAS
GeneLCMT1AuthorityHGNC:17557Mapping file id51451 NCBI fileEvidenceTAS
GeneLIN37AuthorityHGNC:33234Mapping file id55957 NCBI fileEvidenceTAS
GeneLIN52AuthorityHGNC:19856Mapping file id91750 NCBI fileEvidenceTAS
GeneLIN54AuthorityHGNC:25397Mapping file id132660 NCBI fileEvidenceTAS
GeneLIN9AuthorityHGNC:30830Mapping file id286826 NCBI fileEvidenceTAS
GeneMAPRE1AuthorityHGNC:6890Mapping file id22919 NCBI fileEvidenceTAS
GeneMIS18BP1AuthorityHGNC:20190Mapping file id55320 NCBI fileEvidenceTAS
GeneMNAT1AuthorityHGNC:7181Mapping file id4331 NCBI fileEvidenceTAS
GeneMYBL2AuthorityHGNC:7548Mapping file id4605 NCBI fileEvidenceTAS
GeneMZT1AuthorityHGNC:33830Mapping file id440145 NCBI fileEvidenceTAS
GeneMZT2AAuthorityHGNC:33187Mapping file id653784 NCBI fileEvidenceTAS
GeneMZT2BAuthorityHGNC:25886Mapping file id80097 NCBI fileEvidenceTAS
GeneNDE1AuthorityHGNC:17619Mapping file id54820 NCBI fileEvidenceTAS
GeneNEDD1AuthorityHGNC:7723Mapping file id121441 NCBI fileEvidenceTAS
GeneNEK2AuthorityHGNC:7745Mapping file id4751 NCBI fileEvidenceTAS
GeneNINLAuthorityHGNC:29163Mapping file id22981 NCBI fileEvidenceTAS
GeneNME7AuthorityHGNC:20461Mapping file id29922 NCBI fileEvidenceTAS
GeneOBI1AuthorityHGNC:20308Mapping file id79596 NCBI fileEvidenceTAS
GeneODF2AuthorityHGNC:8114Mapping file id4957 NCBI fileEvidenceTAS
GeneOFD1AuthorityHGNC:2567Mapping file id8481 NCBI fileEvidenceTAS
GeneOPTNAuthorityHGNC:17142Mapping file id10133 NCBI fileEvidenceTAS
GenePAFAH1B1AuthorityHGNC:8574Mapping file id5048 NCBI fileEvidenceTAS
GenePCM1AuthorityHGNC:8727Mapping file id5108 NCBI fileEvidenceTAS
GenePCNTAuthorityHGNC:16068Mapping file id5116 NCBI fileEvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.