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Pathway Human Homo sapiens

Mitochondrial Fatty Acid Beta-Oxidation

R-HSA-77289 in Reactome release 97: under Fatty acid metabolism, with 37 genes placed in it by the mapping files and 3 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-77289 (mouse), R-RNO-77289 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 37 genes in this human pathway; showing 1 to 37, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
GeneACAA2AuthorityHGNC:83Mapping file id10449 NCBI fileEvidenceTAS
GeneACAD10AuthorityHGNC:21597Mapping file id80724 NCBI fileEvidenceTAS
GeneACAD11AuthorityHGNC:30211Mapping file id84129 NCBI fileEvidenceTAS
GeneACADLAuthorityHGNC:88Mapping file id33 NCBI fileEvidenceTAS
GeneACADMAuthorityHGNC:89Mapping file id34 NCBI fileEvidenceTAS
GeneACADSAuthorityHGNC:90Mapping file id35 NCBI fileEvidenceTAS
GeneACADVLAuthorityHGNC:92Mapping file id37 NCBI fileEvidenceTAS
GeneACBD6AuthorityHGNC:23339Mapping file id84320 NCBI fileEvidenceTAS
GeneACBD7AuthorityHGNC:17715Mapping file id414149 NCBI fileEvidenceTAS
GeneACOT1AuthorityHGNC:33128Mapping file id641371 NCBI fileEvidenceTAS
GeneACOT11AuthorityHGNC:18156Mapping file id26027 NCBI fileEvidenceTAS
GeneACOT12AuthorityHGNC:24436Mapping file id134526 NCBI fileEvidenceTAS
GeneACOT13AuthorityHGNC:20999Mapping file id55856 NCBI fileEvidenceTAS
GeneACOT2AuthorityHGNC:18431Mapping file id10965 NCBI fileEvidenceTAS
GeneACOT7AuthorityHGNC:24157Mapping file id11332 NCBI fileEvidenceTAS
GeneACOT9AuthorityHGNC:17152Mapping file id23597 NCBI fileEvidenceTAS
GeneACSF2AuthorityHGNC:26101Mapping file id80221 NCBI fileEvidenceTAS
GeneACSM3AuthorityHGNC:10522Mapping file id6296 NCBI fileEvidenceIEA
GeneACSM6AuthorityHGNC:31665Mapping file id142827 NCBI fileEvidenceIEA
GeneDBIAuthorityHGNC:2690Mapping file id1622 NCBI fileEvidenceTAS
GeneDECR1AuthorityHGNC:2753Mapping file id1666 NCBI fileEvidenceTAS
GeneECHS1AuthorityHGNC:3151Mapping file id1892 NCBI fileEvidenceTAS
GeneECI1AuthorityHGNC:2703Mapping file id1632 NCBI fileEvidenceTAS
GeneHADHAuthorityHGNC:4799Mapping file id3033 NCBI fileEvidenceTAS
GeneHADHAAuthorityHGNC:4801Mapping file id3030 NCBI fileEvidenceTAS
GeneHADHBAuthorityHGNC:4803Mapping file id3032 NCBI fileEvidenceTAS
GeneMCATAuthorityHGNC:29622Mapping file id27349 NCBI fileEvidenceTAS
GeneMCEEAuthorityHGNC:16732Mapping file id84693 NCBI fileEvidenceTAS
GeneMECRAuthorityHGNC:19691Mapping file id51102 NCBI fileEvidenceTAS
GeneMMAAAuthorityHGNC:18871Mapping file id166785 NCBI fileEvidenceTAS
GeneMMUTAuthorityHGNC:7526Mapping file id4594 NCBI fileEvidenceTAS
GeneNDUFAB1AuthorityHGNC:7694Mapping file id4706 NCBI fileEvidenceTAS
GenePCCAAuthorityHGNC:8653Mapping file id5095 NCBI fileEvidenceTAS
GenePCCBAuthorityHGNC:8654Mapping file id5096 NCBI fileEvidenceTAS
GenePCTPAuthorityHGNC:8752Mapping file id58488 NCBI fileEvidenceTAS
GeneTHEM4AuthorityHGNC:17947Mapping file id117145 NCBI fileEvidenceTAS
GeneTHEM5AuthorityHGNC:26755Mapping file id284486 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.