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Pathway Human Homo sapiens

Fatty acid metabolism

R-HSA-8978868 in Reactome release 97: under Metabolism of lipids, with 175 genes placed in it by the mapping files and 6 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-8978868 (mouse), R-RNO-8978868 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 175 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 2
GeneABCC1AuthorityHGNC:51Mapping file id4363 NCBI fileEvidenceTAS
GeneABCD1AuthorityHGNC:61Mapping file id215 NCBI fileEvidenceTAS
GeneACAA1AuthorityHGNC:82Mapping file id30 NCBI fileEvidenceTAS
GeneACAA2AuthorityHGNC:83Mapping file id10449 NCBI fileEvidenceTAS
GeneACACAAuthorityHGNC:84Mapping file id31 NCBI fileEvidenceTAS
GeneACACBAuthorityHGNC:85Mapping file id32 NCBI fileEvidenceTAS
GeneACAD10AuthorityHGNC:21597Mapping file id80724 NCBI fileEvidenceTAS
GeneACAD11AuthorityHGNC:30211Mapping file id84129 NCBI fileEvidenceTAS
GeneACADLAuthorityHGNC:88Mapping file id33 NCBI fileEvidenceTAS
GeneACADMAuthorityHGNC:89Mapping file id34 NCBI fileEvidenceTAS
GeneACADSAuthorityHGNC:90Mapping file id35 NCBI fileEvidenceTAS
GeneACADVLAuthorityHGNC:92Mapping file id37 NCBI fileEvidenceTAS
GeneACBD4AuthorityHGNC:23337Mapping file id79777 NCBI fileEvidenceTAS
GeneACBD5AuthorityHGNC:23338Mapping file id91452 NCBI fileEvidenceTAS
GeneACBD6AuthorityHGNC:23339Mapping file id84320 NCBI fileEvidenceTAS
GeneACBD7AuthorityHGNC:17715Mapping file id414149 NCBI fileEvidenceTAS
GeneACLYAuthorityHGNC:115Mapping file id47 NCBI fileEvidenceTAS
GeneACOT1AuthorityHGNC:33128Mapping file id641371 NCBI fileEvidenceTAS
GeneACOT11AuthorityHGNC:18156Mapping file id26027 NCBI fileEvidenceTAS
GeneACOT12AuthorityHGNC:24436Mapping file id134526 NCBI fileEvidenceTAS
GeneACOT13AuthorityHGNC:20999Mapping file id55856 NCBI fileEvidenceTAS
GeneACOT2AuthorityHGNC:18431Mapping file id10965 NCBI fileEvidenceTAS
GeneACOT4AuthorityHGNC:19748Mapping file id122970 NCBI fileEvidenceTAS
GeneACOT7AuthorityHGNC:24157Mapping file id11332 NCBI fileEvidenceTAS
GeneACOT8AuthorityHGNC:15919Mapping file id10005 NCBI fileEvidenceTAS
GeneACOT9AuthorityHGNC:17152Mapping file id23597 NCBI fileEvidenceTAS
GeneACOX1AuthorityHGNC:119Mapping file id51 NCBI fileEvidenceTAS
GeneACOX2AuthorityHGNC:120Mapping file id8309 NCBI fileEvidenceTAS
GeneACOX3AuthorityHGNC:121Mapping file id8310 NCBI fileEvidenceTAS
GeneACOXLAuthorityHGNC:25621Mapping file id55289 NCBI fileEvidenceTAS
GeneACSBG1AuthorityHGNC:29567Mapping file id23205 NCBI fileEvidenceTAS
GeneACSBG2AuthorityHGNC:24174Mapping file id81616 NCBI fileEvidenceTAS
GeneACSF2AuthorityHGNC:26101Mapping file id80221 NCBI fileEvidenceTAS
GeneACSF3AuthorityHGNC:27288Mapping file id197322 NCBI fileEvidenceTAS
GeneACSL1AuthorityHGNC:3569Mapping file id2180 NCBI fileEvidenceTAS
GeneACSL3AuthorityHGNC:3570Mapping file id2181 NCBI fileEvidenceTAS
GeneACSL4AuthorityHGNC:3571Mapping file id2182 NCBI fileEvidenceTAS
GeneACSL5AuthorityHGNC:16526Mapping file id51703 NCBI fileEvidenceTAS
GeneACSL6AuthorityHGNC:16496Mapping file id23305 NCBI fileEvidenceTAS
GeneACSM3AuthorityHGNC:10522Mapping file id6296 NCBI fileEvidenceIEA
GeneACSM6AuthorityHGNC:31665Mapping file id142827 NCBI fileEvidenceIEA
GeneAKR1C3AuthorityHGNC:386Mapping file id8644 NCBI fileEvidenceTAS
GeneALDH3A2AuthorityHGNC:403Mapping file id224 NCBI fileEvidenceTAS
GeneALOX12AuthorityHGNC:429Mapping file id239 NCBI fileEvidenceTAS
GeneALOX12BAuthorityHGNC:430Mapping file id242 NCBI fileEvidenceTAS
GeneALOX15AuthorityHGNC:433Mapping file id246 NCBI fileEvidenceTAS
GeneALOX15BAuthorityHGNC:434Mapping file id247 NCBI fileEvidenceTAS
GeneALOX5AuthorityHGNC:435Mapping file id240 NCBI fileEvidenceTAS
GeneALOX5APAuthorityHGNC:436Mapping file id241 NCBI fileEvidenceTAS
GeneALOXE3AuthorityHGNC:13743Mapping file id59344 NCBI fileEvidenceTAS
GeneAMACRAuthorityHGNC:451Mapping file id23600 NCBI fileEvidenceTAS
GeneAWAT1AuthorityHGNC:23252Mapping file id158833 NCBI fileEvidenceTAS
GeneCBR1AuthorityHGNC:1548Mapping file id873 NCBI fileEvidenceTAS
GeneCBR4AuthorityHGNC:25891Mapping file id84869 NCBI fileEvidenceTAS
GeneCPT1AAuthorityHGNC:2328Mapping file id1374 NCBI fileEvidenceTAS
GeneCPT1BAuthorityHGNC:2329Mapping file id1375 NCBI fileEvidenceTAS
GeneCPT2AuthorityHGNC:2330Mapping file id1376 NCBI fileEvidenceTAS
GeneCRATAuthorityHGNC:2342Mapping file id1384 NCBI fileEvidenceTAS
GeneCROTAuthorityHGNC:2366Mapping file id54677 NCBI fileEvidenceTAS
GeneCYP1A1AuthorityHGNC:2595Mapping file id1543 NCBI fileEvidenceTAS
GeneCYP1A2AuthorityHGNC:2596Mapping file id1544 NCBI fileEvidenceTAS
GeneCYP1B1AuthorityHGNC:2597Mapping file id1545 NCBI fileEvidenceTAS
GeneCYP2C19AuthorityHGNC:2621Mapping file id1557 NCBI fileEvidenceTAS
GeneCYP2C8AuthorityHGNC:2622Mapping file id1558 NCBI fileEvidenceTAS
GeneCYP2C9AuthorityHGNC:2623Mapping file id1559 NCBI fileEvidenceTAS
GeneCYP2J2AuthorityHGNC:2634Mapping file id1573 NCBI fileEvidenceTAS
GeneCYP2U1AuthorityHGNC:20582Mapping file id113612 NCBI fileEvidenceTAS
GeneCYP4A11AuthorityHGNC:2642Mapping file id1579 NCBI fileEvidenceTAS
GeneCYP4A22AuthorityHGNC:20575Mapping file id284541 NCBI fileEvidenceTAS
GeneCYP4B1AuthorityHGNC:2644Mapping file id1580 NCBI fileEvidenceTAS
GeneCYP4F11AuthorityHGNC:13265Mapping file id57834 NCBI fileEvidenceTAS
GeneCYP4F2AuthorityHGNC:2645Mapping file id8529 NCBI fileEvidenceTAS
GeneCYP4F22AuthorityHGNC:26820Mapping file id126410 NCBI fileEvidenceTAS
GeneCYP4F3AuthorityHGNC:2646Mapping file id4051 NCBI fileEvidenceTAS
GeneCYP4F8AuthorityHGNC:2648Mapping file id11283 NCBI fileEvidenceTAS
GeneCYP8B1AuthorityHGNC:2653Mapping file id1582 NCBI fileEvidenceTAS
GeneDBIAuthorityHGNC:2690Mapping file id1622 NCBI fileEvidenceTAS
GeneDECR1AuthorityHGNC:2753Mapping file id1666 NCBI fileEvidenceTAS
GeneDECR2AuthorityHGNC:2754Mapping file id26063 NCBI fileEvidenceTAS
GeneDPEP1AuthorityHGNC:3002Mapping file id1800 NCBI fileEvidenceTAS
GeneDPEP2AuthorityHGNC:23028Mapping file id64174 NCBI fileEvidenceTAS
GeneECHS1AuthorityHGNC:3151Mapping file id1892 NCBI fileEvidenceTAS
GeneECI1AuthorityHGNC:2703Mapping file id1632 NCBI fileEvidenceTAS
GeneECI2AuthorityHGNC:14601Mapping file id10455 NCBI fileEvidenceTAS
GeneEHHADHAuthorityHGNC:3247Mapping file id1962 NCBI fileEvidenceTAS
GeneELOVL1AuthorityHGNC:14418Mapping file id64834 NCBI fileEvidenceIEA, TAS
GeneELOVL2AuthorityHGNC:14416Mapping file id54898 NCBI fileEvidenceTAS
GeneELOVL3AuthorityHGNC:18047Mapping file id83401 NCBI fileEvidenceTAS
GeneELOVL4AuthorityHGNC:14415Mapping file id6785 NCBI fileEvidenceIEA
GeneELOVL5AuthorityHGNC:21308Mapping file id60481 NCBI fileEvidenceTAS
GeneELOVL6AuthorityHGNC:15829Mapping file id79071 NCBI fileEvidenceTAS
GeneELOVL7AuthorityHGNC:26292Mapping file id79993 NCBI fileEvidenceTAS
GeneEPHX2AuthorityHGNC:3402Mapping file id2053 NCBI fileEvidenceTAS
GeneFAAHAuthorityHGNC:3553Mapping file id2166 NCBI fileEvidenceTAS
GeneFAAH2AuthorityHGNC:26440Mapping file id158584 NCBI fileEvidenceTAS
GeneFADS1AuthorityHGNC:3574Mapping file id3992 NCBI fileEvidenceTAS
GeneFADS2AuthorityHGNC:3575Mapping file id9415 NCBI fileEvidenceIEA, TAS
GeneFASNAuthorityHGNC:3594Mapping file id2194 NCBI fileEvidenceIEA, TAS
GeneGGT1AuthorityHGNC:4250Mapping file id2678 NCBI fileEvidenceTAS
GeneGGT5AuthorityHGNC:4260Mapping file id2687 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.