Pathway Human Homo sapiens
Fatty acid metabolism
R-HSA-8978868 in Reactome release 97: under Metabolism of lipids, with 175 genes placed in it by the mapping files and 6 child pathways in the hierarchy.
The same number in the other species
Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-8978868 (mouse), R-RNO-8978868 (rat). Whether the event was inferred from this one is what the record says.
01The record
Reactome's own record of this pathway
What this tells you
The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.
Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions.
[R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.
On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available.
[R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required.
[R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.
A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].
- [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
- [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
- [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
- [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
- [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
02The genes
Genes Reactome places in this human pathway
The mapping files place 175 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.
| Gene | Authority id | Mapping file id | Evidence codes |
|---|---|---|---|
| GeneABCC1 | AuthorityHGNC:51 | Mapping file id4363 NCBI file | EvidenceTAS |
| GeneABCD1 | AuthorityHGNC:61 | Mapping file id215 NCBI file | EvidenceTAS |
| GeneACAA1 | AuthorityHGNC:82 | Mapping file id30 NCBI file | EvidenceTAS |
| GeneACAA2 | AuthorityHGNC:83 | Mapping file id10449 NCBI file | EvidenceTAS |
| GeneACACA | AuthorityHGNC:84 | Mapping file id31 NCBI file | EvidenceTAS |
| GeneACACB | AuthorityHGNC:85 | Mapping file id32 NCBI file | EvidenceTAS |
| GeneACAD10 | AuthorityHGNC:21597 | Mapping file id80724 NCBI file | EvidenceTAS |
| GeneACAD11 | AuthorityHGNC:30211 | Mapping file id84129 NCBI file | EvidenceTAS |
| GeneACADL | AuthorityHGNC:88 | Mapping file id33 NCBI file | EvidenceTAS |
| GeneACADM | AuthorityHGNC:89 | Mapping file id34 NCBI file | EvidenceTAS |
| GeneACADS | AuthorityHGNC:90 | Mapping file id35 NCBI file | EvidenceTAS |
| GeneACADVL | AuthorityHGNC:92 | Mapping file id37 NCBI file | EvidenceTAS |
| GeneACBD4 | AuthorityHGNC:23337 | Mapping file id79777 NCBI file | EvidenceTAS |
| GeneACBD5 | AuthorityHGNC:23338 | Mapping file id91452 NCBI file | EvidenceTAS |
| GeneACBD6 | AuthorityHGNC:23339 | Mapping file id84320 NCBI file | EvidenceTAS |
| GeneACBD7 | AuthorityHGNC:17715 | Mapping file id414149 NCBI file | EvidenceTAS |
| GeneACLY | AuthorityHGNC:115 | Mapping file id47 NCBI file | EvidenceTAS |
| GeneACOT1 | AuthorityHGNC:33128 | Mapping file id641371 NCBI file | EvidenceTAS |
| GeneACOT11 | AuthorityHGNC:18156 | Mapping file id26027 NCBI file | EvidenceTAS |
| GeneACOT12 | AuthorityHGNC:24436 | Mapping file id134526 NCBI file | EvidenceTAS |
| GeneACOT13 | AuthorityHGNC:20999 | Mapping file id55856 NCBI file | EvidenceTAS |
| GeneACOT2 | AuthorityHGNC:18431 | Mapping file id10965 NCBI file | EvidenceTAS |
| GeneACOT4 | AuthorityHGNC:19748 | Mapping file id122970 NCBI file | EvidenceTAS |
| GeneACOT7 | AuthorityHGNC:24157 | Mapping file id11332 NCBI file | EvidenceTAS |
| GeneACOT8 | AuthorityHGNC:15919 | Mapping file id10005 NCBI file | EvidenceTAS |
| GeneACOT9 | AuthorityHGNC:17152 | Mapping file id23597 NCBI file | EvidenceTAS |
| GeneACOX1 | AuthorityHGNC:119 | Mapping file id51 NCBI file | EvidenceTAS |
| GeneACOX2 | AuthorityHGNC:120 | Mapping file id8309 NCBI file | EvidenceTAS |
| GeneACOX3 | AuthorityHGNC:121 | Mapping file id8310 NCBI file | EvidenceTAS |
| GeneACOXL | AuthorityHGNC:25621 | Mapping file id55289 NCBI file | EvidenceTAS |
| GeneACSBG1 | AuthorityHGNC:29567 | Mapping file id23205 NCBI file | EvidenceTAS |
| GeneACSBG2 | AuthorityHGNC:24174 | Mapping file id81616 NCBI file | EvidenceTAS |
| GeneACSF2 | AuthorityHGNC:26101 | Mapping file id80221 NCBI file | EvidenceTAS |
| GeneACSF3 | AuthorityHGNC:27288 | Mapping file id197322 NCBI file | EvidenceTAS |
| GeneACSL1 | AuthorityHGNC:3569 | Mapping file id2180 NCBI file | EvidenceTAS |
| GeneACSL3 | AuthorityHGNC:3570 | Mapping file id2181 NCBI file | EvidenceTAS |
| GeneACSL4 | AuthorityHGNC:3571 | Mapping file id2182 NCBI file | EvidenceTAS |
| GeneACSL5 | AuthorityHGNC:16526 | Mapping file id51703 NCBI file | EvidenceTAS |
| GeneACSL6 | AuthorityHGNC:16496 | Mapping file id23305 NCBI file | EvidenceTAS |
| GeneACSM3 | AuthorityHGNC:10522 | Mapping file id6296 NCBI file | EvidenceIEA |
| GeneACSM6 | AuthorityHGNC:31665 | Mapping file id142827 NCBI file | EvidenceIEA |
| GeneAKR1C3 | AuthorityHGNC:386 | Mapping file id8644 NCBI file | EvidenceTAS |
| GeneALDH3A2 | AuthorityHGNC:403 | Mapping file id224 NCBI file | EvidenceTAS |
| GeneALOX12 | AuthorityHGNC:429 | Mapping file id239 NCBI file | EvidenceTAS |
| GeneALOX12B | AuthorityHGNC:430 | Mapping file id242 NCBI file | EvidenceTAS |
| GeneALOX15 | AuthorityHGNC:433 | Mapping file id246 NCBI file | EvidenceTAS |
| GeneALOX15B | AuthorityHGNC:434 | Mapping file id247 NCBI file | EvidenceTAS |
| GeneALOX5 | AuthorityHGNC:435 | Mapping file id240 NCBI file | EvidenceTAS |
| GeneALOX5AP | AuthorityHGNC:436 | Mapping file id241 NCBI file | EvidenceTAS |
| GeneALOXE3 | AuthorityHGNC:13743 | Mapping file id59344 NCBI file | EvidenceTAS |
| GeneAMACR | AuthorityHGNC:451 | Mapping file id23600 NCBI file | EvidenceTAS |
| GeneAWAT1 | AuthorityHGNC:23252 | Mapping file id158833 NCBI file | EvidenceTAS |
| GeneCBR1 | AuthorityHGNC:1548 | Mapping file id873 NCBI file | EvidenceTAS |
| GeneCBR4 | AuthorityHGNC:25891 | Mapping file id84869 NCBI file | EvidenceTAS |
| GeneCPT1A | AuthorityHGNC:2328 | Mapping file id1374 NCBI file | EvidenceTAS |
| GeneCPT1B | AuthorityHGNC:2329 | Mapping file id1375 NCBI file | EvidenceTAS |
| GeneCPT2 | AuthorityHGNC:2330 | Mapping file id1376 NCBI file | EvidenceTAS |
| GeneCRAT | AuthorityHGNC:2342 | Mapping file id1384 NCBI file | EvidenceTAS |
| GeneCROT | AuthorityHGNC:2366 | Mapping file id54677 NCBI file | EvidenceTAS |
| GeneCYP1A1 | AuthorityHGNC:2595 | Mapping file id1543 NCBI file | EvidenceTAS |
| GeneCYP1A2 | AuthorityHGNC:2596 | Mapping file id1544 NCBI file | EvidenceTAS |
| GeneCYP1B1 | AuthorityHGNC:2597 | Mapping file id1545 NCBI file | EvidenceTAS |
| GeneCYP2C19 | AuthorityHGNC:2621 | Mapping file id1557 NCBI file | EvidenceTAS |
| GeneCYP2C8 | AuthorityHGNC:2622 | Mapping file id1558 NCBI file | EvidenceTAS |
| GeneCYP2C9 | AuthorityHGNC:2623 | Mapping file id1559 NCBI file | EvidenceTAS |
| GeneCYP2J2 | AuthorityHGNC:2634 | Mapping file id1573 NCBI file | EvidenceTAS |
| GeneCYP2U1 | AuthorityHGNC:20582 | Mapping file id113612 NCBI file | EvidenceTAS |
| GeneCYP4A11 | AuthorityHGNC:2642 | Mapping file id1579 NCBI file | EvidenceTAS |
| GeneCYP4A22 | AuthorityHGNC:20575 | Mapping file id284541 NCBI file | EvidenceTAS |
| GeneCYP4B1 | AuthorityHGNC:2644 | Mapping file id1580 NCBI file | EvidenceTAS |
| GeneCYP4F11 | AuthorityHGNC:13265 | Mapping file id57834 NCBI file | EvidenceTAS |
| GeneCYP4F2 | AuthorityHGNC:2645 | Mapping file id8529 NCBI file | EvidenceTAS |
| GeneCYP4F22 | AuthorityHGNC:26820 | Mapping file id126410 NCBI file | EvidenceTAS |
| GeneCYP4F3 | AuthorityHGNC:2646 | Mapping file id4051 NCBI file | EvidenceTAS |
| GeneCYP4F8 | AuthorityHGNC:2648 | Mapping file id11283 NCBI file | EvidenceTAS |
| GeneCYP8B1 | AuthorityHGNC:2653 | Mapping file id1582 NCBI file | EvidenceTAS |
| GeneDBI | AuthorityHGNC:2690 | Mapping file id1622 NCBI file | EvidenceTAS |
| GeneDECR1 | AuthorityHGNC:2753 | Mapping file id1666 NCBI file | EvidenceTAS |
| GeneDECR2 | AuthorityHGNC:2754 | Mapping file id26063 NCBI file | EvidenceTAS |
| GeneDPEP1 | AuthorityHGNC:3002 | Mapping file id1800 NCBI file | EvidenceTAS |
| GeneDPEP2 | AuthorityHGNC:23028 | Mapping file id64174 NCBI file | EvidenceTAS |
| GeneECHS1 | AuthorityHGNC:3151 | Mapping file id1892 NCBI file | EvidenceTAS |
| GeneECI1 | AuthorityHGNC:2703 | Mapping file id1632 NCBI file | EvidenceTAS |
| GeneECI2 | AuthorityHGNC:14601 | Mapping file id10455 NCBI file | EvidenceTAS |
| GeneEHHADH | AuthorityHGNC:3247 | Mapping file id1962 NCBI file | EvidenceTAS |
| GeneELOVL1 | AuthorityHGNC:14418 | Mapping file id64834 NCBI file | EvidenceIEA, TAS |
| GeneELOVL2 | AuthorityHGNC:14416 | Mapping file id54898 NCBI file | EvidenceTAS |
| GeneELOVL3 | AuthorityHGNC:18047 | Mapping file id83401 NCBI file | EvidenceTAS |
| GeneELOVL4 | AuthorityHGNC:14415 | Mapping file id6785 NCBI file | EvidenceIEA |
| GeneELOVL5 | AuthorityHGNC:21308 | Mapping file id60481 NCBI file | EvidenceTAS |
| GeneELOVL6 | AuthorityHGNC:15829 | Mapping file id79071 NCBI file | EvidenceTAS |
| GeneELOVL7 | AuthorityHGNC:26292 | Mapping file id79993 NCBI file | EvidenceTAS |
| GeneEPHX2 | AuthorityHGNC:3402 | Mapping file id2053 NCBI file | EvidenceTAS |
| GeneFAAH | AuthorityHGNC:3553 | Mapping file id2166 NCBI file | EvidenceTAS |
| GeneFAAH2 | AuthorityHGNC:26440 | Mapping file id158584 NCBI file | EvidenceTAS |
| GeneFADS1 | AuthorityHGNC:3574 | Mapping file id3992 NCBI file | EvidenceTAS |
| GeneFADS2 | AuthorityHGNC:3575 | Mapping file id9415 NCBI file | EvidenceIEA, TAS |
| GeneFASN | AuthorityHGNC:3594 | Mapping file id2194 NCBI file | EvidenceIEA, TAS |
| GeneGGT1 | AuthorityHGNC:4250 | Mapping file id2678 NCBI file | EvidenceTAS |
| GeneGGT5 | AuthorityHGNC:4260 | Mapping file id2687 NCBI file | EvidenceTAS |
Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.
- Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.
03The hierarchy
Parents and children in this release's hierarchy
Children
- alpha-linolenic (omega3) and linoleic (omega6) acid metabolismR-HSA-204610413 genes
- Arachidonate metabolismR-HSA-214275359 genes
- Carnitine shuttleR-HSA-20042514 genes
- Fatty acyl-CoA biosynthesisR-HSA-7510537 genes
- Mitochondrial Fatty Acid Beta-OxidationR-HSA-7728937 genes
- Peroxisomal lipid metabolismR-HSA-39091828 genes
Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.
- Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.