Pathway Human Homo sapiens

TBC/RABGAPs

R-HSA-8854214 in Reactome release 97: under Rab regulation of trafficking, with 45 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-8854214 (mouse), R-RNO-8854214 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-8854214.2
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2016-12-12
Events inside: 14, counted from the record

Rab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases serve as multifaceted organizers of almost all membrane trafficking processes in eukaryotic cells. To perform these diverse processes, Rab GTPases interconvert between an active GTP-bound form and an inactive, GDP-bound form. The GTP-bound activated form mediates membrane transport through specific interaction with multiple effector molecules (Zerial & McBride 2001, Stenmark 2009, Zhen & Stenmark 2015, Cherfils & Zeghouf 2013). Conversion from the GTP- to the GDP-bound form occurs through GTP hydrolysis, which is not only driven by the intrinsic GTPase activity of the Rab protein but is also catalysed by GTPase-activating proteins (GAPs). GAPs not only increase the rate of GTP hydrolysis, but they are also involved in the inactivation of RABs, making sure they are inactivated at the correct membrane. Human cells contain as many as 70 Rabs and at least 51 putative Rab GAPs (Pfeffer 2005). Only a few of these GAPs have been matched to a specific Rab substrate. The Tre-2/Bub2/Cdc16 (TBC) domain-containing RAB-specific GAPs (TBC/RABGAPs) are a key family of RAB regulators, where the TBC domain facilitates the inactivation of RABs by facilitating activation of GTPase activity of the RAB (Pan et al. 2006, Frasa et al. 2012, Stenmark 2009). Studies suggest that TBC/RABGAPs are more than just negative regulators of RABs and can integrate signalling between RABs and other small GTPases, thereby regulating numerous cellular processes like intracellular trafficking (Frasa et al. 2012).

Literature Reactome attaches

Illuminating the functional and structural repertoire of human TBC/RABGAPsNat. Rev. Mol. Cell Biol., 2012, vol. 13, p. 67-73PubMed 22251903

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 45 genes in this human pathway; showing 1 to 45, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneARF6	AuthorityHGNC:659	Mapping file id382 NCBI file	EvidenceTAS
GeneGABARAP	AuthorityHGNC:4067	Mapping file id11337 NCBI file	EvidenceTAS
GeneGABARAPL2	AuthorityHGNC:13291	Mapping file id11345 NCBI file	EvidenceTAS
GeneGGA1	AuthorityHGNC:17842	Mapping file id26088 NCBI file	EvidenceTAS
GeneGGA2	AuthorityHGNC:16064	Mapping file id23062 NCBI file	EvidenceTAS
GeneGGA3	AuthorityHGNC:17079	Mapping file id23163 NCBI file	EvidenceTAS
GeneMAP1LC3B	AuthorityHGNC:13352	Mapping file id81631 NCBI file	EvidenceTAS
GeneOPTN	AuthorityHGNC:17142	Mapping file id10133 NCBI file	EvidenceTAS
GeneRAB11A	AuthorityHGNC:9760	Mapping file id8766 NCBI file	EvidenceTAS
GeneRAB11B	AuthorityHGNC:9761	Mapping file id9230 NCBI file	EvidenceTAS
GeneRAB33A	AuthorityHGNC:9773	Mapping file id9363 NCBI file	EvidenceTAS
GeneRAB33B	AuthorityHGNC:16075	Mapping file id83452 NCBI file	EvidenceTAS
GeneRAB35	AuthorityHGNC:9774	Mapping file id11021 NCBI file	EvidenceTAS
GeneRAB4A	AuthorityHGNC:9781	Mapping file id5867 NCBI file	EvidenceTAS
GeneRAB5A	AuthorityHGNC:9783	Mapping file id5868 NCBI file	EvidenceTAS
GeneRAB5B	AuthorityHGNC:9784	Mapping file id5869 NCBI file	EvidenceTAS
GeneRAB5C	AuthorityHGNC:9785	Mapping file id5878 NCBI file	EvidenceTAS
GeneRAB6A	AuthorityHGNC:9786	Mapping file id5870 NCBI file	EvidenceTAS
GeneRAB6B	AuthorityHGNC:14902	Mapping file id51560 NCBI file	EvidenceTAS
GeneRAB7A	AuthorityHGNC:9788	Mapping file id7879 NCBI file	EvidenceTAS
GeneRAB7B	AuthorityHGNC:30513	Mapping file id338382 NCBI file	EvidenceTAS
GeneRAB8A	AuthorityHGNC:7007	Mapping file id4218 NCBI file	EvidenceTAS
GeneRAB8B	AuthorityHGNC:30273	Mapping file id51762 NCBI file	EvidenceTAS
GeneRABEP1	AuthorityHGNC:17677	Mapping file id9135 NCBI file	EvidenceTAS
GeneRABGAP1	AuthorityHGNC:17155	Mapping file id23637 NCBI file	EvidenceTAS
GeneRABGEF1	AuthorityHGNC:17676	Mapping file id27342 NCBI file	EvidenceTAS
GeneSYTL1	AuthorityHGNC:15584	Mapping file id84958 NCBI file	EvidenceTAS
GeneTBC1D10A	AuthorityHGNC:23609	Mapping file id83874 NCBI file	EvidenceTAS
GeneTBC1D10B	AuthorityHGNC:24510	Mapping file id26000 NCBI file	EvidenceTAS
GeneTBC1D10C	AuthorityHGNC:24702	Mapping file id374403 NCBI file	EvidenceTAS
GeneTBC1D13	AuthorityHGNC:25571	Mapping file id54662 NCBI file	EvidenceTAS
GeneTBC1D14	AuthorityHGNC:29246	Mapping file id57533 NCBI file	EvidenceTAS
GeneTBC1D15	AuthorityHGNC:25694	Mapping file id64786 NCBI file	EvidenceTAS
GeneTBC1D16	AuthorityHGNC:28356	Mapping file id125058 NCBI file	EvidenceTAS
GeneTBC1D17	AuthorityHGNC:25699	Mapping file id79735 NCBI file	EvidenceTAS
GeneTBC1D2	AuthorityHGNC:18026	Mapping file id55357 NCBI file	EvidenceTAS
GeneTBC1D20	AuthorityHGNC:16133	Mapping file id128637 NCBI file	EvidenceTAS
GeneTBC1D24	AuthorityHGNC:29203	Mapping file id57465 NCBI file	EvidenceTAS
GeneTBC1D25	AuthorityHGNC:8092	Mapping file id4943 NCBI file	EvidenceTAS
GeneTBC1D3	AuthorityHGNC:19031	Mapping file id729873 NCBI file	EvidenceTAS
GeneTBC1D3C	AuthorityHGNC:24889	Mapping file id414060 NCBI file	EvidenceTAS
GeneTBC1D7	AuthorityHGNC:21066	Mapping file id51256 NCBI file	EvidenceTAS
GeneTSC1	AuthorityHGNC:12362	Mapping file id7248 NCBI file	EvidenceTAS
GeneTSC2	AuthorityHGNC:12363	Mapping file id7249 NCBI file	EvidenceTAS
GeneULK1	AuthorityHGNC:12558	Mapping file id8408 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Rab regulation of traffickingR-HSA-9007101123 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.