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Pathway Human Homo sapiens

Rab regulation of trafficking

R-HSA-9007101 in Reactome release 97: under Membrane Trafficking, with 123 genes placed in it by the mapping files and 2 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-9007101 (mouse), R-RNO-9007101 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 123 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 2
GeneAKT1AuthorityHGNC:391Mapping file id207 NCBI fileEvidenceTAS
GeneAKT2AuthorityHGNC:392Mapping file id208 NCBI fileEvidenceTAS
GeneAKT3AuthorityHGNC:393Mapping file id10000 NCBI fileEvidenceTAS
GeneALS2AuthorityHGNC:443Mapping file id57679 NCBI fileEvidenceTAS
GeneALS2CLAuthorityHGNC:20605Mapping file id259173 NCBI fileEvidenceTAS
GeneANKRD27AuthorityHGNC:25310Mapping file id84079 NCBI fileEvidenceTAS
GeneARF6AuthorityHGNC:659Mapping file id382 NCBI fileEvidenceTAS
GeneCCZ1AuthorityHGNC:21691Mapping file id51622 NCBI fileEvidenceTAS
GeneCCZ1BAuthorityHGNC:21717Mapping file id221960 NCBI fileEvidenceTAS
GeneCHMAuthorityHGNC:1940Mapping file id1121 NCBI fileEvidenceTAS
GeneCHMLAuthorityHGNC:1941Mapping file id1122 NCBI fileEvidenceTAS
GeneDENND1AAuthorityHGNC:29324Mapping file id57706 NCBI fileEvidenceTAS
GeneDENND1BAuthorityHGNC:28404Mapping file id163486 NCBI fileEvidenceTAS
GeneDENND1CAuthorityHGNC:26225Mapping file id79958 NCBI fileEvidenceTAS
GeneDENND2AAuthorityHGNC:22212Mapping file id27147 NCBI fileEvidenceTAS
GeneDENND2BAuthorityHGNC:11350Mapping file id6764 NCBI fileEvidenceTAS
GeneDENND2CAuthorityHGNC:24748Mapping file id163259 NCBI fileEvidenceTAS
GeneDENND2DAuthorityHGNC:26192Mapping file id79961 NCBI fileEvidenceTAS
GeneDENND3AuthorityHGNC:29134Mapping file id22898 NCBI fileEvidenceTAS
GeneDENND4AAuthorityHGNC:24321Mapping file id10260 NCBI fileEvidenceTAS
GeneDENND4BAuthorityHGNC:29044Mapping file id9909 NCBI fileEvidenceTAS
GeneDENND4CAuthorityHGNC:26079Mapping file id55667 NCBI fileEvidenceTAS
GeneDENND5AAuthorityHGNC:19344Mapping file id23258 NCBI fileEvidenceTAS
GeneDENND5BAuthorityHGNC:28338Mapping file id160518 NCBI fileEvidenceTAS
GeneDENND6AAuthorityHGNC:26635Mapping file id201627 NCBI fileEvidenceTAS
GeneDENND6BAuthorityHGNC:32690Mapping file id414918 NCBI fileEvidenceTAS
GeneGABARAPAuthorityHGNC:4067Mapping file id11337 NCBI fileEvidenceTAS
GeneGABARAPL2AuthorityHGNC:13291Mapping file id11345 NCBI fileEvidenceTAS
GeneGAPVD1AuthorityHGNC:23375Mapping file id26130 NCBI fileEvidenceTAS
GeneGDI1AuthorityHGNC:4226Mapping file id2664 NCBI fileEvidenceTAS
GeneGDI2AuthorityHGNC:4227Mapping file id2665 NCBI fileEvidenceTAS
GeneGGA1AuthorityHGNC:17842Mapping file id26088 NCBI fileEvidenceTAS
GeneGGA2AuthorityHGNC:16064Mapping file id23062 NCBI fileEvidenceTAS
GeneGGA3AuthorityHGNC:17079Mapping file id23163 NCBI fileEvidenceTAS
GeneHPS1AuthorityHGNC:5163Mapping file id3257 NCBI fileEvidenceTAS
GeneHPS4AuthorityHGNC:15844Mapping file id89781 NCBI fileEvidenceTAS
GeneMADDAuthorityHGNC:6766Mapping file id8567 NCBI fileEvidenceTAS
GeneMAP1LC3BAuthorityHGNC:13352Mapping file id81631 NCBI fileEvidenceTAS
GeneMON1AAuthorityHGNC:28207Mapping file id84315 NCBI fileEvidenceTAS
GeneMON1BAuthorityHGNC:25020Mapping file id22879 NCBI fileEvidenceTAS
GeneOPTNAuthorityHGNC:17142Mapping file id10133 NCBI fileEvidenceTAS
GeneRAB10AuthorityHGNC:9759Mapping file id10890 NCBI fileEvidenceTAS
GeneRAB11AAuthorityHGNC:9760Mapping file id8766 NCBI fileEvidenceTAS
GeneRAB11BAuthorityHGNC:9761Mapping file id9230 NCBI fileEvidenceTAS
GeneRAB12AuthorityHGNC:31332Mapping file id201475 NCBI fileEvidenceTAS
GeneRAB13AuthorityHGNC:9762Mapping file id5872 NCBI fileEvidenceTAS
GeneRAB14AuthorityHGNC:16524Mapping file id51552 NCBI fileEvidenceTAS
GeneRAB18AuthorityHGNC:14244Mapping file id22931 NCBI fileEvidenceTAS
GeneRAB1AAuthorityHGNC:9758Mapping file id5861 NCBI fileEvidenceTAS
GeneRAB1BAuthorityHGNC:18370Mapping file id81876 NCBI fileEvidenceTAS
GeneRAB21AuthorityHGNC:18263Mapping file id23011 NCBI fileEvidenceTAS
GeneRAB27AAuthorityHGNC:9766Mapping file id5873 NCBI fileEvidenceTAS
GeneRAB27BAuthorityHGNC:9767Mapping file id5874 NCBI fileEvidenceTAS
GeneRAB31AuthorityHGNC:9771Mapping file id11031 NCBI fileEvidenceTAS
GeneRAB32AuthorityHGNC:9772Mapping file id10981 NCBI fileEvidenceTAS
GeneRAB33AAuthorityHGNC:9773Mapping file id9363 NCBI fileEvidenceTAS
GeneRAB33BAuthorityHGNC:16075Mapping file id83452 NCBI fileEvidenceTAS
GeneRAB35AuthorityHGNC:9774Mapping file id11021 NCBI fileEvidenceTAS
GeneRAB38AuthorityHGNC:9776Mapping file id23682 NCBI fileEvidenceTAS
GeneRAB39AAuthorityHGNC:16521Mapping file id54734 NCBI fileEvidenceTAS
GeneRAB39BAuthorityHGNC:16499Mapping file id116442 NCBI fileEvidenceTAS
GeneRAB3AAuthorityHGNC:9777Mapping file id5864 NCBI fileEvidenceTAS
GeneRAB3GAP1AuthorityHGNC:17063Mapping file id22930 NCBI fileEvidenceTAS
GeneRAB3GAP2AuthorityHGNC:17168Mapping file id25782 NCBI fileEvidenceTAS
GeneRAB3IL1AuthorityHGNC:9780Mapping file id5866 NCBI fileEvidenceTAS
GeneRAB3IPAuthorityHGNC:16508Mapping file id117177 NCBI fileEvidenceTAS
GeneRAB4AAuthorityHGNC:9781Mapping file id5867 NCBI fileEvidenceTAS
GeneRAB5AAuthorityHGNC:9783Mapping file id5868 NCBI fileEvidenceTAS
GeneRAB5BAuthorityHGNC:9784Mapping file id5869 NCBI fileEvidenceTAS
GeneRAB5CAuthorityHGNC:9785Mapping file id5878 NCBI fileEvidenceTAS
GeneRAB6AAuthorityHGNC:9786Mapping file id5870 NCBI fileEvidenceTAS
GeneRAB6BAuthorityHGNC:14902Mapping file id51560 NCBI fileEvidenceTAS
GeneRAB7AAuthorityHGNC:9788Mapping file id7879 NCBI fileEvidenceTAS
GeneRAB7BAuthorityHGNC:30513Mapping file id338382 NCBI fileEvidenceTAS
GeneRAB8AAuthorityHGNC:7007Mapping file id4218 NCBI fileEvidenceTAS
GeneRAB8BAuthorityHGNC:30273Mapping file id51762 NCBI fileEvidenceTAS
GeneRAB9AAuthorityHGNC:9792Mapping file id9367 NCBI fileEvidenceTAS
GeneRAB9BAuthorityHGNC:14090Mapping file id51209 NCBI fileEvidenceTAS
GeneRABEP1AuthorityHGNC:17677Mapping file id9135 NCBI fileEvidenceTAS
GeneRABGAP1AuthorityHGNC:17155Mapping file id23637 NCBI fileEvidenceTAS
GeneRABGEF1AuthorityHGNC:17676Mapping file id27342 NCBI fileEvidenceTAS
GeneRGP1AuthorityHGNC:21965Mapping file id9827 NCBI fileEvidenceTAS
GeneRIC1AuthorityHGNC:17686Mapping file id57589 NCBI fileEvidenceTAS
GeneRIN1AuthorityHGNC:18749Mapping file id9610 NCBI fileEvidenceTAS
GeneRIN2AuthorityHGNC:18750Mapping file id54453 NCBI fileEvidenceTAS
GeneRIN3AuthorityHGNC:18751Mapping file id79890 NCBI fileEvidenceTAS
GeneRINLAuthorityHGNC:24795Mapping file id126432 NCBI fileEvidenceTAS
GeneSBF1AuthorityHGNC:10542Mapping file id6305 NCBI fileEvidenceTAS
GeneSBF2AuthorityHGNC:2135Mapping file id81846 NCBI fileEvidenceTAS
GeneSYTL1AuthorityHGNC:15584Mapping file id84958 NCBI fileEvidenceTAS
GeneTBC1D10AAuthorityHGNC:23609Mapping file id83874 NCBI fileEvidenceTAS
GeneTBC1D10BAuthorityHGNC:24510Mapping file id26000 NCBI fileEvidenceTAS
GeneTBC1D10CAuthorityHGNC:24702Mapping file id374403 NCBI fileEvidenceTAS
GeneTBC1D13AuthorityHGNC:25571Mapping file id54662 NCBI fileEvidenceTAS
GeneTBC1D14AuthorityHGNC:29246Mapping file id57533 NCBI fileEvidenceTAS
GeneTBC1D15AuthorityHGNC:25694Mapping file id64786 NCBI fileEvidenceTAS
GeneTBC1D16AuthorityHGNC:28356Mapping file id125058 NCBI fileEvidenceTAS
GeneTBC1D17AuthorityHGNC:25699Mapping file id79735 NCBI fileEvidenceTAS
GeneTBC1D2AuthorityHGNC:18026Mapping file id55357 NCBI fileEvidenceTAS
GeneTBC1D20AuthorityHGNC:16133Mapping file id128637 NCBI fileEvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.