Pathway Human Homo sapiens
Rab regulation of trafficking
R-HSA-9007101 in Reactome release 97: under Membrane Trafficking, with 123 genes placed in it by the mapping files and 2 child pathways in the hierarchy.
The same number in the other species
Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-9007101 (mouse), R-RNO-9007101 (rat). Whether the event was inferred from this one is what the record says.
01The record
Reactome's own record of this pathway
What this tells you
The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.
Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions.
[R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.
On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available.
[R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required.
[R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.
A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].
- [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
- [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
- [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
- [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
- [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
02The genes
Genes Reactome places in this human pathway
The mapping files place 123 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.
| Gene | Authority id | Mapping file id | Evidence codes |
|---|---|---|---|
| GeneAKT1 | AuthorityHGNC:391 | Mapping file id207 NCBI file | EvidenceTAS |
| GeneAKT2 | AuthorityHGNC:392 | Mapping file id208 NCBI file | EvidenceTAS |
| GeneAKT3 | AuthorityHGNC:393 | Mapping file id10000 NCBI file | EvidenceTAS |
| GeneALS2 | AuthorityHGNC:443 | Mapping file id57679 NCBI file | EvidenceTAS |
| GeneALS2CL | AuthorityHGNC:20605 | Mapping file id259173 NCBI file | EvidenceTAS |
| GeneANKRD27 | AuthorityHGNC:25310 | Mapping file id84079 NCBI file | EvidenceTAS |
| GeneARF6 | AuthorityHGNC:659 | Mapping file id382 NCBI file | EvidenceTAS |
| GeneCCZ1 | AuthorityHGNC:21691 | Mapping file id51622 NCBI file | EvidenceTAS |
| GeneCCZ1B | AuthorityHGNC:21717 | Mapping file id221960 NCBI file | EvidenceTAS |
| GeneCHM | AuthorityHGNC:1940 | Mapping file id1121 NCBI file | EvidenceTAS |
| GeneCHML | AuthorityHGNC:1941 | Mapping file id1122 NCBI file | EvidenceTAS |
| GeneDENND1A | AuthorityHGNC:29324 | Mapping file id57706 NCBI file | EvidenceTAS |
| GeneDENND1B | AuthorityHGNC:28404 | Mapping file id163486 NCBI file | EvidenceTAS |
| GeneDENND1C | AuthorityHGNC:26225 | Mapping file id79958 NCBI file | EvidenceTAS |
| GeneDENND2A | AuthorityHGNC:22212 | Mapping file id27147 NCBI file | EvidenceTAS |
| GeneDENND2B | AuthorityHGNC:11350 | Mapping file id6764 NCBI file | EvidenceTAS |
| GeneDENND2C | AuthorityHGNC:24748 | Mapping file id163259 NCBI file | EvidenceTAS |
| GeneDENND2D | AuthorityHGNC:26192 | Mapping file id79961 NCBI file | EvidenceTAS |
| GeneDENND3 | AuthorityHGNC:29134 | Mapping file id22898 NCBI file | EvidenceTAS |
| GeneDENND4A | AuthorityHGNC:24321 | Mapping file id10260 NCBI file | EvidenceTAS |
| GeneDENND4B | AuthorityHGNC:29044 | Mapping file id9909 NCBI file | EvidenceTAS |
| GeneDENND4C | AuthorityHGNC:26079 | Mapping file id55667 NCBI file | EvidenceTAS |
| GeneDENND5A | AuthorityHGNC:19344 | Mapping file id23258 NCBI file | EvidenceTAS |
| GeneDENND5B | AuthorityHGNC:28338 | Mapping file id160518 NCBI file | EvidenceTAS |
| GeneDENND6A | AuthorityHGNC:26635 | Mapping file id201627 NCBI file | EvidenceTAS |
| GeneDENND6B | AuthorityHGNC:32690 | Mapping file id414918 NCBI file | EvidenceTAS |
| GeneGABARAP | AuthorityHGNC:4067 | Mapping file id11337 NCBI file | EvidenceTAS |
| GeneGABARAPL2 | AuthorityHGNC:13291 | Mapping file id11345 NCBI file | EvidenceTAS |
| GeneGAPVD1 | AuthorityHGNC:23375 | Mapping file id26130 NCBI file | EvidenceTAS |
| GeneGDI1 | AuthorityHGNC:4226 | Mapping file id2664 NCBI file | EvidenceTAS |
| GeneGDI2 | AuthorityHGNC:4227 | Mapping file id2665 NCBI file | EvidenceTAS |
| GeneGGA1 | AuthorityHGNC:17842 | Mapping file id26088 NCBI file | EvidenceTAS |
| GeneGGA2 | AuthorityHGNC:16064 | Mapping file id23062 NCBI file | EvidenceTAS |
| GeneGGA3 | AuthorityHGNC:17079 | Mapping file id23163 NCBI file | EvidenceTAS |
| GeneHPS1 | AuthorityHGNC:5163 | Mapping file id3257 NCBI file | EvidenceTAS |
| GeneHPS4 | AuthorityHGNC:15844 | Mapping file id89781 NCBI file | EvidenceTAS |
| GeneMADD | AuthorityHGNC:6766 | Mapping file id8567 NCBI file | EvidenceTAS |
| GeneMAP1LC3B | AuthorityHGNC:13352 | Mapping file id81631 NCBI file | EvidenceTAS |
| GeneMON1A | AuthorityHGNC:28207 | Mapping file id84315 NCBI file | EvidenceTAS |
| GeneMON1B | AuthorityHGNC:25020 | Mapping file id22879 NCBI file | EvidenceTAS |
| GeneOPTN | AuthorityHGNC:17142 | Mapping file id10133 NCBI file | EvidenceTAS |
| GeneRAB10 | AuthorityHGNC:9759 | Mapping file id10890 NCBI file | EvidenceTAS |
| GeneRAB11A | AuthorityHGNC:9760 | Mapping file id8766 NCBI file | EvidenceTAS |
| GeneRAB11B | AuthorityHGNC:9761 | Mapping file id9230 NCBI file | EvidenceTAS |
| GeneRAB12 | AuthorityHGNC:31332 | Mapping file id201475 NCBI file | EvidenceTAS |
| GeneRAB13 | AuthorityHGNC:9762 | Mapping file id5872 NCBI file | EvidenceTAS |
| GeneRAB14 | AuthorityHGNC:16524 | Mapping file id51552 NCBI file | EvidenceTAS |
| GeneRAB18 | AuthorityHGNC:14244 | Mapping file id22931 NCBI file | EvidenceTAS |
| GeneRAB1A | AuthorityHGNC:9758 | Mapping file id5861 NCBI file | EvidenceTAS |
| GeneRAB1B | AuthorityHGNC:18370 | Mapping file id81876 NCBI file | EvidenceTAS |
| GeneRAB21 | AuthorityHGNC:18263 | Mapping file id23011 NCBI file | EvidenceTAS |
| GeneRAB27A | AuthorityHGNC:9766 | Mapping file id5873 NCBI file | EvidenceTAS |
| GeneRAB27B | AuthorityHGNC:9767 | Mapping file id5874 NCBI file | EvidenceTAS |
| GeneRAB31 | AuthorityHGNC:9771 | Mapping file id11031 NCBI file | EvidenceTAS |
| GeneRAB32 | AuthorityHGNC:9772 | Mapping file id10981 NCBI file | EvidenceTAS |
| GeneRAB33A | AuthorityHGNC:9773 | Mapping file id9363 NCBI file | EvidenceTAS |
| GeneRAB33B | AuthorityHGNC:16075 | Mapping file id83452 NCBI file | EvidenceTAS |
| GeneRAB35 | AuthorityHGNC:9774 | Mapping file id11021 NCBI file | EvidenceTAS |
| GeneRAB38 | AuthorityHGNC:9776 | Mapping file id23682 NCBI file | EvidenceTAS |
| GeneRAB39A | AuthorityHGNC:16521 | Mapping file id54734 NCBI file | EvidenceTAS |
| GeneRAB39B | AuthorityHGNC:16499 | Mapping file id116442 NCBI file | EvidenceTAS |
| GeneRAB3A | AuthorityHGNC:9777 | Mapping file id5864 NCBI file | EvidenceTAS |
| GeneRAB3GAP1 | AuthorityHGNC:17063 | Mapping file id22930 NCBI file | EvidenceTAS |
| GeneRAB3GAP2 | AuthorityHGNC:17168 | Mapping file id25782 NCBI file | EvidenceTAS |
| GeneRAB3IL1 | AuthorityHGNC:9780 | Mapping file id5866 NCBI file | EvidenceTAS |
| GeneRAB3IP | AuthorityHGNC:16508 | Mapping file id117177 NCBI file | EvidenceTAS |
| GeneRAB4A | AuthorityHGNC:9781 | Mapping file id5867 NCBI file | EvidenceTAS |
| GeneRAB5A | AuthorityHGNC:9783 | Mapping file id5868 NCBI file | EvidenceTAS |
| GeneRAB5B | AuthorityHGNC:9784 | Mapping file id5869 NCBI file | EvidenceTAS |
| GeneRAB5C | AuthorityHGNC:9785 | Mapping file id5878 NCBI file | EvidenceTAS |
| GeneRAB6A | AuthorityHGNC:9786 | Mapping file id5870 NCBI file | EvidenceTAS |
| GeneRAB6B | AuthorityHGNC:14902 | Mapping file id51560 NCBI file | EvidenceTAS |
| GeneRAB7A | AuthorityHGNC:9788 | Mapping file id7879 NCBI file | EvidenceTAS |
| GeneRAB7B | AuthorityHGNC:30513 | Mapping file id338382 NCBI file | EvidenceTAS |
| GeneRAB8A | AuthorityHGNC:7007 | Mapping file id4218 NCBI file | EvidenceTAS |
| GeneRAB8B | AuthorityHGNC:30273 | Mapping file id51762 NCBI file | EvidenceTAS |
| GeneRAB9A | AuthorityHGNC:9792 | Mapping file id9367 NCBI file | EvidenceTAS |
| GeneRAB9B | AuthorityHGNC:14090 | Mapping file id51209 NCBI file | EvidenceTAS |
| GeneRABEP1 | AuthorityHGNC:17677 | Mapping file id9135 NCBI file | EvidenceTAS |
| GeneRABGAP1 | AuthorityHGNC:17155 | Mapping file id23637 NCBI file | EvidenceTAS |
| GeneRABGEF1 | AuthorityHGNC:17676 | Mapping file id27342 NCBI file | EvidenceTAS |
| GeneRGP1 | AuthorityHGNC:21965 | Mapping file id9827 NCBI file | EvidenceTAS |
| GeneRIC1 | AuthorityHGNC:17686 | Mapping file id57589 NCBI file | EvidenceTAS |
| GeneRIN1 | AuthorityHGNC:18749 | Mapping file id9610 NCBI file | EvidenceTAS |
| GeneRIN2 | AuthorityHGNC:18750 | Mapping file id54453 NCBI file | EvidenceTAS |
| GeneRIN3 | AuthorityHGNC:18751 | Mapping file id79890 NCBI file | EvidenceTAS |
| GeneRINL | AuthorityHGNC:24795 | Mapping file id126432 NCBI file | EvidenceTAS |
| GeneSBF1 | AuthorityHGNC:10542 | Mapping file id6305 NCBI file | EvidenceTAS |
| GeneSBF2 | AuthorityHGNC:2135 | Mapping file id81846 NCBI file | EvidenceTAS |
| GeneSYTL1 | AuthorityHGNC:15584 | Mapping file id84958 NCBI file | EvidenceTAS |
| GeneTBC1D10A | AuthorityHGNC:23609 | Mapping file id83874 NCBI file | EvidenceTAS |
| GeneTBC1D10B | AuthorityHGNC:24510 | Mapping file id26000 NCBI file | EvidenceTAS |
| GeneTBC1D10C | AuthorityHGNC:24702 | Mapping file id374403 NCBI file | EvidenceTAS |
| GeneTBC1D13 | AuthorityHGNC:25571 | Mapping file id54662 NCBI file | EvidenceTAS |
| GeneTBC1D14 | AuthorityHGNC:29246 | Mapping file id57533 NCBI file | EvidenceTAS |
| GeneTBC1D15 | AuthorityHGNC:25694 | Mapping file id64786 NCBI file | EvidenceTAS |
| GeneTBC1D16 | AuthorityHGNC:28356 | Mapping file id125058 NCBI file | EvidenceTAS |
| GeneTBC1D17 | AuthorityHGNC:25699 | Mapping file id79735 NCBI file | EvidenceTAS |
| GeneTBC1D2 | AuthorityHGNC:18026 | Mapping file id55357 NCBI file | EvidenceTAS |
| GeneTBC1D20 | AuthorityHGNC:16133 | Mapping file id128637 NCBI file | EvidenceTAS |
Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.
- Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.
03The hierarchy
Parents and children in this release's hierarchy
Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.
- Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.