Pathway Human Homo sapiens

Rab regulation of trafficking

R-HSA-9007101 in Reactome release 97: under Membrane Trafficking, with 123 genes placed in it by the mapping files and 2 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-9007101 (mouse), R-RNO-9007101 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-9007101.4
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2016-09-19
Events inside: 2, counted from the record

Human cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of different organelles and interacting with effectors such as sorting adaptors, tethering factors, kinases, phosphatases and tubular-vesicular cargo (reviewed in Stenmark et al, 2009; Wandinger-Ness and Zerial, 2014; Zhen and Stenmark, 2015).

RAB localization depends on a number of factors including C-terminal prenylation, the sequence of upstream hypervariable regions and what nucleotide is bound, as well as interaction with RAB-interacting proteins (Chavrier et al, 1991; Ullrich et al, 1993; Soldati et al, 1994; Farnsworth et al, 1994; Seabra, 1996; Wu et al, 2010; reviewed in Stenmark, 2009; Wandinger-Ness and Zerial, 2014). More recently, the activity of RAB GEFs has also been implicated in regulating the localization of RAB proteins (Blumer et al, 2103; Schoebel et al, 2009; Cabrera and Ungermann, 2013; reviewed in Barr, 2013; Zhen and Stenmark, 2015).

Literature Reactome attaches

Rab GEFs and GAPsCurr. Opin. Cell Biol., 2010, vol. 22, p. 461-70PubMed 20466531
Rab GTPases as coordinators of vesicle trafficNat. Rev. Mol. Cell Biol., 2009, vol. 10, p. 513-25PubMed 19603039

Reactome's record lists 14 orthologous events, R-RNO-9007101 (Rattus norvegicus), R-MMU-9007101 (Mus musculus) among the species this site serves, and 12 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-10-01 ET · Reactome pathway browser"Rab regulation of trafficking". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-9007101 with StableID: R-HSA-9007101.4 (accessed 2026-10-01 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 123 genes in this human pathway; showing 101 to 123, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 2
Gene	Authority id	Mapping file id	Evidence codes
GeneTBC1D24	AuthorityHGNC:29203	Mapping file id57465 NCBI file	EvidenceTAS
GeneTBC1D25	AuthorityHGNC:8092	Mapping file id4943 NCBI file	EvidenceTAS
GeneTBC1D3	AuthorityHGNC:19031	Mapping file id729873 NCBI file	EvidenceTAS
GeneTBC1D3C	AuthorityHGNC:24889	Mapping file id414060 NCBI file	EvidenceTAS
GeneTBC1D7	AuthorityHGNC:21066	Mapping file id51256 NCBI file	EvidenceTAS
GeneTRAPPC1	AuthorityHGNC:19894	Mapping file id58485 NCBI file	EvidenceTAS
GeneTRAPPC10	AuthorityHGNC:11868	Mapping file id7109 NCBI file	EvidenceTAS
GeneTRAPPC11	AuthorityHGNC:25751	Mapping file id60684 NCBI file	EvidenceTAS
GeneTRAPPC12	AuthorityHGNC:24284	Mapping file id51112 NCBI file	EvidenceTAS
GeneTRAPPC13	AuthorityHGNC:25828	Mapping file id80006 NCBI file	EvidenceTAS
GeneTRAPPC2	AuthorityHGNC:23068	Mapping file id6399 NCBI file	EvidenceTAS
GeneTRAPPC2L	AuthorityHGNC:30887	Mapping file id51693 NCBI file	EvidenceTAS
GeneTRAPPC3	AuthorityHGNC:19942	Mapping file id27095 NCBI file	EvidenceTAS
GeneTRAPPC4	AuthorityHGNC:19943	Mapping file id51399 NCBI file	EvidenceTAS
GeneTRAPPC5	AuthorityHGNC:23067	Mapping file id126003 NCBI file	EvidenceTAS
GeneTRAPPC6A	AuthorityHGNC:23069	Mapping file id79090 NCBI file	EvidenceTAS
GeneTRAPPC6B	AuthorityHGNC:23066	Mapping file id122553 NCBI file	EvidenceTAS
GeneTRAPPC8	AuthorityHGNC:29169	Mapping file id22878 NCBI file	EvidenceTAS
GeneTRAPPC9	AuthorityHGNC:30832	Mapping file id83696 NCBI file	EvidenceTAS
GeneTSC1	AuthorityHGNC:12362	Mapping file id7248 NCBI file	EvidenceTAS
GeneTSC2	AuthorityHGNC:12363	Mapping file id7249 NCBI file	EvidenceTAS
GeneULK1	AuthorityHGNC:12558	Mapping file id8408 NCBI file	EvidenceTAS
GeneYWHAE	AuthorityHGNC:12851	Mapping file id7531 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Membrane TraffickingR-HSA-199991636 genes

Children

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.