Pathway Human Homo sapiens

Postmitotic nuclear pore complex (NPC) reformation

R-HSA-9615933 in Reactome release 97: under Nuclear Envelope (NE) Reassembly, with 27 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-9615933 (mouse), R-RNO-9615933 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-9615933.2
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2020-03-17
Events inside: 10, counted from the record

The NPC is reassembled during late anaphase/telophase when nascent nuclear membranes associate with the chromatin surfaces (reviewed by Wandke and Kutay 2013). Assembly of specific NPC proteins (nucleoporins) into the reforming NPC occurs in a temporally ordered fashion (reviewed by Otsuka and Ellenberg 2018). The GTPase RAN plays a central role in regulating NPC assembly during telophase, as well as earlier events in mitosis, such as mitotic spindle assembly (reviewed by Zierhut and Funabiki 2015). The active form of RAN (RAN:GTP), which is generated by the chromatin-associated RAN guanine nucleotide exchange factor RCC1, is converted to the inactive form (RAN:GDP) by the cytoplasmically localized RAN GTPase activating protein RANGAP1. During telophase, the elevated RAN:GTP near chromatin releases nucleoporins from complexes with nuclear transport receptors, including KPNB1/KPNA (importin alpha/beta) and TPNO1 (transportin), thereby liberating the nucleoporins for NPC assembly (reviewed by Forbes et al. 2015).

Literature Reactome attaches

Nucleosome functions in spindle assembly and nuclear envelope formationBioessays, 2015, vol. 37, p. 1074-85PubMed 26222742
Mechanisms of nuclear pore complex assembly - two different ways of building one molecular machineFEBS Lett., 2018, vol. 592, p. 475-488PubMed 29119545
Enclosing chromatin: reassembly of the nucleus after open mitosisCell, 2013, vol. 152, p. 1222-5PubMed 23498932
Nuclear transport factors: global regulation of mitosisCurr. Opin. Cell Biol., 2015, vol. 35, p. 78-90PubMed 25982429

Reactome's record lists 14 orthologous events, R-RNO-9615933 (Rattus norvegicus), R-MMU-9615933 (Mus musculus) among the species this site serves, and 12 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-09-30 ET · Reactome pathway browser"Postmitotic nuclear pore complex (NPC) reformation". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-9615933 with StableID: R-HSA-9615933.2 (accessed 2026-09-30 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 27 genes in this human pathway; showing 1 to 27, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneAHCTF1	AuthorityHGNC:24618	Mapping file id25909 NCBI file	EvidenceIEA, TAS
GeneKPNB1	AuthorityHGNC:6400	Mapping file id3837 NCBI file	EvidenceIEA
GeneNDC1	AuthorityHGNC:25525	Mapping file id55706 NCBI file	EvidenceIEA, TAS
GeneNUP107	AuthorityHGNC:29914	Mapping file id57122 NCBI file	EvidenceIEA, TAS
GeneNUP133	AuthorityHGNC:18016	Mapping file id55746 NCBI file	EvidenceIEA, TAS
GeneNUP155	AuthorityHGNC:8063	Mapping file id9631 NCBI file	EvidenceIEA, TAS
GeneNUP160	AuthorityHGNC:18017	Mapping file id23279 NCBI file	EvidenceIEA, TAS
GeneNUP188	AuthorityHGNC:17859	Mapping file id23511 NCBI file	EvidenceIEA, TAS
GeneNUP205	AuthorityHGNC:18658	Mapping file id23165 NCBI file	EvidenceIEA, TAS
GeneNUP35	AuthorityHGNC:29797	Mapping file id129401 NCBI file	EvidenceIEA, TAS
GeneNUP37	AuthorityHGNC:29929	Mapping file id79023 NCBI file	EvidenceIEA, TAS
GeneNUP43	AuthorityHGNC:21182	Mapping file id348995 NCBI file	EvidenceIEA, TAS
GeneNUP54	AuthorityHGNC:17359	Mapping file id53371 NCBI file	EvidenceIEA
GeneNUP58	AuthorityHGNC:20261	Mapping file id9818 NCBI file	EvidenceIEA
GeneNUP62	AuthorityHGNC:8066	Mapping file id23636 NCBI file	EvidenceIEA
GeneNUP85	AuthorityHGNC:8734	Mapping file id79902 NCBI file	EvidenceIEA, TAS
GeneNUP93	AuthorityHGNC:28958	Mapping file id9688 NCBI file	EvidenceIEA, TAS
GeneNUP98	AuthorityHGNC:8068	Mapping file id4928 NCBI file	EvidenceIEA, TAS
GenePOM121	AuthorityHGNC:19702	Mapping file id9883 NCBI file	EvidenceIEA, TAS
GeneRAN	AuthorityHGNC:9846	Mapping file id5901 NCBI file	EvidenceIEA, TAS
GeneRANGAP1	AuthorityHGNC:9854	Mapping file id5905 NCBI file	EvidenceTAS
GeneRCC1	AuthorityHGNC:1913	Mapping file id1104 NCBI file	EvidenceTAS
GeneSEC13	AuthorityHGNC:10697	Mapping file id6396 NCBI file	EvidenceIEA, TAS
GeneSEH1L	AuthorityHGNC:30379	Mapping file id81929 NCBI file	EvidenceIEA, TAS
GeneSUMO1	AuthorityHGNC:12502	Mapping file id7341 NCBI file	EvidenceTAS
GeneTNPO1	AuthorityHGNC:6401	Mapping file id3842 NCBI file	EvidenceIEA
GeneUBE2I	AuthorityHGNC:12485	Mapping file id7329 NCBI file	EvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Nuclear Envelope (NE) ReassemblyR-HSA-299541077 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.