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Pathway Human Homo sapiens

Parasitic Infection Pathways

R-HSA-9824443 in Reactome release 97: under Infectious disease, with 223 genes placed in it by the mapping files and 1 child pathway in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id; neither of the other two lists holds it. Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 223 genes in this human pathway; showing 101 to 200, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 3
GeneIGHV2-5AuthorityHGNC:5576Mapping file idENSG00000211937 Ensembl fileEvidenceIEA, TAS
GeneIGHV2-70AuthorityHGNC:5577Mapping file idENSG00000274576 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-11AuthorityHGNC:5580Mapping file idENSG00000211941 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-13AuthorityHGNC:5581Mapping file idENSG00000211942 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-23AuthorityHGNC:5588Mapping file idENSG00000211949 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-30AuthorityHGNC:5591Mapping file idENSG00000270550 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-33AuthorityHGNC:5596Mapping file idENSG00000211955 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-48AuthorityHGNC:5606Mapping file idENSG00000211964 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-53AuthorityHGNC:5610Mapping file idENSG00000211967 Ensembl fileEvidenceIEA, TAS
GeneIGHV3-7AuthorityHGNC:5620Mapping file idENSG00000211938 Ensembl fileEvidenceIEA, TAS
GeneIGHV4-34AuthorityHGNC:5650Mapping file idENSG00000211956 Ensembl fileEvidenceIEA, TAS
GeneIGHV4-39AuthorityHGNC:5651Mapping file idENSG00000211959 Ensembl fileEvidenceIEA, TAS
GeneIGHV4-59AuthorityHGNC:5654Mapping file idENSG00000224373 Ensembl fileEvidenceIEA, TAS
GeneIGKV1-12AuthorityHGNC:5730Mapping file idENSG00000243290 Ensembl fileEvidenceIEA, TAS
GeneIGKV1-16AuthorityHGNC:5732Mapping file idENSG00000240864 Ensembl fileEvidenceIEA, TAS
GeneIGKV1-17AuthorityHGNC:5733Mapping file idENSG00000240382 Ensembl fileEvidenceIEA, TAS
GeneIGKV1-33AuthorityHGNC:5737Mapping file idENSG00000242076 Ensembl fileEvidenceIEA, TAS
GeneIGKV1-39AuthorityHGNC:5740Mapping file idENSG00000242371 Ensembl fileEvidenceIEA, TAS
GeneIGKV1-5AuthorityHGNC:5741Mapping file idENSG00000243466 Ensembl fileEvidenceIEA, TAS
GeneIGKV1D-12AuthorityHGNC:5746Mapping file idENSG00000278857 Ensembl fileEvidenceIEA, TAS
GeneIGKV1D-16AuthorityHGNC:5748Mapping file idENSG00000241244 Ensembl fileEvidenceIEA, TAS
GeneIGKV1D-33AuthorityHGNC:5753Mapping file idENSG00000239975 Ensembl fileEvidenceIEA, TAS
GeneIGKV1D-39AuthorityHGNC:5756Mapping file idENSG00000251546 Ensembl fileEvidenceIEA, TAS
GeneIGKV2-28AuthorityHGNC:5783Mapping file idENSG00000244116 Ensembl fileEvidenceIEA, TAS
GeneIGKV2-30AuthorityHGNC:5785Mapping file idENSG00000243238 Ensembl fileEvidenceIEA, TAS
GeneIGKV2D-28AuthorityHGNC:5799Mapping file idENSG00000242534 Ensembl fileEvidenceIEA, TAS
GeneIGKV2D-30AuthorityHGNC:5801Mapping file idENSG00000239571 Ensembl fileEvidenceIEA, TAS
GeneIGKV2D-40AuthorityHGNC:5804Mapping file idENSG00000251039 Ensembl fileEvidenceIEA, TAS
GeneIGKV3-11AuthorityHGNC:5815Mapping file idENSG00000241351 Ensembl fileEvidenceIEA, TAS
GeneIGKV3-15AuthorityHGNC:5816Mapping file idENSG00000244437 Ensembl fileEvidenceIEA, TAS
GeneIGKV3-20AuthorityHGNC:5817Mapping file idENSG00000239951 Ensembl fileEvidenceIEA, TAS
GeneIGKV3D-20AuthorityHGNC:5825Mapping file idENSG00000211625 Ensembl fileEvidenceIEA, TAS
GeneIGKV4-1AuthorityHGNC:5834Mapping file idENSG00000211598 Ensembl fileEvidenceIEA, TAS
GeneIGKV5-2AuthorityHGNC:5835Mapping file idENSG00000211599 Ensembl fileEvidenceIEA, TAS
GeneIGLC2AuthorityHGNC:5856Mapping file idENSG00000211677 Ensembl fileEvidenceIEA, TAS
GeneIGLC3AuthorityHGNC:5857Mapping file idENSG00000211679 Ensembl fileEvidenceIEA, TAS
GeneIGLV1-40AuthorityHGNC:5877Mapping file idENSG00000211653 Ensembl fileEvidenceIEA, TAS
GeneIGLV1-44AuthorityHGNC:5879Mapping file idENSG00000211651 Ensembl fileEvidenceIEA, TAS
GeneIGLV1-47AuthorityHGNC:5880Mapping file idENSG00000211648 Ensembl fileEvidenceIEA, TAS
GeneIGLV1-51AuthorityHGNC:5882Mapping file idENSG00000211644 Ensembl fileEvidenceIEA, TAS
GeneIGLV2-11AuthorityHGNC:5887Mapping file idENSG00000211668 Ensembl fileEvidenceIEA, TAS
GeneIGLV2-14AuthorityHGNC:5888Mapping file idENSG00000211666 Ensembl fileEvidenceIEA, TAS
GeneIGLV2-23AuthorityHGNC:5890Mapping file idENSG00000211660 Ensembl fileEvidenceIEA, TAS
GeneIGLV2-8AuthorityHGNC:5895Mapping file idENSG00000278196 Ensembl fileEvidenceIEA, TAS
GeneIGLV3-1AuthorityHGNC:5896Mapping file idENSG00000211673 Ensembl fileEvidenceIEA, TAS
GeneIGLV3-19AuthorityHGNC:5903Mapping file idENSG00000211663 Ensembl fileEvidenceIEA, TAS
GeneIGLV3-21AuthorityHGNC:5905Mapping file idENSG00000211662 Ensembl fileEvidenceIEA, TAS
GeneIGLV3-25AuthorityHGNC:5908Mapping file idENSG00000211659 Ensembl fileEvidenceIEA, TAS
GeneIGLV3-27AuthorityHGNC:5910Mapping file idENSG00000211658 Ensembl fileEvidenceIEA, TAS
GeneIGLV6-57AuthorityHGNC:5927Mapping file idENSG00000211640 Ensembl fileEvidenceIEA, TAS
GeneIGLV7-43AuthorityHGNC:5929Mapping file idENSG00000211652 Ensembl fileEvidenceIEA, TAS
GeneIL10AuthorityHGNC:5962Mapping file id3586 NCBI fileEvidenceTAS
GeneIL18AuthorityHGNC:5986Mapping file id3606 NCBI fileEvidenceTAS
GeneIL1AAuthorityHGNC:5991Mapping file id3552 NCBI fileEvidenceTAS
GeneIL1BAuthorityHGNC:5992Mapping file id3553 NCBI fileEvidenceTAS
GeneIL6AuthorityHGNC:6018Mapping file id3569 NCBI fileEvidenceTAS
GeneITPR1AuthorityHGNC:6180Mapping file id3708 NCBI fileEvidenceIEA
GeneITPR2AuthorityHGNC:6181Mapping file id3709 NCBI fileEvidenceIEA
GeneITPR3AuthorityHGNC:6182Mapping file id3710 NCBI fileEvidenceIEA
GeneJUNAuthorityHGNC:6204Mapping file id3725 NCBI fileEvidenceTAS
GeneLYNAuthorityHGNC:6735Mapping file id4067 NCBI fileEvidenceTAS
GeneMAPK1AuthorityHGNC:6871Mapping file id5594 NCBI fileEvidenceTAS
GeneMAPK14AuthorityHGNC:6876Mapping file id1432 NCBI fileEvidenceTAS
GeneMAPK3AuthorityHGNC:6877Mapping file id5595 NCBI fileEvidenceTAS
GeneMAPK8AuthorityHGNC:6881Mapping file id5599 NCBI fileEvidenceTAS
GeneMEFVAuthorityHGNC:6998Mapping file id4210 NCBI fileEvidenceTAS
GeneMYH2AuthorityHGNC:7572Mapping file id4620 NCBI fileEvidenceTAS
GeneMYH9AuthorityHGNC:7579Mapping file id4627 NCBI fileEvidenceTAS
GeneMYO10AuthorityHGNC:7593Mapping file id4651 NCBI fileEvidenceTAS
GeneMYO1CAuthorityHGNC:7597Mapping file id4641 NCBI fileEvidenceTAS
GeneMYO5AAuthorityHGNC:7602Mapping file id4644 NCBI fileEvidenceTAS
GeneMYO9BAuthorityHGNC:7609Mapping file id4650 NCBI fileEvidenceTAS
GeneNCK1AuthorityHGNC:7664Mapping file id4690 NCBI fileEvidenceIEA, TAS
GeneNCKAP1AuthorityHGNC:7666Mapping file id10787 NCBI fileEvidenceIEA, TAS
GeneNCKAP1LAuthorityHGNC:4862Mapping file id3071 NCBI fileEvidenceIEA, TAS
GeneNCKIPSDAuthorityHGNC:15486Mapping file id51517 NCBI fileEvidenceIEA, TAS
GeneNFKB1AuthorityHGNC:7794Mapping file id4790 NCBI fileEvidenceTAS
GeneNFKB2AuthorityHGNC:7795Mapping file id4791 NCBI fileEvidenceTAS
GeneNLRP3AuthorityHGNC:16400Mapping file id114548 NCBI fileEvidenceIEA, TAS
GeneNOX1AuthorityHGNC:7889Mapping file id27035 NCBI fileEvidenceTAS
GeneNOXA1AuthorityHGNC:10668Mapping file id10811 NCBI fileEvidenceTAS
GeneNOXO1AuthorityHGNC:19404Mapping file id124056 NCBI fileEvidenceTAS
GeneNT5EAuthorityHGNC:8021Mapping file id4907 NCBI fileEvidenceTAS
GeneP2RX4AuthorityHGNC:8535Mapping file id5025 NCBI fileEvidenceTAS
GeneP2RX7AuthorityHGNC:8537Mapping file id5027 NCBI fileEvidenceTAS
GenePLCG1AuthorityHGNC:9065Mapping file id5335 NCBI fileEvidenceTAS
GenePLCG2AuthorityHGNC:9066Mapping file id5336 NCBI fileEvidenceTAS
GenePLK2AuthorityHGNC:19699Mapping file id10769 NCBI fileEvidenceTAS
GenePRKACAAuthorityHGNC:9380Mapping file id5566 NCBI fileEvidenceIEA, TAS
GenePRKACBAuthorityHGNC:9381Mapping file id5567 NCBI fileEvidenceIEA, TAS
GenePRKACGAuthorityHGNC:9382Mapping file id5568 NCBI fileEvidenceIEA, TAS
GenePRKAR1AAuthorityHGNC:9388Mapping file id5573 NCBI fileEvidenceTAS
GenePRKAR1BAuthorityHGNC:9390Mapping file id5575 NCBI fileEvidenceTAS
GenePRKAR2AAuthorityHGNC:9391Mapping file id5576 NCBI fileEvidenceTAS
GenePRKAR2BAuthorityHGNC:9392Mapping file id5577 NCBI fileEvidenceTAS
GenePRKXAuthorityHGNC:9441Mapping file id5613 NCBI fileEvidenceIEA
GenePSTPIP1AuthorityHGNC:9580Mapping file id9051 NCBI fileEvidenceTAS
GenePTK2AuthorityHGNC:9611Mapping file id5747 NCBI fileEvidenceTAS
GenePYCARDAuthorityHGNC:16608Mapping file id29108 NCBI fileEvidenceTAS
GeneRAC1AuthorityHGNC:9801Mapping file id5879 NCBI fileEvidenceIEA, TAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.