Pathway Human Homo sapiens
Aerobic respiration and respiratory electron transport
R-HSA-1428517 in Reactome release 97: under Metabolism, with 261 genes placed in it by the mapping files and 6 child pathways in the hierarchy.
The same number in the other species
Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-1428517 (mouse), R-RNO-1428517 (rat). Whether the event was inferred from this one is what the record says.
01The record
Reactome's own record of this pathway
What this tells you
The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.
Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions.
[R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.
On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available.
[R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required.
[R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.
A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].
- [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
- [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
- [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
- [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
- [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
02The genes
Genes Reactome places in this human pathway
The mapping files place 261 genes in this human pathway; showing 1 to 100, in pages of 100, sorted by symbol for reading. The order carries no ranking.
| Gene | Authority id | Mapping file id | Evidence codes |
|---|---|---|---|
| GeneACAD9 | AuthorityHGNC:21497 | Mapping file id28976 NCBI file | EvidenceTAS |
| GeneACAT1 | AuthorityHGNC:93 | Mapping file id38 NCBI file | EvidenceTAS |
| GeneACO2 | AuthorityHGNC:118 | Mapping file id50 NCBI file | EvidenceTAS |
| GeneADHFE1 | AuthorityHGNC:16354 | Mapping file id137872 NCBI file | EvidenceTAS |
| GeneARMC8 | AuthorityHGNC:24999 | Mapping file id25852 NCBI file | EvidenceTAS |
| GeneATP5F1A | AuthorityHGNC:823 | Mapping file id498 NCBI file | EvidenceTAS |
| GeneATP5F1B | AuthorityHGNC:830 | Mapping file id506 NCBI file | EvidenceTAS |
| GeneATP5F1C | AuthorityHGNC:833 | Mapping file id509 NCBI file | EvidenceTAS |
| GeneATP5F1D | AuthorityHGNC:837 | Mapping file id513 NCBI file | EvidenceTAS |
| GeneATP5F1E | AuthorityHGNC:838 | Mapping file id514 NCBI file | EvidenceTAS |
| GeneATP5MC1 | AuthorityHGNC:841 | Mapping file id516 NCBI file | EvidenceTAS |
| GeneATP5MC2 | AuthorityHGNC:842 | Mapping file id517 NCBI file | EvidenceTAS |
| GeneATP5MC3 | AuthorityHGNC:843 | Mapping file id518 NCBI file | EvidenceTAS |
| GeneATP5ME | AuthorityHGNC:846 | Mapping file id521 NCBI file | EvidenceTAS |
| GeneATP5MF | AuthorityHGNC:848 | Mapping file id9551 NCBI file | EvidenceTAS |
| GeneATP5MG | AuthorityHGNC:14247 | Mapping file id10632 NCBI file | EvidenceTAS |
| GeneATP5MJ | AuthorityHGNC:1188 | Mapping file id9556 NCBI file | EvidenceTAS |
| GeneATP5MK | AuthorityHGNC:30889 | Mapping file id84833 NCBI file | EvidenceTAS |
| GeneATP5PB | AuthorityHGNC:840 | Mapping file id515 NCBI file | EvidenceTAS |
| GeneATP5PD | AuthorityHGNC:845 | Mapping file id10476 NCBI file | EvidenceTAS |
| GeneATP5PF | AuthorityHGNC:847 | Mapping file id522 NCBI file | EvidenceTAS |
| GeneATP5PO | AuthorityHGNC:850 | Mapping file id539 NCBI file | EvidenceTAS |
| GeneBCS1L | AuthorityHGNC:1020 | Mapping file id617 NCBI file | EvidenceIEA |
| GeneCMC1 | AuthorityHGNC:28783 | Mapping file id152100 NCBI file | EvidenceTAS |
| GeneCOA1 | AuthorityHGNC:21868 | Mapping file id55744 NCBI file | EvidenceTAS |
| GeneCOA3 | AuthorityHGNC:24990 | Mapping file id28958 NCBI file | EvidenceTAS |
| GeneCOA5 | AuthorityHGNC:33848 | Mapping file id493753 NCBI file | EvidenceTAS |
| GeneCOQ10A | AuthorityHGNC:26515 | Mapping file id93058 NCBI file | EvidenceTAS |
| GeneCOQ10B | AuthorityHGNC:25819 | Mapping file id80219 NCBI file | EvidenceTAS |
| GeneCOX11 | AuthorityHGNC:2261 | Mapping file id1353 NCBI file | EvidenceTAS |
| GeneCOX14 | AuthorityHGNC:28216 | Mapping file id84987 NCBI file | EvidenceTAS |
| GeneCOX15 | AuthorityHGNC:2263 | Mapping file id1355 NCBI file | EvidenceTAS |
| GeneCOX16 | AuthorityHGNC:20213 | Mapping file id51241 NCBI file | EvidenceTAS |
| GeneCOX17 | AuthorityHGNC:2264 | Mapping file id10063 NCBI file | EvidenceTAS |
| GeneCOX18 | AuthorityHGNC:26801 | Mapping file id285521 NCBI file | EvidenceTAS |
| GeneCOX19 | AuthorityHGNC:28074 | Mapping file id90639 NCBI file | EvidenceTAS |
| GeneCOX20 | AuthorityHGNC:26970 | Mapping file id116228 NCBI file | EvidenceTAS |
| GeneCOX4I1 | AuthorityHGNC:2265 | Mapping file id1327 NCBI file | EvidenceTAS |
| GeneCOX4I2 | AuthorityHGNC:16232 | Mapping file id84701 NCBI file | EvidenceTAS |
| GeneCOX5A | AuthorityHGNC:2267 | Mapping file id9377 NCBI file | EvidenceTAS |
| GeneCOX5B | AuthorityHGNC:2269 | Mapping file id1329 NCBI file | EvidenceTAS |
| GeneCOX6A1 | AuthorityHGNC:2277 | Mapping file id1337 NCBI file | EvidenceTAS |
| GeneCOX6A2 | AuthorityHGNC:2279 | Mapping file id1339 NCBI file | EvidenceTAS |
| GeneCOX6B1 | AuthorityHGNC:2280 | Mapping file id1340 NCBI file | EvidenceTAS |
| GeneCOX6B2 | AuthorityHGNC:24380 | Mapping file id125965 NCBI file | EvidenceTAS |
| GeneCOX6C | AuthorityHGNC:2285 | Mapping file id1345 NCBI file | EvidenceTAS |
| GeneCOX7A1 | AuthorityHGNC:2287 | Mapping file id1346 NCBI file | EvidenceTAS |
| GeneCOX7A2 | AuthorityHGNC:2288 | Mapping file id1347 NCBI file | EvidenceTAS |
| GeneCOX7A2L | AuthorityHGNC:2289 | Mapping file id9167 NCBI file | EvidenceTAS |
| GeneCOX7B | AuthorityHGNC:2291 | Mapping file id1349 NCBI file | EvidenceTAS |
| GeneCOX7C | AuthorityHGNC:2292 | Mapping file id1350 NCBI file | EvidenceTAS |
| GeneCOX8A | AuthorityHGNC:2294 | Mapping file id1351 NCBI file | EvidenceTAS |
| GeneCOX8C | AuthorityHGNC:24382 | Mapping file id341947 NCBI file | EvidenceTAS |
| GeneCOXFA4 | AuthorityHGNC:7687 | Mapping file id4697 NCBI file | EvidenceTAS |
| GeneCS | AuthorityHGNC:2422 | Mapping file id1431 NCBI file | EvidenceTAS |
| GeneCSKMT | AuthorityHGNC:33113 | Mapping file id751071 NCBI file | EvidenceTAS |
| GeneCYC1 | AuthorityHGNC:2579 | Mapping file id1537 NCBI file | EvidenceIEA, TAS |
| GeneCYCS | AuthorityHGNC:19986 | Mapping file id54205 NCBI file | EvidenceTAS |
| GeneD2HGDH | AuthorityHGNC:28358 | Mapping file id728294 NCBI file | EvidenceTAS |
| GeneDLAT | AuthorityHGNC:2896 | Mapping file id1737 NCBI file | EvidenceTAS |
| GeneDLD | AuthorityHGNC:2898 | Mapping file id1738 NCBI file | EvidenceTAS |
| GeneDLST | AuthorityHGNC:2911 | Mapping file id1743 NCBI file | EvidenceTAS |
| GeneDMAC1 | AuthorityHGNC:30536 | Mapping file id90871 NCBI file | EvidenceTAS |
| GeneDMAC2 | AuthorityHGNC:25496 | Mapping file id55101 NCBI file | EvidenceTAS |
| GeneDMAC2L | AuthorityHGNC:18799 | Mapping file id27109 NCBI file | EvidenceTAS |
| GeneECSIT | AuthorityHGNC:29548 | Mapping file id51295 NCBI file | EvidenceTAS |
| GeneETFA | AuthorityHGNC:3481 | Mapping file id2108 NCBI file | EvidenceTAS |
| GeneETFB | AuthorityHGNC:3482 | Mapping file id2109 NCBI file | EvidenceTAS |
| GeneETFDH | AuthorityHGNC:3483 | Mapping file id2110 NCBI file | EvidenceTAS |
| GeneFAHD1 | AuthorityHGNC:14169 | Mapping file id81889 NCBI file | EvidenceTAS |
| GeneFH | AuthorityHGNC:3700 | Mapping file id2271 NCBI file | EvidenceTAS |
| GeneFOXRED1 | AuthorityHGNC:26927 | Mapping file id55572 NCBI file | EvidenceTAS |
| GeneFXN | AuthorityHGNC:3951 | Mapping file id2395 NCBI file | EvidenceTAS |
| GeneGID4 | AuthorityHGNC:28453 | Mapping file id79018 NCBI file | EvidenceTAS |
| GeneGID8 | AuthorityHGNC:15857 | Mapping file id54994 NCBI file | EvidenceTAS |
| GeneGLO1 | AuthorityHGNC:4323 | Mapping file id2739 NCBI file | EvidenceTAS |
| GeneGOT1 | AuthorityHGNC:4432 | Mapping file id2805 NCBI file | EvidenceTAS |
| GeneGOT2 | AuthorityHGNC:4433 | Mapping file id2806 NCBI file | EvidenceTAS |
| GeneGPT | AuthorityHGNC:4552 | Mapping file id2875 NCBI file | EvidenceTAS |
| GeneGSTZ1 | AuthorityHGNC:4643 | Mapping file id2954 NCBI file | EvidenceTAS |
| GeneHAGH | AuthorityHGNC:4805 | Mapping file id3029 NCBI file | EvidenceTAS |
| GeneHCCS | AuthorityHGNC:4837 | Mapping file id3052 NCBI file | EvidenceTAS |
| GeneHIGD1A | AuthorityHGNC:29527 | Mapping file id25994 NCBI file | EvidenceTAS |
| GeneHIGD1C | AuthorityHGNC:28044 | Mapping file id613227 NCBI file | EvidenceTAS |
| GeneHIGD2A | AuthorityHGNC:28311 | Mapping file id192286 NCBI file | EvidenceTAS |
| GeneHSCB | AuthorityHGNC:28913 | Mapping file id150274 NCBI file | EvidenceTAS |
| GeneHSPA9 | AuthorityHGNC:5244 | Mapping file id3313 NCBI file | EvidenceTAS |
| GeneIDH2 | AuthorityHGNC:5383 | Mapping file id3418 NCBI file | EvidenceTAS |
| GeneIDH3A | AuthorityHGNC:5384 | Mapping file id3419 NCBI file | EvidenceTAS |
| GeneIDH3B | AuthorityHGNC:5385 | Mapping file id3420 NCBI file | EvidenceTAS |
| GeneIDH3G | AuthorityHGNC:5386 | Mapping file id3421 NCBI file | EvidenceTAS |
| GeneISCA1 | AuthorityHGNC:28660 | Mapping file id81689 NCBI file | EvidenceTAS |
| GeneISCA2 | AuthorityHGNC:19857 | Mapping file id122961 NCBI file | EvidenceTAS |
| GeneISCU | AuthorityHGNC:29882 | Mapping file id23479 NCBI file | EvidenceTAS |
| GeneKGD4 | AuthorityHGNC:16631 | Mapping file id92259 NCBI file | EvidenceTAS |
| GeneL2HGDH | AuthorityHGNC:20499 | Mapping file id79944 NCBI file | EvidenceTAS |
| GeneLDHA | AuthorityHGNC:6535 | Mapping file id3939 NCBI file | EvidenceTAS |
| GeneLDHAL6A | AuthorityHGNC:28335 | Mapping file id160287 NCBI file | EvidenceTAS |
| GeneLDHAL6B | AuthorityHGNC:21481 | Mapping file id92483 NCBI file | EvidenceTAS |
| GeneLDHB | AuthorityHGNC:6541 | Mapping file id3945 NCBI file | EvidenceTAS |
Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.
- Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.
03The hierarchy
Parents and children in this release's hierarchy
Children
- Citric acid cycle (TCA cycle)R-HSA-7140334 genes
- Formation of ATP by chemiosmotic couplingR-HSA-16321020 genes
- Interconversion of 2-oxoglutarate and 2-hydroxyglutarateR-HSA-8800093 genes
- Mitochondrial UncouplingR-HSA-1661877 genes
- Pyruvate metabolismR-HSA-7026849 genes
- Respiratory electron transportR-HSA-611105159 genes
Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.
- Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.