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Pathway Human Homo sapiens

Aerobic respiration and respiratory electron transport

R-HSA-1428517 in Reactome release 97: under Metabolism, with 261 genes placed in it by the mapping files and 6 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-1428517 (mouse), R-RNO-1428517 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 261 genes in this human pathway; showing 101 to 200, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 3
GeneLDHCAuthorityHGNC:6544Mapping file id3948 NCBI fileEvidenceTAS
GeneLETM1AuthorityHGNC:6556Mapping file id3954 NCBI fileEvidenceIEA
GeneLYRM2AuthorityHGNC:25229Mapping file id57226 NCBI fileEvidenceTAS
GeneLYRM4AuthorityHGNC:21365Mapping file id57128 NCBI fileEvidenceTAS
GeneLYRM7AuthorityHGNC:28072Mapping file id90624 NCBI fileEvidenceTAS
GeneMAEAAuthorityHGNC:13731Mapping file id10296 NCBI fileEvidenceTAS
GeneMDH1AuthorityHGNC:6970Mapping file id4190 NCBI fileEvidenceTAS
GeneMDH2AuthorityHGNC:6971Mapping file id4191 NCBI fileEvidenceTAS
GeneME1AuthorityHGNC:6983Mapping file id4199 NCBI fileEvidenceTAS
GeneME2AuthorityHGNC:6984Mapping file id4200 NCBI fileEvidenceTAS
GeneME3AuthorityHGNC:6985Mapping file id10873 NCBI fileEvidenceTAS
GeneMKLN1AuthorityHGNC:7109Mapping file id4289 NCBI fileEvidenceTAS
GeneMPC1AuthorityHGNC:21606Mapping file id51660 NCBI fileEvidenceIEA
GeneMPC1LAuthorityHGNC:44205Mapping file id347411 NCBI fileEvidenceIEA
GeneMPC2AuthorityHGNC:24515Mapping file id25874 NCBI fileEvidenceIEA
GeneMT-ATP6AuthorityHGNC:7414Mapping file id4508 NCBI fileEvidenceTAS
GeneMT-ATP8AuthorityHGNC:7415Mapping file id4509 NCBI fileEvidenceTAS
GeneMT-CO1AuthorityHGNC:7419Mapping file id4512 NCBI fileEvidenceTAS
GeneMT-CO2AuthorityHGNC:7421Mapping file id4513 NCBI fileEvidenceTAS
GeneMT-CO3AuthorityHGNC:7422Mapping file id4514 NCBI fileEvidenceTAS
GeneMT-CYBAuthorityHGNC:7427Mapping file id4519 NCBI fileEvidenceIEA, TAS
GeneMT-ND1AuthorityHGNC:7455Mapping file id4535 NCBI fileEvidenceTAS
GeneMT-ND2AuthorityHGNC:7456Mapping file id4536 NCBI fileEvidenceTAS
GeneMT-ND3AuthorityHGNC:7458Mapping file id4537 NCBI fileEvidenceTAS
GeneMT-ND4AuthorityHGNC:7459Mapping file id4538 NCBI fileEvidenceTAS
GeneMT-ND5AuthorityHGNC:7461Mapping file id4540 NCBI fileEvidenceTAS
GeneMT-ND6AuthorityHGNC:7462Mapping file id4541 NCBI fileEvidenceTAS
GeneNDUFA1AuthorityHGNC:7683Mapping file id4694 NCBI fileEvidenceTAS
GeneNDUFA10AuthorityHGNC:7684Mapping file id4705 NCBI fileEvidenceTAS
GeneNDUFA11AuthorityHGNC:20371Mapping file id126328 NCBI fileEvidenceTAS
GeneNDUFA12AuthorityHGNC:23987Mapping file id55967 NCBI fileEvidenceTAS
GeneNDUFA13AuthorityHGNC:17194Mapping file id51079 NCBI fileEvidenceTAS
GeneNDUFA2AuthorityHGNC:7685Mapping file id4695 NCBI fileEvidenceTAS
GeneNDUFA3AuthorityHGNC:7686Mapping file id4696 NCBI fileEvidenceTAS
GeneNDUFA5AuthorityHGNC:7688Mapping file id4698 NCBI fileEvidenceTAS
GeneNDUFA6AuthorityHGNC:7690Mapping file id4700 NCBI fileEvidenceTAS
GeneNDUFA7AuthorityHGNC:7691Mapping file id4701 NCBI fileEvidenceTAS
GeneNDUFA8AuthorityHGNC:7692Mapping file id4702 NCBI fileEvidenceTAS
GeneNDUFA9AuthorityHGNC:7693Mapping file id4704 NCBI fileEvidenceTAS
GeneNDUFAB1AuthorityHGNC:7694Mapping file id4706 NCBI fileEvidenceTAS
GeneNDUFAF1AuthorityHGNC:18828Mapping file id51103 NCBI fileEvidenceTAS
GeneNDUFAF2AuthorityHGNC:28086Mapping file id91942 NCBI fileEvidenceTAS
GeneNDUFAF3AuthorityHGNC:29918Mapping file id25915 NCBI fileEvidenceTAS
GeneNDUFAF4AuthorityHGNC:21034Mapping file id29078 NCBI fileEvidenceTAS
GeneNDUFAF5AuthorityHGNC:15899Mapping file id79133 NCBI fileEvidenceTAS
GeneNDUFAF6AuthorityHGNC:28625Mapping file id137682 NCBI fileEvidenceTAS
GeneNDUFAF7AuthorityHGNC:28816Mapping file id55471 NCBI fileEvidenceTAS
GeneNDUFAF8AuthorityHGNC:33551Mapping file id284184 NCBI fileEvidenceTAS
GeneNDUFB1AuthorityHGNC:7695Mapping file id4707 NCBI fileEvidenceTAS
GeneNDUFB10AuthorityHGNC:7696Mapping file id4716 NCBI fileEvidenceTAS
GeneNDUFB11AuthorityHGNC:20372Mapping file id54539 NCBI fileEvidenceTAS
GeneNDUFB2AuthorityHGNC:7697Mapping file id4708 NCBI fileEvidenceTAS
GeneNDUFB3AuthorityHGNC:7698Mapping file id4709 NCBI fileEvidenceTAS
GeneNDUFB4AuthorityHGNC:7699Mapping file id4710 NCBI fileEvidenceTAS
GeneNDUFB5AuthorityHGNC:7700Mapping file id4711 NCBI fileEvidenceTAS
GeneNDUFB6AuthorityHGNC:7701Mapping file id4712 NCBI fileEvidenceTAS
GeneNDUFB7AuthorityHGNC:7702Mapping file id4713 NCBI fileEvidenceTAS
GeneNDUFB8AuthorityHGNC:7703Mapping file id4714 NCBI fileEvidenceTAS
GeneNDUFB9AuthorityHGNC:7704Mapping file id4715 NCBI fileEvidenceTAS
GeneNDUFC1AuthorityHGNC:7705Mapping file id4717 NCBI fileEvidenceTAS
GeneNDUFC2AuthorityHGNC:7706Mapping file id4718 NCBI fileEvidenceTAS
GeneNDUFS1AuthorityHGNC:7707Mapping file id4719 NCBI fileEvidenceTAS
GeneNDUFS2AuthorityHGNC:7708Mapping file id4720 NCBI fileEvidenceTAS
GeneNDUFS3AuthorityHGNC:7710Mapping file id4722 NCBI fileEvidenceTAS
GeneNDUFS4AuthorityHGNC:7711Mapping file id4724 NCBI fileEvidenceTAS
GeneNDUFS5AuthorityHGNC:7712Mapping file id4725 NCBI fileEvidenceTAS
GeneNDUFS6AuthorityHGNC:7713Mapping file id4726 NCBI fileEvidenceTAS
GeneNDUFS7AuthorityHGNC:7714Mapping file id374291 NCBI fileEvidenceTAS
GeneNDUFS8AuthorityHGNC:7715Mapping file id4728 NCBI fileEvidenceTAS
GeneNDUFV1AuthorityHGNC:7716Mapping file id4723 NCBI fileEvidenceTAS
GeneNDUFV2AuthorityHGNC:7717Mapping file id4729 NCBI fileEvidenceTAS
GeneNDUFV3AuthorityHGNC:7719Mapping file id4731 NCBI fileEvidenceTAS
GeneNEK1AuthorityHGNC:7744Mapping file id4750 NCBI fileEvidenceTAS
GeneNFS1AuthorityHGNC:15910Mapping file id9054 NCBI fileEvidenceTAS
GeneNNTAuthorityHGNC:7863Mapping file id23530 NCBI fileEvidenceTAS
GeneNUBPLAuthorityHGNC:20278Mapping file id80224 NCBI fileEvidenceTAS
GeneOGDHAuthorityHGNC:8124Mapping file id4967 NCBI fileEvidenceTAS
GeneOXA1LAuthorityHGNC:8526Mapping file id5018 NCBI fileEvidenceTAS
GenePCAuthorityHGNC:8636Mapping file id5091 NCBI fileEvidenceTAS
GenePDHA1AuthorityHGNC:8806Mapping file id5160 NCBI fileEvidenceTAS
GenePDHA2AuthorityHGNC:8807Mapping file id5161 NCBI fileEvidenceTAS
GenePDHBAuthorityHGNC:8808Mapping file id5162 NCBI fileEvidenceTAS
GenePDHXAuthorityHGNC:21350Mapping file id8050 NCBI fileEvidenceTAS
GenePDK1AuthorityHGNC:8809Mapping file id5163 NCBI fileEvidenceTAS
GenePDK2AuthorityHGNC:8810Mapping file id5164 NCBI fileEvidenceTAS
GenePDK3AuthorityHGNC:8811Mapping file id5165 NCBI fileEvidenceTAS
GenePDK4AuthorityHGNC:8812Mapping file id5166 NCBI fileEvidenceTAS
GenePDP1AuthorityHGNC:9279Mapping file id54704 NCBI fileEvidenceTAS
GenePDP2AuthorityHGNC:30263Mapping file id57546 NCBI fileEvidenceTAS
GenePDPRAuthorityHGNC:30264Mapping file id55066 NCBI fileEvidenceTAS
GenePET100AuthorityHGNC:40038Mapping file id100131801 NCBI fileEvidenceTAS
GenePET117AuthorityHGNC:40045Mapping file id100303755 NCBI fileEvidenceTAS
GenePGAM5AuthorityHGNC:28763Mapping file id192111 NCBI fileEvidenceTAS
GenePKLRAuthorityHGNC:9020Mapping file id5313 NCBI fileEvidenceTAS
GenePKMAuthorityHGNC:9021Mapping file id5315 NCBI fileEvidenceTAS
GenePM20D1AuthorityHGNC:26518Mapping file id148811 NCBI fileEvidenceTAS
GenePNKDAuthorityHGNC:9153Mapping file id25953 NCBI fileEvidenceTAS
GenePYURFAuthorityHGNC:44317Mapping file id100996939 NCBI fileEvidenceTAS
GeneRAB5IFAuthorityHGNC:15870Mapping file id55969 NCBI fileEvidenceTAS
GeneRANBP9AuthorityHGNC:13727Mapping file id10048 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.