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Pathway Human Homo sapiens

Aerobic respiration and respiratory electron transport

R-HSA-1428517 in Reactome release 97: under Metabolism, with 261 genes placed in it by the mapping files and 6 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-1428517 (mouse), R-RNO-1428517 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 261 genes in this human pathway; showing 201 to 261, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 3 of 3
GeneRMND5AAuthorityHGNC:25850Mapping file id64795 NCBI fileEvidenceTAS
GeneRMND5BAuthorityHGNC:26181Mapping file id64777 NCBI fileEvidenceTAS
GeneRPS27AAuthorityHGNC:10417Mapping file id6233 NCBI fileEvidenceTAS
GeneSCO1AuthorityHGNC:10603Mapping file id6341 NCBI fileEvidenceTAS
GeneSCO2AuthorityHGNC:10604Mapping file id9997 NCBI fileEvidenceTAS
GeneSDHAAuthorityHGNC:10680Mapping file id6389 NCBI fileEvidenceIEA, TAS
GeneSDHAF1AuthorityHGNC:33867Mapping file id644096 NCBI fileEvidenceTAS
GeneSDHAF2AuthorityHGNC:26034Mapping file id54949 NCBI fileEvidenceTAS
GeneSDHAF3AuthorityHGNC:21752Mapping file id57001 NCBI fileEvidenceTAS
GeneSDHAF4AuthorityHGNC:20957Mapping file id135154 NCBI fileEvidenceTAS
GeneSDHBAuthorityHGNC:10681Mapping file id6390 NCBI fileEvidenceIEA, TAS
GeneSDHCAuthorityHGNC:10682Mapping file id6391 NCBI fileEvidenceIEA, TAS
GeneSDHDAuthorityHGNC:10683Mapping file id6392 NCBI fileEvidenceIEA, TAS
GeneSFXN4AuthorityHGNC:16088Mapping file id119559 NCBI fileEvidenceTAS
GeneSIRT3AuthorityHGNC:14931Mapping file id23410 NCBI fileEvidenceTAS
GeneSIRT4AuthorityHGNC:14932Mapping file id23409 NCBI fileEvidenceTAS
GeneSLC25A11AuthorityHGNC:10981Mapping file id8402 NCBI fileEvidenceTAS
GeneSLC25A12AuthorityHGNC:10982Mapping file id8604 NCBI fileEvidenceTAS
GeneSLC25A13AuthorityHGNC:10983Mapping file id10165 NCBI fileEvidenceTAS
GeneSLC25A14AuthorityHGNC:10984Mapping file id9016 NCBI fileEvidenceTAS
GeneSLC25A18AuthorityHGNC:10988Mapping file id83733 NCBI fileEvidenceTAS
GeneSLC25A22AuthorityHGNC:19954Mapping file id79751 NCBI fileEvidenceTAS
GeneSLC25A27AuthorityHGNC:21065Mapping file id9481 NCBI fileEvidenceTAS
GeneSLC25A4AuthorityHGNC:10990Mapping file id291 NCBI fileEvidenceTAS
GeneSMIM20AuthorityHGNC:37260Mapping file id389203 NCBI fileEvidenceTAS
GeneSUCLA2AuthorityHGNC:11448Mapping file id8803 NCBI fileEvidenceTAS
GeneSUCLG1AuthorityHGNC:11449Mapping file id8802 NCBI fileEvidenceTAS
GeneSUCLG2AuthorityHGNC:11450Mapping file id8801 NCBI fileEvidenceTAS
GeneSURF1AuthorityHGNC:11474Mapping file id6834 NCBI fileEvidenceTAS
GeneTACO1AuthorityHGNC:24316Mapping file id51204 NCBI fileEvidenceTAS
GeneTIMM21AuthorityHGNC:25010Mapping file id29090 NCBI fileEvidenceTAS
GeneTIMMDC1AuthorityHGNC:1321Mapping file id51300 NCBI fileEvidenceTAS
GeneTMEM126AAuthorityHGNC:25382Mapping file id84233 NCBI fileEvidenceTAS
GeneTMEM126BAuthorityHGNC:30883Mapping file id55863 NCBI fileEvidenceTAS
GeneTMEM177AuthorityHGNC:28143Mapping file id80775 NCBI fileEvidenceTAS
GeneTMEM186AuthorityHGNC:24530Mapping file id25880 NCBI fileEvidenceTAS
GeneTMEM223AuthorityHGNC:28464Mapping file id79064 NCBI fileEvidenceTAS
GeneTRAP1AuthorityHGNC:16264Mapping file id10131 NCBI fileEvidenceIEA, TAS
GeneTTC19AuthorityHGNC:26006Mapping file id54902 NCBI fileEvidenceTAS
GeneUBA52AuthorityHGNC:12458Mapping file id7311 NCBI fileEvidenceTAS
GeneUBBAuthorityHGNC:12463Mapping file id7314 NCBI fileEvidenceTAS
GeneUBCAuthorityHGNC:12468Mapping file id7316 NCBI fileEvidenceTAS
GeneUCP1AuthorityHGNC:12517Mapping file id7350 NCBI fileEvidenceTAS
GeneUCP2AuthorityHGNC:12518Mapping file id7351 NCBI fileEvidenceTAS
GeneUCP3AuthorityHGNC:12519Mapping file id7352 NCBI fileEvidenceTAS
GeneUQCC1AuthorityHGNC:15891Mapping file id55245 NCBI fileEvidenceIEA
GeneUQCC2AuthorityHGNC:21237Mapping file id84300 NCBI fileEvidenceIEA
GeneUQCC3AuthorityHGNC:34399Mapping file id790955 NCBI fileEvidenceIEA
GeneUQCC5AuthorityHGNC:37257Mapping file id440957 NCBI fileEvidenceIEA
GeneUQCC6AuthorityHGNC:34450Mapping file id728568 NCBI fileEvidenceIEA
GeneUQCR10AuthorityHGNC:30863Mapping file id29796 NCBI fileEvidenceIEA, TAS
GeneUQCR11AuthorityHGNC:30862Mapping file id10975 NCBI fileEvidenceIEA, TAS
GeneUQCRBAuthorityHGNC:12582Mapping file id7381 NCBI fileEvidenceIEA, TAS
GeneUQCRC1AuthorityHGNC:12585Mapping file id7384 NCBI fileEvidenceIEA, TAS
GeneUQCRC2AuthorityHGNC:12586Mapping file id7385 NCBI fileEvidenceIEA, TAS
GeneUQCRFS1AuthorityHGNC:12587Mapping file id7386 NCBI fileEvidenceIEA, TAS
GeneUQCRHAuthorityHGNC:12590Mapping file id7388 NCBI fileEvidenceIEA, TAS
GeneUQCRHLAuthorityHGNC:51714Mapping file id440567 NCBI fileEvidenceIEA, TAS
GeneUQCRQAuthorityHGNC:29594Mapping file id27089 NCBI fileEvidenceIEA, TAS
GeneVDAC1AuthorityHGNC:12669Mapping file id7416 NCBI fileEvidenceTAS
GeneWDR26AuthorityHGNC:21208Mapping file id80232 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.