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Pathway Human Homo sapiens

Mitotic Metaphase and Anaphase

R-HSA-2555396 in Reactome release 97: under M Phase, with 226 genes placed in it by the mapping files and 2 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-2555396 (mouse), R-RNO-2555396 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 226 genes in this human pathway; showing 101 to 200, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 3
GeneNUP155AuthorityHGNC:8063Mapping file id9631 NCBI fileEvidenceIEA, TAS
GeneNUP160AuthorityHGNC:18017Mapping file id23279 NCBI fileEvidenceIEA, TAS
GeneNUP188AuthorityHGNC:17859Mapping file id23511 NCBI fileEvidenceIEA, TAS
GeneNUP205AuthorityHGNC:18658Mapping file id23165 NCBI fileEvidenceIEA, TAS
GeneNUP35AuthorityHGNC:29797Mapping file id129401 NCBI fileEvidenceIEA, TAS
GeneNUP37AuthorityHGNC:29929Mapping file id79023 NCBI fileEvidenceIEA, TAS
GeneNUP43AuthorityHGNC:21182Mapping file id348995 NCBI fileEvidenceIEA, TAS
GeneNUP54AuthorityHGNC:17359Mapping file id53371 NCBI fileEvidenceIEA
GeneNUP58AuthorityHGNC:20261Mapping file id9818 NCBI fileEvidenceIEA
GeneNUP62AuthorityHGNC:8066Mapping file id23636 NCBI fileEvidenceIEA
GeneNUP85AuthorityHGNC:8734Mapping file id79902 NCBI fileEvidenceIEA, TAS
GeneNUP93AuthorityHGNC:28958Mapping file id9688 NCBI fileEvidenceIEA, TAS
GeneNUP98AuthorityHGNC:8068Mapping file id4928 NCBI fileEvidenceIEA, TAS
GenePAFAH1B1AuthorityHGNC:8574Mapping file id5048 NCBI fileEvidenceTAS
GenePDS5AAuthorityHGNC:29088Mapping file id23244 NCBI fileEvidenceTAS
GenePDS5BAuthorityHGNC:20418Mapping file id23047 NCBI fileEvidenceTAS
GenePLK1AuthorityHGNC:9077Mapping file id5347 NCBI fileEvidenceTAS
GenePMF1AuthorityHGNC:9112Mapping file id11243 NCBI fileEvidenceTAS
GenePMF1-BGLAPAuthorityHGNC:42953Mapping file id100527963 NCBI fileEvidenceTAS
GenePOM121AuthorityHGNC:19702Mapping file id9883 NCBI fileEvidenceIEA, TAS
GenePPP1CCAuthorityHGNC:9283Mapping file id5501 NCBI fileEvidenceTAS
GenePPP2CAAuthorityHGNC:9299Mapping file id5515 NCBI fileEvidenceTAS
GenePPP2CBAuthorityHGNC:9300Mapping file id5516 NCBI fileEvidenceTAS
GenePPP2R1AAuthorityHGNC:9302Mapping file id5518 NCBI fileEvidenceTAS
GenePPP2R1BAuthorityHGNC:9303Mapping file id5519 NCBI fileEvidenceTAS
GenePPP2R2AAuthorityHGNC:9304Mapping file id5520 NCBI fileEvidenceTAS
GenePPP2R5AAuthorityHGNC:9309Mapping file id5525 NCBI fileEvidenceTAS
GenePPP2R5BAuthorityHGNC:9310Mapping file id5526 NCBI fileEvidenceTAS
GenePPP2R5CAuthorityHGNC:9311Mapping file id5527 NCBI fileEvidenceTAS
GenePPP2R5DAuthorityHGNC:9312Mapping file id5528 NCBI fileEvidenceTAS
GenePPP2R5EAuthorityHGNC:9313Mapping file id5529 NCBI fileEvidenceTAS
GenePSMA1AuthorityHGNC:9530Mapping file id5682 NCBI fileEvidenceTAS
GenePSMA2AuthorityHGNC:9531Mapping file id5683 NCBI fileEvidenceTAS
GenePSMA3AuthorityHGNC:9532Mapping file id5684 NCBI fileEvidenceTAS
GenePSMA4AuthorityHGNC:9533Mapping file id5685 NCBI fileEvidenceTAS
GenePSMA5AuthorityHGNC:9534Mapping file id5686 NCBI fileEvidenceTAS
GenePSMA6AuthorityHGNC:9535Mapping file id5687 NCBI fileEvidenceTAS
GenePSMA7AuthorityHGNC:9536Mapping file id5688 NCBI fileEvidenceTAS
GenePSMB1AuthorityHGNC:9537Mapping file id5689 NCBI fileEvidenceTAS
GenePSMB2AuthorityHGNC:9539Mapping file id5690 NCBI fileEvidenceTAS
GenePSMB3AuthorityHGNC:9540Mapping file id5691 NCBI fileEvidenceTAS
GenePSMB4AuthorityHGNC:9541Mapping file id5692 NCBI fileEvidenceTAS
GenePSMB5AuthorityHGNC:9542Mapping file id5693 NCBI fileEvidenceTAS
GenePSMB6AuthorityHGNC:9543Mapping file id5694 NCBI fileEvidenceTAS
GenePSMB7AuthorityHGNC:9544Mapping file id5695 NCBI fileEvidenceTAS
GenePSMC1AuthorityHGNC:9547Mapping file id5700 NCBI fileEvidenceTAS
GenePSMC2AuthorityHGNC:9548Mapping file id5701 NCBI fileEvidenceTAS
GenePSMC3AuthorityHGNC:9549Mapping file id5702 NCBI fileEvidenceTAS
GenePSMC4AuthorityHGNC:9551Mapping file id5704 NCBI fileEvidenceTAS
GenePSMC5AuthorityHGNC:9552Mapping file id5705 NCBI fileEvidenceTAS
GenePSMC6AuthorityHGNC:9553Mapping file id5706 NCBI fileEvidenceTAS
GenePSMD1AuthorityHGNC:9554Mapping file id5707 NCBI fileEvidenceTAS
GenePSMD11AuthorityHGNC:9556Mapping file id5717 NCBI fileEvidenceTAS
GenePSMD12AuthorityHGNC:9557Mapping file id5718 NCBI fileEvidenceTAS
GenePSMD13AuthorityHGNC:9558Mapping file id5719 NCBI fileEvidenceTAS
GenePSMD14AuthorityHGNC:16889Mapping file id10213 NCBI fileEvidenceTAS
GenePSMD2AuthorityHGNC:9559Mapping file id5708 NCBI fileEvidenceTAS
GenePSMD3AuthorityHGNC:9560Mapping file id5709 NCBI fileEvidenceTAS
GenePSMD6AuthorityHGNC:9564Mapping file id9861 NCBI fileEvidenceTAS
GenePSMD7AuthorityHGNC:9565Mapping file id5713 NCBI fileEvidenceTAS
GenePSMD8AuthorityHGNC:9566Mapping file id5714 NCBI fileEvidenceTAS
GenePTTG1AuthorityHGNC:9690Mapping file id9232 NCBI fileEvidenceTAS
GeneRAD21AuthorityHGNC:9811Mapping file id5885 NCBI fileEvidenceTAS
GeneRANAuthorityHGNC:9846Mapping file id5901 NCBI fileEvidenceIEA, TAS
GeneRANBP2AuthorityHGNC:9848Mapping file id5903 NCBI fileEvidenceTAS
GeneRANGAP1AuthorityHGNC:9854Mapping file id5905 NCBI fileEvidenceTAS
GeneRCC1AuthorityHGNC:1913Mapping file id1104 NCBI fileEvidenceTAS
GeneRCC2AuthorityHGNC:30297Mapping file id55920 NCBI fileEvidenceTAS
GeneRNF103-CHMP3AuthorityHGNC:38847Mapping file id100526767 NCBI fileEvidenceTAS
GeneRPS27AuthorityHGNC:10416Mapping file id6232 NCBI fileEvidenceTAS
GeneRPS27AAuthorityHGNC:10417Mapping file id6233 NCBI fileEvidenceTAS
GeneSEC13AuthorityHGNC:10697Mapping file id6396 NCBI fileEvidenceIEA, TAS
GeneSEH1LAuthorityHGNC:30379Mapping file id81929 NCBI fileEvidenceIEA, TAS
GeneSEM1AuthorityHGNC:10845Mapping file id7979 NCBI fileEvidenceTAS
GeneSGO1AuthorityHGNC:25088Mapping file id151648 NCBI fileEvidenceTAS
GeneSGO2AuthorityHGNC:30812Mapping file id151246 NCBI fileEvidenceTAS
GeneSIRT2AuthorityHGNC:10886Mapping file id22933 NCBI fileEvidenceTAS
GeneSKA1AuthorityHGNC:28109Mapping file id220134 NCBI fileEvidenceTAS
GeneSKA2AuthorityHGNC:28006Mapping file id348235 NCBI fileEvidenceTAS
GeneSMC1AAuthorityHGNC:11111Mapping file id8243 NCBI fileEvidenceTAS
GeneSMC3AuthorityHGNC:2468Mapping file id9126 NCBI fileEvidenceTAS
GeneSPASTAuthorityHGNC:11233Mapping file id6683 NCBI fileEvidenceTAS
GeneSPC24AuthorityHGNC:26913Mapping file id147841 NCBI fileEvidenceTAS
GeneSPC25AuthorityHGNC:24031Mapping file id57405 NCBI fileEvidenceTAS
GeneSPDL1AuthorityHGNC:26010Mapping file id54908 NCBI fileEvidenceTAS
GeneSTAG1AuthorityHGNC:11354Mapping file id10274 NCBI fileEvidenceTAS
GeneSTAG2AuthorityHGNC:11355Mapping file id10735 NCBI fileEvidenceTAS
GeneSUMO1AuthorityHGNC:12502Mapping file id7341 NCBI fileEvidenceTAS
GeneTAOK1AuthorityHGNC:29259Mapping file id57551 NCBI fileEvidenceTAS
GeneTMPOAuthorityHGNC:11875Mapping file id7112 NCBI fileEvidenceTAS
GeneTNPO1AuthorityHGNC:6401Mapping file id3842 NCBI fileEvidenceIEA
GeneTUBA1AAuthorityHGNC:20766Mapping file id7846 NCBI fileEvidenceTAS
GeneTUBA1BAuthorityHGNC:18809Mapping file id10376 NCBI fileEvidenceTAS
GeneTUBA1CAuthorityHGNC:20768Mapping file id84790 NCBI fileEvidenceTAS
GeneTUBA3CAuthorityHGNC:12408Mapping file id7278 NCBI fileEvidenceTAS
GeneTUBA3DAuthorityHGNC:24071Mapping file id113457 NCBI fileEvidenceTAS
GeneTUBA3EAuthorityHGNC:20765Mapping file id112714 NCBI fileEvidenceTAS
GeneTUBA4AAuthorityHGNC:12407Mapping file id7277 NCBI fileEvidenceTAS
GeneTUBA4BAuthorityHGNC:18637Mapping file id80086 NCBI fileEvidenceTAS
GeneTUBA8AuthorityHGNC:12410Mapping file id51807 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.