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Pathway Human Homo sapiens

Association of TriC/CCT with target proteins during biosynthesis

R-HSA-390471 in Reactome release 97: under Chaperonin-mediated protein folding, with 39 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-390471 (mouse), R-RNO-390471 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 39 genes in this human pathway; showing 1 to 39, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
GeneAP3M1AuthorityHGNC:569Mapping file id26985 NCBI fileEvidenceIEA
GeneARFGEF2AuthorityHGNC:15853Mapping file id10564 NCBI fileEvidenceIEA
GeneCCNE1AuthorityHGNC:1589Mapping file id898 NCBI fileEvidenceIEA
GeneCCNE2AuthorityHGNC:1590Mapping file id9134 NCBI fileEvidenceIEA
GeneCCT2AuthorityHGNC:1615Mapping file id10576 NCBI fileEvidenceIEA, TAS
GeneCCT3AuthorityHGNC:1616Mapping file id7203 NCBI fileEvidenceIEA, TAS
GeneCCT4AuthorityHGNC:1617Mapping file id10575 NCBI fileEvidenceIEA, TAS
GeneCCT5AuthorityHGNC:1618Mapping file id22948 NCBI fileEvidenceIEA, TAS
GeneCCT6AAuthorityHGNC:1620Mapping file id908 NCBI fileEvidenceIEA, TAS
GeneCCT6BAuthorityHGNC:1621Mapping file id10693 NCBI fileEvidenceIEA, TAS
GeneCCT7AuthorityHGNC:1622Mapping file id10574 NCBI fileEvidenceIEA, TAS
GeneCCT8AuthorityHGNC:1623Mapping file id10694 NCBI fileEvidenceIEA, TAS
GeneDCAF7AuthorityHGNC:30915Mapping file id10238 NCBI fileEvidenceIEA
GeneFBXL3AuthorityHGNC:13599Mapping file id26224 NCBI fileEvidenceIEA
GeneFBXL5AuthorityHGNC:13602Mapping file id26234 NCBI fileEvidenceIEA
GeneFBXO4AuthorityHGNC:13583Mapping file id26272 NCBI fileEvidenceIEA
GeneFBXO6AuthorityHGNC:13585Mapping file id26270 NCBI fileEvidenceIEA
GeneFBXW10AuthorityHGNC:1211Mapping file id10517 NCBI fileEvidenceIEA
GeneFBXW2AuthorityHGNC:13608Mapping file id26190 NCBI fileEvidenceIEA
GeneFBXW4AuthorityHGNC:10847Mapping file id6468 NCBI fileEvidenceIEA
GeneFBXW5AuthorityHGNC:13613Mapping file id54461 NCBI fileEvidenceIEA
GeneFBXW7AuthorityHGNC:16712Mapping file id55294 NCBI fileEvidenceIEA
GeneFBXW9AuthorityHGNC:28136Mapping file id84261 NCBI fileEvidenceIEA
GeneFKBP9AuthorityHGNC:3725Mapping file id11328 NCBI fileEvidenceIEA
GeneGAPDHSAuthorityHGNC:24864Mapping file id26330 NCBI fileEvidenceIEA
GeneGBA1AuthorityHGNC:4177Mapping file id2629 NCBI fileEvidenceIEA
GeneHDAC3AuthorityHGNC:4854Mapping file id8841 NCBI fileEvidenceIEA
GeneKIF13AAuthorityHGNC:14566Mapping file id63971 NCBI fileEvidenceIEA
GeneKIFC3AuthorityHGNC:6326Mapping file id3801 NCBI fileEvidenceIEA
GeneLONP2AuthorityHGNC:20598Mapping file id83752 NCBI fileEvidenceIEA
GeneNOP56AuthorityHGNC:15911Mapping file id10528 NCBI fileEvidenceIEA
GeneSKIC2AuthorityHGNC:10898Mapping file id6499 NCBI fileEvidenceIEA
GeneSPHK1AuthorityHGNC:11240Mapping file id8877 NCBI fileEvidenceTAS
GeneSTAT3AuthorityHGNC:11364Mapping file id6774 NCBI fileEvidenceIEA
GeneTCP1AuthorityHGNC:11655Mapping file id6950 NCBI fileEvidenceIEA, TAS
GeneTP53AuthorityHGNC:11998Mapping file id7157 NCBI fileEvidenceIEA
GeneUSP11AuthorityHGNC:12609Mapping file idENSG00000102226 Ensembl fileEvidenceIEA
GeneWRAP53AuthorityHGNC:25522Mapping file id55135 NCBI fileEvidenceIEA
GeneXRN2AuthorityHGNC:12836Mapping file id22803 NCBI fileEvidenceIEA

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.