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Pathway Human Homo sapiens

Peroxisomal lipid metabolism

R-HSA-390918 in Reactome release 97: under Fatty acid metabolism, with 28 genes placed in it by the mapping files and 3 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-390918 (mouse), R-RNO-390918 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 28 genes in this human pathway; showing 1 to 28, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
GeneABCD1AuthorityHGNC:61Mapping file id215 NCBI fileEvidenceTAS
GeneACAA1AuthorityHGNC:82Mapping file id30 NCBI fileEvidenceTAS
GeneACBD4AuthorityHGNC:23337Mapping file id79777 NCBI fileEvidenceTAS
GeneACBD5AuthorityHGNC:23338Mapping file id91452 NCBI fileEvidenceTAS
GeneACOT4AuthorityHGNC:19748Mapping file id122970 NCBI fileEvidenceTAS
GeneACOT8AuthorityHGNC:15919Mapping file id10005 NCBI fileEvidenceTAS
GeneACOX1AuthorityHGNC:119Mapping file id51 NCBI fileEvidenceTAS
GeneACOX2AuthorityHGNC:120Mapping file id8309 NCBI fileEvidenceTAS
GeneACOX3AuthorityHGNC:121Mapping file id8310 NCBI fileEvidenceTAS
GeneACOXLAuthorityHGNC:25621Mapping file id55289 NCBI fileEvidenceTAS
GeneALDH3A2AuthorityHGNC:403Mapping file id224 NCBI fileEvidenceTAS
GeneAMACRAuthorityHGNC:451Mapping file id23600 NCBI fileEvidenceTAS
GeneCRATAuthorityHGNC:2342Mapping file id1384 NCBI fileEvidenceTAS
GeneCROTAuthorityHGNC:2366Mapping file id54677 NCBI fileEvidenceTAS
GeneDECR2AuthorityHGNC:2754Mapping file id26063 NCBI fileEvidenceTAS
GeneECI2AuthorityHGNC:14601Mapping file id10455 NCBI fileEvidenceTAS
GeneEHHADHAuthorityHGNC:3247Mapping file id1962 NCBI fileEvidenceTAS
GeneHACL1AuthorityHGNC:17856Mapping file id26061 NCBI fileEvidenceTAS
GeneHAO2AuthorityHGNC:4810Mapping file id51179 NCBI fileEvidenceTAS
GeneHSD17B4AuthorityHGNC:5213Mapping file id3295 NCBI fileEvidenceTAS
GeneMLYCDAuthorityHGNC:7150Mapping file id23417 NCBI fileEvidenceTAS
GeneNUDT19AuthorityHGNC:32036Mapping file id390916 NCBI fileEvidenceTAS
GeneNUDT7AuthorityHGNC:8054Mapping file id283927 NCBI fileEvidenceIEA
GenePECRAuthorityHGNC:18281Mapping file id55825 NCBI fileEvidenceTAS
GenePHYHAuthorityHGNC:8940Mapping file id5264 NCBI fileEvidenceTAS
GeneSCP2AuthorityHGNC:10606Mapping file id6342 NCBI fileEvidenceTAS
GeneSLC25A17AuthorityHGNC:10987Mapping file id10478 NCBI fileEvidenceTAS
GeneSLC27A2AuthorityHGNC:10996Mapping file id11001 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.