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Pathway Human Homo sapiens

Cell Cycle, Mitotic

R-HSA-69278 in Reactome release 97: under Cell Cycle, with 555 genes placed in it by the mapping files and 5 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-69278 (mouse), R-RNO-69278 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 555 genes in this human pathway; showing 301 to 400, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 4 of 6
GeneMIS12AuthorityHGNC:24967Mapping file id79003 NCBI fileEvidenceTAS
GeneMIS18BP1AuthorityHGNC:20190Mapping file id55320 NCBI fileEvidenceTAS
GeneMNAT1AuthorityHGNC:7181Mapping file id4331 NCBI fileEvidenceTAS
GeneMYBL2AuthorityHGNC:7548Mapping file id4605 NCBI fileEvidenceIEA, TAS
GeneMYCAuthorityHGNC:7553Mapping file id4609 NCBI fileEvidenceTAS
GeneMZT1AuthorityHGNC:33830Mapping file id440145 NCBI fileEvidenceTAS
GeneMZT2AAuthorityHGNC:33187Mapping file id653784 NCBI fileEvidenceTAS
GeneMZT2BAuthorityHGNC:25886Mapping file id80097 NCBI fileEvidenceTAS
GeneNCAPD2AuthorityHGNC:24305Mapping file id9918 NCBI fileEvidenceIEA, TAS
GeneNCAPD3AuthorityHGNC:28952Mapping file id23310 NCBI fileEvidenceTAS
GeneNCAPGAuthorityHGNC:24304Mapping file id64151 NCBI fileEvidenceIEA, TAS
GeneNCAPG2AuthorityHGNC:21904Mapping file id54892 NCBI fileEvidenceTAS
GeneNCAPHAuthorityHGNC:1112Mapping file id23397 NCBI fileEvidenceIEA, TAS
GeneNCAPH2AuthorityHGNC:25071Mapping file id29781 NCBI fileEvidenceTAS
GeneNDC1AuthorityHGNC:25525Mapping file id55706 NCBI fileEvidenceIEA, TAS
GeneNDC80AuthorityHGNC:16909Mapping file id10403 NCBI fileEvidenceTAS
GeneNDE1AuthorityHGNC:17619Mapping file id54820 NCBI fileEvidenceTAS
GeneNDEL1AuthorityHGNC:17620Mapping file id81565 NCBI fileEvidenceTAS
GeneNEDD1AuthorityHGNC:7723Mapping file id121441 NCBI fileEvidenceTAS
GeneNEK2AuthorityHGNC:7745Mapping file id4751 NCBI fileEvidenceTAS
GeneNEK6AuthorityHGNC:7749Mapping file id10783 NCBI fileEvidenceTAS
GeneNEK7AuthorityHGNC:13386Mapping file id140609 NCBI fileEvidenceTAS
GeneNEK9AuthorityHGNC:18591Mapping file id91754 NCBI fileEvidenceTAS
GeneNINLAuthorityHGNC:29163Mapping file id22981 NCBI fileEvidenceTAS
GeneNIPBLAuthorityHGNC:28862Mapping file id25836 NCBI fileEvidenceTAS
GeneNME7AuthorityHGNC:20461Mapping file id29922 NCBI fileEvidenceTAS
GeneNSL1AuthorityHGNC:24548Mapping file id25936 NCBI fileEvidenceTAS
GeneNUDCAuthorityHGNC:8045Mapping file id10726 NCBI fileEvidenceTAS
GeneNUF2AuthorityHGNC:14621Mapping file id83540 NCBI fileEvidenceTAS
GeneNUMA1AuthorityHGNC:8059Mapping file id4926 NCBI fileEvidenceTAS
GeneNUP107AuthorityHGNC:29914Mapping file id57122 NCBI fileEvidenceIEA, TAS
GeneNUP133AuthorityHGNC:18016Mapping file id55746 NCBI fileEvidenceIEA, TAS
GeneNUP153AuthorityHGNC:8062Mapping file id9972 NCBI fileEvidenceTAS
GeneNUP155AuthorityHGNC:8063Mapping file id9631 NCBI fileEvidenceIEA, TAS
GeneNUP160AuthorityHGNC:18017Mapping file id23279 NCBI fileEvidenceIEA, TAS
GeneNUP188AuthorityHGNC:17859Mapping file id23511 NCBI fileEvidenceIEA, TAS
GeneNUP205AuthorityHGNC:18658Mapping file id23165 NCBI fileEvidenceIEA, TAS
GeneNUP210AuthorityHGNC:30052Mapping file id23225 NCBI fileEvidenceTAS
GeneNUP214AuthorityHGNC:8064Mapping file id8021 NCBI fileEvidenceTAS
GeneNUP35AuthorityHGNC:29797Mapping file id129401 NCBI fileEvidenceIEA, TAS
GeneNUP37AuthorityHGNC:29929Mapping file id79023 NCBI fileEvidenceIEA, TAS
GeneNUP42AuthorityHGNC:17010Mapping file id11097 NCBI fileEvidenceTAS
GeneNUP43AuthorityHGNC:21182Mapping file id348995 NCBI fileEvidenceIEA, TAS
GeneNUP50AuthorityHGNC:8065Mapping file id10762 NCBI fileEvidenceTAS
GeneNUP54AuthorityHGNC:17359Mapping file id53371 NCBI fileEvidenceIEA, TAS
GeneNUP58AuthorityHGNC:20261Mapping file id9818 NCBI fileEvidenceIEA, TAS
GeneNUP62AuthorityHGNC:8066Mapping file id23636 NCBI fileEvidenceIEA, TAS
GeneNUP85AuthorityHGNC:8734Mapping file id79902 NCBI fileEvidenceIEA, TAS
GeneNUP88AuthorityHGNC:8067Mapping file id4927 NCBI fileEvidenceTAS
GeneNUP93AuthorityHGNC:28958Mapping file id9688 NCBI fileEvidenceIEA, TAS
GeneNUP98AuthorityHGNC:8068Mapping file id4928 NCBI fileEvidenceIEA, TAS
GeneOBI1AuthorityHGNC:20308Mapping file id79596 NCBI fileEvidenceTAS
GeneODF2AuthorityHGNC:8114Mapping file id4957 NCBI fileEvidenceTAS
GeneOFD1AuthorityHGNC:2567Mapping file id8481 NCBI fileEvidenceTAS
GeneOPTNAuthorityHGNC:17142Mapping file id10133 NCBI fileEvidenceTAS
GeneORC1AuthorityHGNC:8487Mapping file id4998 NCBI fileEvidenceIEA, TAS
GeneORC2AuthorityHGNC:8488Mapping file id4999 NCBI fileEvidenceIEA, TAS
GeneORC3AuthorityHGNC:8489Mapping file id23595 NCBI fileEvidenceIEA, TAS
GeneORC4AuthorityHGNC:8490Mapping file id5000 NCBI fileEvidenceIEA, TAS
GeneORC5AuthorityHGNC:8491Mapping file id5001 NCBI fileEvidenceIEA, TAS
GeneORC6AuthorityHGNC:17151Mapping file id23594 NCBI fileEvidenceIEA, TAS
GenePAFAH1B1AuthorityHGNC:8574Mapping file id5048 NCBI fileEvidenceTAS
GenePCM1AuthorityHGNC:8727Mapping file id5108 NCBI fileEvidenceTAS
GenePCNAAuthorityHGNC:8729Mapping file id5111 NCBI fileEvidenceTAS
GenePCNTAuthorityHGNC:16068Mapping file id5116 NCBI fileEvidenceTAS
GenePDS5AAuthorityHGNC:29088Mapping file id23244 NCBI fileEvidenceTAS
GenePDS5BAuthorityHGNC:20418Mapping file id23047 NCBI fileEvidenceTAS
GenePHF8AuthorityHGNC:20672Mapping file id23133 NCBI fileEvidenceTAS
GenePHLDA1AuthorityHGNC:8933Mapping file id22822 NCBI fileEvidenceTAS
GenePKMYT1AuthorityHGNC:29650Mapping file id9088 NCBI fileEvidenceTAS
GenePLK1AuthorityHGNC:9077Mapping file id5347 NCBI fileEvidenceIEA, TAS
GenePLK4AuthorityHGNC:11397Mapping file id10733 NCBI fileEvidenceTAS
GenePMF1AuthorityHGNC:9112Mapping file id11243 NCBI fileEvidenceTAS
GenePMF1-BGLAPAuthorityHGNC:42953Mapping file id100527963 NCBI fileEvidenceTAS
GenePOLA1AuthorityHGNC:9173Mapping file id5422 NCBI fileEvidenceTAS
GenePOLA2AuthorityHGNC:30073Mapping file id23649 NCBI fileEvidenceTAS
GenePOLD1AuthorityHGNC:9175Mapping file id5424 NCBI fileEvidenceTAS
GenePOLD2AuthorityHGNC:9176Mapping file id5425 NCBI fileEvidenceTAS
GenePOLD3AuthorityHGNC:20932Mapping file id10714 NCBI fileEvidenceTAS
GenePOLD4AuthorityHGNC:14106Mapping file id57804 NCBI fileEvidenceTAS
GenePOLEAuthorityHGNC:9177Mapping file id5426 NCBI fileEvidenceTAS
GenePOLE2AuthorityHGNC:9178Mapping file id5427 NCBI fileEvidenceTAS
GenePOLE3AuthorityHGNC:13546Mapping file id54107 NCBI fileEvidenceTAS
GenePOLE4AuthorityHGNC:18755Mapping file id56655 NCBI fileEvidenceTAS
GenePOM121AuthorityHGNC:19702Mapping file id9883 NCBI fileEvidenceIEA, TAS
GenePOM121CAuthorityHGNC:34005Mapping file idENSG00000272391 Ensembl fileEvidenceTAS
GenePPME1AuthorityHGNC:30178Mapping file id51400 NCBI fileEvidenceTAS
GenePPP1CBAuthorityHGNC:9282Mapping file id5500 NCBI fileEvidenceTAS
GenePPP1CCAuthorityHGNC:9283Mapping file id5501 NCBI fileEvidenceTAS
GenePPP1R12AAuthorityHGNC:7618Mapping file id4659 NCBI fileEvidenceTAS
GenePPP1R12BAuthorityHGNC:7619Mapping file id4660 NCBI fileEvidenceTAS
GenePPP2CAAuthorityHGNC:9299Mapping file id5515 NCBI fileEvidenceIEA, TAS
GenePPP2CBAuthorityHGNC:9300Mapping file id5516 NCBI fileEvidenceIEA, TAS
GenePPP2R1AAuthorityHGNC:9302Mapping file id5518 NCBI fileEvidenceIEA, TAS
GenePPP2R1BAuthorityHGNC:9303Mapping file id5519 NCBI fileEvidenceIEA, TAS
GenePPP2R2AAuthorityHGNC:9304Mapping file id5520 NCBI fileEvidenceTAS
GenePPP2R2DAuthorityHGNC:23732Mapping file id55844 NCBI fileEvidenceIEA
GenePPP2R3BAuthorityHGNC:13417Mapping file id28227 NCBI fileEvidenceTAS
GenePPP2R5AAuthorityHGNC:9309Mapping file id5525 NCBI fileEvidenceTAS
GenePPP2R5BAuthorityHGNC:9310Mapping file id5526 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.