Pathway Human Homo sapiens
Cell Cycle, Mitotic
R-HSA-69278 in Reactome release 97: under Cell Cycle, with 555 genes placed in it by the mapping files and 5 child pathways in the hierarchy.
The same number in the other species
Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-69278 (mouse), R-RNO-69278 (rat). Whether the event was inferred from this one is what the record says.
01The record
Reactome's own record of this pathway
What this tells you
The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.
Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions.
[R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.
On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available.
[R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required.
[R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.
A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].
- [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
- [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
- [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
- [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
- [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
02The genes
Genes Reactome places in this human pathway
The mapping files place 555 genes in this human pathway; showing 301 to 400, in pages of 100, sorted by symbol for reading. The order carries no ranking.
| Gene | Authority id | Mapping file id | Evidence codes |
|---|---|---|---|
| GeneMIS12 | AuthorityHGNC:24967 | Mapping file id79003 NCBI file | EvidenceTAS |
| GeneMIS18BP1 | AuthorityHGNC:20190 | Mapping file id55320 NCBI file | EvidenceTAS |
| GeneMNAT1 | AuthorityHGNC:7181 | Mapping file id4331 NCBI file | EvidenceTAS |
| GeneMYBL2 | AuthorityHGNC:7548 | Mapping file id4605 NCBI file | EvidenceIEA, TAS |
| GeneMYC | AuthorityHGNC:7553 | Mapping file id4609 NCBI file | EvidenceTAS |
| GeneMZT1 | AuthorityHGNC:33830 | Mapping file id440145 NCBI file | EvidenceTAS |
| GeneMZT2A | AuthorityHGNC:33187 | Mapping file id653784 NCBI file | EvidenceTAS |
| GeneMZT2B | AuthorityHGNC:25886 | Mapping file id80097 NCBI file | EvidenceTAS |
| GeneNCAPD2 | AuthorityHGNC:24305 | Mapping file id9918 NCBI file | EvidenceIEA, TAS |
| GeneNCAPD3 | AuthorityHGNC:28952 | Mapping file id23310 NCBI file | EvidenceTAS |
| GeneNCAPG | AuthorityHGNC:24304 | Mapping file id64151 NCBI file | EvidenceIEA, TAS |
| GeneNCAPG2 | AuthorityHGNC:21904 | Mapping file id54892 NCBI file | EvidenceTAS |
| GeneNCAPH | AuthorityHGNC:1112 | Mapping file id23397 NCBI file | EvidenceIEA, TAS |
| GeneNCAPH2 | AuthorityHGNC:25071 | Mapping file id29781 NCBI file | EvidenceTAS |
| GeneNDC1 | AuthorityHGNC:25525 | Mapping file id55706 NCBI file | EvidenceIEA, TAS |
| GeneNDC80 | AuthorityHGNC:16909 | Mapping file id10403 NCBI file | EvidenceTAS |
| GeneNDE1 | AuthorityHGNC:17619 | Mapping file id54820 NCBI file | EvidenceTAS |
| GeneNDEL1 | AuthorityHGNC:17620 | Mapping file id81565 NCBI file | EvidenceTAS |
| GeneNEDD1 | AuthorityHGNC:7723 | Mapping file id121441 NCBI file | EvidenceTAS |
| GeneNEK2 | AuthorityHGNC:7745 | Mapping file id4751 NCBI file | EvidenceTAS |
| GeneNEK6 | AuthorityHGNC:7749 | Mapping file id10783 NCBI file | EvidenceTAS |
| GeneNEK7 | AuthorityHGNC:13386 | Mapping file id140609 NCBI file | EvidenceTAS |
| GeneNEK9 | AuthorityHGNC:18591 | Mapping file id91754 NCBI file | EvidenceTAS |
| GeneNINL | AuthorityHGNC:29163 | Mapping file id22981 NCBI file | EvidenceTAS |
| GeneNIPBL | AuthorityHGNC:28862 | Mapping file id25836 NCBI file | EvidenceTAS |
| GeneNME7 | AuthorityHGNC:20461 | Mapping file id29922 NCBI file | EvidenceTAS |
| GeneNSL1 | AuthorityHGNC:24548 | Mapping file id25936 NCBI file | EvidenceTAS |
| GeneNUDC | AuthorityHGNC:8045 | Mapping file id10726 NCBI file | EvidenceTAS |
| GeneNUF2 | AuthorityHGNC:14621 | Mapping file id83540 NCBI file | EvidenceTAS |
| GeneNUMA1 | AuthorityHGNC:8059 | Mapping file id4926 NCBI file | EvidenceTAS |
| GeneNUP107 | AuthorityHGNC:29914 | Mapping file id57122 NCBI file | EvidenceIEA, TAS |
| GeneNUP133 | AuthorityHGNC:18016 | Mapping file id55746 NCBI file | EvidenceIEA, TAS |
| GeneNUP153 | AuthorityHGNC:8062 | Mapping file id9972 NCBI file | EvidenceTAS |
| GeneNUP155 | AuthorityHGNC:8063 | Mapping file id9631 NCBI file | EvidenceIEA, TAS |
| GeneNUP160 | AuthorityHGNC:18017 | Mapping file id23279 NCBI file | EvidenceIEA, TAS |
| GeneNUP188 | AuthorityHGNC:17859 | Mapping file id23511 NCBI file | EvidenceIEA, TAS |
| GeneNUP205 | AuthorityHGNC:18658 | Mapping file id23165 NCBI file | EvidenceIEA, TAS |
| GeneNUP210 | AuthorityHGNC:30052 | Mapping file id23225 NCBI file | EvidenceTAS |
| GeneNUP214 | AuthorityHGNC:8064 | Mapping file id8021 NCBI file | EvidenceTAS |
| GeneNUP35 | AuthorityHGNC:29797 | Mapping file id129401 NCBI file | EvidenceIEA, TAS |
| GeneNUP37 | AuthorityHGNC:29929 | Mapping file id79023 NCBI file | EvidenceIEA, TAS |
| GeneNUP42 | AuthorityHGNC:17010 | Mapping file id11097 NCBI file | EvidenceTAS |
| GeneNUP43 | AuthorityHGNC:21182 | Mapping file id348995 NCBI file | EvidenceIEA, TAS |
| GeneNUP50 | AuthorityHGNC:8065 | Mapping file id10762 NCBI file | EvidenceTAS |
| GeneNUP54 | AuthorityHGNC:17359 | Mapping file id53371 NCBI file | EvidenceIEA, TAS |
| GeneNUP58 | AuthorityHGNC:20261 | Mapping file id9818 NCBI file | EvidenceIEA, TAS |
| GeneNUP62 | AuthorityHGNC:8066 | Mapping file id23636 NCBI file | EvidenceIEA, TAS |
| GeneNUP85 | AuthorityHGNC:8734 | Mapping file id79902 NCBI file | EvidenceIEA, TAS |
| GeneNUP88 | AuthorityHGNC:8067 | Mapping file id4927 NCBI file | EvidenceTAS |
| GeneNUP93 | AuthorityHGNC:28958 | Mapping file id9688 NCBI file | EvidenceIEA, TAS |
| GeneNUP98 | AuthorityHGNC:8068 | Mapping file id4928 NCBI file | EvidenceIEA, TAS |
| GeneOBI1 | AuthorityHGNC:20308 | Mapping file id79596 NCBI file | EvidenceTAS |
| GeneODF2 | AuthorityHGNC:8114 | Mapping file id4957 NCBI file | EvidenceTAS |
| GeneOFD1 | AuthorityHGNC:2567 | Mapping file id8481 NCBI file | EvidenceTAS |
| GeneOPTN | AuthorityHGNC:17142 | Mapping file id10133 NCBI file | EvidenceTAS |
| GeneORC1 | AuthorityHGNC:8487 | Mapping file id4998 NCBI file | EvidenceIEA, TAS |
| GeneORC2 | AuthorityHGNC:8488 | Mapping file id4999 NCBI file | EvidenceIEA, TAS |
| GeneORC3 | AuthorityHGNC:8489 | Mapping file id23595 NCBI file | EvidenceIEA, TAS |
| GeneORC4 | AuthorityHGNC:8490 | Mapping file id5000 NCBI file | EvidenceIEA, TAS |
| GeneORC5 | AuthorityHGNC:8491 | Mapping file id5001 NCBI file | EvidenceIEA, TAS |
| GeneORC6 | AuthorityHGNC:17151 | Mapping file id23594 NCBI file | EvidenceIEA, TAS |
| GenePAFAH1B1 | AuthorityHGNC:8574 | Mapping file id5048 NCBI file | EvidenceTAS |
| GenePCM1 | AuthorityHGNC:8727 | Mapping file id5108 NCBI file | EvidenceTAS |
| GenePCNA | AuthorityHGNC:8729 | Mapping file id5111 NCBI file | EvidenceTAS |
| GenePCNT | AuthorityHGNC:16068 | Mapping file id5116 NCBI file | EvidenceTAS |
| GenePDS5A | AuthorityHGNC:29088 | Mapping file id23244 NCBI file | EvidenceTAS |
| GenePDS5B | AuthorityHGNC:20418 | Mapping file id23047 NCBI file | EvidenceTAS |
| GenePHF8 | AuthorityHGNC:20672 | Mapping file id23133 NCBI file | EvidenceTAS |
| GenePHLDA1 | AuthorityHGNC:8933 | Mapping file id22822 NCBI file | EvidenceTAS |
| GenePKMYT1 | AuthorityHGNC:29650 | Mapping file id9088 NCBI file | EvidenceTAS |
| GenePLK1 | AuthorityHGNC:9077 | Mapping file id5347 NCBI file | EvidenceIEA, TAS |
| GenePLK4 | AuthorityHGNC:11397 | Mapping file id10733 NCBI file | EvidenceTAS |
| GenePMF1 | AuthorityHGNC:9112 | Mapping file id11243 NCBI file | EvidenceTAS |
| GenePMF1-BGLAP | AuthorityHGNC:42953 | Mapping file id100527963 NCBI file | EvidenceTAS |
| GenePOLA1 | AuthorityHGNC:9173 | Mapping file id5422 NCBI file | EvidenceTAS |
| GenePOLA2 | AuthorityHGNC:30073 | Mapping file id23649 NCBI file | EvidenceTAS |
| GenePOLD1 | AuthorityHGNC:9175 | Mapping file id5424 NCBI file | EvidenceTAS |
| GenePOLD2 | AuthorityHGNC:9176 | Mapping file id5425 NCBI file | EvidenceTAS |
| GenePOLD3 | AuthorityHGNC:20932 | Mapping file id10714 NCBI file | EvidenceTAS |
| GenePOLD4 | AuthorityHGNC:14106 | Mapping file id57804 NCBI file | EvidenceTAS |
| GenePOLE | AuthorityHGNC:9177 | Mapping file id5426 NCBI file | EvidenceTAS |
| GenePOLE2 | AuthorityHGNC:9178 | Mapping file id5427 NCBI file | EvidenceTAS |
| GenePOLE3 | AuthorityHGNC:13546 | Mapping file id54107 NCBI file | EvidenceTAS |
| GenePOLE4 | AuthorityHGNC:18755 | Mapping file id56655 NCBI file | EvidenceTAS |
| GenePOM121 | AuthorityHGNC:19702 | Mapping file id9883 NCBI file | EvidenceIEA, TAS |
| GenePOM121C | AuthorityHGNC:34005 | Mapping file idENSG00000272391 Ensembl file | EvidenceTAS |
| GenePPME1 | AuthorityHGNC:30178 | Mapping file id51400 NCBI file | EvidenceTAS |
| GenePPP1CB | AuthorityHGNC:9282 | Mapping file id5500 NCBI file | EvidenceTAS |
| GenePPP1CC | AuthorityHGNC:9283 | Mapping file id5501 NCBI file | EvidenceTAS |
| GenePPP1R12A | AuthorityHGNC:7618 | Mapping file id4659 NCBI file | EvidenceTAS |
| GenePPP1R12B | AuthorityHGNC:7619 | Mapping file id4660 NCBI file | EvidenceTAS |
| GenePPP2CA | AuthorityHGNC:9299 | Mapping file id5515 NCBI file | EvidenceIEA, TAS |
| GenePPP2CB | AuthorityHGNC:9300 | Mapping file id5516 NCBI file | EvidenceIEA, TAS |
| GenePPP2R1A | AuthorityHGNC:9302 | Mapping file id5518 NCBI file | EvidenceIEA, TAS |
| GenePPP2R1B | AuthorityHGNC:9303 | Mapping file id5519 NCBI file | EvidenceIEA, TAS |
| GenePPP2R2A | AuthorityHGNC:9304 | Mapping file id5520 NCBI file | EvidenceTAS |
| GenePPP2R2D | AuthorityHGNC:23732 | Mapping file id55844 NCBI file | EvidenceIEA |
| GenePPP2R3B | AuthorityHGNC:13417 | Mapping file id28227 NCBI file | EvidenceTAS |
| GenePPP2R5A | AuthorityHGNC:9309 | Mapping file id5525 NCBI file | EvidenceTAS |
| GenePPP2R5B | AuthorityHGNC:9310 | Mapping file id5526 NCBI file | EvidenceTAS |
Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.
- Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.
03The hierarchy
Parents and children in this release's hierarchy
Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.
- Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.