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Pathway Human Homo sapiens

Cell Cycle, Mitotic

R-HSA-69278 in Reactome release 97: under Cell Cycle, with 555 genes placed in it by the mapping files and 5 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-69278 (mouse), R-RNO-69278 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 555 genes in this human pathway; showing 201 to 300, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 3 of 6
GeneH2BC17AuthorityHGNC:4758Mapping file id8348 NCBI fileEvidenceTAS
GeneH2BC21AuthorityHGNC:4760Mapping file id8349 NCBI fileEvidenceTAS
GeneH2BC26AuthorityHGNC:20514Mapping file id128312 NCBI fileEvidenceTAS
GeneH2BC3AuthorityHGNC:4751Mapping file id3018 NCBI fileEvidenceTAS
GeneH2BC4AuthorityHGNC:4757Mapping file id8347 NCBI fileEvidenceTAS
GeneH2BC5AuthorityHGNC:4747Mapping file id3017 NCBI fileEvidenceTAS
GeneH2BC6AuthorityHGNC:4753Mapping file id8344 NCBI fileEvidenceTAS
GeneH2BC7AuthorityHGNC:4752Mapping file id8343 NCBI fileEvidenceTAS
GeneH2BC8AuthorityHGNC:4746Mapping file id8339 NCBI fileEvidenceTAS
GeneH2BC9AuthorityHGNC:4755Mapping file id8345 NCBI fileEvidenceTAS
GeneH3-3AAuthorityHGNC:4764Mapping file id3020 NCBI fileEvidenceTAS
GeneH3-3BAuthorityHGNC:4765Mapping file id3021 NCBI fileEvidenceTAS
GeneH3-4AuthorityHGNC:4778Mapping file id8290 NCBI fileEvidenceTAS
GeneH3C1AuthorityHGNC:4766Mapping file id8350 NCBI fileEvidenceTAS
GeneH3C10AuthorityHGNC:4775Mapping file id8357 NCBI fileEvidenceTAS
GeneH3C11AuthorityHGNC:4771Mapping file id8354 NCBI fileEvidenceTAS
GeneH3C12AuthorityHGNC:4774Mapping file id8356 NCBI fileEvidenceTAS
GeneH3C13AuthorityHGNC:25311Mapping file id653604 NCBI fileEvidenceTAS
GeneH3C14AuthorityHGNC:20503Mapping file id126961 NCBI fileEvidenceTAS
GeneH3C15AuthorityHGNC:20505Mapping file id333932 NCBI fileEvidenceTAS
GeneH3C2AuthorityHGNC:4776Mapping file id8358 NCBI fileEvidenceTAS
GeneH3C3AuthorityHGNC:4768Mapping file id8352 NCBI fileEvidenceTAS
GeneH3C4AuthorityHGNC:4767Mapping file id8351 NCBI fileEvidenceTAS
GeneH3C6AuthorityHGNC:4769Mapping file id8353 NCBI fileEvidenceTAS
GeneH3C7AuthorityHGNC:4773Mapping file id8968 NCBI fileEvidenceTAS
GeneH3C8AuthorityHGNC:4772Mapping file id8355 NCBI fileEvidenceTAS
GeneH4C1AuthorityHGNC:4781Mapping file id8359 NCBI fileEvidenceTAS
GeneH4C11AuthorityHGNC:4785Mapping file id8363 NCBI fileEvidenceTAS
GeneH4C12AuthorityHGNC:4784Mapping file id8362 NCBI fileEvidenceTAS
GeneH4C13AuthorityHGNC:4791Mapping file id8368 NCBI fileEvidenceTAS
GeneH4C14AuthorityHGNC:4794Mapping file id8370 NCBI fileEvidenceTAS
GeneH4C15AuthorityHGNC:29607Mapping file id554313 NCBI fileEvidenceTAS
GeneH4C16AuthorityHGNC:20510Mapping file id121504 NCBI fileEvidenceTAS
GeneH4C2AuthorityHGNC:4789Mapping file id8366 NCBI fileEvidenceTAS
GeneH4C3AuthorityHGNC:4787Mapping file id8364 NCBI fileEvidenceTAS
GeneH4C4AuthorityHGNC:4782Mapping file id8360 NCBI fileEvidenceTAS
GeneH4C5AuthorityHGNC:4790Mapping file id8367 NCBI fileEvidenceTAS
GeneH4C6AuthorityHGNC:4783Mapping file id8361 NCBI fileEvidenceTAS
GeneH4C8AuthorityHGNC:4788Mapping file id8365 NCBI fileEvidenceTAS
GeneH4C9AuthorityHGNC:4793Mapping file id8294 NCBI fileEvidenceTAS
GeneHAUS1AuthorityHGNC:25174Mapping file id115106 NCBI fileEvidenceTAS
GeneHAUS2AuthorityHGNC:25530Mapping file id55142 NCBI fileEvidenceTAS
GeneHAUS3AuthorityHGNC:28719Mapping file id79441 NCBI fileEvidenceTAS
GeneHAUS4AuthorityHGNC:20163Mapping file id54930 NCBI fileEvidenceTAS
GeneHAUS5AuthorityHGNC:29130Mapping file id23354 NCBI fileEvidenceTAS
GeneHAUS6AuthorityHGNC:25948Mapping file id54801 NCBI fileEvidenceTAS
GeneHAUS7AuthorityHGNC:32979Mapping file id55559 NCBI fileEvidenceTAS
GeneHAUS8AuthorityHGNC:30532Mapping file id93323 NCBI fileEvidenceTAS
GeneHDAC1AuthorityHGNC:4852Mapping file id3065 NCBI fileEvidenceIEA, TAS
GeneHDAC8AuthorityHGNC:13315Mapping file id55869 NCBI fileEvidenceTAS
GeneHJURPAuthorityHGNC:25444Mapping file id55355 NCBI fileEvidenceTAS
GeneHMMRAuthorityHGNC:5012Mapping file id3161 NCBI fileEvidenceTAS
GeneHSP90AA1AuthorityHGNC:5253Mapping file id3320 NCBI fileEvidenceTAS
GeneHSP90AB1AuthorityHGNC:5258Mapping file id3326 NCBI fileEvidenceTAS
GeneINCENPAuthorityHGNC:6058Mapping file id3619 NCBI fileEvidenceTAS
GeneIST1AuthorityHGNC:28977Mapping file id9798 NCBI fileEvidenceTAS
GeneITGB3BPAuthorityHGNC:6157Mapping file id23421 NCBI fileEvidenceTAS
GeneJAK2AuthorityHGNC:6192Mapping file id3717 NCBI fileEvidenceTAS
GeneKIF18AAuthorityHGNC:29441Mapping file id81930 NCBI fileEvidenceTAS
GeneKIF20AAuthorityHGNC:9787Mapping file id10112 NCBI fileEvidenceTAS
GeneKIF23AuthorityHGNC:6392Mapping file id9493 NCBI fileEvidenceTAS
GeneKIF2AAuthorityHGNC:6318Mapping file id3796 NCBI fileEvidenceTAS
GeneKIF2BAuthorityHGNC:29443Mapping file id84643 NCBI fileEvidenceTAS
GeneKIF2CAuthorityHGNC:6393Mapping file id11004 NCBI fileEvidenceTAS
GeneKMT5AAuthorityHGNC:29489Mapping file id387893 NCBI fileEvidenceTAS
GeneKNL1AuthorityHGNC:24054Mapping file id57082 NCBI fileEvidenceTAS
GeneKNTC1AuthorityHGNC:17255Mapping file id9735 NCBI fileEvidenceTAS
GeneKPNB1AuthorityHGNC:6400Mapping file id3837 NCBI fileEvidenceIEA, TAS
GeneLBRAuthorityHGNC:6518Mapping file id3930 NCBI fileEvidenceTAS
GeneLCMT1AuthorityHGNC:17557Mapping file id51451 NCBI fileEvidenceTAS
GeneLEMD2AuthorityHGNC:21244Mapping file id221496 NCBI fileEvidenceTAS
GeneLEMD3AuthorityHGNC:28887Mapping file id23592 NCBI fileEvidenceTAS
GeneLIG1AuthorityHGNC:6598Mapping file id3978 NCBI fileEvidenceTAS
GeneLIN37AuthorityHGNC:33234Mapping file id55957 NCBI fileEvidenceIEA, TAS
GeneLIN52AuthorityHGNC:19856Mapping file id91750 NCBI fileEvidenceIEA, TAS
GeneLIN54AuthorityHGNC:25397Mapping file id132660 NCBI fileEvidenceIEA, TAS
GeneLIN9AuthorityHGNC:30830Mapping file id286826 NCBI fileEvidenceIEA, TAS
GeneLMNAAuthorityHGNC:6636Mapping file id4000 NCBI fileEvidenceTAS
GeneLMNB1AuthorityHGNC:6637Mapping file id4001 NCBI fileEvidenceTAS
GeneLPIN1AuthorityHGNC:13345Mapping file id23175 NCBI fileEvidenceTAS
GeneLPIN2AuthorityHGNC:14450Mapping file id9663 NCBI fileEvidenceTAS
GeneLPIN3AuthorityHGNC:14451Mapping file id64900 NCBI fileEvidenceTAS
GeneLYNAuthorityHGNC:6735Mapping file id4067 NCBI fileEvidenceTAS
GeneMAD1L1AuthorityHGNC:6762Mapping file id8379 NCBI fileEvidenceTAS
GeneMAD2L1AuthorityHGNC:6763Mapping file id4085 NCBI fileEvidenceTAS
GeneMAPK1AuthorityHGNC:6871Mapping file id5594 NCBI fileEvidenceTAS
GeneMAPK3AuthorityHGNC:6877Mapping file id5595 NCBI fileEvidenceTAS
GeneMAPRE1AuthorityHGNC:6890Mapping file id22919 NCBI fileEvidenceTAS
GeneMASTLAuthorityHGNC:19042Mapping file id84930 NCBI fileEvidenceIEA, TAS
GeneMAU2AuthorityHGNC:29140Mapping file id23383 NCBI fileEvidenceTAS
GeneMAXAuthorityHGNC:6913Mapping file id4149 NCBI fileEvidenceTAS
GeneMCM10AuthorityHGNC:18043Mapping file id55388 NCBI fileEvidenceTAS
GeneMCM2AuthorityHGNC:6944Mapping file id4171 NCBI fileEvidenceIEA, TAS
GeneMCM3AuthorityHGNC:6945Mapping file id4172 NCBI fileEvidenceIEA, TAS
GeneMCM4AuthorityHGNC:6947Mapping file id4173 NCBI fileEvidenceIEA, TAS
GeneMCM5AuthorityHGNC:6948Mapping file id4174 NCBI fileEvidenceIEA, TAS
GeneMCM6AuthorityHGNC:6949Mapping file id4175 NCBI fileEvidenceIEA, TAS
GeneMCM7AuthorityHGNC:6950Mapping file id4176 NCBI fileEvidenceIEA, TAS
GeneMCM8AuthorityHGNC:16147Mapping file id84515 NCBI fileEvidenceIEA, TAS
GeneMCPH1AuthorityHGNC:6954Mapping file id79648 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.