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Pathway Human Homo sapiens

Transport of small molecules

R-HSA-382551 in Reactome release 97: a top-level pathway, with 722 genes placed in it by the mapping files and 11 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-382551 (mouse), R-RNO-382551 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 722 genes in this human pathway; showing 401 to 500, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 5 of 8
GenePSMD8AuthorityHGNC:9566Mapping file id5714 NCBI fileEvidenceTAS
GeneRAB11AAuthorityHGNC:9760Mapping file id8766 NCBI fileEvidenceTAS
GeneRAB11FIP2AuthorityHGNC:29152Mapping file id22841 NCBI fileEvidenceTAS
GeneRAF1AuthorityHGNC:9829Mapping file id5894 NCBI fileEvidenceTAS
GeneRHAGAuthorityHGNC:10006Mapping file id6005 NCBI fileEvidenceTAS
GeneRHBGAuthorityHGNC:14572Mapping file id57127 NCBI fileEvidenceTAS
GeneRHCGAuthorityHGNC:18140Mapping file id51458 NCBI fileEvidenceTAS
GeneRIPK1AuthorityHGNC:10019Mapping file id8737 NCBI fileEvidenceTAS
GeneRIPK3AuthorityHGNC:10021Mapping file id11035 NCBI fileEvidenceTAS
GeneRNF185AuthorityHGNC:26783Mapping file id91445 NCBI fileEvidenceTAS
GeneRNF5AuthorityHGNC:10068Mapping file id6048 NCBI fileEvidenceTAS
GeneRPS27AAuthorityHGNC:10417Mapping file id6233 NCBI fileEvidenceTAS
GeneRUNX1AuthorityHGNC:10471Mapping file id861 NCBI fileEvidenceTAS
GeneRYR1AuthorityHGNC:10483Mapping file id6261 NCBI fileEvidenceTAS
GeneRYR2AuthorityHGNC:10484Mapping file id6262 NCBI fileEvidenceTAS
GeneRYR3AuthorityHGNC:10485Mapping file id6263 NCBI fileEvidenceTAS
GeneSAR1BAuthorityHGNC:10535Mapping file id51128 NCBI fileEvidenceTAS
GeneSCARB1AuthorityHGNC:1664Mapping file id949 NCBI fileEvidenceTAS
GeneSCNN1AAuthorityHGNC:10599Mapping file id6337 NCBI fileEvidenceTAS
GeneSCNN1BAuthorityHGNC:10600Mapping file id6338 NCBI fileEvidenceTAS
GeneSCNN1DAuthorityHGNC:10601Mapping file id6339 NCBI fileEvidenceTAS
GeneSCNN1GAuthorityHGNC:10602Mapping file id6340 NCBI fileEvidenceTAS
GeneSEL1LAuthorityHGNC:10717Mapping file id6400 NCBI fileEvidenceTAS
GeneSEM1AuthorityHGNC:10845Mapping file id7979 NCBI fileEvidenceTAS
GeneSGK1AuthorityHGNC:10810Mapping file id6446 NCBI fileEvidenceTAS
GeneSGK2AuthorityHGNC:13900Mapping file id10110 NCBI fileEvidenceTAS
GeneSGK3AuthorityHGNC:10812Mapping file id23678 NCBI fileEvidenceTAS
GeneSKP1AuthorityHGNC:10899Mapping file id6500 NCBI fileEvidenceTAS
GeneSLC10A6AuthorityHGNC:30603Mapping file id345274 NCBI fileEvidenceTAS
GeneSLC11A1AuthorityHGNC:10907Mapping file id6556 NCBI fileEvidenceTAS
GeneSLC11A2AuthorityHGNC:10908Mapping file id4891 NCBI fileEvidenceTAS
GeneSLC12A1AuthorityHGNC:10910Mapping file id6557 NCBI fileEvidenceTAS
GeneSLC12A2AuthorityHGNC:10911Mapping file id6558 NCBI fileEvidenceTAS
GeneSLC12A3AuthorityHGNC:10912Mapping file id6559 NCBI fileEvidenceTAS
GeneSLC12A4AuthorityHGNC:10913Mapping file id6560 NCBI fileEvidenceTAS
GeneSLC12A5AuthorityHGNC:13818Mapping file id57468 NCBI fileEvidenceTAS
GeneSLC12A6AuthorityHGNC:10914Mapping file id9990 NCBI fileEvidenceTAS
GeneSLC12A7AuthorityHGNC:10915Mapping file id10723 NCBI fileEvidenceTAS
GeneSLC13A1AuthorityHGNC:10916Mapping file id6561 NCBI fileEvidenceTAS
GeneSLC13A2AuthorityHGNC:10917Mapping file id9058 NCBI fileEvidenceTAS
GeneSLC13A3AuthorityHGNC:14430Mapping file id64849 NCBI fileEvidenceTAS
GeneSLC13A4AuthorityHGNC:15827Mapping file id26266 NCBI fileEvidenceTAS
GeneSLC13A5AuthorityHGNC:23089Mapping file id284111 NCBI fileEvidenceTAS
GeneSLC14A1AuthorityHGNC:10918Mapping file id6563 NCBI fileEvidenceTAS
GeneSLC14A2AuthorityHGNC:10919Mapping file id8170 NCBI fileEvidenceTAS
GeneSLC15A1AuthorityHGNC:10920Mapping file id6564 NCBI fileEvidenceTAS
GeneSLC15A3AuthorityHGNC:18068Mapping file id51296 NCBI fileEvidenceTAS
GeneSLC15A4AuthorityHGNC:23090Mapping file id121260 NCBI fileEvidenceTAS
GeneSLC16A1AuthorityHGNC:10922Mapping file id6566 NCBI fileEvidenceTAS
GeneSLC16A10AuthorityHGNC:17027Mapping file id117247 NCBI fileEvidenceTAS
GeneSLC16A2AuthorityHGNC:10923Mapping file id6567 NCBI fileEvidenceTAS
GeneSLC16A3AuthorityHGNC:10924Mapping file id9123 NCBI fileEvidenceTAS
GeneSLC16A7AuthorityHGNC:10928Mapping file id9194 NCBI fileEvidenceTAS
GeneSLC16A8AuthorityHGNC:16270Mapping file id23539 NCBI fileEvidenceTAS
GeneSLC17A1AuthorityHGNC:10929Mapping file id6568 NCBI fileEvidenceTAS
GeneSLC17A3AuthorityHGNC:10931Mapping file id10786 NCBI fileEvidenceTAS
GeneSLC17A5AuthorityHGNC:10933Mapping file id26503 NCBI fileEvidenceTAS
GeneSLC17A6AuthorityHGNC:16703Mapping file id57084 NCBI fileEvidenceTAS
GeneSLC17A7AuthorityHGNC:16704Mapping file id57030 NCBI fileEvidenceTAS
GeneSLC17A8AuthorityHGNC:20151Mapping file id246213 NCBI fileEvidenceTAS
GeneSLC1A1AuthorityHGNC:10939Mapping file id6505 NCBI fileEvidenceTAS
GeneSLC1A2AuthorityHGNC:10940Mapping file id6506 NCBI fileEvidenceTAS
GeneSLC1A3AuthorityHGNC:10941Mapping file id6507 NCBI fileEvidenceTAS
GeneSLC1A4AuthorityHGNC:10942Mapping file id6509 NCBI fileEvidenceTAS
GeneSLC1A5AuthorityHGNC:10943Mapping file id6510 NCBI fileEvidenceTAS
GeneSLC1A6AuthorityHGNC:10944Mapping file id6511 NCBI fileEvidenceTAS
GeneSLC1A7AuthorityHGNC:10945Mapping file id6512 NCBI fileEvidenceTAS
GeneSLC20A1AuthorityHGNC:10946Mapping file id6574 NCBI fileEvidenceTAS
GeneSLC20A2AuthorityHGNC:10947Mapping file id6575 NCBI fileEvidenceTAS
GeneSLC22A1AuthorityHGNC:10963Mapping file id6580 NCBI fileEvidenceTAS
GeneSLC22A11AuthorityHGNC:18120Mapping file id55867 NCBI fileEvidenceTAS
GeneSLC22A12AuthorityHGNC:17989Mapping file id116085 NCBI fileEvidenceTAS
GeneSLC22A15AuthorityHGNC:20301Mapping file id55356 NCBI fileEvidenceTAS
GeneSLC22A16AuthorityHGNC:20302Mapping file id85413 NCBI fileEvidenceTAS
GeneSLC22A17AuthorityHGNC:23095Mapping file id51310 NCBI fileEvidenceIEA, TAS
GeneSLC22A2AuthorityHGNC:10966Mapping file id6582 NCBI fileEvidenceTAS
GeneSLC22A3AuthorityHGNC:10967Mapping file id6581 NCBI fileEvidenceTAS
GeneSLC22A4AuthorityHGNC:10968Mapping file id6583 NCBI fileEvidenceTAS
GeneSLC22A5AuthorityHGNC:10969Mapping file id6584 NCBI fileEvidenceTAS
GeneSLC22A6AuthorityHGNC:10970Mapping file id9356 NCBI fileEvidenceTAS
GeneSLC22A7AuthorityHGNC:10971Mapping file id10864 NCBI fileEvidenceTAS
GeneSLC22A8AuthorityHGNC:10972Mapping file id9376 NCBI fileEvidenceTAS
GeneSLC24A1AuthorityHGNC:10975Mapping file id9187 NCBI fileEvidenceTAS
GeneSLC24A2AuthorityHGNC:10976Mapping file id25769 NCBI fileEvidenceTAS
GeneSLC24A3AuthorityHGNC:10977Mapping file id57419 NCBI fileEvidenceTAS
GeneSLC24A4AuthorityHGNC:10978Mapping file id123041 NCBI fileEvidenceTAS
GeneSLC24A5AuthorityHGNC:20611Mapping file id283652 NCBI fileEvidenceTAS
GeneSLC25A1AuthorityHGNC:10979Mapping file id6576 NCBI fileEvidenceTAS
GeneSLC25A10AuthorityHGNC:10980Mapping file id1468 NCBI fileEvidenceTAS
GeneSLC25A11AuthorityHGNC:10981Mapping file id8402 NCBI fileEvidenceTAS
GeneSLC25A18AuthorityHGNC:10988Mapping file id83733 NCBI fileEvidenceTAS
GeneSLC25A22AuthorityHGNC:19954Mapping file id79751 NCBI fileEvidenceTAS
GeneSLC25A26AuthorityHGNC:20661Mapping file id115286 NCBI fileEvidenceTAS
GeneSLC25A29AuthorityHGNC:20116Mapping file id123096 NCBI fileEvidenceTAS
GeneSLC25A4AuthorityHGNC:10990Mapping file id291 NCBI fileEvidenceTAS
GeneSLC25A5AuthorityHGNC:10991Mapping file id292 NCBI fileEvidenceTAS
GeneSLC25A6AuthorityHGNC:10992Mapping file id293 NCBI fileEvidenceTAS
GeneSLC26A1AuthorityHGNC:10993Mapping file id10861 NCBI fileEvidenceTAS
GeneSLC26A11AuthorityHGNC:14471Mapping file id284129 NCBI fileEvidenceTAS
GeneSLC26A2AuthorityHGNC:10994Mapping file id1836 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.