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Pathway Human Homo sapiens

Transport of small molecules

R-HSA-382551 in Reactome release 97: a top-level pathway, with 722 genes placed in it by the mapping files and 11 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-382551 (mouse), R-RNO-382551 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 722 genes in this human pathway; showing 301 to 400, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 4 of 8
GeneLIPGAuthorityHGNC:6623Mapping file id9388 NCBI fileEvidenceTAS
GeneLMF1AuthorityHGNC:14154Mapping file id64788 NCBI fileEvidenceTAS
GeneLMF2AuthorityHGNC:25096Mapping file id91289 NCBI fileEvidenceTAS
GeneLPAAuthorityHGNC:6667Mapping file id4018 NCBI fileEvidenceTAS
GeneLPLAuthorityHGNC:6677Mapping file id4023 NCBI fileEvidenceTAS
GeneLRRC8AAuthorityHGNC:19027Mapping file id56262 NCBI fileEvidenceTAS
GeneLRRC8BAuthorityHGNC:30692Mapping file id23507 NCBI fileEvidenceTAS
GeneLRRC8CAuthorityHGNC:25075Mapping file id84230 NCBI fileEvidenceTAS
GeneLRRC8DAuthorityHGNC:16992Mapping file id55144 NCBI fileEvidenceTAS
GeneLRRC8EAuthorityHGNC:26272Mapping file id80131 NCBI fileEvidenceTAS
GeneLSRAuthorityHGNC:29572Mapping file id51599 NCBI fileEvidenceIEA
GeneMAGT1AuthorityHGNC:28880Mapping file id84061 NCBI fileEvidenceTAS
GeneMAIP1AuthorityHGNC:26198Mapping file id79568 NCBI fileEvidenceTAS
GeneMBAuthorityHGNC:6915Mapping file id4151 NCBI fileEvidenceTAS
GeneMBTPS1AuthorityHGNC:15456Mapping file id8720 NCBI fileEvidenceIEA
GeneMBTPS2AuthorityHGNC:15455Mapping file id51360 NCBI fileEvidenceIEA
GeneMCOLN1AuthorityHGNC:13356Mapping file id57192 NCBI fileEvidenceTAS
GeneMCOLN2AuthorityHGNC:13357Mapping file id255231 NCBI fileEvidenceTAS
GeneMCOLN3AuthorityHGNC:13358Mapping file id55283 NCBI fileEvidenceTAS
GeneMCUAuthorityHGNC:23526Mapping file id90550 NCBI fileEvidenceTAS
GeneMCUBAuthorityHGNC:26076Mapping file id55013 NCBI fileEvidenceTAS
GeneMICU1AuthorityHGNC:1530Mapping file id10367 NCBI fileEvidenceTAS
GeneMICU2AuthorityHGNC:31830Mapping file id221154 NCBI fileEvidenceTAS
GeneMICU3AuthorityHGNC:27820Mapping file id286097 NCBI fileEvidenceTAS
GeneMIPAuthorityHGNC:7103Mapping file id4284 NCBI fileEvidenceTAS
GeneMLKLAuthorityHGNC:26617Mapping file id197259 NCBI fileEvidenceTAS
GeneMMGT1AuthorityHGNC:28100Mapping file id93380 NCBI fileEvidenceIEA
GeneMRS2AuthorityHGNC:13785Mapping file id57380 NCBI fileEvidenceTAS
GeneMTTPAuthorityHGNC:7467Mapping file id4547 NCBI fileEvidenceTAS
GeneMYLIPAuthorityHGNC:21155Mapping file id29116 NCBI fileEvidenceTAS
GeneMYO5BAuthorityHGNC:7603Mapping file id4645 NCBI fileEvidenceTAS
GeneNALCNAuthorityHGNC:19082Mapping file id259232 NCBI fileEvidenceTAS
GeneNCEH1AuthorityHGNC:29260Mapping file id57552 NCBI fileEvidenceTAS
GeneNEDD4LAuthorityHGNC:7728Mapping file id23327 NCBI fileEvidenceTAS
GeneNEDD8AuthorityHGNC:7732Mapping file id4738 NCBI fileEvidenceTAS
GeneNGBAuthorityHGNC:14077Mapping file id58157 NCBI fileEvidenceTAS
GeneNIPA1AuthorityHGNC:17043Mapping file id123606 NCBI fileEvidenceTAS
GeneNIPA2AuthorityHGNC:17044Mapping file id81614 NCBI fileEvidenceTAS
GeneNIPAL1AuthorityHGNC:27194Mapping file id152519 NCBI fileEvidenceTAS
GeneNIPAL2AuthorityHGNC:25854Mapping file id79815 NCBI fileEvidenceTAS
GeneNIPAL3AuthorityHGNC:25233Mapping file id57185 NCBI fileEvidenceTAS
GeneNIPAL4AuthorityHGNC:28018Mapping file id348938 NCBI fileEvidenceTAS
GeneNPC1AuthorityHGNC:7897Mapping file id4864 NCBI fileEvidenceTAS
GeneNPC2AuthorityHGNC:14537Mapping file id10577 NCBI fileEvidenceTAS
GeneNR1H2AuthorityHGNC:7965Mapping file id7376 NCBI fileEvidenceTAS
GeneNR1H3AuthorityHGNC:7966Mapping file id10062 NCBI fileEvidenceTAS
GeneOS9AuthorityHGNC:16994Mapping file id10956 NCBI fileEvidenceTAS
GeneOSTM1AuthorityHGNC:21652Mapping file id28962 NCBI fileEvidenceTAS
GeneP4HBAuthorityHGNC:8548Mapping file id5034 NCBI fileEvidenceTAS
GenePARLAuthorityHGNC:18253Mapping file id55486 NCBI fileEvidenceTAS
GenePCSK5AuthorityHGNC:8747Mapping file id5125 NCBI fileEvidenceTAS
GenePCSK6AuthorityHGNC:8569Mapping file id5046 NCBI fileEvidenceTAS
GenePCSK9AuthorityHGNC:20001Mapping file id255738 NCBI fileEvidenceTAS
GenePDZD11AuthorityHGNC:28034Mapping file id51248 NCBI fileEvidenceTAS
GenePEX19AuthorityHGNC:9713Mapping file id5824 NCBI fileEvidenceTAS
GenePEX3AuthorityHGNC:8858Mapping file id8504 NCBI fileEvidenceTAS
GenePHB1AuthorityHGNC:8912Mapping file id5245 NCBI fileEvidenceTAS
GenePHB2AuthorityHGNC:30306Mapping file id11331 NCBI fileEvidenceTAS
GenePIPAuthorityHGNC:8993Mapping file id5304 NCBI fileEvidenceTAS
GenePLEKHA8AuthorityHGNC:30037Mapping file id84725 NCBI fileEvidenceTAS
GenePLNAuthorityHGNC:9080Mapping file id5350 NCBI fileEvidenceTAS
GenePLTPAuthorityHGNC:9093Mapping file id5360 NCBI fileEvidenceTAS
GenePMPCAAuthorityHGNC:18667Mapping file id23203 NCBI fileEvidenceTAS
GenePMPCBAuthorityHGNC:9119Mapping file id9512 NCBI fileEvidenceTAS
GenePRKACAAuthorityHGNC:9380Mapping file id5566 NCBI fileEvidenceTAS
GenePRKACBAuthorityHGNC:9381Mapping file id5567 NCBI fileEvidenceTAS
GenePRKACGAuthorityHGNC:9382Mapping file id5568 NCBI fileEvidenceTAS
GenePRKAR1AAuthorityHGNC:9388Mapping file id5573 NCBI fileEvidenceTAS
GenePRKAR1BAuthorityHGNC:9390Mapping file id5575 NCBI fileEvidenceTAS
GenePRKAR2AAuthorityHGNC:9391Mapping file id5576 NCBI fileEvidenceTAS
GenePRKAR2BAuthorityHGNC:9392Mapping file id5577 NCBI fileEvidenceTAS
GenePSMA1AuthorityHGNC:9530Mapping file id5682 NCBI fileEvidenceTAS
GenePSMA2AuthorityHGNC:9531Mapping file id5683 NCBI fileEvidenceTAS
GenePSMA3AuthorityHGNC:9532Mapping file id5684 NCBI fileEvidenceTAS
GenePSMA4AuthorityHGNC:9533Mapping file id5685 NCBI fileEvidenceTAS
GenePSMA5AuthorityHGNC:9534Mapping file id5686 NCBI fileEvidenceTAS
GenePSMA6AuthorityHGNC:9535Mapping file id5687 NCBI fileEvidenceTAS
GenePSMA7AuthorityHGNC:9536Mapping file id5688 NCBI fileEvidenceTAS
GenePSMB1AuthorityHGNC:9537Mapping file id5689 NCBI fileEvidenceTAS
GenePSMB2AuthorityHGNC:9539Mapping file id5690 NCBI fileEvidenceTAS
GenePSMB3AuthorityHGNC:9540Mapping file id5691 NCBI fileEvidenceTAS
GenePSMB4AuthorityHGNC:9541Mapping file id5692 NCBI fileEvidenceTAS
GenePSMB5AuthorityHGNC:9542Mapping file id5693 NCBI fileEvidenceTAS
GenePSMB6AuthorityHGNC:9543Mapping file id5694 NCBI fileEvidenceTAS
GenePSMB7AuthorityHGNC:9544Mapping file id5695 NCBI fileEvidenceTAS
GenePSMC1AuthorityHGNC:9547Mapping file id5700 NCBI fileEvidenceTAS
GenePSMC2AuthorityHGNC:9548Mapping file id5701 NCBI fileEvidenceTAS
GenePSMC3AuthorityHGNC:9549Mapping file id5702 NCBI fileEvidenceTAS
GenePSMC4AuthorityHGNC:9551Mapping file id5704 NCBI fileEvidenceTAS
GenePSMC5AuthorityHGNC:9552Mapping file id5705 NCBI fileEvidenceTAS
GenePSMC6AuthorityHGNC:9553Mapping file id5706 NCBI fileEvidenceTAS
GenePSMD1AuthorityHGNC:9554Mapping file id5707 NCBI fileEvidenceTAS
GenePSMD11AuthorityHGNC:9556Mapping file id5717 NCBI fileEvidenceTAS
GenePSMD12AuthorityHGNC:9557Mapping file id5718 NCBI fileEvidenceTAS
GenePSMD13AuthorityHGNC:9558Mapping file id5719 NCBI fileEvidenceTAS
GenePSMD14AuthorityHGNC:16889Mapping file id10213 NCBI fileEvidenceTAS
GenePSMD2AuthorityHGNC:9559Mapping file id5708 NCBI fileEvidenceTAS
GenePSMD3AuthorityHGNC:9560Mapping file id5709 NCBI fileEvidenceTAS
GenePSMD6AuthorityHGNC:9564Mapping file id9861 NCBI fileEvidenceTAS
GenePSMD7AuthorityHGNC:9565Mapping file id5713 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.