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Pathway Human Homo sapiens

Cell Cycle, Mitotic

R-HSA-69278 in Reactome release 97: under Cell Cycle, with 555 genes placed in it by the mapping files and 5 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-69278 (mouse), R-RNO-69278 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 555 genes in this human pathway; showing 101 to 200, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 6
GeneCEP41AuthorityHGNC:12370Mapping file id95681 NCBI fileEvidenceTAS
GeneCEP43AuthorityHGNC:17012Mapping file id11116 NCBI fileEvidenceTAS
GeneCEP57AuthorityHGNC:30794Mapping file id9702 NCBI fileEvidenceTAS
GeneCEP63AuthorityHGNC:25815Mapping file id80254 NCBI fileEvidenceTAS
GeneCEP70AuthorityHGNC:29972Mapping file id80321 NCBI fileEvidenceTAS
GeneCEP72AuthorityHGNC:25547Mapping file id55722 NCBI fileEvidenceTAS
GeneCEP76AuthorityHGNC:25727Mapping file id79959 NCBI fileEvidenceTAS
GeneCEP78AuthorityHGNC:25740Mapping file id84131 NCBI fileEvidenceTAS
GeneCETN2AuthorityHGNC:1867Mapping file id1069 NCBI fileEvidenceTAS
GeneCHMP2AAuthorityHGNC:30216Mapping file id27243 NCBI fileEvidenceTAS
GeneCHMP2BAuthorityHGNC:24537Mapping file id25978 NCBI fileEvidenceTAS
GeneCHMP3AuthorityHGNC:29865Mapping file id51652 NCBI fileEvidenceTAS
GeneCHMP4AAuthorityHGNC:20274Mapping file id29082 NCBI fileEvidenceTAS
GeneCHMP4BAuthorityHGNC:16171Mapping file id128866 NCBI fileEvidenceTAS
GeneCHMP4CAuthorityHGNC:30599Mapping file id92421 NCBI fileEvidenceTAS
GeneCHMP6AuthorityHGNC:25675Mapping file id79643 NCBI fileEvidenceTAS
GeneCHMP7AuthorityHGNC:28439Mapping file id91782 NCBI fileEvidenceTAS
GeneCKAP5AuthorityHGNC:28959Mapping file id9793 NCBI fileEvidenceTAS
GeneCKS1BAuthorityHGNC:19083Mapping file id1163 NCBI fileEvidenceTAS
GeneCLASP1AuthorityHGNC:17088Mapping file id23332 NCBI fileEvidenceTAS
GeneCLASP2AuthorityHGNC:17078Mapping file id23122 NCBI fileEvidenceTAS
GeneCLIP1AuthorityHGNC:10461Mapping file id6249 NCBI fileEvidenceTAS
GeneCNEP1R1AuthorityHGNC:26759Mapping file id255919 NCBI fileEvidenceTAS
GeneCNTRLAuthorityHGNC:1858Mapping file id11064 NCBI fileEvidenceTAS
GeneCPAPAuthorityHGNC:17272Mapping file id55835 NCBI fileEvidenceTAS
GeneCSNK1DAuthorityHGNC:2452Mapping file id1453 NCBI fileEvidenceTAS
GeneCSNK1EAuthorityHGNC:2453Mapping file id1454 NCBI fileEvidenceTAS
GeneCSNK2A1AuthorityHGNC:2457Mapping file id1457 NCBI fileEvidenceTAS
GeneCSNK2A2AuthorityHGNC:2459Mapping file id1459 NCBI fileEvidenceTAS
GeneCSNK2BAuthorityHGNC:2460Mapping file id1460 NCBI fileEvidenceTAS
GeneCTDNEP1AuthorityHGNC:19085Mapping file id23399 NCBI fileEvidenceTAS
GeneCUL1AuthorityHGNC:2551Mapping file id8454 NCBI fileEvidenceTAS
GeneDBF4AuthorityHGNC:17364Mapping file id10926 NCBI fileEvidenceTAS
GeneDCTN1AuthorityHGNC:2711Mapping file id1639 NCBI fileEvidenceTAS
GeneDCTN2AuthorityHGNC:2712Mapping file id10540 NCBI fileEvidenceTAS
GeneDCTN3AuthorityHGNC:2713Mapping file id11258 NCBI fileEvidenceTAS
GeneDHFRAuthorityHGNC:2861Mapping file id1719 NCBI fileEvidenceTAS
GeneDNA2AuthorityHGNC:2939Mapping file id1763 NCBI fileEvidenceTAS
GeneDSN1AuthorityHGNC:16165Mapping file id79980 NCBI fileEvidenceTAS
GeneDYNC1H1AuthorityHGNC:2961Mapping file id1778 NCBI fileEvidenceTAS
GeneDYNC1I1AuthorityHGNC:2963Mapping file id1780 NCBI fileEvidenceTAS
GeneDYNC1I2AuthorityHGNC:2964Mapping file id1781 NCBI fileEvidenceTAS
GeneDYNC1LI1AuthorityHGNC:18745Mapping file id51143 NCBI fileEvidenceTAS
GeneDYNC1LI2AuthorityHGNC:2966Mapping file id1783 NCBI fileEvidenceTAS
GeneDYNLL1AuthorityHGNC:15476Mapping file id8655 NCBI fileEvidenceTAS
GeneDYNLL2AuthorityHGNC:24596Mapping file id140735 NCBI fileEvidenceTAS
GeneDYRK1AAuthorityHGNC:3091Mapping file id1859 NCBI fileEvidenceTAS
GeneE2F1AuthorityHGNC:3113Mapping file id1869 NCBI fileEvidenceIEA, TAS
GeneE2F2AuthorityHGNC:3114Mapping file id1870 NCBI fileEvidenceTAS
GeneE2F3AuthorityHGNC:3115Mapping file id1871 NCBI fileEvidenceTAS
GeneE2F4AuthorityHGNC:3118Mapping file id1874 NCBI fileEvidenceIEA, TAS
GeneE2F5AuthorityHGNC:3119Mapping file id1875 NCBI fileEvidenceIEA, TAS
GeneE2F6AuthorityHGNC:3120Mapping file id1876 NCBI fileEvidenceTAS
GeneEMDAuthorityHGNC:3331Mapping file id2010 NCBI fileEvidenceTAS
GeneEML4AuthorityHGNC:1316Mapping file id27436 NCBI fileEvidenceTAS
GeneENSAAuthorityHGNC:3360Mapping file id2029 NCBI fileEvidenceIEA, TAS
GeneEP300AuthorityHGNC:3373Mapping file id2033 NCBI fileEvidenceTAS
GeneERCC6LAuthorityHGNC:20794Mapping file id54821 NCBI fileEvidenceTAS
GeneESCO1AuthorityHGNC:24645Mapping file id114799 NCBI fileEvidenceTAS
GeneESCO2AuthorityHGNC:27230Mapping file id157570 NCBI fileEvidenceTAS
GeneESPL1AuthorityHGNC:16856Mapping file id9700 NCBI fileEvidenceTAS
GeneFBXL18AuthorityHGNC:21874Mapping file id80028 NCBI fileEvidenceTAS
GeneFBXL7AuthorityHGNC:13604Mapping file id23194 NCBI fileEvidenceTAS
GeneFBXO5AuthorityHGNC:13584Mapping file id26271 NCBI fileEvidenceTAS
GeneFBXW11AuthorityHGNC:13607Mapping file id23291 NCBI fileEvidenceTAS
GeneFEN1AuthorityHGNC:3650Mapping file id2237 NCBI fileEvidenceTAS
GeneFIRRMAuthorityHGNC:25565Mapping file id55732 NCBI fileEvidenceTAS
GeneFKBPLAuthorityHGNC:13949Mapping file id63943 NCBI fileEvidenceTAS
GeneFOXM1AuthorityHGNC:3818Mapping file id2305 NCBI fileEvidenceTAS
GeneFZR1AuthorityHGNC:24824Mapping file id51343 NCBI fileEvidenceTAS
GeneGINS1AuthorityHGNC:28980Mapping file id9837 NCBI fileEvidenceIEA, TAS
GeneGINS2AuthorityHGNC:24575Mapping file id51659 NCBI fileEvidenceIEA, TAS
GeneGINS3AuthorityHGNC:25851Mapping file id64785 NCBI fileEvidenceIEA, TAS
GeneGINS4AuthorityHGNC:28226Mapping file id84296 NCBI fileEvidenceIEA, TAS
GeneGMNNAuthorityHGNC:17493Mapping file id51053 NCBI fileEvidenceTAS
GeneGOLGA2AuthorityHGNC:4425Mapping file id2801 NCBI fileEvidenceIEA, TAS
GeneGORASP1AuthorityHGNC:16769Mapping file id64689 NCBI fileEvidenceIEA, TAS
GeneGORASP2AuthorityHGNC:17500Mapping file id26003 NCBI fileEvidenceTAS
GeneGSK3BAuthorityHGNC:4617Mapping file id2932 NCBI fileEvidenceIEA
GeneGTSE1AuthorityHGNC:13698Mapping file id51512 NCBI fileEvidenceTAS
GeneH2AB1AuthorityHGNC:22516Mapping file id474382 NCBI fileEvidenceTAS
GeneH2AC14AuthorityHGNC:4727Mapping file id8331 NCBI fileEvidenceTAS
GeneH2AC18AuthorityHGNC:4736Mapping file id8337 NCBI fileEvidenceTAS
GeneH2AC19AuthorityHGNC:29668Mapping file id723790 NCBI fileEvidenceTAS
GeneH2AC20AuthorityHGNC:4738Mapping file id8338 NCBI fileEvidenceTAS
GeneH2AC4AuthorityHGNC:4734Mapping file id8335 NCBI fileEvidenceTAS
GeneH2AC6AuthorityHGNC:4733Mapping file id8334 NCBI fileEvidenceTAS
GeneH2AC7AuthorityHGNC:4729Mapping file id3013 NCBI fileEvidenceTAS
GeneH2AC8AuthorityHGNC:4724Mapping file id3012 NCBI fileEvidenceTAS
GeneH2AJAuthorityHGNC:14456Mapping file id55766 NCBI fileEvidenceTAS
GeneH2AXAuthorityHGNC:4739Mapping file id3014 NCBI fileEvidenceTAS
GeneH2AZ2AuthorityHGNC:20664Mapping file id94239 NCBI fileEvidenceTAS
GeneH2BC1AuthorityHGNC:18730Mapping file id255626 NCBI fileEvidenceTAS
GeneH2BC10AuthorityHGNC:4756Mapping file id8346 NCBI fileEvidenceTAS
GeneH2BC11AuthorityHGNC:4761Mapping file id8970 NCBI fileEvidenceTAS
GeneH2BC12AuthorityHGNC:13954Mapping file id85236 NCBI fileEvidenceTAS
GeneH2BC12LAuthorityHGNC:4762Mapping file id54145 NCBI fileEvidenceTAS
GeneH2BC13AuthorityHGNC:4748Mapping file id8340 NCBI fileEvidenceTAS
GeneH2BC14AuthorityHGNC:4750Mapping file id8342 NCBI fileEvidenceTAS
GeneH2BC15AuthorityHGNC:4749Mapping file id8341 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.