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Pathway Human Homo sapiens

Fatty acid metabolism

R-HSA-8978868 in Reactome release 97: under Metabolism of lipids, with 175 genes placed in it by the mapping files and 6 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-8978868 (mouse), R-RNO-8978868 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 175 genes in this human pathway; showing 101 to 175, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 2
GeneGPX1AuthorityHGNC:4553Mapping file id2876 NCBI fileEvidenceIEA, TAS
GeneGPX2AuthorityHGNC:4554Mapping file id2877 NCBI fileEvidenceIEA, TAS
GeneGPX4AuthorityHGNC:4556Mapping file id2879 NCBI fileEvidenceIEA, TAS
GeneHACD1AuthorityHGNC:9639Mapping file id9200 NCBI fileEvidenceTAS
GeneHACD2AuthorityHGNC:9640Mapping file id201562 NCBI fileEvidenceTAS
GeneHACD3AuthorityHGNC:24175Mapping file id51495 NCBI fileEvidenceTAS
GeneHACD4AuthorityHGNC:20920Mapping file id401494 NCBI fileEvidenceTAS
GeneHACL1AuthorityHGNC:17856Mapping file id26061 NCBI fileEvidenceTAS
GeneHADHAuthorityHGNC:4799Mapping file id3033 NCBI fileEvidenceTAS
GeneHADHAAuthorityHGNC:4801Mapping file id3030 NCBI fileEvidenceTAS
GeneHADHBAuthorityHGNC:4803Mapping file id3032 NCBI fileEvidenceTAS
GeneHAO2AuthorityHGNC:4810Mapping file id51179 NCBI fileEvidenceTAS
GeneHPGDAuthorityHGNC:5154Mapping file id3248 NCBI fileEvidenceIEA
GeneHPGDSAuthorityHGNC:17890Mapping file id27306 NCBI fileEvidenceTAS
GeneHSD17B12AuthorityHGNC:18646Mapping file id51144 NCBI fileEvidenceTAS
GeneHSD17B3AuthorityHGNC:5212Mapping file id3293 NCBI fileEvidenceTAS
GeneHSD17B4AuthorityHGNC:5213Mapping file id3295 NCBI fileEvidenceTAS
GeneHSD17B8AuthorityHGNC:3554Mapping file id7923 NCBI fileEvidenceTAS
GeneHTD2AuthorityHGNC:53111Mapping file id109703458 NCBI fileEvidenceTAS
GeneLTA4HAuthorityHGNC:6710Mapping file id4048 NCBI fileEvidenceTAS
GeneLTC4SAuthorityHGNC:6719Mapping file id4056 NCBI fileEvidenceTAS
GeneMAPKAPK2AuthorityHGNC:6887Mapping file id9261 NCBI fileEvidenceTAS
GeneMCATAuthorityHGNC:29622Mapping file id27349 NCBI fileEvidenceTAS
GeneMCEEAuthorityHGNC:16732Mapping file id84693 NCBI fileEvidenceTAS
GeneMECRAuthorityHGNC:19691Mapping file id51102 NCBI fileEvidenceTAS
GeneMID1IP1AuthorityHGNC:20715Mapping file id58526 NCBI fileEvidenceTAS
GeneMLYCDAuthorityHGNC:7150Mapping file id23417 NCBI fileEvidenceTAS
GeneMMAAAuthorityHGNC:18871Mapping file id166785 NCBI fileEvidenceTAS
GeneMMUTAuthorityHGNC:7526Mapping file id4594 NCBI fileEvidenceTAS
GeneMORC2AuthorityHGNC:23573Mapping file id22880 NCBI fileEvidenceTAS
GeneNDUFAB1AuthorityHGNC:7694Mapping file id4706 NCBI fileEvidenceTAS
GeneNUDT19AuthorityHGNC:32036Mapping file id390916 NCBI fileEvidenceTAS
GeneNUDT7AuthorityHGNC:8054Mapping file id283927 NCBI fileEvidenceIEA
GeneOLAHAuthorityHGNC:25625Mapping file id55301 NCBI fileEvidenceIEA
GenePCCAAuthorityHGNC:8653Mapping file id5095 NCBI fileEvidenceTAS
GenePCCBAuthorityHGNC:8654Mapping file id5096 NCBI fileEvidenceTAS
GenePCTPAuthorityHGNC:8752Mapping file id58488 NCBI fileEvidenceTAS
GenePECRAuthorityHGNC:18281Mapping file id55825 NCBI fileEvidenceTAS
GenePHYHAuthorityHGNC:8940Mapping file id5264 NCBI fileEvidenceTAS
GenePLA2G4AAuthorityHGNC:9035Mapping file id5321 NCBI fileEvidenceTAS
GenePON1AuthorityHGNC:9204Mapping file id5444 NCBI fileEvidenceTAS
GenePON2AuthorityHGNC:9205Mapping file id5445 NCBI fileEvidenceTAS
GenePON3AuthorityHGNC:9206Mapping file id5446 NCBI fileEvidenceTAS
GenePPARDAuthorityHGNC:9235Mapping file id5467 NCBI fileEvidenceTAS
GenePPT1AuthorityHGNC:9325Mapping file id5538 NCBI fileEvidenceTAS
GenePPT2AuthorityHGNC:9326Mapping file id9374 NCBI fileEvidenceTAS
GenePRKAA2AuthorityHGNC:9377Mapping file id5563 NCBI fileEvidenceTAS
GenePRKAB2AuthorityHGNC:9379Mapping file id5565 NCBI fileEvidenceTAS
GenePRKAG2AuthorityHGNC:9386Mapping file id51422 NCBI fileEvidenceTAS
GenePRXL2BAuthorityHGNC:28390Mapping file id127281 NCBI fileEvidenceIEA
GenePTGDSAuthorityHGNC:9592Mapping file id5730 NCBI fileEvidenceTAS
GenePTGESAuthorityHGNC:9599Mapping file id9536 NCBI fileEvidenceTAS
GenePTGES2AuthorityHGNC:17822Mapping file id80142 NCBI fileEvidenceTAS
GenePTGES3AuthorityHGNC:16049Mapping file id10728 NCBI fileEvidenceTAS
GenePTGISAuthorityHGNC:9603Mapping file id5740 NCBI fileEvidenceTAS
GenePTGR1AuthorityHGNC:18429Mapping file id22949 NCBI fileEvidenceIEA
GenePTGR2AuthorityHGNC:20149Mapping file id145482 NCBI fileEvidenceIEA
GenePTGS1AuthorityHGNC:9604Mapping file id5742 NCBI fileEvidenceTAS
GenePTGS2AuthorityHGNC:9605Mapping file id5743 NCBI fileEvidenceTAS
GeneRXRAAuthorityHGNC:10477Mapping file id6256 NCBI fileEvidenceTAS
GeneSCDAuthorityHGNC:10571Mapping file id6319 NCBI fileEvidenceTAS
GeneSCD5AuthorityHGNC:21088Mapping file id79966 NCBI fileEvidenceTAS
GeneSCP2AuthorityHGNC:10606Mapping file id6342 NCBI fileEvidenceTAS
GeneSLC22A5AuthorityHGNC:10969Mapping file id6584 NCBI fileEvidenceTAS
GeneSLC25A17AuthorityHGNC:10987Mapping file id10478 NCBI fileEvidenceTAS
GeneSLC25A20AuthorityHGNC:1421Mapping file id788 NCBI fileEvidenceTAS
GeneSLC27A1AuthorityHGNC:10995Mapping file id376497 NCBI fileEvidenceIEA
GeneSLC27A2AuthorityHGNC:10996Mapping file id11001 NCBI fileEvidenceTAS
GeneSLC27A3AuthorityHGNC:10997Mapping file id11000 NCBI fileEvidenceIEA
GeneTBXAS1AuthorityHGNC:11609Mapping file id6916 NCBI fileEvidenceTAS
GeneTECRAuthorityHGNC:4551Mapping file id9524 NCBI fileEvidenceTAS
GeneTECRLAuthorityHGNC:27365Mapping file id253017 NCBI fileEvidenceTAS
GeneTHEM4AuthorityHGNC:17947Mapping file id117145 NCBI fileEvidenceTAS
GeneTHEM5AuthorityHGNC:26755Mapping file id284486 NCBI fileEvidenceTAS
GeneTHRSPAuthorityHGNC:11800Mapping file id7069 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.