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Pathway Human Homo sapiens

Dengue Virus Infection

R-HSA-9839923 in Reactome release 97: under Viral Infection Pathways, with 404 genes placed in it by the mapping files and 4 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id; neither of the other two lists holds it. Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 404 genes in this human pathway; showing 201 to 300, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 3 of 5
GeneHSP90AB1AuthorityHGNC:5258Mapping file id3326 NCBI fileEvidenceTAS
GeneHSPA1AAuthorityHGNC:5232Mapping file id3303 NCBI fileEvidenceTAS
GeneHSPA1BAuthorityHGNC:5233Mapping file id3304 NCBI fileEvidenceTAS
GeneHSPA5AuthorityHGNC:5238Mapping file id3309 NCBI fileEvidenceTAS
GeneHSPA8AuthorityHGNC:5241Mapping file id3312 NCBI fileEvidenceTAS
GeneHSPG2AuthorityHGNC:5273Mapping file id3339 NCBI fileEvidenceTAS
GeneHYOU1AuthorityHGNC:16931Mapping file id10525 NCBI fileEvidenceTAS
GeneIFIH1AuthorityHGNC:18873Mapping file id64135 NCBI fileEvidenceTAS
GeneIKBKEAuthorityHGNC:14552Mapping file id9641 NCBI fileEvidenceTAS
GeneIPO7AuthorityHGNC:9852Mapping file id10527 NCBI fileEvidenceTAS
GeneISY1AuthorityHGNC:29201Mapping file id57461 NCBI fileEvidenceTAS
GeneISY1-RAB43AuthorityHGNC:42969Mapping file id100534599 NCBI fileEvidenceTAS
GeneKDELR1AuthorityHGNC:6304Mapping file id10945 NCBI fileEvidenceTAS
GeneKPNA1AuthorityHGNC:6394Mapping file id3836 NCBI fileEvidenceIEA, TAS
GeneKPNA2AuthorityHGNC:6395Mapping file id3838 NCBI fileEvidenceIEA, TAS
GeneKPNA3AuthorityHGNC:6396Mapping file id3839 NCBI fileEvidenceIEA, TAS
GeneKPNA4AuthorityHGNC:6397Mapping file id3840 NCBI fileEvidenceIEA, TAS
GeneKPNA5AuthorityHGNC:6398Mapping file id3841 NCBI fileEvidenceIEA, TAS
GeneKPNA7AuthorityHGNC:21839Mapping file id402569 NCBI fileEvidenceIEA, TAS
GeneKPNB1AuthorityHGNC:6400Mapping file id3837 NCBI fileEvidenceIEA, TAS
GeneLEO1AuthorityHGNC:30401Mapping file id123169 NCBI fileEvidenceTAS
GeneLY6EAuthorityHGNC:6727Mapping file id4061 NCBI fileEvidenceTAS
GeneLY96AuthorityHGNC:17156Mapping file id23643 NCBI fileEvidenceTAS
GeneLYNAuthorityHGNC:6735Mapping file id4067 NCBI fileEvidenceTAS
GeneMAGT1AuthorityHGNC:28880Mapping file id84061 NCBI fileEvidenceTAS
GeneMAP1LC3BAuthorityHGNC:13352Mapping file id81631 NCBI fileEvidenceTAS
GeneMAPKAP1AuthorityHGNC:18752Mapping file id79109 NCBI fileEvidenceTAS
GeneMAPRE3AuthorityHGNC:6892Mapping file id22924 NCBI fileEvidenceTAS
GeneMAVSAuthorityHGNC:29233Mapping file id57506 NCBI fileEvidenceTAS
GeneMBL2AuthorityHGNC:6922Mapping file id4153 NCBI fileEvidenceTAS
GeneMERTKAuthorityHGNC:7027Mapping file id10461 NCBI fileEvidenceTAS
GeneMLST8AuthorityHGNC:24825Mapping file id64223 NCBI fileEvidenceTAS
GeneMMP9AuthorityHGNC:7176Mapping file id4318 NCBI fileEvidenceTAS
GeneMRC1AuthorityHGNC:7228Mapping file id4360 NCBI fileEvidenceTAS
GeneMTORAuthorityHGNC:3942Mapping file id2475 NCBI fileEvidenceTAS
GeneNACAAuthorityHGNC:7629Mapping file id4666 NCBI fileEvidenceTAS
GeneNCBP1AuthorityHGNC:7658Mapping file id4686 NCBI fileEvidenceTAS
GeneNCBP2AuthorityHGNC:7659Mapping file id22916 NCBI fileEvidenceTAS
GeneNEK2AuthorityHGNC:7745Mapping file id4751 NCBI fileEvidenceTAS
GeneNFKBIAAuthorityHGNC:7797Mapping file id4792 NCBI fileEvidenceTAS
GeneNFKBIBAuthorityHGNC:7798Mapping file id4793 NCBI fileEvidenceTAS
GeneNMT1AuthorityHGNC:7857Mapping file id4836 NCBI fileEvidenceTAS
GeneNPLOC4AuthorityHGNC:18261Mapping file id55666 NCBI fileEvidenceTAS
GeneNRBP1AuthorityHGNC:7993Mapping file id29959 NCBI fileEvidenceTAS
GeneNUCLEOLINAuthorityHGNC:7667Mapping file id4691 NCBI fileEvidenceTAS
GeneNUDT21AuthorityHGNC:13870Mapping file id11051 NCBI fileEvidenceTAS
GeneOST4AuthorityHGNC:32483Mapping file id100128731 NCBI fileEvidenceTAS
GeneOSTCAuthorityHGNC:24448Mapping file id58505 NCBI fileEvidenceTAS
GeneP4HA1AuthorityHGNC:8546Mapping file id5033 NCBI fileEvidenceTAS
GeneP4HA2AuthorityHGNC:8547Mapping file id8974 NCBI fileEvidenceTAS
GeneP4HA3AuthorityHGNC:30135Mapping file id283208 NCBI fileEvidenceTAS
GeneP4HBAuthorityHGNC:8548Mapping file id5034 NCBI fileEvidenceTAS
GenePABPC1AuthorityHGNC:8554Mapping file id26986 NCBI fileEvidenceTAS
GenePABPN1AuthorityHGNC:8565Mapping file id8106 NCBI fileEvidenceTAS
GenePAF1AuthorityHGNC:25459Mapping file id54623 NCBI fileEvidenceTAS
GenePAPOLAAuthorityHGNC:14981Mapping file id10914 NCBI fileEvidenceTAS
GenePCBP1AuthorityHGNC:8647Mapping file id5093 NCBI fileEvidenceTAS
GenePCBP2AuthorityHGNC:8648Mapping file id5094 NCBI fileEvidenceTAS
GenePCF11AuthorityHGNC:30097Mapping file id51585 NCBI fileEvidenceTAS
GenePDCD6IPAuthorityHGNC:8766Mapping file id10015 NCBI fileEvidenceTAS
GenePDIA3AuthorityHGNC:4606Mapping file id2923 NCBI fileEvidenceTAS
GenePEX19AuthorityHGNC:9713Mapping file id5824 NCBI fileEvidenceTAS
GenePHF5AAuthorityHGNC:18000Mapping file id84844 NCBI fileEvidenceTAS
GenePIK3C3AuthorityHGNC:8974Mapping file id5289 NCBI fileEvidenceTAS
GenePIK3R1AuthorityHGNC:8979Mapping file id5295 NCBI fileEvidenceTAS
GenePIK3R4AuthorityHGNC:8982Mapping file id30849 NCBI fileEvidenceTAS
GenePLRG1AuthorityHGNC:9089Mapping file id5356 NCBI fileEvidenceTAS
GenePMLAuthorityHGNC:9113Mapping file id5371 NCBI fileEvidenceTAS
GenePOLR2AAuthorityHGNC:9187Mapping file id5430 NCBI fileEvidenceTAS
GenePOLR2BAuthorityHGNC:9188Mapping file id5431 NCBI fileEvidenceTAS
GenePOLR2CAuthorityHGNC:9189Mapping file id5432 NCBI fileEvidenceTAS
GenePOLR2DAuthorityHGNC:9191Mapping file id5433 NCBI fileEvidenceTAS
GenePOLR2EAuthorityHGNC:9192Mapping file id5434 NCBI fileEvidenceTAS
GenePOLR2FAuthorityHGNC:9193Mapping file id5435 NCBI fileEvidenceTAS
GenePOLR2GAuthorityHGNC:9194Mapping file id5436 NCBI fileEvidenceTAS
GenePOLR2HAuthorityHGNC:9195Mapping file id5437 NCBI fileEvidenceTAS
GenePOLR2IAuthorityHGNC:9196Mapping file id5438 NCBI fileEvidenceTAS
GenePOLR2JAuthorityHGNC:9197Mapping file id5439 NCBI fileEvidenceTAS
GenePOLR2KAuthorityHGNC:9198Mapping file id5440 NCBI fileEvidenceTAS
GenePOLR2LAuthorityHGNC:9199Mapping file id5441 NCBI fileEvidenceTAS
GenePPIEAuthorityHGNC:9258Mapping file id10450 NCBI fileEvidenceTAS
GenePPIL1AuthorityHGNC:9260Mapping file id51645 NCBI fileEvidenceTAS
GenePPIL3AuthorityHGNC:9262Mapping file id53938 NCBI fileEvidenceTAS
GenePPIL4AuthorityHGNC:15702Mapping file id85313 NCBI fileEvidenceTAS
GenePPIL6AuthorityHGNC:21557Mapping file id285755 NCBI fileEvidenceTAS
GenePQBP1AuthorityHGNC:9330Mapping file id10084 NCBI fileEvidenceTAS
GenePRCCAuthorityHGNC:9343Mapping file id5546 NCBI fileEvidenceTAS
GenePRKG1AuthorityHGNC:9414Mapping file id5592 NCBI fileEvidenceIEA
GenePRKG2AuthorityHGNC:9416Mapping file id5593 NCBI fileEvidenceIEA
GenePROS1AuthorityHGNC:9456Mapping file id5627 NCBI fileEvidenceTAS
GenePRPF19AuthorityHGNC:17896Mapping file id27339 NCBI fileEvidenceTAS
GenePRPF6AuthorityHGNC:15860Mapping file id24148 NCBI fileEvidenceTAS
GenePRPF8AuthorityHGNC:17340Mapping file id10594 NCBI fileEvidenceTAS
GenePRR5AuthorityHGNC:31682Mapping file id55615 NCBI fileEvidenceTAS
GenePTBP1AuthorityHGNC:9583Mapping file id5725 NCBI fileEvidenceTAS
GenePUF60AuthorityHGNC:17042Mapping file id22827 NCBI fileEvidenceTAS
GeneRBM10AuthorityHGNC:9896Mapping file id8241 NCBI fileEvidenceTAS
GeneRBM17AuthorityHGNC:16944Mapping file id84991 NCBI fileEvidenceTAS
GeneRBM22AuthorityHGNC:25503Mapping file id55696 NCBI fileEvidenceTAS
GeneRBM5AuthorityHGNC:9902Mapping file id10181 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.