Pathway Human Homo sapiens
Transport of small molecules
R-HSA-382551 in Reactome release 97: a top-level pathway, with 722 genes placed in it by the mapping files and 11 child pathways in the hierarchy.
The same number in the other species
Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-382551 (mouse), R-RNO-382551 (rat). Whether the event was inferred from this one is what the record says.
01The record
Reactome's own record of this pathway
What this tells you
The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.
Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions.
[R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.
On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available.
[R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required.
[R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.
A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].
- [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
- [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
- [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
- [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
- [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
02The genes
Genes Reactome places in this human pathway
The mapping files place 722 genes in this human pathway; showing 201 to 300, in pages of 100, sorted by symbol for reading. The order carries no ranking.
| Gene | Authority id | Mapping file id | Evidence codes |
|---|---|---|---|
| GeneCLCA2 | AuthorityHGNC:2016 | Mapping file id9635 NCBI file | EvidenceTAS |
| GeneCLCA4 | AuthorityHGNC:2018 | Mapping file id22802 NCBI file | EvidenceTAS |
| GeneCLCN1 | AuthorityHGNC:2019 | Mapping file id1180 NCBI file | EvidenceTAS |
| GeneCLCN2 | AuthorityHGNC:2020 | Mapping file id1181 NCBI file | EvidenceTAS |
| GeneCLCN3 | AuthorityHGNC:2021 | Mapping file id1182 NCBI file | EvidenceIEA |
| GeneCLCN4 | AuthorityHGNC:2022 | Mapping file id1183 NCBI file | EvidenceTAS |
| GeneCLCN5 | AuthorityHGNC:2023 | Mapping file id1184 NCBI file | EvidenceTAS |
| GeneCLCN6 | AuthorityHGNC:2024 | Mapping file id1185 NCBI file | EvidenceTAS |
| GeneCLCN7 | AuthorityHGNC:2025 | Mapping file id1186 NCBI file | EvidenceTAS |
| GeneCLCNKA | AuthorityHGNC:2026 | Mapping file id1187 NCBI file | EvidenceTAS |
| GeneCLCNKB | AuthorityHGNC:2027 | Mapping file id1188 NCBI file | EvidenceTAS |
| GeneCLIC2 | AuthorityHGNC:2063 | Mapping file id1193 NCBI file | EvidenceTAS |
| GeneCLN3 | AuthorityHGNC:2074 | Mapping file id1201 NCBI file | EvidenceTAS |
| GeneCLTA | AuthorityHGNC:2090 | Mapping file id1211 NCBI file | EvidenceTAS |
| GeneCLTC | AuthorityHGNC:2092 | Mapping file id1213 NCBI file | EvidenceTAS |
| GeneCP | AuthorityHGNC:2295 | Mapping file id1356 NCBI file | EvidenceTAS |
| GeneCPTP | AuthorityHGNC:28116 | Mapping file id80772 NCBI file | EvidenceTAS |
| GeneCREB3L3 | AuthorityHGNC:18855 | Mapping file id84699 NCBI file | EvidenceIEA |
| GeneCSN1S1 | AuthorityHGNC:2445 | Mapping file id1446 NCBI file | EvidenceTAS |
| GeneCSN3 | AuthorityHGNC:2446 | Mapping file id1448 NCBI file | EvidenceTAS |
| GeneCTNS | AuthorityHGNC:2518 | Mapping file id1497 NCBI file | EvidenceTAS |
| GeneCUBN | AuthorityHGNC:2548 | Mapping file id8029 NCBI file | EvidenceTAS |
| GeneCUL1 | AuthorityHGNC:2551 | Mapping file id8454 NCBI file | EvidenceTAS |
| GeneCUTC | AuthorityHGNC:24271 | Mapping file id51076 NCBI file | EvidenceIEA |
| GeneCYB5R1 | AuthorityHGNC:13397 | Mapping file id51706 NCBI file | EvidenceTAS |
| GeneCYB5R2 | AuthorityHGNC:24376 | Mapping file id51700 NCBI file | EvidenceTAS |
| GeneCYB5R4 | AuthorityHGNC:20147 | Mapping file id51167 NCBI file | EvidenceTAS |
| GeneCYB5RL | AuthorityHGNC:32220 | Mapping file id606495 NCBI file | EvidenceTAS |
| GeneCYBRD1 | AuthorityHGNC:20797 | Mapping file id79901 NCBI file | EvidenceTAS |
| GeneCYGB | AuthorityHGNC:16505 | Mapping file id114757 NCBI file | EvidenceTAS |
| GeneDERL1 | AuthorityHGNC:28454 | Mapping file id79139 NCBI file | EvidenceTAS |
| GeneDERL2 | AuthorityHGNC:17943 | Mapping file id51009 NCBI file | EvidenceTAS |
| GeneDERL3 | AuthorityHGNC:14236 | Mapping file id91319 NCBI file | EvidenceTAS |
| GeneDMTN | AuthorityHGNC:3382 | Mapping file id2039 NCBI file | EvidenceTAS |
| GeneEIF2S1 | AuthorityHGNC:3265 | Mapping file id1965 NCBI file | EvidenceTAS |
| GeneEIF2S2 | AuthorityHGNC:3266 | Mapping file id8894 NCBI file | EvidenceTAS |
| GeneEIF2S3 | AuthorityHGNC:3267 | Mapping file id1968 NCBI file | EvidenceTAS |
| GeneEMB | AuthorityHGNC:30465 | Mapping file id133418 NCBI file | EvidenceTAS |
| GeneERLEC1 | AuthorityHGNC:25222 | Mapping file id27248 NCBI file | EvidenceTAS |
| GeneERLIN1 | AuthorityHGNC:16947 | Mapping file id10613 NCBI file | EvidenceTAS |
| GeneERLIN2 | AuthorityHGNC:1356 | Mapping file id11160 NCBI file | EvidenceTAS |
| GeneESYT1 | AuthorityHGNC:29534 | Mapping file id23344 NCBI file | EvidenceTAS |
| GeneESYT2 | AuthorityHGNC:22211 | Mapping file id57488 NCBI file | EvidenceTAS |
| GeneESYT3 | AuthorityHGNC:24295 | Mapping file id83850 NCBI file | EvidenceTAS |
| GeneFBXL5 | AuthorityHGNC:13602 | Mapping file id26234 NCBI file | EvidenceTAS |
| GeneFGF21 | AuthorityHGNC:3678 | Mapping file id26291 NCBI file | EvidenceIEA, TAS |
| GeneFKBP1B | AuthorityHGNC:3712 | Mapping file id2281 NCBI file | EvidenceTAS |
| GeneFLVCR1 | AuthorityHGNC:24682 | Mapping file id28982 NCBI file | EvidenceTAS |
| GeneFTH1 | AuthorityHGNC:3976 | Mapping file id2495 NCBI file | EvidenceTAS |
| GeneFTL | AuthorityHGNC:3999 | Mapping file id2512 NCBI file | EvidenceTAS |
| GeneFTMT | AuthorityHGNC:17345 | Mapping file id94033 NCBI file | EvidenceTAS |
| GeneFURIN | AuthorityHGNC:8568 | Mapping file id5045 NCBI file | EvidenceTAS |
| GeneFXYD1 | AuthorityHGNC:4025 | Mapping file id5348 NCBI file | EvidenceTAS |
| GeneFXYD2 | AuthorityHGNC:4026 | Mapping file id486 NCBI file | EvidenceTAS |
| GeneFXYD3 | AuthorityHGNC:4027 | Mapping file id5349 NCBI file | EvidenceTAS |
| GeneFXYD4 | AuthorityHGNC:4028 | Mapping file id53828 NCBI file | EvidenceTAS |
| GeneFXYD6 | AuthorityHGNC:4030 | Mapping file id53826 NCBI file | EvidenceTAS |
| GeneFXYD7 | AuthorityHGNC:4034 | Mapping file id53822 NCBI file | EvidenceTAS |
| GeneGLRX3 | AuthorityHGNC:15987 | Mapping file id10539 NCBI file | EvidenceTAS |
| GeneGLTP | AuthorityHGNC:24867 | Mapping file id51228 NCBI file | EvidenceTAS |
| GeneGNAS | AuthorityHGNC:4392 | Mapping file id2778 NCBI file | EvidenceTAS |
| GeneGNB1 | AuthorityHGNC:4396 | Mapping file id2782 NCBI file | EvidenceTAS |
| GeneGNB2 | AuthorityHGNC:4398 | Mapping file id2783 NCBI file | EvidenceTAS |
| GeneGNB3 | AuthorityHGNC:4400 | Mapping file id2784 NCBI file | EvidenceTAS |
| GeneGNB4 | AuthorityHGNC:20731 | Mapping file id59345 NCBI file | EvidenceTAS |
| GeneGNB5 | AuthorityHGNC:4401 | Mapping file id10681 NCBI file | EvidenceTAS |
| GeneGNG10 | AuthorityHGNC:4402 | Mapping file id2790 NCBI file | EvidenceTAS |
| GeneGNG11 | AuthorityHGNC:4403 | Mapping file id2791 NCBI file | EvidenceTAS |
| GeneGNG12 | AuthorityHGNC:19663 | Mapping file id55970 NCBI file | EvidenceTAS |
| GeneGNG13 | AuthorityHGNC:14131 | Mapping file id51764 NCBI file | EvidenceTAS |
| GeneGNG2 | AuthorityHGNC:4404 | Mapping file id54331 NCBI file | EvidenceTAS |
| GeneGNG3 | AuthorityHGNC:4405 | Mapping file id2785 NCBI file | EvidenceTAS |
| GeneGNG4 | AuthorityHGNC:4407 | Mapping file id2786 NCBI file | EvidenceTAS |
| GeneGNG5 | AuthorityHGNC:4408 | Mapping file id2787 NCBI file | EvidenceTAS |
| GeneGNG7 | AuthorityHGNC:4410 | Mapping file id2788 NCBI file | EvidenceTAS |
| GeneGNG8 | AuthorityHGNC:19664 | Mapping file id94235 NCBI file | EvidenceTAS |
| GeneGNGT1 | AuthorityHGNC:4411 | Mapping file id2792 NCBI file | EvidenceTAS |
| GeneGNGT2 | AuthorityHGNC:4412 | Mapping file id2793 NCBI file | EvidenceTAS |
| GeneGPIHBP1 | AuthorityHGNC:24945 | Mapping file id338328 NCBI file | EvidenceTAS |
| GeneHBA1 | AuthorityHGNC:4823 | Mapping file id3039 NCBI file | EvidenceTAS |
| GeneHBA2 | AuthorityHGNC:4824 | Mapping file id3040 NCBI file | EvidenceTAS |
| GeneHBB | AuthorityHGNC:4827 | Mapping file id3043 NCBI file | EvidenceTAS |
| GeneHDLBP | AuthorityHGNC:4857 | Mapping file id3069 NCBI file | EvidenceTAS |
| GeneHEPH | AuthorityHGNC:4866 | Mapping file id9843 NCBI file | EvidenceTAS |
| GeneHFE | AuthorityHGNC:4886 | Mapping file id3077 NCBI file | EvidenceTAS |
| GeneHMOX1 | AuthorityHGNC:5013 | Mapping file id3162 NCBI file | EvidenceTAS |
| GeneHMOX2 | AuthorityHGNC:5014 | Mapping file id3163 NCBI file | EvidenceTAS |
| GeneIREB2 | AuthorityHGNC:6115 | Mapping file id3658 NCBI file | EvidenceTAS |
| GeneKCNJ11 | AuthorityHGNC:6257 | Mapping file id3767 NCBI file | EvidenceTAS |
| GeneLCAT | AuthorityHGNC:6522 | Mapping file id3931 NCBI file | EvidenceTAS |
| GeneLCN1 | AuthorityHGNC:6525 | Mapping file id3933 NCBI file | EvidenceTAS |
| GeneLCN12 | AuthorityHGNC:28733 | Mapping file id286256 NCBI file | EvidenceTAS |
| GeneLCN15 | AuthorityHGNC:33777 | Mapping file id389812 NCBI file | EvidenceTAS |
| GeneLCN2 | AuthorityHGNC:6526 | Mapping file id3934 NCBI file | EvidenceIEA, TAS |
| GeneLCN9 | AuthorityHGNC:17442 | Mapping file idENSG00000148386 Ensembl file | EvidenceTAS |
| GeneLDLR | AuthorityHGNC:6547 | Mapping file id3949 NCBI file | EvidenceIEA, TAS |
| GeneLDLRAP1 | AuthorityHGNC:18640 | Mapping file id26119 NCBI file | EvidenceTAS |
| GeneLETM1 | AuthorityHGNC:6556 | Mapping file id3954 NCBI file | EvidenceIEA |
| GeneLIPA | AuthorityHGNC:6617 | Mapping file id3988 NCBI file | EvidenceTAS |
| GeneLIPC | AuthorityHGNC:6619 | Mapping file id3990 NCBI file | EvidenceTAS |
Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.
- Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.
03The hierarchy
Parents and children in this release's hierarchy
Parents
None: this is a top-level pathway of the release.
Children
- ABC-family protein mediated transportR-HSA-38255690 genes
- Aquaporin-mediated transportR-HSA-44571752 genes
- Glycosphingolipid transportR-HSA-98455768 genes
- Intracellular oxygen transportR-HSA-89816073 genes
- Ion channel transportR-HSA-983712185 genes
- Iron uptake and transportR-HSA-91793758 genes
- Miscellaneous transport and binding eventsR-HSA-522334529 genes
- Mitochondrial calcium ion transportR-HSA-894921523 genes
- O2/CO2 exchange in erythrocytesR-HSA-148092613 genes
- Plasma lipoprotein assembly, remodeling, and clearanceR-HSA-17482475 genes
- SLC-mediated transmembrane transportR-HSA-425407245 genes
Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.
- Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.