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Pathway Human Homo sapiens

Transport of small molecules

R-HSA-382551 in Reactome release 97: a top-level pathway, with 722 genes placed in it by the mapping files and 11 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-382551 (mouse), R-RNO-382551 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 722 genes in this human pathway; showing 201 to 300, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 3 of 8
GeneCLCA2AuthorityHGNC:2016Mapping file id9635 NCBI fileEvidenceTAS
GeneCLCA4AuthorityHGNC:2018Mapping file id22802 NCBI fileEvidenceTAS
GeneCLCN1AuthorityHGNC:2019Mapping file id1180 NCBI fileEvidenceTAS
GeneCLCN2AuthorityHGNC:2020Mapping file id1181 NCBI fileEvidenceTAS
GeneCLCN3AuthorityHGNC:2021Mapping file id1182 NCBI fileEvidenceIEA
GeneCLCN4AuthorityHGNC:2022Mapping file id1183 NCBI fileEvidenceTAS
GeneCLCN5AuthorityHGNC:2023Mapping file id1184 NCBI fileEvidenceTAS
GeneCLCN6AuthorityHGNC:2024Mapping file id1185 NCBI fileEvidenceTAS
GeneCLCN7AuthorityHGNC:2025Mapping file id1186 NCBI fileEvidenceTAS
GeneCLCNKAAuthorityHGNC:2026Mapping file id1187 NCBI fileEvidenceTAS
GeneCLCNKBAuthorityHGNC:2027Mapping file id1188 NCBI fileEvidenceTAS
GeneCLIC2AuthorityHGNC:2063Mapping file id1193 NCBI fileEvidenceTAS
GeneCLN3AuthorityHGNC:2074Mapping file id1201 NCBI fileEvidenceTAS
GeneCLTAAuthorityHGNC:2090Mapping file id1211 NCBI fileEvidenceTAS
GeneCLTCAuthorityHGNC:2092Mapping file id1213 NCBI fileEvidenceTAS
GeneCPAuthorityHGNC:2295Mapping file id1356 NCBI fileEvidenceTAS
GeneCPTPAuthorityHGNC:28116Mapping file id80772 NCBI fileEvidenceTAS
GeneCREB3L3AuthorityHGNC:18855Mapping file id84699 NCBI fileEvidenceIEA
GeneCSN1S1AuthorityHGNC:2445Mapping file id1446 NCBI fileEvidenceTAS
GeneCSN3AuthorityHGNC:2446Mapping file id1448 NCBI fileEvidenceTAS
GeneCTNSAuthorityHGNC:2518Mapping file id1497 NCBI fileEvidenceTAS
GeneCUBNAuthorityHGNC:2548Mapping file id8029 NCBI fileEvidenceTAS
GeneCUL1AuthorityHGNC:2551Mapping file id8454 NCBI fileEvidenceTAS
GeneCUTCAuthorityHGNC:24271Mapping file id51076 NCBI fileEvidenceIEA
GeneCYB5R1AuthorityHGNC:13397Mapping file id51706 NCBI fileEvidenceTAS
GeneCYB5R2AuthorityHGNC:24376Mapping file id51700 NCBI fileEvidenceTAS
GeneCYB5R4AuthorityHGNC:20147Mapping file id51167 NCBI fileEvidenceTAS
GeneCYB5RLAuthorityHGNC:32220Mapping file id606495 NCBI fileEvidenceTAS
GeneCYBRD1AuthorityHGNC:20797Mapping file id79901 NCBI fileEvidenceTAS
GeneCYGBAuthorityHGNC:16505Mapping file id114757 NCBI fileEvidenceTAS
GeneDERL1AuthorityHGNC:28454Mapping file id79139 NCBI fileEvidenceTAS
GeneDERL2AuthorityHGNC:17943Mapping file id51009 NCBI fileEvidenceTAS
GeneDERL3AuthorityHGNC:14236Mapping file id91319 NCBI fileEvidenceTAS
GeneDMTNAuthorityHGNC:3382Mapping file id2039 NCBI fileEvidenceTAS
GeneEIF2S1AuthorityHGNC:3265Mapping file id1965 NCBI fileEvidenceTAS
GeneEIF2S2AuthorityHGNC:3266Mapping file id8894 NCBI fileEvidenceTAS
GeneEIF2S3AuthorityHGNC:3267Mapping file id1968 NCBI fileEvidenceTAS
GeneEMBAuthorityHGNC:30465Mapping file id133418 NCBI fileEvidenceTAS
GeneERLEC1AuthorityHGNC:25222Mapping file id27248 NCBI fileEvidenceTAS
GeneERLIN1AuthorityHGNC:16947Mapping file id10613 NCBI fileEvidenceTAS
GeneERLIN2AuthorityHGNC:1356Mapping file id11160 NCBI fileEvidenceTAS
GeneESYT1AuthorityHGNC:29534Mapping file id23344 NCBI fileEvidenceTAS
GeneESYT2AuthorityHGNC:22211Mapping file id57488 NCBI fileEvidenceTAS
GeneESYT3AuthorityHGNC:24295Mapping file id83850 NCBI fileEvidenceTAS
GeneFBXL5AuthorityHGNC:13602Mapping file id26234 NCBI fileEvidenceTAS
GeneFGF21AuthorityHGNC:3678Mapping file id26291 NCBI fileEvidenceIEA, TAS
GeneFKBP1BAuthorityHGNC:3712Mapping file id2281 NCBI fileEvidenceTAS
GeneFLVCR1AuthorityHGNC:24682Mapping file id28982 NCBI fileEvidenceTAS
GeneFTH1AuthorityHGNC:3976Mapping file id2495 NCBI fileEvidenceTAS
GeneFTLAuthorityHGNC:3999Mapping file id2512 NCBI fileEvidenceTAS
GeneFTMTAuthorityHGNC:17345Mapping file id94033 NCBI fileEvidenceTAS
GeneFURINAuthorityHGNC:8568Mapping file id5045 NCBI fileEvidenceTAS
GeneFXYD1AuthorityHGNC:4025Mapping file id5348 NCBI fileEvidenceTAS
GeneFXYD2AuthorityHGNC:4026Mapping file id486 NCBI fileEvidenceTAS
GeneFXYD3AuthorityHGNC:4027Mapping file id5349 NCBI fileEvidenceTAS
GeneFXYD4AuthorityHGNC:4028Mapping file id53828 NCBI fileEvidenceTAS
GeneFXYD6AuthorityHGNC:4030Mapping file id53826 NCBI fileEvidenceTAS
GeneFXYD7AuthorityHGNC:4034Mapping file id53822 NCBI fileEvidenceTAS
GeneGLRX3AuthorityHGNC:15987Mapping file id10539 NCBI fileEvidenceTAS
GeneGLTPAuthorityHGNC:24867Mapping file id51228 NCBI fileEvidenceTAS
GeneGNASAuthorityHGNC:4392Mapping file id2778 NCBI fileEvidenceTAS
GeneGNB1AuthorityHGNC:4396Mapping file id2782 NCBI fileEvidenceTAS
GeneGNB2AuthorityHGNC:4398Mapping file id2783 NCBI fileEvidenceTAS
GeneGNB3AuthorityHGNC:4400Mapping file id2784 NCBI fileEvidenceTAS
GeneGNB4AuthorityHGNC:20731Mapping file id59345 NCBI fileEvidenceTAS
GeneGNB5AuthorityHGNC:4401Mapping file id10681 NCBI fileEvidenceTAS
GeneGNG10AuthorityHGNC:4402Mapping file id2790 NCBI fileEvidenceTAS
GeneGNG11AuthorityHGNC:4403Mapping file id2791 NCBI fileEvidenceTAS
GeneGNG12AuthorityHGNC:19663Mapping file id55970 NCBI fileEvidenceTAS
GeneGNG13AuthorityHGNC:14131Mapping file id51764 NCBI fileEvidenceTAS
GeneGNG2AuthorityHGNC:4404Mapping file id54331 NCBI fileEvidenceTAS
GeneGNG3AuthorityHGNC:4405Mapping file id2785 NCBI fileEvidenceTAS
GeneGNG4AuthorityHGNC:4407Mapping file id2786 NCBI fileEvidenceTAS
GeneGNG5AuthorityHGNC:4408Mapping file id2787 NCBI fileEvidenceTAS
GeneGNG7AuthorityHGNC:4410Mapping file id2788 NCBI fileEvidenceTAS
GeneGNG8AuthorityHGNC:19664Mapping file id94235 NCBI fileEvidenceTAS
GeneGNGT1AuthorityHGNC:4411Mapping file id2792 NCBI fileEvidenceTAS
GeneGNGT2AuthorityHGNC:4412Mapping file id2793 NCBI fileEvidenceTAS
GeneGPIHBP1AuthorityHGNC:24945Mapping file id338328 NCBI fileEvidenceTAS
GeneHBA1AuthorityHGNC:4823Mapping file id3039 NCBI fileEvidenceTAS
GeneHBA2AuthorityHGNC:4824Mapping file id3040 NCBI fileEvidenceTAS
GeneHBBAuthorityHGNC:4827Mapping file id3043 NCBI fileEvidenceTAS
GeneHDLBPAuthorityHGNC:4857Mapping file id3069 NCBI fileEvidenceTAS
GeneHEPHAuthorityHGNC:4866Mapping file id9843 NCBI fileEvidenceTAS
GeneHFEAuthorityHGNC:4886Mapping file id3077 NCBI fileEvidenceTAS
GeneHMOX1AuthorityHGNC:5013Mapping file id3162 NCBI fileEvidenceTAS
GeneHMOX2AuthorityHGNC:5014Mapping file id3163 NCBI fileEvidenceTAS
GeneIREB2AuthorityHGNC:6115Mapping file id3658 NCBI fileEvidenceTAS
GeneKCNJ11AuthorityHGNC:6257Mapping file id3767 NCBI fileEvidenceTAS
GeneLCATAuthorityHGNC:6522Mapping file id3931 NCBI fileEvidenceTAS
GeneLCN1AuthorityHGNC:6525Mapping file id3933 NCBI fileEvidenceTAS
GeneLCN12AuthorityHGNC:28733Mapping file id286256 NCBI fileEvidenceTAS
GeneLCN15AuthorityHGNC:33777Mapping file id389812 NCBI fileEvidenceTAS
GeneLCN2AuthorityHGNC:6526Mapping file id3934 NCBI fileEvidenceIEA, TAS
GeneLCN9AuthorityHGNC:17442Mapping file idENSG00000148386 Ensembl fileEvidenceTAS
GeneLDLRAuthorityHGNC:6547Mapping file id3949 NCBI fileEvidenceIEA, TAS
GeneLDLRAP1AuthorityHGNC:18640Mapping file id26119 NCBI fileEvidenceTAS
GeneLETM1AuthorityHGNC:6556Mapping file id3954 NCBI fileEvidenceIEA
GeneLIPAAuthorityHGNC:6617Mapping file id3988 NCBI fileEvidenceTAS
GeneLIPCAuthorityHGNC:6619Mapping file id3990 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.